RPIA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPIA_HUMAN
• UniProt AC: P49247
• Protein Name: Ribose-5-phosphate isomerase
• Gene Name: RPIA
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Protein Sequence: MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNSWDLPGSHVRLPGRAQSGTRGGAGNTSTSCGDSNSICPAPSTMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPMAYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QRPGPFSTLYGRVLA CCCCCCCHHCCEEEE	25.12	24719451
11	Phosphorylation	PGPFSTLYGRVLAPL CCCCCHHCCEEEECC	11.72	24719451
21	Methylation	VLAPLPGRAGGAASG EEECCCCCCCCCCCC	28.28	54558863
27	Phosphorylation	GRAGGAASGGGGNSW CCCCCCCCCCCCCCC	37.12	-
33	Phosphorylation	ASGGGGNSWDLPGSH CCCCCCCCCCCCCCC	25.83	-
39	Phosphorylation	NSWDLPGSHVRLPGR CCCCCCCCCCCCCCC	19.50	26074081
42	Methylation	DLPGSHVRLPGRAQS CCCCCCCCCCCCCCC	29.73	24391375
46	Methylation	SHVRLPGRAQSGTRG CCCCCCCCCCCCCCC	27.75	30760921
49	Phosphorylation	RLPGRAQSGTRGGAG CCCCCCCCCCCCCCC	40.94	26074081
51	Phosphorylation	PGRAQSGTRGGAGNT CCCCCCCCCCCCCCC	31.24	26074081
52	Methylation	GRAQSGTRGGAGNTS CCCCCCCCCCCCCCC	45.10	24129315
58	Phosphorylation	TRGGAGNTSTSCGDS CCCCCCCCCCCCCCC	32.25	26074081
59	Phosphorylation	RGGAGNTSTSCGDSN CCCCCCCCCCCCCCC	23.48	26074081
60	Phosphorylation	GGAGNTSTSCGDSNS CCCCCCCCCCCCCCC	26.46	26074081
61	Phosphorylation	GAGNTSTSCGDSNSI CCCCCCCCCCCCCCC	18.83	26074081
104	Phosphorylation	NQVLGIGSGSTIVHA CEEEEECCCHHHHHH	27.87	23927012
106	Phosphorylation	VLGIGSGSTIVHAVQ EEEECCCHHHHHHHH	19.36	28731282
107	Phosphorylation	LGIGSGSTIVHAVQR EEECCCHHHHHHHHH	30.46	23927012
120	Ubiquitination	QRIAERVKQENLNLV HHHHHHHHHHCCCEE	59.10	22053931
173	Ubiquitination	DADLNLIKGGGGCLT CCCCCEECCCCCCCC	55.45	-
183	Ubiquitination	GGCLTQEKIVAGYAS CCCCCHHHHHHCEEC	32.44	-
200	Ubiquitination	IVIADFRKDSKNLGD EEEEEHHHCCCCCHH	67.36	23000965
203	Ubiquitination	ADFRKDSKNLGDQWH EEHHHCCCCCHHCCC	67.34	23000965
211	Ubiquitination	NLGDQWHKGIPIEVI CCHHCCCCCCCCEEE	56.42	-
261	Acetylation	GNFILDWKFDRVHKW CCEEEEEECCCCCCH	36.73	24471107
267	Ubiquitination	WKFDRVHKWSEVNTA EECCCCCCHHHHHHH	49.94	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPIA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPIA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPIA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
VTA1_HUMAN	VTA1	physical	16189514
NTAQ1_HUMAN	WDYHV1	physical	16189514
RPIA_HUMAN	RPIA	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
THIOM_HUMAN	TXN2	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
FOXP2_HUMAN	FOXP2	physical	25416956
CENPP_HUMAN	CENPP	physical	25416956
RN208_HUMAN	RNF208	physical	25416956
GUAA_HUMAN	GMPS	physical	26344197
PEPD_HUMAN	PEPD	physical	26344197
RPE_HUMAN	RPE	physical	26344197
TKT_HUMAN	TKT	physical	26344197
TRXR1_HUMAN	TXNRD1	physical	26344197
GORS2_HUMAN	GORASP2	physical	21516116
PTN11_HUMAN	PTPN11	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608611: Ribose 5-phosphate isomerase deficiency (RPID)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.