dbPTM

CWC22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CWC22_HUMAN
UniProt AC	Q9HCG8
Protein Name	Pre-mRNA-splicing factor CWC22 homolog
Gene Name	CWC22
Organism	Homo sapiens (Human).
Sequence Length	908
Subcellular Localization	Nucleus . Nucleus speckle . Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.
Protein Description	Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay..
Protein Sequence	MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGRSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKSSVAQIK ------CCCCCCCCC	51.98	115973779
3	Phosphorylation	-----MKSSVAQIKP -----CCCCCCCCCC	28.84	-
11	Phosphorylation	SVAQIKPSSGHDRRE CCCCCCCCCCCCHHH	43.90	28555341
12	Phosphorylation	VAQIKPSSGHDRREN CCCCCCCCCCCHHHH	48.99	28555341
22	Phosphorylation	DRRENLNSYQRNSSP CHHHHHHHHCCCCCH	26.30	26074081
23	Phosphorylation	RRENLNSYQRNSSPE HHHHHHHHCCCCCHH	15.49	26074081
27	Phosphorylation	LNSYQRNSSPEDRYE HHHHCCCCCHHHHHH	49.84	29255136
28	Phosphorylation	NSYQRNSSPEDRYEE HHHCCCCCHHHHHHH	35.54	23401153
33	Phosphorylation	NSSPEDRYEEQERSP CCCHHHHHHHHHCCC	35.82	21955146
39	Phosphorylation	RYEEQERSPRDRDYF HHHHHHCCCCCCCCC	24.43	29255136
45	Phosphorylation	RSPRDRDYFDYSRSD CCCCCCCCCCCCHHH	10.15	28796482
48	Phosphorylation	RDRDYFDYSRSDYEH CCCCCCCCCHHHHCC	8.97	28796482
49	Phosphorylation	DRDYFDYSRSDYEHS CCCCCCCCHHHHCCC	27.44	28796482
51	Phosphorylation	DYFDYSRSDYEHSRR CCCCCCHHHHCCCCC	38.31	30108239
52	Phosphorylation	YFDYSRSDYEHSRRG CCCCCHHHHCCCCCC	52.29	33259812
53	Phosphorylation	FDYSRSDYEHSRRGR CCCCHHHHCCCCCCC	19.45	28796482
56	Phosphorylation	SRSDYEHSRRGRSYD CHHHHCCCCCCCCCC	16.25	27251275
58	Methylation	SDYEHSRRGRSYDSS HHHCCCCCCCCCCHH	48.14	115388795
61	Phosphorylation	EHSRRGRSYDSSMES CCCCCCCCCCHHHHH	35.80	29255136
62	Phosphorylation	HSRRGRSYDSSMESR CCCCCCCCCHHHHHH	20.62	29255136
64	Phosphorylation	RRGRSYDSSMESRNR CCCCCCCHHHHHHHH	24.29	23927012
65	Phosphorylation	RGRSYDSSMESRNRD CCCCCCHHHHHHHHH	24.54	30576142
68	Phosphorylation	SYDSSMESRNRDREK CCCHHHHHHHHHHHH	26.64	30108239
88	Phosphorylation	RDTDRKRSRKSPSPG HHHHHHHHCCCCCCC	47.28	26074081
91	Phosphorylation	DRKRSRKSPSPGRRN HHHHHCCCCCCCCCC	29.51	26503892
93	Phosphorylation	KRSRKSPSPGRRNPE HHHCCCCCCCCCCCC	47.26	26503892
101	Phosphorylation	PGRRNPETSVTQSSS CCCCCCCCCCCCCCC	29.74	25849741
102	Phosphorylation	GRRNPETSVTQSSSA CCCCCCCCCCCCCCC	22.85	25849741
