dbPTM

M18BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	M18BP_HUMAN
UniProt AC	Q6P0N0
Protein Name	Mis18-binding protein 1
Gene Name	MIS18BP1
Organism	Homo sapiens (Human).
Sequence Length	1132
Subcellular Localization	Nucleus. Chromosome. Chromosome, centromere. Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Protein Description	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis..
Protein Sequence	MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKEKVLRDKQEQPSRNSSLLEPQKSGNNETFTPNRVEKKKLQHTYLCEEKENNKSFQSDDSSLRASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLTYELPTLNQEQENFLAVEARNKTLTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSADEQFQNTNAETLSTNCIPIKNGSLLMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPGSMKDTCKIVLATPRLHITIPRRSKRNISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIERIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRAGEKNREKTKQKQKTGRSVRDIRKSMKNDARENQTDTAQRATTTYDFDCDNLELKSNKHSESPGATELNMCHSNCQNKPTLRFPDDQVNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIGERTNERIIKSQKQETTEELDVSIDILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKVIEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLENTFEGHKSKNKEDCDERDLLTVNRKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAMSFYKHQSSPDLSSEESETEKEIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVKETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKPGFWSEVAAAVGSRSPEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIKITAKVGTLKRKQQMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDKNPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKLVETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	O-linked_Glycosylation	----MIATPLKHSRI ----CCCCCCCCCCE	34.52	30379171
4	Phosphorylation	----MIATPLKHSRI ----CCCCCCCCCCE	34.52	23401153
7	Sumoylation	-MIATPLKHSRIYLP -CCCCCCCCCCEECC	40.51	28112733
7	Ubiquitination	-MIATPLKHSRIYLP -CCCCCCCCCCEECC	40.51	23000965
9	Phosphorylation	IATPLKHSRIYLPPE CCCCCCCCCEECCCH	20.84	25003641
18	Phosphorylation	IYLPPEASSQRRNLP EECCCHHHHCCCCCC	25.91	25627689
19	Phosphorylation	YLPPEASSQRRNLPM ECCCHHHHCCCCCCC	34.45	25159151
33	Phosphorylation	MDAIFFDSIPSGTLT CCEEEECCCCCCCCC	31.10	29255136
36	Phosphorylation	IFFDSIPSGTLTPVK EEECCCCCCCCCCHH	42.62	29255136
38	Phosphorylation	FDSIPSGTLTPVKDL ECCCCCCCCCCHHHH	31.62	29255136
40	Phosphorylation	SIPSGTLTPVKDLVK CCCCCCCCCHHHHHH	26.35	29255136
43	Ubiquitination	SGTLTPVKDLVKYQN CCCCCCHHHHHHHCC	46.69	23000965
47	Sumoylation	TPVKDLVKYQNSSLK CCHHHHHHHCCCCCC	48.71	-
47	Sumoylation	TPVKDLVKYQNSSLK CCHHHHHHHCCCCCC	48.71	-
47	Ubiquitination	TPVKDLVKYQNSSLK CCHHHHHHHCCCCCC	48.71	23000965
48	Phosphorylation	PVKDLVKYQNSSLKL CHHHHHHHCCCCCCC	12.87	21406692
51	Phosphorylation	DLVKYQNSSLKLNDH HHHHHCCCCCCCCCC	22.86	29396449
52	Phosphorylation	LVKYQNSSLKLNDHK HHHHCCCCCCCCCCH	36.75	29396449
54	Ubiquitination	KYQNSSLKLNDHKKN HHCCCCCCCCCCHHC	47.38	29967540
