| UniProt ID | SYNE1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NF91 | |
| Protein Name | Nesprin-1 | |
| Gene Name | SYNE1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 8797 | |
| Subcellular Localization |
Nucleus outer membrane Single-pass type IV membrane protein Cytoplasmic side . Nucleus. Nucleus envelope. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere. The largest part of the protein is cytoplasmic, while its C-terminal part is assoc |
|
| Protein Description | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.. | |
| Protein Sequence | MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MATSRGASRCPRDIA CCCCCCCCCCHHHHH | 36.92 | 27251275 | |
| 104 (in isoform 4) | Phosphorylation | - | 3.93 | 27251275 | |
| 109 | Phosphorylation | RKIKLVNINSTDIAD CCEEEEECCCCCCCC | 3.16 | 27251275 | |
| 109 (in isoform 4) | Phosphorylation | - | 3.16 | 23090842 | |
| 165 | Phosphorylation | IVSSETPSPPSKRKV HHCCCCCCCCCCCCC | 57.79 | 20058876 | |
| 174 | Phosphorylation | PSKRKVTTKIQGNAK CCCCCCCCEECCHHH | 29.19 | 24425749 | |
| 379 | Phosphorylation | LHRDGKLSLDQALVK CCCCCCCCHHHHHHH | 33.13 | 27251275 | |
| 393 | Phosphorylation | KQSWDRVTSRLFDWH HHCHHHHHHHHHHHH | 14.71 | - | |
| 489 (in isoform 9) | Phosphorylation | - | 3.84 | 22199227 | |
| 494 (in isoform 3) | Phosphorylation | - | 30.56 | 22199227 | |
| 504 (in isoform 9) | Phosphorylation | - | 41.38 | 22199227 | |
| 505 (in isoform 9) | Phosphorylation | - | 6.01 | 25850435 | |
| 509 (in isoform 3) | Phosphorylation | - | 20.96 | 22199227 | |
| 509 (in isoform 9) | Phosphorylation | - | 20.96 | 22199227 | |
| 510 (in isoform 3) | Phosphorylation | - | 21.08 | 25850435 | |
| 513 (in isoform 9) | Phosphorylation | - | 2.22 | 22199227 | |
| 514 (in isoform 3) | Phosphorylation | - | 25.01 | 22199227 | |
| 518 (in isoform 3) | Phosphorylation | - | 4.40 | 22199227 | |
| 525 | Phosphorylation | LAESKLKSWIIKYGR HHHHHHHHHHHHHCC | 33.66 | 27251275 | |
| 530 | Phosphorylation | LKSWIIKYGRRESVE HHHHHHHHCCHHHHH | 12.88 | 27251275 | |
| 590 | Phosphorylation | VMKFMNETTAQWRNL HHHHHHHHHHHHHHC | 23.56 | 20860994 | |
| 591 | Phosphorylation | MKFMNETTAQWRNLS HHHHHHHHHHHHHCH | 15.63 | 28509920 | |
| 598 | Phosphorylation | TAQWRNLSVEVRSVR HHHHHHCHHHHHHHH | 21.56 | 28509920 | |