104	Phosphorylation	RNPETSVTQSSSAQD CCCCCCCCCCCCCCC	23.62	30576142
106	Phosphorylation	PETSVTQSSSAQDEP CCCCCCCCCCCCCCC	19.52	30108239
107	Phosphorylation	ETSVTQSSSAQDEPA CCCCCCCCCCCCCCC	21.63	30108239
108	Phosphorylation	TSVTQSSSAQDEPAT CCCCCCCCCCCCCCC	34.89	25849741
115	Phosphorylation	SAQDEPATKKKKDEL CCCCCCCCCCCHHHC	54.86	21406692
116	Acetylation	AQDEPATKKKKDELD CCCCCCCCCCHHHCC	65.78	26051181
116	Ubiquitination	AQDEPATKKKKDELD CCCCCCCCCCHHHCC	65.78	22817900
117	Ubiquitination	QDEPATKKKKDELDP CCCCCCCCCHHHCCH	61.78	22817900
118	Ubiquitination	DEPATKKKKDELDPL CCCCCCCCHHHCCHH	67.99	22817900
119	Ubiquitination	EPATKKKKDELDPLL CCCCCCCHHHCCHHH	66.37	22817900
123	Ubiquitination	KKKKDELDPLLTRTG CCCHHHCCHHHCCCC	29.74	30230243
127	Phosphorylation	DELDPLLTRTGGAYI HHCCHHHCCCCCCCC	33.59	28555341
138	Acetylation	GAYIPPAKLRMMQEQ CCCCCHHHHHHHHHH	42.26	25953088
138	Ubiquitination	GAYIPPAKLRMMQEQ CCCCCHHHHHHHHHH	42.26	29967540
149	Acetylation	MQEQITDKNSLAYQR HHHHHCCCCCHHHHH	39.52	23954790
149	Ubiquitination	MQEQITDKNSLAYQR HHHHHCCCCCHHHHH	39.52	21906983
154	Phosphorylation	TDKNSLAYQRMSWEA CCCCCHHHHHHCHHH	11.27	-
164	Ubiquitination	MSWEALKKSINGLIN HCHHHHHHHHHHHHH	58.37	30230243
165	Phosphorylation	SWEALKKSINGLINK CHHHHHHHHHHHHHH	21.50	30108239
411	Phosphorylation	EILDEGDTDSNTDQD HHHCCCCCCCCCCCC	52.78	25137130
413	Phosphorylation	LDEGDTDSNTDQDAG HCCCCCCCCCCCCCC	43.66	25137130
415	Phosphorylation	EGDTDSNTDQDAGSS CCCCCCCCCCCCCCC	38.70	25137130
421	Phosphorylation	NTDQDAGSSEEDEEE CCCCCCCCCCHHHHH	35.98	25137130
422	Phosphorylation	TDQDAGSSEEDEEEE CCCCCCCCCHHHHHH	44.05	25137130
478	Acetylation	ECAHKLLKMEFPESQ HHHHHHHHCCCCHHH	46.98	25953088
521	Phosphorylation	FCMLKKEYMESFEGI HHHHHHHHHHHCCHH	18.30	28509920
524	Phosphorylation	LKKEYMESFEGIFKE HHHHHHHHCCHHHHH	16.45	28509920
533	Phosphorylation	EGIFKEQYDTIHRLE CHHHHHHHHHHHHHH	19.02	29083192
535	Phosphorylation	IFKEQYDTIHRLETN HHHHHHHHHHHHHHH	17.47	29083192
541	Phosphorylation	DTIHRLETNKLRNVA HHHHHHHHHHHHHHH	42.09	29083192
543	Ubiquitination	IHRLETNKLRNVAKM HHHHHHHHHHHHHHH	57.13	29967540
571	Phosphorylation	VLECIKLSEETTTSS HHHHHHCCCCCCCCC	28.52	20860994
575	Phosphorylation	IKLSEETTTSSSRIF HHCCCCCCCCCHHHH	28.14	20860994
577	Phosphorylation	LSEETTTSSSRIFVK CCCCCCCCCHHHHHH	24.99	-
578	Phosphorylation	SEETTTSSSRIFVKI CCCCCCCCHHHHHHH	22.88	-
579	Phosphorylation	EETTTSSSRIFVKIF CCCCCCCHHHHHHHH	29.21	-
