dbPTM

APRV1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	APRV1_HUMAN
UniProt AC	Q53RT3
Protein Name	Retroviral-like aspartic protease 1
Gene Name	ASPRV1 {ECO:0000250\|UniProtKB:Q09PK2}
Organism	Homo sapiens (Human).
Sequence Length	343
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description
Protein Sequence	MGSPGASLGIKKALQSEQATALPASAPAVSQPTAPAPSCLPKAGQVIPTLLREAPFSSVIAPTLLCGFLFLAWVAAEVPEESSRMAGSGARSEEGRRQHAFVPEPFDGANVVPNLWLHSFEVINDLNHWDHITKLRFLKESLRGEALGVYNRLSPQDQGDYGTVKEALLKAFGVPGAAPSHLPKEIVFANSMGKGYYLKGKIGKVPVRFLVDSGAQVSVVHPNLWEEVTDGDLDTLQPFENVVKVANGAEMKILGVWDTAVSLGKLKLKAQFLVANASAEEAIIGTDVLQDHNAILDFEHRTCTLKGKKFRLLPVGGSLEDEFDLELIEEDPSSEEGRQELSH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGSPGASLGIKKAL -CCCCCHHHHHHHHH	32.80	29396449
161	Phosphorylation	SPQDQGDYGTVKEAL CCCCCCCHHHHHHHH	22.86	-
180	Phosphorylation	GVPGAAPSHLPKEIV CCCCCCCCCCCCEEE	32.69	-
196	Phosphorylation	ANSMGKGYYLKGKIG ECCCCCCEEECCCCC	14.76	22817900
197	Phosphorylation	NSMGKGYYLKGKIGK CCCCCCEEECCCCCE	15.59	22817900
276	N-linked_Glycosylation	KAQFLVANASAEEAI HHEEEEECCCHHHHH	27.27	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of APRV1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of APRV1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of APRV1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
WIPI3_HUMAN	WDR45B	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of APRV1_HUMAN

Related Literatures of Post-Translational Modification