| 603 | Phosphorylation | NLSVEVRSVRSMLEE HCHHHHHHHHHHHHH | 27.36 | 28509920 | |
| 618 | Phosphorylation | VISNWDRYGNTVASL HHHCHHHCCCHHHHH | 16.56 | 22461510 | |
| 621 | Phosphorylation | NWDRYGNTVASLQAW CHHHCCCHHHHHHHH | 17.06 | 22461510 | |
| 624 | Phosphorylation | RYGNTVASLQAWLED HCCCHHHHHHHHHHH | 19.37 | 22461510 | |
| 643 | Acetylation | LNQSENAKKDFFRNL HCCCHHHHHHHHHCH | 65.54 | 30592771 | |
| 713 | Phosphorylation | MDRMKKEYTDCVVTL HHHHHHHHHHHHHHH | 19.43 | 21712546 | |
| 714 | Phosphorylation | DRMKKEYTDCVVTLS HHHHHHHHHHHHHHH | 24.82 | 21712546 | |
| 725 | Phosphorylation | VTLSAFATEAHKKLS HHHHHHHHHHHHHCC | 27.53 | 21712546 | |
| 732 | Phosphorylation | TEAHKKLSEPLEVSF HHHHHHCCCCCCCCC | 46.15 | - | |
| 763 | Phosphorylation | VPVMDAQYKIITKTA CCCCCHHHHHHHHHH | 13.08 | 30622161 | |
| 767 | Phosphorylation | DAQYKIITKTAHLIT CHHHHHHHHHHHHHC | 26.30 | 30622161 | |
| 774 | Phosphorylation | TKTAHLITKESPQEE HHHHHHHCCCCCHHH | 34.81 | 24670416 | |
| 790 | Phosphorylation | KEMFATMSKLKEQLT HHHHHHHHHHHHHHH | 30.40 | 24719451 | |
| 791 | Acetylation | EMFATMSKLKEQLTK HHHHHHHHHHHHHHH | 53.40 | 21339330 | |
| 870 | Phosphorylation | ENCKKTLTLIEKGSQ HHHHHHHHHHHHCCH | 30.81 | 29759185 | |
| 915 | Phosphorylation | FQSMVKKTGDWKKHV HHHHHHHHCCHHHHH | 34.36 | 30576142 | |
| 926 | Phosphorylation | KKHVETNSRLMKKFE HHHHHHHHHHHHHHH | 33.92 | 30576142 | |
| 935 | Phosphorylation | LMKKFEESRAELEKV HHHHHHHHHHHHHHH | 29.59 | 28509920 | |
| 1180 | Phosphorylation | GVTKRGETLSWLKSR CCCCCCHHHHHHHHH | 28.99 | 30266825 | |
| 1182 | Phosphorylation | TKRGETLSWLKSRLK CCCCHHHHHHHHHHH | 37.47 | 30266825 | |
| 1244 | Phosphorylation | YKEIVKNSLEELISG HHHHHHHHHHHHHHC | 31.29 | 30266825 | |
| 1250 | Phosphorylation | NSLEELISGSKEVQE HHHHHHHHCCHHHHH | 50.03 | 30266825 | |
| 1252 | Phosphorylation | LEELISGSKEVQEQA HHHHHHCCHHHHHHH | 20.89 | 30266825 | |
| 1265 | Phosphorylation | QAEKILDTENLFEAQ HHHHHCCCCCHHHHH | 24.27 | - | |
| 1286 | O-linked_Glycosylation | QQKTKRISAKKRDVQ HHHHHHHCHHHHHHH | 37.76 | 30379171 | |
| 1319 | Phosphorylation | EELRKLESTLDGLER HHHHHHHHHHHHHHH | 44.71 | 29759185 | |
| 1320 | Phosphorylation | ELRKLESTLDGLERS HHHHHHHHHHHHHHH | 21.35 | 29759185 | |
| 1327 | Phosphorylation | TLDGLERSRERQERR HHHHHHHHHHHHHHH | 29.17 | 20068231 | |