59	Ubiquitination	SLKLNDHKKNQFLKM CCCCCCCHHCCCEEE	57.17	23000965
60	Sumoylation	LKLNDHKKNQFLKMT CCCCCCHHCCCEEEE	53.19	-
60	Sumoylation	LKLNDHKKNQFLKMT CCCCCCHHCCCEEEE	53.19	-
60	Ubiquitination	LKLNDHKKNQFLKMT CCCCCCHHCCCEEEE	53.19	23000965
65	Sumoylation	HKKNQFLKMTTFNNK CHHCCCEEEEEECCC	35.17	-
65	Sumoylation	HKKNQFLKMTTFNNK CHHCCCEEEEEECCC	35.17	28112733
65	Ubiquitination	HKKNQFLKMTTFNNK CHHCCCEEEEEECCC	35.17	23000965
65 (in isoform 1)	Ubiquitination	-	35.17	21890473
65 (in isoform 2)	Ubiquitination	-	35.17	21890473
67	Phosphorylation	KNQFLKMTTFNNKNI HCCCEEEEEECCCCC	27.01	25690035
68	Phosphorylation	NQFLKMTTFNNKNIF CCCEEEEEECCCCCE	22.37	25690035
70	Ubiquitination	FLKMTTFNNKNIFQS CEEEEEECCCCCEEE	57.38	21890473
93	Phosphorylation	SNSSLDISAIKPNKD CCCCCCEEEECCCCC	24.49	26437602
108	Phosphorylation	GLKNKANYESPGKIF CCCCCCCCCCCCCHH	23.73	24732914
110	Phosphorylation	KNKANYESPGKIFLR CCCCCCCCCCCHHHH	28.70	25159151
113	Sumoylation	ANYESPGKIFLRMKE CCCCCCCCHHHHHHH	33.40	-
113	Acetylation	ANYESPGKIFLRMKE CCCCCCCCHHHHHHH	33.40	25953088
113	Sumoylation	ANYESPGKIFLRMKE CCCCCCCCHHHHHHH	33.40	-
113	Ubiquitination	ANYESPGKIFLRMKE CCCCCCCCHHHHHHH	33.40	23000965
113 (in isoform 1)	Ubiquitination	-	33.40	21890473
113 (in isoform 2)	Ubiquitination	-	33.40	21890473
119	Ubiquitination	GKIFLRMKEKVLRDK CCHHHHHHHHHHHCC	48.20	23000965
126	Sumoylation	KEKVLRDKQEQPSRN HHHHHHCCCCCCCCC	49.66	-
126	Sumoylation	KEKVLRDKQEQPSRN HHHHHHCCCCCCCCC	49.66	-
131	Phosphorylation	RDKQEQPSRNSSLLE HCCCCCCCCCCCCCC	43.73	30108239
134	Phosphorylation	QEQPSRNSSLLEPQK CCCCCCCCCCCCCCC	22.66	30266825
135	Phosphorylation	EQPSRNSSLLEPQKS CCCCCCCCCCCCCCC	40.29	30266825
141	Ubiquitination	SSLLEPQKSGNNETF CCCCCCCCCCCCCCC	71.67	29967540
142	Phosphorylation	SLLEPQKSGNNETFT CCCCCCCCCCCCCCC	41.32	25159151
146	Ubiquitination	PQKSGNNETFTPNRV CCCCCCCCCCCCCHH	49.66	22817900
147	Phosphorylation	QKSGNNETFTPNRVE CCCCCCCCCCCCHHH	34.63	25159151
149	Phosphorylation	SGNNETFTPNRVEKK CCCCCCCCCCHHHHH	27.37	25159151
149	Ubiquitination	SGNNETFTPNRVEKK CCCCCCCCCCHHHHH	27.37	21963094
157	Sumoylation	PNRVEKKKLQHTYLC CCHHHHHHCCCEEEC	65.53	-
157	Sumoylation	PNRVEKKKLQHTYLC CCHHHHHHCCCEEEC	65.53	-
157	Ubiquitination	PNRVEKKKLQHTYLC CCHHHHHHCCCEEEC	65.53	29967540
161	Phosphorylation	EKKKLQHTYLCEEKE HHHHCCCEEECCCHH	12.77	25849741
162	Phosphorylation	KKKLQHTYLCEEKEN HHHCCCEEECCCHHC	13.77	28634298
167	Ubiquitination	HTYLCEEKENNKSFQ CEEECCCHHCCCCCC	43.37	22817900
171	Sumoylation	CEEKENNKSFQSDDS CCCHHCCCCCCCCCC	65.32	-
171	Sumoylation	CEEKENNKSFQSDDS CCCHHCCCCCCCCCC	65.32	-
171	Ubiquitination	CEEKENNKSFQSDDS CCCHHCCCCCCCCCC	65.32	22817900
171 (in isoform 1)	Ubiquitination	-	65.32	21890473
171 (in isoform 2)	Ubiquitination	-	65.32	21890473
172	Phosphorylation	EEKENNKSFQSDDSS CCHHCCCCCCCCCCH	30.55	25159151
175	Phosphorylation	ENNKSFQSDDSSLRA HCCCCCCCCCCHHHH	41.18	21815630