604	Ubiquitination	PKLNARLKDETLQPF CHHHHHCCCCCCHHH	48.22	22817900
658	Acetylation	PKVIVAQKPDVEQNK CCEEEECCCCCCCCC	33.19	25953088
698	Phosphorylation	DSSSESSSEESDSSS CCCCCCCCCCCCCCC	55.45	28787133
701	Phosphorylation	SESSSEESDSSSISS CCCCCCCCCCCCCCC	38.45	28787133
703	Phosphorylation	SSSEESDSSSISSHS CCCCCCCCCCCCCCC	34.95	28787133
725	Phosphorylation	RKKGHGKTRSKEVDK HHCCCCCCCHHHHHH	44.78	23312004
727	Phosphorylation	KGHGKTRSKEVDKLI CCCCCCCHHHHHHHH	38.10	30624053
728	Acetylation	GHGKTRSKEVDKLIR CCCCCCHHHHHHHHH	59.47	26051181
739	Phosphorylation	KLIRNQQTNDRKQKE HHHHCCHHCHHHHHH	29.35	26074081
782	Phosphorylation	SNWRDPITKYTSDKD CCCCCCHHHHCCCCC	24.32	26074081
784	Phosphorylation	WRDPITKYTSDKDVP CCCCHHHHCCCCCCC	11.65	29255136
785	Phosphorylation	RDPITKYTSDKDVPS CCCHHHHCCCCCCCC	31.82	29255136
786	Phosphorylation	DPITKYTSDKDVPSE CCHHHHCCCCCCCCC	39.30	23401153
788	Phosphorylation	ITKYTSDKDVPSERN HHHHCCCCCCCCCCC	61.46	32645325
788	Acetylation	ITKYTSDKDVPSERN HHHHCCCCCCCCCCC	61.46	25953088
792	Phosphorylation	TSDKDVPSERNNYSR CCCCCCCCCCCCCCC	49.38	28985074
797	Phosphorylation	VPSERNNYSRVANDR CCCCCCCCCCCCCCC	11.03	-
808	Sulfoxidation	ANDRDQEMHIDLENK CCCCCCCCCEECCCC	2.52	21406390
829	Phosphorylation	KRGERRNSFSENEKH CCCCCCCCCCCCCHH	28.47	29255136
831	Phosphorylation	GERRNSFSENEKHTH CCCCCCCCCCCHHHH	39.06	29255136
841	Methylation	EKHTHRIKDSENFRR CHHHHHCCCCHHHHH	55.98	115973783
849	Ubiquitination	DSENFRRKDRSKSKE CCHHHHHHCHHHCHH	53.92	29967540
862	Phosphorylation	KEMNRKHSGSRSDED HHHHHHCCCCCCHHH	41.31	30108239
864	Phosphorylation	MNRKHSGSRSDEDRY HHHHCCCCCCHHHHH	31.46	30576142
866	Phosphorylation	RKHSGSRSDEDRYQN HHCCCCCCHHHHHHH	47.23	23401153
871	Phosphorylation	SRSDEDRYQNGAERR CCCHHHHHHHHHHHH	20.74	30576142
903	Phosphorylation	QDRRREKSPAKQK-- HHHHHHHCCCCCC--	25.90	27422710

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CWC22_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CWC22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CWC22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF4A3_HUMAN	EIF4A3	physical	22365833
FRG1_HUMAN	FRG1	physical	22365833
FA32A_HUMAN	FAM32A	physical	22365833
IF4A3_HUMAN	EIF4A3	physical	22961380
PRP19_HUMAN	PRPF19	physical	22961380

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CWC22_HUMAN

Related Literatures of Post-Translational Modification