FA32A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA32A_HUMAN
• UniProt AC: Q9Y421
• Protein Name: Protein FAM32A
• Gene Name: FAM32A
• Organism: Homo sapiens (Human).
• Sequence Length: 112
• Subcellular Localization: Isoform 1: Nucleus.; Isoform 2: Nucleus.
• Protein Description: Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli..
• Protein Sequence: MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAYEQVQ -------CHHHHHHH	6.32	-
4	Phosphorylation	----MEAYEQVQKGP ----CHHHHHHHCCC	8.12	25159151
24	Acetylation	VAELGVTKRKKKKKD HHHHCCCCCCCCCCC	60.87	25953088
43	Phosphorylation	KLLEAMGTSKKNEEE HHHHHHCCCCCCHHH	25.04	-
44	Phosphorylation	LLEAMGTSKKNEEEK HHHHHCCCCCCHHHH	35.58	-
59	Phosphorylation	RRGLDKRTPAQAAFE HHCCCCCCHHHHHHH	28.81	28555341
98	Phosphorylation	DFNRHLDTLTEHYDI HHHHHHHHHHHHCCC	41.77	29978859
100	Phosphorylation	NRHLDTLTEHYDIPK HHHHHHHHHHCCCCC	23.86	27642862
103	Phosphorylation	LDTLTEHYDIPKVSW HHHHHHHCCCCCCCC	14.88	25884760
107	Ubiquitination	TEHYDIPKVSWTK-- HHHCCCCCCCCCC--	49.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA32A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA32A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA32A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CWC22_HUMAN	CWC22	physical	22365833

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330