WDR5B_HUMAN - dbPTM
WDR5B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR5B_HUMAN
UniProt AC Q86VZ2
Protein Name WD repeat-containing protein 5B
Gene Name WDR5B
Organism Homo sapiens (Human).
Sequence Length 330
Subcellular Localization
Protein Description May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex..
Protein Sequence MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationAKAQLALSSSANQSK
HHHHHHHHCCCCCCC
19.3529759185
17PhosphorylationKAQLALSSSANQSKE
HHHHHHHCCCCCCCC
34.0329759185
18PhosphorylationAQLALSSSANQSKEV
HHHHHHCCCCCCCCC
28.0629759185
22PhosphorylationLSSSANQSKEVPENP
HHCCCCCCCCCCCCC
30.5029759185
50PhosphorylationAVSSVKFSPNGEWLA
CCEEEEECCCCCEEC
16.25-
60PhosphorylationGEWLASSSADRLIII
CCEECCCCCCEEEEE
31.5220058876
78PhosphorylationYDGKYEKTLYGHNLE
CCCCCEEEEECCCCE
17.1725278378
80PhosphorylationGKYEKTLYGHNLEIS
CCCEEEEECCCCEEE
22.9025278378
87PhosphorylationYGHNLEISDVAWSSD
ECCCCEEEEEEECCC
19.3625278378
92PhosphorylationEISDVAWSSDSSRLV
EEEEEEECCCCCCEE
17.9625278378
93PhosphorylationISDVAWSSDSSRLVS
EEEEEECCCCCCEEE
30.7025278378
95PhosphorylationDVAWSSDSSRLVSAS
EEEECCCCCCEEECC
21.2125278378
96PhosphorylationVAWSSDSSRLVSASD
EEECCCCCCEEECCC
34.3225278378
127PhosphorylationTLKGHSNYVFCCNFN
EECCCCCEEEEECCC
9.64-
239PhosphorylationNTLKLWDYSRGRCLK
CCEEEEEECCCCEEE
6.67-
263PhosphorylationYCIFANFSVTGGKWI
EEEEEEEEEECCEEE
20.6917924679
286PhosphorylationVYIWNLQTKEIVQKL
EEEEECCHHHHHHHH
33.54-
287UbiquitinationYIWNLQTKEIVQKLQ
EEEECCHHHHHHHHC
32.2729967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR5B_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR5B_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR5_HUMANWDR5physical
17041588
RPIA_HUMANRPIAphysical
28514442
RN220_HUMANRNF220physical
28514442
HSF2_HUMANHSF2physical
28514442
SELN_HUMANSEPN1physical
28514442
CLH2_HUMANCLTCL1physical
28514442
ZNRF2_HUMANZNRF2physical
28514442
TCPD_HUMANCCT4physical
28514442
TCPB_HUMANCCT2physical
28514442
TCPG_HUMANCCT3physical
28514442
RRP12_HUMANRRP12physical
28514442
TCPW_HUMANCCT6Bphysical
28514442
TCPA_HUMANTCP1physical
28514442
TCPZ_HUMANCCT6Aphysical
28514442
TCPH_HUMANCCT7physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR5B_HUMAN

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Related Literatures of Post-Translational Modification

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