MIPO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIPO1_HUMAN
• UniProt AC: Q8TD10
• Protein Name: Mirror-image polydactyly gene 1 protein
• Gene Name: MIPOL1
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Protein Sequence: MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMRTVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	EKSMHRKSTELVNEI HHHHCHHHHHHHHHH	27.37	28348404
43	Phosphorylation	KSMHRKSTELVNEIT HHHCHHHHHHHHHHC	36.05	24719451
50	Phosphorylation	TELVNEITCENTEWP HHHHHHHCCCCCCCC	13.95	29449344
58 (in isoform 2)	Ubiquitination	-	36.28	21906983
77	Phosphorylation	YPDDESVYCTTEKYN CCCCCCEEEECCCCC	8.05	27642862
95	Phosphorylation	HRHNDMHYECMTPCQ CCCCCCCCEEECCCE	12.27	21945579
99	Phosphorylation	DMHYECMTPCQVTSD CCCCEEECCCEECCC	32.35	21945579
104	Phosphorylation	CMTPCQVTSDSDKEK EECCCEECCCCCHHH	10.84	21945579
105	Phosphorylation	MTPCQVTSDSDKEKT ECCCEECCCCCHHHH	35.94	21945579
112	Phosphorylation	SDSDKEKTIAFLLKE CCCCHHHHHHHHHHH	20.73	27251275
147	Methylation	EQRKLKFKLELQEKE HHHHHHHHHHHHHHH	39.19	-
153	Methylation	FKLELQEKETEAKIA HHHHHHHHHHHHHHH	57.91	-
175	Ubiquitination	EEVYFAQKERDEAVM HHHHHHHHHHHHHHH	51.81	-
205	Phosphorylation	RAKHMEMSLKVLENI HHHHHHHHHHHHHHC	16.25	29691806
239	Ubiquitination	DTGIAIQKNGAIIVD CCCEEEEECCEEEEE	51.76	2190698
239 (in isoform 1)	Ubiquitination	-	51.76	21906983
249	Phosphorylation	AIIVDRIYKTKECKM EEEEECCCCCCCCCC	17.31	23403867
350	Phosphorylation	YSLHKSLSQEENLKD HHHHHCCCCCCCHHH	42.51	28348404
356	Ubiquitination	LSQEENLKDQFNYTL CCCCCCHHHHHCHHH	62.15	-
435	Phosphorylation	VLRKKVGTGTMRTVI HHHHHHCCCCCCCCC	32.25	18691976

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIPO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIPO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIPO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIPO1_HUMAN	MIPOL1	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
MAGA6_HUMAN	MAGEA6	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.