| 1338 | Phosphorylation | QERRIQVTLRKWERF HHHHHHHHHHCHHHH | 12.41 | 29970186 | |
| 1355 | Phosphorylation | NKETVVRYLFQTGSS CHHHHHHHHHHCCCC | 10.56 | - | |
| 1368 | Phosphorylation | SSHERFLSFSSLESL CCCHHCCCHHHHHHH | 21.99 | 29691806 | |
| 1370 | Phosphorylation | HERFLSFSSLESLSS CHHCCCHHHHHHHHH | 30.55 | 29691806 | |
| 1371 | Phosphorylation | ERFLSFSSLESLSSE HHCCCHHHHHHHHHH | 33.86 | 29691806 | |
| 1374 | Phosphorylation | LSFSSLESLSSELEQ CCHHHHHHHHHHHHH | 38.55 | 29691806 | |
| 1376 | Phosphorylation | FSSLESLSSELEQTK HHHHHHHHHHHHHHH | 30.92 | 27732954 | |
| 1383 | Methylation | SSELEQTKEFSKRTE HHHHHHHHHHHHHHH | 57.36 | - | |
| 1446 | Phosphorylation | KTMEMVKTKWDHFGS HHHHHHHHCCHHCCC | 26.42 | 23403867 | |
| 1474 | Phosphorylation | KELNALETSSSAMDM HHHCHHHCCCHHHHH | 34.46 | 26471730 | |
| 1475 | Phosphorylation | ELNALETSSSAMDMQ HHCHHHCCCHHHHHH | 16.96 | 26471730 | |
| 1476 | Phosphorylation | LNALETSSSAMDMQI HCHHHCCCHHHHHHH | 29.54 | 26471730 | |
| 1477 | Phosphorylation | NALETSSSAMDMQIS CHHHCCCHHHHHHHH | 27.64 | 26471730 | |
| 1484 | Phosphorylation | SAMDMQISQIKVTIQ HHHHHHHHHHHHHHH | 14.68 | 24719451 | |
| 1665 | Phosphorylation | QRLEKELSSFLTWLE HHHHHHHHHHHHHHH | 21.82 | 28258704 | |
| 1666 | Phosphorylation | RLEKELSSFLTWLER HHHHHHHHHHHHHHH | 36.58 | 28258704 | |
| 1679 | Phosphorylation | ERGEAKASSPEMDIS HHCCCCCCCCCCCCC | 45.80 | 25307156 | |
| 1686 | Phosphorylation | SSPEMDISADRVKVE CCCCCCCCCCCCCCH | 21.61 | - | |
| 1728 | Phosphorylation | ESLFSVASKDDVKMM HHHHHCCCHHHHHHH | 34.17 | 19664994 | |
| 1729 | Ubiquitination | SLFSVASKDDVKMMK HHHHCCCHHHHHHHH | 48.48 | - | |
| 1832 | Phosphorylation | GHLAKLGSLGRAEDL HHHHHHHCCCCHHHH | 37.78 | - | |
| 1899 | Ubiquitination | EATNSMNKNESDLIE HHHHHCCCCHHHHHH | 54.15 | - | |
| 1951 | O-linked_Glycosylation | QRTSCRATADQLCGE CHHHHHHCHHHHHHH | 16.06 | 30379171 | |
| 1971 | Phosphorylation | NLLGTKQSEADALAV HHHCCCCHHHHHHHH | 35.99 | 25599653 | |
| 1987 | Ubiquitination | KKAFQDQKEELLKSI HHHHHHHHHHHHHHH | 62.54 | - | |
| 1993 | Phosphorylation | QKEELLKSIEDIEER HHHHHHHHHHHHHHH | 31.05 | - | |
| 2003 | "N6,N6-dimethyllysine" | DIEERTDKERLKEPT HHHHHCCHHHHCHHH | 44.09 | - | |
| 2003 | Methylation | DIEERTDKERLKEPT HHHHHCCHHHHCHHH | 44.09 | - | |
