ELMD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELMD3_HUMAN
• UniProt AC: Q96FG2
• Protein Name: ELMO domain-containing protein 3
• Gene Name: ELMOD3
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Cell projection, stereocilium . Cell projection, kinocilium. Cytoplasm, cytoskeleton . Also present in the cuticular plate of auditory hair cells. Expressed along the length of the stereocilia, but excluded from the very tip (By similarity). Colocali
• Protein Description: Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity..
• Protein Sequence: MNEKSCSFHSKEELRDGQGERLSAGYSPSYDKDKSVLAFRGIPISELKNHGILQALTTEAYEWEPRVVSTEVVRAQEEWEAVDTIQPETGSQASSEQPGQLISFSEALQHFQTVDLSPFKKRIQPTIRRTGLAALRHYLFGPPKLHQRLREERDLVLTIAQCGLDSQDPVHGRVLQTIYKKLTGSKFDCALHGNHWEDLGFQGANPATDLRGAGFLALLHLLYLVMDSKTLPMAQEIFRLSRHHIQQFPFCLMSVNITHIAIQALREECLSRECNRQQKVIPVVNSFYAATFLHLAHVWRTQRKTISDSGFVLKELEVLAKKSPRRLLKTLELYLARVSKGQASLLGAQKCYGPEAPPFKDLTFTGESDLQSHSSEGVWLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNEKSCSFHSKE ---CCCCCCCCCCHH	14.60	24719451
7	Phosphorylation	-MNEKSCSFHSKEEL -CCCCCCCCCCHHHH	32.84	27251275
10	Phosphorylation	EKSCSFHSKEELRDG CCCCCCCCHHHHCCC	39.49	27251275
26	Phosphorylation	GERLSAGYSPSYDKD CCCCCCCCCCCCCCC	19.68	-
27	Phosphorylation	ERLSAGYSPSYDKDK CCCCCCCCCCCCCCC	13.37	21815630
61	Phosphorylation	QALTTEAYEWEPRVV HHHCCCCHHCCCEEE	18.49	-
223	Phosphorylation	LALLHLLYLVMDSKT HHHHHHHHHHHCCCC	12.01	19835603
228	Phosphorylation	LLYLVMDSKTLPMAQ HHHHHHCCCCCHHHH	14.94	19835603
309	Phosphorylation	QRKTISDSGFVLKEL CCCCCCCCCCHHHHH	27.60	-
323	Phosphorylation	LEVLAKKSPRRLLKT HHHHHHCCHHHHHHH	23.96	-
330	Phosphorylation	SPRRLLKTLELYLAR CHHHHHHHHHHHHHH	25.98	26657352
334	Phosphorylation	LLKTLELYLARVSKG HHHHHHHHHHHHCCC	6.74	26657352
340	Acetylation	LYLARVSKGQASLLG HHHHHHCCCHHHHHC	52.78	24431573

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELMD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELMD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELMD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APRV1_HUMAN	ASPRV1	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
APRV1_HUMAN	ASPRV1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615429: Deafness, autosomal recessive, 88 (DFNB88)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.