UniProt ID | WDR5B_HUMAN | |
---|---|---|
UniProt AC | Q86VZ2 | |
Protein Name | WD repeat-containing protein 5B | |
Gene Name | WDR5B | |
Organism | Homo sapiens (Human). | |
Sequence Length | 330 | |
Subcellular Localization | ||
Protein Description | May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.. | |
Protein Sequence | MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
16 | Phosphorylation | AKAQLALSSSANQSK HHHHHHHHCCCCCCC | 19.35 | 29759185 | |
17 | Phosphorylation | KAQLALSSSANQSKE HHHHHHHCCCCCCCC | 34.03 | 29759185 | |
18 | Phosphorylation | AQLALSSSANQSKEV HHHHHHCCCCCCCCC | 28.06 | 29759185 | |
22 | Phosphorylation | LSSSANQSKEVPENP HHCCCCCCCCCCCCC | 30.50 | 29759185 | |
50 | Phosphorylation | AVSSVKFSPNGEWLA CCEEEEECCCCCEEC | 16.25 | - | |
60 | Phosphorylation | GEWLASSSADRLIII CCEECCCCCCEEEEE | 31.52 | 20058876 | |
78 | Phosphorylation | YDGKYEKTLYGHNLE CCCCCEEEEECCCCE | 17.17 | 25278378 | |
80 | Phosphorylation | GKYEKTLYGHNLEIS CCCEEEEECCCCEEE | 22.90 | 25278378 | |
87 | Phosphorylation | YGHNLEISDVAWSSD ECCCCEEEEEEECCC | 19.36 | 25278378 | |
92 | Phosphorylation | EISDVAWSSDSSRLV EEEEEEECCCCCCEE | 17.96 | 25278378 | |
93 | Phosphorylation | ISDVAWSSDSSRLVS EEEEEECCCCCCEEE | 30.70 | 25278378 | |
95 | Phosphorylation | DVAWSSDSSRLVSAS EEEECCCCCCEEECC | 21.21 | 25278378 | |
96 | Phosphorylation | VAWSSDSSRLVSASD EEECCCCCCEEECCC | 34.32 | 25278378 | |
127 | Phosphorylation | TLKGHSNYVFCCNFN EECCCCCEEEEECCC | 9.64 | - | |
239 | Phosphorylation | NTLKLWDYSRGRCLK CCEEEEEECCCCEEE | 6.67 | - | |
263 | Phosphorylation | YCIFANFSVTGGKWI EEEEEEEEEECCEEE | 20.69 | 17924679 | |
286 | Phosphorylation | VYIWNLQTKEIVQKL EEEEECCHHHHHHHH | 33.54 | - | |
287 | Ubiquitination | YIWNLQTKEIVQKLQ EEEECCHHHHHHHHC | 32.27 | 29967540 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WDR5B_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WDR5B_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WDR5B_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
WDR5_HUMAN | WDR5 | physical | 17041588 | |
RPIA_HUMAN | RPIA | physical | 28514442 | |
RN220_HUMAN | RNF220 | physical | 28514442 | |
HSF2_HUMAN | HSF2 | physical | 28514442 | |
SELN_HUMAN | SEPN1 | physical | 28514442 | |
CLH2_HUMAN | CLTCL1 | physical | 28514442 | |
ZNRF2_HUMAN | ZNRF2 | physical | 28514442 | |
TCPD_HUMAN | CCT4 | physical | 28514442 | |
TCPB_HUMAN | CCT2 | physical | 28514442 | |
TCPG_HUMAN | CCT3 | physical | 28514442 | |
RRP12_HUMAN | RRP12 | physical | 28514442 | |
TCPW_HUMAN | CCT6B | physical | 28514442 | |
TCPA_HUMAN | TCP1 | physical | 28514442 | |
TCPZ_HUMAN | CCT6A | physical | 28514442 | |
TCPH_HUMAN | CCT7 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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