| 2091 | Phosphorylation | LIDLMREYQNLKSAV HHHHHHHHHHHHHHH | 7.73 | 17053785 | |
| 2111 | Phosphorylation | NASSVIVTRTTIKDQ HCCCEEEEECCCCCH | 15.92 | - | |
| 2161 | Phosphorylation | SELKKIHSSDFSLVK HHHHHHHCCCCCCCC | 34.77 | 29396449 | |
| 2162 | Phosphorylation | ELKKIHSSDFSLVKT HHHHHHCCCCCCCCC | 28.63 | 29396449 | |
| 2165 | Phosphorylation | KIHSSDFSLVKTDME HHHCCCCCCCCCCHH | 36.92 | 29396449 | |
| 2169 | Phosphorylation | SDFSLVKTDMESTVD CCCCCCCCCHHHHHH | 32.85 | 29396449 | |
| 2213 | Phosphorylation | RDEIEGWSNNCVPQM HHHHCCCCCCCHHHH | 29.08 | - | |
| 2270 | Phosphorylation | ELTKNLETPPDLQFI HHHHCCCCCCCCHHH | 43.20 | 24076635 | |
| 2292 | Phosphorylation | LEHAKEITEVAKGTL HHHHHHHHHHHHCCH | 26.04 | 23917254 | |
| 2370 | Phosphorylation | LNSLCRKYHSAELES HHHHHHHHHHHHHHH | 5.01 | 20068231 | |
| 2372 | Phosphorylation | SLCRKYHSAELESLG HHHHHHHHHHHHHHH | 21.98 | 20068231 | |
| 2377 | Phosphorylation | YHSAELESLGRAMTG HHHHHHHHHHHHHHH | 49.07 | 20068231 | |
| 2383 | Phosphorylation | ESLGRAMTGLIKKHE HHHHHHHHHHHHHHH | 28.05 | 20068231 | |
| 2804 | Phosphorylation | SRELYEKTEDESFKD HHHHHHHCCCCCHHH | 36.41 | 26074081 | |
| 2808 | Phosphorylation | YEKTEDESFKDTAQE HHHCCCCCHHHHHHH | 50.33 | 26074081 | |
| 2812 | Phosphorylation | EDESFKDTAQEELKT CCCCHHHHHHHHHHH | 30.72 | 26074081 | |
| 2819 | Phosphorylation | TAQEELKTQFNDIMT HHHHHHHHHHHHHHH | 51.52 | 26074081 | |
| 2826 | Phosphorylation | TQFNDIMTVAKEKMR HHHHHHHHHHHHHHH | 20.04 | 26074081 | |
| 2865 | Methylation | SAKEELHRWSDMSGD HHHHHHHHHHCCCCC | 47.41 | 115387747 | |
| 2873 | Phosphorylation | WSDMSGDSSATQKKL HHCCCCCCHHHHHHH | 25.95 | - | |
| 2874 | Phosphorylation | SDMSGDSSATQKKLS HCCCCCCHHHHHHHH | 39.82 | - | |
| 2876 | Phosphorylation | MSGDSSATQKKLSKI CCCCCHHHHHHHHHH | 42.75 | - | |
| 2978 | Phosphorylation | QFSALLKTWAQQLTL HHHHHHHHHHHHHHH | 26.46 | 20068231 | |
| 2984 | Phosphorylation | KTWAQQLTLLEGKNT HHHHHHHHHHCCCCC | 25.59 | 20068231 | |
| 3011 | Ubiquitination | EILDALQKAEPRTED HHHHHHHHCCCCCHH | 56.41 | - | |
| 3020 | Ubiquitination | EPRTEDLKSQLNELC CCCCHHHHHHHHHHH | 48.77 | - | |
| 3037 | Phosphorylation | SRDLSTYSGKVSGLI HCCCHHHCCCHHHHH | 32.02 | - | |
| 3068 | Methylation | KEQILQQRFRKAFRD HHHHHHHHHHHHHHH | 22.00 | 115387755 | |
| 3146 | Malonylation | KAKGIQAKVTAAKED HHHCCCHHHHHCHHH | 24.60 | 26320211 | |