178	Phosphorylation	KSFQSDDSSLRASVQ CCCCCCCCHHHHHCC	35.94	21815630
179	Phosphorylation	SFQSDDSSLRASVQG CCCCCCCHHHHHCCC	28.95	25954137
183	Phosphorylation	DDSSLRASVQGVPLE CCCHHHHHCCCCCCC	14.45	29978859
191	Phosphorylation	VQGVPLESSNNDIFL CCCCCCCCCCCCCEE	46.15	30278072
192	Phosphorylation	QGVPLESSNNDIFLP CCCCCCCCCCCCEEE	30.22	30278072
199	Ubiquitination	SNNDIFLPVKQKIQC CCCCCEEEHHHHHCC	22.10	22817900
200	Ubiquitination	NNDIFLPVKQKIQCQ CCCCEEEHHHHHCCC	12.79	22817900
201	Sumoylation	NDIFLPVKQKIQCQQ CCCEEEHHHHHCCCC	43.89	-
201	Sumoylation	NDIFLPVKQKIQCQQ CCCEEEHHHHHCCCC	43.89	-
201	Ubiquitination	NDIFLPVKQKIQCQQ CCCEEEHHHHHCCCC	43.89	21906983
201 (in isoform 1)	Ubiquitination	-	43.89	21890473
201 (in isoform 2)	Ubiquitination	-	43.89	21890473
203	Sumoylation	IFLPVKQKIQCQQEK CEEEHHHHHCCCCCC	29.09	-
203	Sumoylation	IFLPVKQKIQCQQEK CEEEHHHHHCCCCCC	29.09	-
203	Ubiquitination	IFLPVKQKIQCQQEK CEEEHHHHHCCCCCC	29.09	22817900
211	Sumoylation	IQCQQEKKAPLHNLT HCCCCCCCCCCCCCE	55.26	-
211	Sumoylation	IQCQQEKKAPLHNLT HCCCCCCCCCCCCCE	55.26	28112733
211	Ubiquitination	IQCQQEKKAPLHNLT HCCCCCCCCCCCCCE	55.26	29967540
218	Phosphorylation	KAPLHNLTYELPTLN CCCCCCCEEECCCCC	21.92	28450419
219	Phosphorylation	APLHNLTYELPTLNQ CCCCCCEEECCCCCH	20.73	28450419
223	Phosphorylation	NLTYELPTLNQEQEN CCEEECCCCCHHHHC	51.47	28450419
248	Ubiquitination	LTRAQLAKQIFHSKE CCHHHHHHHHHCCCC	53.14	23000965
253	Phosphorylation	LAKQIFHSKESIVAT HHHHHHCCCCCEEEE	27.63	24719451
254	Ubiquitination	AKQIFHSKESIVATT HHHHHCCCCCEEEEC	47.08	23000965
256	Phosphorylation	QIFHSKESIVATTKS HHHCCCCCEEEECCC	26.54	24719451
258	Ubiquitination	FHSKESIVATTKSKK HCCCCCEEEECCCCC	5.57	22817900
259	Ubiquitination	HSKESIVATTKSKKD CCCCCEEEECCCCCC	14.10	21890473
260	Phosphorylation	SKESIVATTKSKKDT CCCCEEEECCCCCCE	24.70	21406692
261	Phosphorylation	KESIVATTKSKKDTF CCCEEEECCCCCCEE	24.47	17081983
262	Sumoylation	ESIVATTKSKKDTFV CCEEEECCCCCCEEE	56.79	-
262	Sumoylation	ESIVATTKSKKDTFV CCEEEECCCCCCEEE	56.79	28112733
262	Ubiquitination	ESIVATTKSKKDTFV CCEEEECCCCCCEEE	56.79	29967540
263	Phosphorylation	SIVATTKSKKDTFVL CEEEECCCCCCEEEE	42.73	21406692
267	Phosphorylation	TTKSKKDTFVLESVD ECCCCCCEEEEEECC	25.23	-
268	Ubiquitination	TKSKKDTFVLESVDS CCCCCCEEEEEECCC	9.41	23000965
271	Ubiquitination	KKDTFVLESVDSADE CCCEEEEEECCCHHH	43.33	23000965
272	Phosphorylation	KDTFVLESVDSADEQ CCEEEEEECCCHHHH	27.36	28348404
275	Phosphorylation	FVLESVDSADEQFQN EEEEECCCHHHHHHC	35.15	28348404
283	Phosphorylation	ADEQFQNTNAETLST HHHHHHCCCCCHHCC	25.64	28348404
287	Phosphorylation	FQNTNAETLSTNCIP HHCCCCCHHCCCEEE	24.49	28348404
299	Phosphorylation	CIPIKNGSLLMVSDS EEEECCCCEEEEECC	27.94	23401153
301	Ubiquitination	PIKNGSLLMVSDSER EECCCCEEEEECCCC	3.22	22817900
304	Phosphorylation	NGSLLMVSDSERTTE CCCEEEEECCCCCCC	22.81	30108239
306	Phosphorylation	SLLMVSDSERTTEGT CEEEEECCCCCCCCC	22.82	30108239
306	Ubiquitination	SLLMVSDSERTTEGT CEEEEECCCCCCCCC	22.82	22817900
