WDR5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR5B_HUMAN
• UniProt AC: Q86VZ2
• Protein Name: WD repeat-containing protein 5B
• Gene Name: WDR5B
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Protein Description: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex..
• Protein Sequence: MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	AKAQLALSSSANQSK HHHHHHHHCCCCCCC	19.35	29759185
17	Phosphorylation	KAQLALSSSANQSKE HHHHHHHCCCCCCCC	34.03	29759185
18	Phosphorylation	AQLALSSSANQSKEV HHHHHHCCCCCCCCC	28.06	29759185
22	Phosphorylation	LSSSANQSKEVPENP HHCCCCCCCCCCCCC	30.50	29759185
50	Phosphorylation	AVSSVKFSPNGEWLA CCEEEEECCCCCEEC	16.25	-
60	Phosphorylation	GEWLASSSADRLIII CCEECCCCCCEEEEE	31.52	20058876
78	Phosphorylation	YDGKYEKTLYGHNLE CCCCCEEEEECCCCE	17.17	25278378
80	Phosphorylation	GKYEKTLYGHNLEIS CCCEEEEECCCCEEE	22.90	25278378
87	Phosphorylation	YGHNLEISDVAWSSD ECCCCEEEEEEECCC	19.36	25278378
92	Phosphorylation	EISDVAWSSDSSRLV EEEEEEECCCCCCEE	17.96	25278378
93	Phosphorylation	ISDVAWSSDSSRLVS EEEEEECCCCCCEEE	30.70	25278378
95	Phosphorylation	DVAWSSDSSRLVSAS EEEECCCCCCEEECC	21.21	25278378
96	Phosphorylation	VAWSSDSSRLVSASD EEECCCCCCEEECCC	34.32	25278378
127	Phosphorylation	TLKGHSNYVFCCNFN EECCCCCEEEEECCC	9.64	-
239	Phosphorylation	NTLKLWDYSRGRCLK CCEEEEEECCCCEEE	6.67	-
263	Phosphorylation	YCIFANFSVTGGKWI EEEEEEEEEECCEEE	20.69	17924679
286	Phosphorylation	VYIWNLQTKEIVQKL EEEEECCHHHHHHHH	33.54	-
287	Ubiquitination	YIWNLQTKEIVQKLQ EEEECCHHHHHHHHC	32.27	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR5B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR5_HUMAN	WDR5	physical	17041588
RPIA_HUMAN	RPIA	physical	28514442
RN220_HUMAN	RNF220	physical	28514442
HSF2_HUMAN	HSF2	physical	28514442
SELN_HUMAN	SEPN1	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
ZNRF2_HUMAN	ZNRF2	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.