| 3176 | Acetylation | ENLKIQMKDFEVSAE HHHCHHHHCCEECCH | 42.78 | 30592759 | |
| 3191 | Acetylation | PIQDWLSKTEKMVHE HHHHHHHHHHHHHHH | 59.54 | 30592763 | |
| 3191 | Ubiquitination | PIQDWLSKTEKMVHE HHHHHHHHHHHHHHH | 59.54 | - | |
| 3209 | Ubiquitination | RLYDLPAKRREQQKL CCCCCCHHHHHHHHH | 50.47 | - | |
| 3328 | Phosphorylation | LKLEALLSVKQEKEI CHHHHHHCCCCHHHH | 28.28 | 24719451 | |
| 3382 | O-linked_Glycosylation | SAGIRCKSQLEGALS HHCCCCHHHHHHHHH | 43.56 | 30379171 | |
| 3426 | Phosphorylation | HAELRDKTTMLGKAK HHHHHHHHHHHHHHH | 23.02 | 24702127 | |
| 3427 | Phosphorylation | AELRDKTTMLGKAKL HHHHHHHHHHHHHHH | 19.01 | 24702127 | |
| 3442 | Phosphorylation | LNEEVLSYSSLLETI CCHHHHCCHHHHHHH | 9.71 | 24719451 | |
| 3444 | Phosphorylation | EEVLSYSSLLETIEV HHHHCCHHHHHHHCC | 28.83 | 24719451 | |
| 3481 | Acetylation | RAIQERAKEAVTKSE HHHHHHHHHHCHHHH | 53.05 | 20167786 | |
| 3485 | Phosphorylation | ERAKEAVTKSEKLVR HHHHHHCHHHHHHHH | 35.58 | 21955146 | |
| 3487 | Phosphorylation | AKEAVTKSEKLVRLH HHHHCHHHHHHHHHH | 30.51 | 21955146 | |
| 3574 | Phosphorylation | AEDRALESLRQDWQA HHHHHHHHHHHHHHH | 29.69 | 19413330 | |
| 3582 | Phosphorylation | LRQDWQAYQHRLSET HHHHHHHHHHHHHHH | 6.97 | 23322592 | |
| 3616 | Phosphorylation | QVDEWLKTAEEKVSP HHHHHHHHHHHHCCH | 36.81 | - | |
| 3622 | Phosphorylation | KTAEEKVSPRTRRQS HHHHHHCCHHHHHHC | 21.52 | - | |
| 3629 | Phosphorylation | SPRTRRQSNRATKEI CHHHHHHCHHHCHHH | 26.86 | - | |
| 3633 | Phosphorylation | RRQSNRATKEIQLHQ HHHCHHHCHHHHHHH | 26.44 | - | |
| 3680 | Phosphorylation | SRMGCQATQLTSRYQ CCCCHHHHHHHHHHH | 9.76 | - | |
| 3683 | Phosphorylation | GCQATQLTSRYQALL CHHHHHHHHHHHHHH | 11.01 | - | |
| 3684 | Phosphorylation | CQATQLTSRYQALLL HHHHHHHHHHHHHHH | 37.27 | - | |
| 3722 (in isoform 4) | Ubiquitination | - | 23.09 | - | |
| 3730 (in isoform 4) | Ubiquitination | - | 25.23 | - | |
| 3762 | Phosphorylation | KDMEKGHSLLKSARE HHHHHHHHHHHHHHH | 44.03 | 24719451 | |
| 3777 | Phosphorylation | KGERAVKYLEEGEAE HHHHHHHHHHHHHHH | 16.85 | 22964224 | |
| 3804 (in isoform 4) | Ubiquitination | - | 9.13 | - | |
| 3861 | Phosphorylation | AQLSKYKSLQQTVLS HHHHHHHHHHHHHHC | 28.46 | 22210691 | |
| 3865 | Phosphorylation | KYKSLQQTVLSHEPS HHHHHHHHHHCCCCC | 15.51 | 23403867 | |