309	Phosphorylation	MVSDSERTTEGTSQQ EEECCCCCCCCCCCC	25.75	29449344
310	Phosphorylation	VSDSERTTEGTSQQK EECCCCCCCCCCCCE	38.34	29449344
313	Phosphorylation	SERTTEGTSQQKVKE CCCCCCCCCCCEEEC	19.68	29449344
314	Phosphorylation	ERTTEGTSQQKVKEG CCCCCCCCCCEEECC	41.28	29449344
330	Phosphorylation	GKTVPGETGLPGSMK CCCCCCCCCCCCCHH	50.35	-
335	Phosphorylation	GETGLPGSMKDTCKI CCCCCCCCHHHHEEE	22.25	25159151
337	Ubiquitination	TGLPGSMKDTCKIVL CCCCCCHHHHEEEEE	52.13	23000965
339	Phosphorylation	LPGSMKDTCKIVLAT CCCCHHHHEEEEEEC	15.35	-
339	Ubiquitination	LPGSMKDTCKIVLAT CCCCHHHHEEEEEEC	15.35	23000965
341	Ubiquitination	GSMKDTCKIVLATPR CCHHHHEEEEEECCC	37.63	23000965
345	Ubiquitination	DTCKIVLATPRLHIT HHEEEEEECCCCEEE	12.50	23000965
346	Phosphorylation	TCKIVLATPRLHITI HEEEEEECCCCEEEE	12.55	20860994
352	Phosphorylation	ATPRLHITIPRRSKR ECCCCEEEECCCCCC	17.74	24719451
362	Phosphorylation	RRSKRNISKLSPPRI CCCCCCHHHCCCCCH	30.97	30266825
365	Phosphorylation	KRNISKLSPPRIFQT CCCHHHCCCCCHHHH	36.27	23401153
372	Phosphorylation	SPPRIFQTVTNGLKK CCCCHHHHHHCCCCH	20.67	23312004
374	Phosphorylation	PRIFQTVTNGLKKNQ CCHHHHHHCCCCHHH	27.27	23312004
378	Ubiquitination	QTVTNGLKKNQVVQL HHHHCCCCHHHEEHH	51.59	27667366
379	Sumoylation	TVTNGLKKNQVVQLQ HHHCCCCHHHEEHHH	58.62	-
379	Sumoylation	TVTNGLKKNQVVQLQ HHHCCCCHHHEEHHH	58.62	-
379	Ubiquitination	TVTNGLKKNQVVQLQ HHHCCCCHHHEEHHH	58.62	-
447	Ubiquitination	MIDQISMKEAGYPNY CHHHHHHHHCCCCHH	37.31	21906983
447 (in isoform 1)	Ubiquitination	-	37.31	21890473
447 (in isoform 2)	Ubiquitination	-	37.31	21890473
457	Ubiquitination	GYPNYLIRKFMFGFP CCCHHHHHHHHHCCC	24.46	23000965
458	Ubiquitination	YPNYLIRKFMFGFPE CCHHHHHHHHHCCCH	33.90	21890473
458 (in isoform 1)	Ubiquitination	-	33.90	21890473
458 (in isoform 2)	Ubiquitination	-	33.90	21890473
462	Ubiquitination	LIRKFMFGFPENWKE HHHHHHHCCCHHHHH	25.97	21890473
483	Ubiquitination	EQLRAGEKNREKTKQ HHHHHCHHHHHHHHH	61.46	29967540
490	Ubiquitination	KNREKTKQKQKTGRS HHHHHHHHHHHHCHH	59.66	21963094
495	Ubiquitination	TKQKQKTGRSVRDIR HHHHHHHCHHHHHHH	27.23	21963094
499	Ubiquitination	QKTGRSVRDIRKSMK HHHCHHHHHHHHHHH	34.58	22817900
506	Sumoylation	RDIRKSMKNDARENQ HHHHHHHHHHHHHCC	59.78	-
506	Sumoylation	RDIRKSMKNDARENQ HHHHHHHHHHHHHCC	59.78	-
521	Phosphorylation	TDTAQRATTTYDFDC CCHHHHHHEEEECCC	23.12	25627689
522	Phosphorylation	DTAQRATTTYDFDCD CHHHHHHEEEECCCC	23.52	25627689
523	Phosphorylation	TAQRATTTYDFDCDN HHHHHHEEEECCCCC	19.42	22617229
524	Phosphorylation	AQRATTTYDFDCDNL HHHHHEEEECCCCCE	16.72	22617229
534	Sumoylation	DCDNLELKSNKHSES CCCCEEECCCCCCCC	42.48	28112733
534	Ubiquitination	DCDNLELKSNKHSES CCCCEEECCCCCCCC	42.48	22817900
535	Phosphorylation	CDNLELKSNKHSESP CCCEEECCCCCCCCC	64.83	27174698
537	Ubiquitination	NLELKSNKHSESPGA CEEECCCCCCCCCCC	56.45	21963094
539	Phosphorylation	ELKSNKHSESPGATE EECCCCCCCCCCCCH	41.18	30108239
