VTA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VTA1_HUMAN
• UniProt AC: Q9NP79
• Protein Name: Vacuolar protein sorting-associated protein VTA1 homolog
• Gene Name: VTA1
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein .
• Protein Description: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding..
• Protein Sequence: MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKLLTTGRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALAPLPP ------CCCCCCCCC	15.93	22223895
15	Acetylation	PPLPAQFKSIQHHLR CCCCHHHHHHHHHHH	34.27	25953088
22	Methylation	KSIQHHLRTAQEHDK HHHHHHHHHHHHHCC	24.53	115919869
43	Sulfoxidation	YYCRLYAMQTGMKID HHHHHHHHHHCCCCC	2.01	30846556
47	Sulfoxidation	LYAMQTGMKIDSKTP HHHHHHCCCCCCCCH	3.79	30846556
52	2-Hydroxyisobutyrylation	TGMKIDSKTPECRKF HCCCCCCCCHHHHHH	65.44	-
62	Acetylation	ECRKFLSKLMDQLEA HHHHHHHHHHHHHHH	50.40	25953088
64	Sulfoxidation	RKFLSKLMDQLEALK HHHHHHHHHHHHHHH	3.38	21406390
71	Acetylation	MDQLEALKKQLGDNE HHHHHHHHHHHCCCH	45.59	25953088
71	2-Hydroxyisobutyrylation	MDQLEALKKQLGDNE HHHHHHHHHHHCCCH	45.59	-
72	Ubiquitination	DQLEALKKQLGDNEA HHHHHHHHHHCCCHH	52.16	-
150	Phosphorylation	KYARWKATYIHNCLK HHHHHHHHHHHHHHH	21.20	28152594
151	Phosphorylation	YARWKATYIHNCLKN HHHHHHHHHHHHHHC	12.68	28152594
155	S-nitrosocysteine	KATYIHNCLKNGETP HHHHHHHHHHCCCCC	3.37	-
155	S-nitrosylation	KATYIHNCLKNGETP HHHHHHHHHHCCCCC	3.37	19483679
242	O-linked_Glycosylation	ASNTIQPTPQTIPAI CCCCCCCCCCCCCCC	16.20	OGP
258	O-linked_Glycosylation	PALFNTISQGDVRLT HHHHCCCCCCCCCCC	26.52	30379171
265	Phosphorylation	SQGDVRLTPEDFARA CCCCCCCCHHHHHHH	17.67	21815630
277	Ubiquitination	ARAQKYCKYAGSALQ HHHHHHHHHCCCCCC	34.74	-
277	Malonylation	ARAQKYCKYAGSALQ HHHHHHHHHCCCCCC	34.74	26320211
277	Acetylation	ARAQKYCKYAGSALQ HHHHHHHHHCCCCCC	34.74	25953088
278	Phosphorylation	RAQKYCKYAGSALQY HHHHHHHHCCCCCCH	16.78	21945579
281	Phosphorylation	KYCKYAGSALQYEDV HHHHHCCCCCCHHCH	20.03	21945579
285	Phosphorylation	YAGSALQYEDVSTAV HCCCCCCHHCHHHHH	18.23	21945579
289	Phosphorylation	ALQYEDVSTAVQNLQ CCCHHCHHHHHHHHH	23.99	21945579
290	Phosphorylation	LQYEDVSTAVQNLQK CCHHCHHHHHHHHHH	30.60	21945579
300	Acetylation	QNLQKALKLLTTGRE HHHHHHHHHHHCCCC	46.43	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VTA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VTA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VTA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BACD1_HUMAN	KCTD13	physical	16189514
NECA2_HUMAN	NECAB2	physical	16189514
MBIP1_HUMAN	MBIP	physical	16189514
KLH12_HUMAN	KLHL12	physical	16189514
DPPA2_HUMAN	DPPA2	physical	16189514
CHMP5_HUMAN	CHMP5	physical	21543490
CHM2A_HUMAN	CHMP2A	physical	21543490
CHMP3_HUMAN	CHMP3	physical	21543490
A4_HUMAN	APP	physical	21832049
XPP1_HUMAN	XPNPEP1	physical	22939629
VATC1_HUMAN	ATP6V1C1	physical	22863883
SRC8_HUMAN	CTTN	physical	22863883
MAOX_HUMAN	ME1	physical	22863883
SYDC_HUMAN	DARS	physical	26344197
DLDH_HUMAN	DLD	physical	26344197
MK03_HUMAN	MAPK3	physical	26344197
XPP1_HUMAN	XPNPEP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330