| 3891 | Phosphorylation | LELVQDVTLKDKIDQ HHHHHHCCHHHHHHH | 36.06 | 17924679 | |
| 3903 | Phosphorylation | IDQLQSDYQDLCSIG HHHHHHHHHHHHHHC | 14.79 | 18083107 | |
| 4023 | Phosphorylation | SYSAICSTAQRMYQS HHHHHHHHHHHHHHH | 23.54 | 23403867 | |
| 4088 | Phosphorylation | ALQEQARTYLDLLCS HHHHHHHHHHHHHHH | 31.30 | 24719451 | |
| 4089 | Phosphorylation | LQEQARTYLDLLCSM HHHHHHHHHHHHHHH | 7.83 | 24719451 | |
| 4095 | Phosphorylation | TYLDLLCSMCDLSNA HHHHHHHHHCCCCCC | 23.55 | - | |
| 4100 | Phosphorylation | LCSMCDLSNASVKTT HHHHCCCCCCCCCCC | 19.66 | - | |
| 4103 | Phosphorylation | MCDLSNASVKTTAKD HCCCCCCCCCCCHHH | 28.53 | - | |
| 4173 | Phosphorylation | NIAQNMVSQVKDFVK HHHHHHHHHHHHHHH | 20.63 | - | |
| 4191 | Phosphorylation | SKQASVNTIIEKVNK HCCHHHHHHHHHHHH | 22.60 | - | |
| 4333 | Trimethylation | FQLEDLIKRKIQVSV HHHHHHHHHCCEEEE | 55.74 | - | |
| 4333 | Methylation | FQLEDLIKRKIQVSV HHHHHHHHHCCEEEE | 55.74 | 23644510 | |
| 4339 | Phosphorylation | IKRKIQVSVTNLEEL HHHCCEEEECCHHHH | 13.57 | 23312004 | |
| 4341 | Phosphorylation | RKIQVSVTNLEELNV HCCEEEECCHHHHHH | 26.95 | 23312004 | |
| 4403 | Phosphorylation | AKQMLLKSLIKDADR HHHHHHHHHHHHHHH | 34.98 | 22496350 | |
| 4505 | Phosphorylation | SAQASLKTYQNEVTG HHHHHHHHHHHHHHH | 35.32 | 20068231 | |
| 4506 | Phosphorylation | AQASLKTYQNEVTGL HHHHHHHHHHHHHHH | 14.04 | 20068231 | |
| 4511 | Phosphorylation | KTYQNEVTGLWAQGR HHHHHHHHHHHHHHH | 22.00 | 20068231 | |
| 4736 | Ubiquitination | AVDELNQKKEGFRST HHHHHHHCCCCCCCC | 52.28 | - | |
| 4802 | Phosphorylation | KSVKEEQSKVNEETL HHHHHHHHHCCCCCC | 41.68 | 28985074 | |
| 4818 | Phosphorylation | AEEKLKMYHSLAGSL HHHHHHHHHHHHHHH | 6.15 | 17081983 | |
| 4820 | Phosphorylation | EKLKMYHSLAGSLQD HHHHHHHHHHHHHHC | 11.48 | 17081983 | |
| 4828 | Phosphorylation | LAGSLQDSGIVLKRV HHHHHHCCCEEEEEE | 19.91 | 17081983 | |
| 4836 | O-linked_Glycosylation | GIVLKRVTIHLEDLA CEEEEEEEEEHHHHH | 13.50 | 30379171 | |
| 4937 | Phosphorylation | HQEEVQSSLRIMNAL CHHHHHHHHHHHHHC | 12.46 | 19664995 | |
| 4945 | Phosphorylation | LRIMNALSHKEKEKF HHHHHHCCHHHHHHH | 30.06 | 19664995 | |
| 4983 | Phosphorylation | DIQEALRTRQATLTE HHHHHHHHHHHHHHH | 28.16 | 29978859 | |
| 4987 | Phosphorylation | ALRTRQATLTEIYSQ HHHHHHHHHHHHHHH | 26.35 | 29978859 | |