541	Phosphorylation	KSNKHSESPGATELN CCCCCCCCCCCCHHH	31.48	23401153
545	Phosphorylation	HSESPGATELNMCHS CCCCCCCCHHHCCCC	47.09	28985074
552	Phosphorylation	TELNMCHSNCQNKPT CHHHCCCCCCCCCCC	34.08	26330541
557	Ubiquitination	CHSNCQNKPTLRFPD CCCCCCCCCCCCCCH	17.32	29967540
559	Phosphorylation	SNCQNKPTLRFPDDQ CCCCCCCCCCCCHHH	31.98	26330541
568	Ubiquitination	RFPDDQVNNTIQNGG CCCHHHHCCCCCCCC	34.00	22817900
570	Phosphorylation	PDDQVNNTIQNGGGD CHHHHCCCCCCCCCC	20.80	28555341
572	Ubiquitination	DQVNNTIQNGGGDDL HHHCCCCCCCCCCCC	40.24	22817900
580	Phosphorylation	NGGGDDLSNQELIGK CCCCCCCCCCCCCCC	43.38	26714015
587	Ubiquitination	SNQELIGKKEYKMSS CCCCCCCCHHEECCC	35.12	21906983
587 (in isoform 1)	Ubiquitination	-	35.12	21890473
588	Ubiquitination	NQELIGKKEYKMSSK CCCCCCCHHEECCCC	62.15	22817900
591	Ubiquitination	LIGKKEYKMSSKKLK CCCCHHEECCCCCCC	33.14	22817900
612	Sumoylation	ERIIKSQKQETTEEL HHHHHHHCCCCCCCC	58.13	28112733
627	Phosphorylation	DVSIDILTSREQFFS CEEEEHHHCHHHHCC	26.52	24719451
634	Phosphorylation	TSREQFFSDEERKYM HCHHHHCCHHHHHHH	45.46	28450419
639	Sumoylation	FFSDEERKYMAINQK HCCHHHHHHHEECCC	42.53	28112733
639	Ubiquitination	FFSDEERKYMAINQK HCCHHHHHHHEECCC	42.53	29967540
640	Phosphorylation	FSDEERKYMAINQKK CCHHHHHHHEECCCE	9.67	30622161
646	Ubiquitination	KYMAINQKKAYILVT HHHEECCCEEEEEEC	34.58	23000965
647	Sumoylation	YMAINQKKAYILVTP HHEECCCEEEEEECC	36.34	-
647	Methylation	YMAINQKKAYILVTP HHEECCCEEEEEECC	36.34	44493351
647	Sumoylation	YMAINQKKAYILVTP HHEECCCEEEEEECC	36.34	28112733
647	Ubiquitination	YMAINQKKAYILVTP HHEECCCEEEEEECC	36.34	22817900
647 (in isoform 1)	Ubiquitination	-	36.34	21890473
649	Phosphorylation	AINQKKAYILVTPLK EECCCEEEEEECCCC	12.03	26074081
653	Phosphorylation	KKAYILVTPLKSRKV CEEEEEECCCCCHHH	21.32	22617229
656	Methylation	YILVTPLKSRKVIEQ EEEECCCCCHHHHHH	49.79	115972207
656	Ubiquitination	YILVTPLKSRKVIEQ EEEECCCCCHHHHHH	49.79	23000965
657	Phosphorylation	ILVTPLKSRKVIEQR EEECCCCCHHHHHHH	45.04	28122231
659	Ubiquitination	VTPLKSRKVIEQRCM ECCCCCHHHHHHHHH	55.44	23000965
671	Phosphorylation	RCMRYNLSAGTIKAV HHHHCCCCHHHHHHH	22.48	25159151
674	Phosphorylation	RYNLSAGTIKAVTDF HCCCCHHHHHHHCCE	21.01	22199227
675	Ubiquitination	YNLSAGTIKAVTDFV CCCCHHHHHHHCCEE	2.36	22817900
676	Ubiquitination	NLSAGTIKAVTDFVI CCCHHHHHHHCCEEC	36.32	29967540
678	Ubiquitination	SAGTIKAVTDFVIPE CHHHHHHHCCEECHH	4.48	21890473
679	Phosphorylation	AGTIKAVTDFVIPEC HHHHHHHCCEECHHH	28.69	24732914
688	Sumoylation	FVIPECQKKSPISKS EECHHHHCCCCCCCC	67.87	-
688	Sumoylation	FVIPECQKKSPISKS EECHHHHCCCCCCCC	67.87	-
688	Ubiquitination	FVIPECQKKSPISKS EECHHHHCCCCCCCC	67.87	29967540
689	Ubiquitination	VIPECQKKSPISKSM ECHHHHCCCCCCCCC	35.27	22817900
690	Phosphorylation	IPECQKKSPISKSMG CHHHHCCCCCCCCCC	34.21	23401153
693	Phosphorylation	CQKKSPISKSMGTLE HHCCCCCCCCCCHHC	23.28	23927012
694	Ubiquitination	QKKSPISKSMGTLEN HCCCCCCCCCCHHCH	45.22	21906983
694 (in isoform 1)	Ubiquitination	-	45.22	21890473
