FRG1_HUMAN - dbPTM
FRG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRG1_HUMAN
UniProt AC Q14331
Protein Name Protein FRG1
Gene Name FRG1
Organism Homo sapiens (Human).
Sequence Length 258
Subcellular Localization Nucleus, Cajal body . Nucleus, nucleolus . Cytoplasm . Cytoplasm, myofibril, sarcomere, Z line . Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytopla
Protein Description Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B..
Protein Sequence MAEYSYVKSTKLVLKGTKTKSKKKKSKDKKRKREEDEETQLDIVGIWWTVTNFGEISGTIAIEMDKGTYIHALDNGLFTLGAPHKEVDEGPSPPEQFTAVKLSDSRIALKSGYGKYLGINSDGLVVGRSDAIGPREQWEPVFQNGKMALLASNSCFIRCNEAGDIEAKSKTAGEEEMIKIRSCAERETKKKDDIPEEDKGNVKQCEINYVKKFQSFQDHKLKISKEDSKILKKARKDGFLHETLLDRRAKLKADRYCK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAEYSYVKSTK
----CCCCCCCCCCE		8.8628442448
5Phosphorylation---MAEYSYVKSTKL
---CCCCCCCCCCEE		18.2428442448
6Phosphorylation--MAEYSYVKSTKLV
--CCCCCCCCCCEEE		15.8228442448
8UbiquitinationMAEYSYVKSTKLVLK
CCCCCCCCCCEEEEE		44.1423000965
9PhosphorylationAEYSYVKSTKLVLKG
CCCCCCCCCEEEEEC		22.26-
11AcetylationYSYVKSTKLVLKGTK
CCCCCCCEEEEECCC		43.6325953088
11UbiquitinationYSYVKSTKLVLKGTK
CCCCCCCEEEEECCC		43.6323000965
92PhosphorylationKEVDEGPSPPEQFTA
CCCCCCCCCHHHCEE		65.0324667141
101UbiquitinationPEQFTAVKLSDSRIA
HHHCEEEEECCCCEE		39.5529967540
110AcetylationSDSRIALKSGYGKYL
CCCCEEEECCCCCEE		32.5825953088
110UbiquitinationSDSRIALKSGYGKYL
CCCCEEEECCCCCEE		32.58-
111PhosphorylationDSRIALKSGYGKYLG
CCCEEEECCCCCEEE		37.7923911959
115AcetylationALKSGYGKYLGINSD
EEECCCCCEEEECCC		28.9026051181
115UbiquitinationALKSGYGKYLGINSD
EEECCCCCEEEECCC		28.9029967540
121PhosphorylationGKYLGINSDGLVVGR
CCEEEECCCCEEEEC		31.0027732954
146UbiquitinationEPVFQNGKMALLASN
CCCCCCCEEEEEECC		28.66-
170UbiquitinationGDIEAKSKTAGEEEM
CCCEEECCCCCHHHH		41.51-
179AcetylationAGEEEMIKIRSCAER
CCHHHHHHHHHHHHH		30.6526051181
179UbiquitinationAGEEEMIKIRSCAER
CCHHHHHHHHHHHHH		30.6529967540
182PhosphorylationEEMIKIRSCAERETK
HHHHHHHHHHHHHCC		22.5825693802
199AcetylationDDIPEEDKGNVKQCE
CCCCHHHCCCEEEEE		56.5226051181
203UbiquitinationEEDKGNVKQCEINYV
HHHCCCEEEEEEEEE		53.9129967540
211UbiquitinationQCEINYVKKFQSFQD
EEEEEEEEECCCHHH		37.19-
211AcetylationQCEINYVKKFQSFQD
EEEEEEEEECCCHHH		37.1925953088
212AcetylationCEINYVKKFQSFQDH
EEEEEEEECCCHHHC		38.2925953088
212UbiquitinationCEINYVKKFQSFQDH
EEEEEEEECCCHHHC		38.2929967540
215PhosphorylationNYVKKFQSFQDHKLK
EEEEECCCHHHCCCC		28.1823401153
220UbiquitinationFQSFQDHKLKISKED
CCCHHHCCCCCCHHH		60.8229967540
236UbiquitinationKILKKARKDGFLHET
HHHHHHHHCCCCCHH		68.0429967540
243PhosphorylationKDGFLHETLLDRRAK
HCCCCCHHHHHHHHH		23.1328555341
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRG1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CWC22_HUMANCWC22physical
22365833
EXOS8_HUMANEXOSC8physical
25416956
LZTS2_HUMANLZTS2physical
25416956
K1C40_HUMANKRT40physical
25416956
UBE2O_HUMANUBE2Ophysical
26186194
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
158900Facioscapulohumeral muscular dystrophy 1 (FSHD1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRG1_HUMAN

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Related Literatures of Post-Translational Modification

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