| 4989 | Phosphorylation | RTRQATLTEIYSQCQ HHHHHHHHHHHHHHH | 18.91 | 29978859 | |
| 4992 | Phosphorylation | QATLTEIYSQCQRYY HHHHHHHHHHHHHHH | 6.10 | 29978859 | |
| 4993 | Phosphorylation | ATLTEIYSQCQRYYQ HHHHHHHHHHHHHHH | 30.09 | 29978859 | |
| 5051 (in isoform 4) | Ubiquitination | - | 55.75 | - | |
| 5077 | Phosphorylation | DLEQKVASLELRSQR HHHHHHHHHHHHHHH | 25.93 | 24719451 | |
| 5128 | Phosphorylation | EKKLSEFSLLKTSSS HHHHHHHHHHHCCCC | 28.83 | 24719451 | |
| 5150 | Phosphorylation | SEHKALVSVVNSFHE HHHHHHHHHHHHHHH | 22.62 | 24114839 | |
| 5193 | Phosphorylation | TTVWQRWTRLRAVAQ HHHHHHHHHHHHHHH | 23.24 | 17081983 | |
| 5237 | Phosphorylation | LQDKLPGSSAEKASK HHHHCCCCCHHHHHH | 25.16 | 26074081 | |
| 5238 | Phosphorylation | QDKLPGSSAEKASKA HHHCCCCCHHHHHHH | 46.49 | 26074081 | |
| 5243 | Phosphorylation | GSSAEKASKAELLTL CCCHHHHHHHHHHHH | 43.39 | 26074081 | |
| 5249 | Phosphorylation | ASKAELLTLLEYHDT HHHHHHHHHHHHHHH | 41.75 | 26074081 | |
| 5253 | Phosphorylation | ELLTLLEYHDTFVLE HHHHHHHHHHHHHHH | 12.64 | 26074081 | |
| 5256 | Phosphorylation | TLLEYHDTFVLELEQ HHHHHHHHHHHHHHH | 11.44 | 24043423 | |
| 5316 | Acetylation | EKVKTNGKLVKQELK HHHHHCCCCHHHHHH | 52.78 | 25953088 | |
| 5334 | Phosphorylation | MVETQINSVKCWVQE HHHHHHHHHHHHHHH | 25.28 | 24719451 | |
| 5353 (in isoform 4) | Ubiquitination | - | 4.74 | - | |
| 5365 (in isoform 4) | Ubiquitination | - | 21.82 | - | |
| 5439 | Malonylation | RQIQKLAKDLTTILT HHHHHHHHHHHHHHH | 64.80 | 26320211 | |
| 5495 | Acetylation | EQNGQLGKPLAKKIG HHCCCCCHHHHHHHH | 45.51 | 30592767 | |
| 5566 | Phosphorylation | ASQLREQYILHQTLL HHHHHHHHHHHHHHH | 10.74 | 20068231 | |
| 5643 | Malonylation | KFEAELKKLQAALEQ HHHHHHHHHHHHHHH | 59.46 | 26320211 | |
| 5657 | Phosphorylation | QAQATLTSPEVGRLS HHHHHCCCHHHHHCC | 23.36 | - | |
| 5789 | Ubiquitination | EELAQKIKGYQEQIA HHHHHHHHHHHHHHH | 59.61 | - | |
| 5791 | Phosphorylation | LAQKIKGYQEQIASL HHHHHHHHHHHHHHH | 12.13 | - | |
| 5838 | Phosphorylation | LDGELLPTPSAHPSV CCCCCCCCCCCCCCE | 29.82 | 26853621 | |
| 5881 | Phosphorylation | SSPPACRSPSPVANT CCCCCCCCCCCCCCC | 29.61 | 28450419 | |
| 5883 | Phosphorylation | PPACRSPSPVANTDA CCCCCCCCCCCCCCC | 33.00 | 26657352 | |
| 5888 | Phosphorylation | SPSPVANTDASVNQD CCCCCCCCCCCCCHH | 24.17 | 28450419 | |