695	Phosphorylation	KKSPISKSMGTLENT CCCCCCCCCCHHCHH	18.69	25159151
698	Phosphorylation	PISKSMGTLENTFEG CCCCCCCHHCHHHCC	23.43	21815630
702	Phosphorylation	SMGTLENTFEGHKSK CCCHHCHHHCCCCCC	17.43	23401153
707	Sumoylation	ENTFEGHKSKNKEDC CHHHCCCCCCCHHHC	74.18	-
707	Sumoylation	ENTFEGHKSKNKEDC CHHHCCCCCCCHHHC	74.18	-
707	Ubiquitination	ENTFEGHKSKNKEDC CHHHCCCCCCCHHHC	74.18	29967540
709	Ubiquitination	TFEGHKSKNKEDCDE HHCCCCCCCHHHCCH	76.48	-
711	Ubiquitination	EGHKSKNKEDCDERD CCCCCCCHHHCCHHH	59.68	29967540
721	Phosphorylation	CDERDLLTVNRKIKI CCHHHHHHHCCEEEC	24.03	28555341
725	Acetylation	DLLTVNRKIKISNLE HHHHHCCEEECCCCC	43.05	7468591
725	Ubiquitination	DLLTVNRKIKISNLE HHHHHCCEEECCCCC	43.05	29967540
727	Sumoylation	LTVNRKIKISNLEKE HHHCCEEECCCCCHH	43.02	-
727	Acetylation	LTVNRKIKISNLEKE HHHCCEEECCCCCHH	43.02	7468599
727	Sumoylation	LTVNRKIKISNLEKE HHHCCEEECCCCCHH	43.02	28112733
727	Ubiquitination	LTVNRKIKISNLEKE HHHCCEEECCCCCHH	43.02	23000965
729	Phosphorylation	VNRKIKISNLEKEQM HCCEEECCCCCHHHH	30.29	25159151
733	Acetylation	IKISNLEKEQMLTSD EECCCCCHHHHHCCH	57.31	7468607
733	Ubiquitination	IKISNLEKEQMLTSD EECCCCCHHHHHCCH	57.31	23000965
738	Phosphorylation	LEKEQMLTSDFKKNT CCHHHHHCCHHHHHH	22.40	27732954
739	Phosphorylation	EKEQMLTSDFKKNTR CHHHHHCCHHHHHHH	36.77	25849741
742	Sumoylation	QMLTSDFKKNTRLLP HHHCCHHHHHHHHHH	50.53	-
742	Sumoylation	QMLTSDFKKNTRLLP HHHCCHHHHHHHHHH	50.53	28112733
742	Ubiquitination	QMLTSDFKKNTRLLP HHHCCHHHHHHHHHH	50.53	29967540
743	Ubiquitination	MLTSDFKKNTRLLPK HHCCHHHHHHHHHHH	64.64	-
753	Sumoylation	RLLPKLKKIENQVAM HHHHHHHHHCHHHHH	66.73	-
753	Sumoylation	RLLPKLKKIENQVAM HHHHHHHHHCHHHHH	66.73	-
761	Phosphorylation	IENQVAMSFYKHQSS HCHHHHHHHHCCCCC	18.71	30576142
763	Phosphorylation	NQVAMSFYKHQSSPD HHHHHHHHCCCCCCC	10.56	30576142
767	Phosphorylation	MSFYKHQSSPDLSSE HHHHCCCCCCCCCCC	43.49	27732954
768	Phosphorylation	SFYKHQSSPDLSSEE HHHCCCCCCCCCCCC	18.83	27732954
772	Phosphorylation	HQSSPDLSSEESETE CCCCCCCCCCCHHHH	42.98	25159151
773	Phosphorylation	QSSPDLSSEESETEK CCCCCCCCCCHHHHH	53.32	25159151
776	Phosphorylation	PDLSSEESETEKEIK CCCCCCCHHHHHHHH	45.85	23663014
778	Phosphorylation	LSSEESETEKEIKRK CCCCCHHHHHHHHHH	62.73	23663014
797	Sumoylation	KTKAGNTKEAVVHLR CCCCCCCHHHEEEEH	47.91	-
797	Sumoylation	KTKAGNTKEAVVHLR CCCCCCCHHHEEEEH	47.91	-
797	Ubiquitination	KTKAGNTKEAVVHLR CCCCCCCHHHEEEEH	47.91	29967540
810	Phosphorylation	LRKSTRNTSNIPVIL EHHCCCCCCCCCEEE	21.62	23927012
811	Phosphorylation	RKSTRNTSNIPVILE HHCCCCCCCCCEEEC	35.99	23927012
821	Phosphorylation	PVILEPETEESENEF CEEECCCCCCCCCCE	56.63	26503892
824	Phosphorylation	LEPETEESENEFYIK ECCCCCCCCCCEEEC	39.22	26503892
829	Phosphorylation	EESENEFYIKQKKAR CCCCCCEEECCCCCC	10.88	23927012
831	Ubiquitination	SENEFYIKQKKARPS CCCCEEECCCCCCCC	44.69	-
838	Phosphorylation	KQKKARPSVKETLQK CCCCCCCCHHHHHHH	40.02	20860994
840	Sumoylation	KKARPSVKETLQKSG CCCCCCHHHHHHHCC	49.68	-
840	Sumoylation	KKARPSVKETLQKSG CCCCCCHHHHHHHCC	49.68	28112733
840	Ubiquitination	KKARPSVKETLQKSG CCCCCCHHHHHHHCC	49.68	29967540
842	Phosphorylation	ARPSVKETLQKSGVR CCCCHHHHHHHCCCC	28.86	28555341
845	Ubiquitination	SVKETLQKSGVRKEF CHHHHHHHCCCCCCC	52.90	23000965
850	Ubiquitination	LQKSGVRKEFPITEA HHHCCCCCCCCCCCC	62.39	23000965
850 (in isoform 1)	Ubiquitination	-	62.39	21890473
855	Phosphorylation	VRKEFPITEAVGSDK CCCCCCCCCCCCCCC	20.38	30266825
860	Phosphorylation	PITEAVGSDKTNRHP CCCCCCCCCCCCCCC	29.36	30266825
862	Ubiquitination	TEAVGSDKTNRHPLE CCCCCCCCCCCCCCC	49.77	29967540
863	Phosphorylation	EAVGSDKTNRHPLEC CCCCCCCCCCCCCCC	42.34	30266825
878	Ubiquitination	LPGLIQDKEWNEKEL CHHHHCCCCCCHHHH	48.53	21963094
883	Sumoylation	QDKEWNEKELQKLHC CCCCCCHHHHHHHHH	61.59	-
883	Sumoylation	QDKEWNEKELQKLHC CCCCCCHHHHHHHHH	61.59	-
883	Ubiquitination	QDKEWNEKELQKLHC CCCCCCHHHHHHHHH	61.59	21963094
887	Ubiquitination	WNEKELQKLHCAFAS CCHHHHHHHHHHHHC	53.47	22817900
894	Phosphorylation	KLHCAFASLPKHKPG HHHHHHHCCCCCCCC	38.46	25159151
899	Sumoylation	FASLPKHKPGFWSEV HHCCCCCCCCCHHHH	53.62	-
899	Acetylation	FASLPKHKPGFWSEV HHCCCCCCCCCHHHH	53.62	26051181
899	Sumoylation	FASLPKHKPGFWSEV HHCCCCCCCCCHHHH	53.62	28112733
899	Ubiquitination	FASLPKHKPGFWSEV HHCCCCCCCCCHHHH	53.62	29967540
904	Phosphorylation	KHKPGFWSEVAAAVG CCCCCCHHHHHHHHC	21.67	21406692
912	Phosphorylation	EVAAAVGSRSPEECQ HHHHHHCCCCHHHHH	24.00	21406692
914	Phosphorylation	AAAVGSRSPEECQRK HHHHCCCCHHHHHHH	38.06	18669648
921	Ubiquitination	SPEECQRKYMENPRG CHHHHHHHHHHCCCC	24.07	-
956	Sumoylation	KRGDADQKQTIKITA CCCCCCHHHHEEEEE	50.37	28112733
956	Ubiquitination	KRGDADQKQTIKITA CCCCCCHHHHEEEEE	50.37	22817900
956 (in isoform 1)	Ubiquitination	-	50.37	21890473
960	Ubiquitination	ADQKQTIKITAKVGT CCHHHHEEEEEECCH	37.07	22817900
964	Acetylation	QTIKITAKVGTLKRK HHEEEEEECCHHHHH	32.33	25953088
964	Sumoylation	QTIKITAKVGTLKRK HHEEEEEECCHHHHH	32.33	28112733
964	Ubiquitination	QTIKITAKVGTLKRK HHEEEEEECCHHHHH	32.33	29967540
983	Sumoylation	EFLEQLPKDDHDDFF HHHHCCCCCCCCCCC	81.84	28112733
983	Ubiquitination	EFLEQLPKDDHDDFF HHHHCCCCCCCCCCC	81.84	29967540
991	Phosphorylation	DDHDDFFSTTPLQHQ CCCCCCCCCCCCCCC	31.22	30266825
992	Phosphorylation	DHDDFFSTTPLQHQR CCCCCCCCCCCCCCE	27.55	30266825
993	Phosphorylation	HDDFFSTTPLQHQRI CCCCCCCCCCCCCEE	22.32	30266825
1004	Phosphorylation	HQRILLPSFQDSEDD CCEEECCCCCCCCCC	35.19	25159151
1008	Phosphorylation	LLPSFQDSEDDDDIL ECCCCCCCCCCCCCC	31.94	25159151
1023	Phosphorylation	PNMDKNPTTPSSVIF CCCCCCCCCCHHHEE	61.81	28450419
1024	Phosphorylation	NMDKNPTTPSSVIFP CCCCCCCCCHHHEEE	23.56	25159151
1026	Phosphorylation	DKNPTTPSSVIFPLV CCCCCCCHHHEEEEE	34.83	21815630
1027	Phosphorylation	KNPTTPSSVIFPLVK CCCCCCHHHEEEEEC	22.04	20068231
1034	Ubiquitination	SVIFPLVKTPQCQHV HHEEEEECCCCCCCC	63.27	23000965
1035	Phosphorylation	VIFPLVKTPQCQHVS HEEEEECCCCCCCCC	15.88	25159151
1042	Phosphorylation	TPQCQHVSPGMLGSI CCCCCCCCCCCCCCC	17.38	25159151
1048	Phosphorylation	VSPGMLGSINRNDCD CCCCCCCCCCHHHHH	16.84	29978859
1056	Acetylation	INRNDCDKYVFRMQK CCHHHHHHHHHHHHH	50.04	26051181
1056	Ubiquitination	INRNDCDKYVFRMQK CCHHHHHHHHHHHHH	50.04	29967540
1057	Phosphorylation	NRNDCDKYVFRMQKY CHHHHHHHHHHHHHH	7.50	28509920
1063	Ubiquitination	KYVFRMQKYHKSNGG HHHHHHHHHHHHCCC	39.72	22817900
1066	Methylation	FRMQKYHKSNGGIVW HHHHHHHHHCCCEEE	42.39	44493361
1066	Ubiquitination	FRMQKYHKSNGGIVW HHHHHHHHHCCCEEE	42.39	22817900
1066 (in isoform 1)	Ubiquitination	-	42.39	21890473
1067	Phosphorylation	RMQKYHKSNGGIVWG HHHHHHHHCCCEEEC	27.65	24114839
1077	Ubiquitination	GIVWGNIKKKLVETD CEEECCHHHHEEECC	48.10	29967540
1078	Ubiquitination	IVWGNIKKKLVETDF EEECCHHHHEEECCC	47.76	-
1079	Sumoylation	VWGNIKKKLVETDFS EECCHHHHEEECCCC	53.41	-
1079	Sumoylation	VWGNIKKKLVETDFS EECCHHHHEEECCCC	53.41	28112733
1079	Ubiquitination	VWGNIKKKLVETDFS EECCHHHHEEECCCC	53.41	29967540
1083	Phosphorylation	IKKKLVETDFSTPTP HHHHEEECCCCCCCC	34.56	29255136
1086	Phosphorylation	KLVETDFSTPTPRRK HEEECCCCCCCCCCC	35.97	29255136
1087	Phosphorylation	LVETDFSTPTPRRKT EEECCCCCCCCCCCC	31.04	29255136
1089	Phosphorylation	ETDFSTPTPRRKTPF ECCCCCCCCCCCCCC	29.52	29255136
1093	Ubiquitination	STPTPRRKTPFNTDL CCCCCCCCCCCCCCC	62.93	29967540
1094	Phosphorylation	TPTPRRKTPFNTDLG CCCCCCCCCCCCCCC	31.16	24732914
1098	Phosphorylation	RRKTPFNTDLGENSG CCCCCCCCCCCCCCC	32.74	24732914
1104	Phosphorylation	NTDLGENSGIGKLFT CCCCCCCCCHHHHHH	27.73	29255136
1108	Sumoylation	GENSGIGKLFTNAVE CCCCCHHHHHHHHHH	38.21	-
1108	Sumoylation	GENSGIGKLFTNAVE CCCCCHHHHHHHHHH	38.21	-
1108	Ubiquitination	GENSGIGKLFTNAVE CCCCCHHHHHHHHHH	38.21	29967540
1116	Phosphorylation	LFTNAVESLDEEEKD HHHHHHHCCCHHHHH	34.22	29255136
1127	Phosphorylation	EEKDYYFSNSDSA-- HHHHHHCCCCCCC--	21.21	28985074
1129	Phosphorylation	KDYYFSNSDSA---- HHHHCCCCCCC----	31.57	30576142
1131	Phosphorylation	YYFSNSDSA------ HHCCCCCCC------	35.38	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of M18BP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of M18BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of M18BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MS18A_HUMAN	MIS18A	physical	26942680
MS18B_HUMAN	OIP5	physical	26942680

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of M18BP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-653; SER-824; SER-1004;SER-1008 AND SER-1104, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110; THR-653; THR-821;SER-824; SER-1008; SER-1086; THR-1087; THR-1089 AND SER-1104, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-299 ANDSER-365, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-824; THR-993 ANDSER-1104, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-261; SER-263; SER-541AND SER-1004, AND MASS SPECTROMETRY.	17081983 [Abstract]