| 5891 | Phosphorylation | PVANTDASVNQDIAY CCCCCCCCCCHHHHH | 25.14 | 28450419 | |
| 5898 | Phosphorylation | SVNQDIAYYQALSAE CCCHHHHHHHHHCHH | 9.10 | 27732954 | |
| 5899 | Phosphorylation | VNQDIAYYQALSAER CCHHHHHHHHHCHHH | 4.36 | 27732954 | |
| 5903 | Phosphorylation | IAYYQALSAERLQTD HHHHHHHCHHHHCCC | 30.97 | 24719451 | |
| 5917 | Phosphorylation | DAAKIHPSTSASQEF CHHHCCCCCCCCHHH | 22.34 | 23663014 | |
| 5918 | Phosphorylation | AAKIHPSTSASQEFY HHHCCCCCCCCHHHC | 32.53 | 23663014 | |
| 5919 | Phosphorylation | AKIHPSTSASQEFYE HHCCCCCCCCHHHCC | 30.20 | 23663014 | |
| 5921 | Phosphorylation | IHPSTSASQEFYEPG CCCCCCCCHHHCCCC | 29.97 | 23663014 | |
| 5925 | Phosphorylation | TSASQEFYEPGLEPS CCCCHHHCCCCCCCC | 22.06 | 28796482 | |
| 5936 | Ubiquitination | LEPSATAKLGDLQRS CCCCHHCHHHHHHHH | 48.96 | - | |
| 5943 | Phosphorylation | KLGDLQRSWETLKNV HHHHHHHHHHHHHHH | 19.12 | 22199227 | |
| 5946 | Phosphorylation | DLQRSWETLKNVISE HHHHHHHHHHHHHHH | 36.45 | 22199227 | |
| 5948 | Ubiquitination | QRSWETLKNVISEKQ HHHHHHHHHHHHHHH | 57.50 | - | |
| 5954 | Ubiquitination | LKNVISEKQRTLYEA HHHHHHHHHHHHHHH | 37.99 | - | |
| 5957 | Phosphorylation | VISEKQRTLYEALER HHHHHHHHHHHHHHH | 31.06 | 28102081 | |
| 5959 | Phosphorylation | SEKQRTLYEALERQQ HHHHHHHHHHHHHHH | 9.88 | 28102081 | |
| 5967 | Ubiquitination | EALERQQKYQDSLQS HHHHHHHHHHHHHHH | 36.22 | - | |
| 5968 | Phosphorylation | ALERQQKYQDSLQSI HHHHHHHHHHHHHHH | 19.77 | 20068231 | |
| 5971 | Phosphorylation | RQQKYQDSLQSISTK HHHHHHHHHHHHHHH | 16.87 | 20068231 | |
| 5974 | Phosphorylation | KYQDSLQSISTKMEA HHHHHHHHHHHHHHH | 24.65 | 24719451 | |
| 5976 | Phosphorylation | QDSLQSISTKMEAIE HHHHHHHHHHHHHHH | 27.50 | 20068231 | |
| 5977 | Phosphorylation | DSLQSISTKMEAIEL HHHHHHHHHHHHHHH | 32.51 | 20068231 | |
| 5987 | Phosphorylation | EAIELKLSESPEPGR HHHHHHHCCCCCCCC | 34.15 | 23312004 | |
| 5989 | Phosphorylation | IELKLSESPEPGRSP HHHHHCCCCCCCCCC | 31.05 | 25850435 | |
| 6097 | Phosphorylation | CEADELDSWLLSTKA CCHHHHHHHHHHCCC | 32.04 | 29759185 | |
| 6101 | Phosphorylation | ELDSWLLSTKATLDT HHHHHHHHCCCCHHH | 26.20 | 24719451 | |
| 6102 | Phosphorylation | LDSWLLSTKATLDTA HHHHHHHCCCCHHHC | 25.35 | 29759185 | |
| 6111 | Phosphorylation | ATLDTALSPPKEPMD CCHHHCCCCCCCCCC | 36.37 | 24719451 | |
| 6168 | Ubiquitination | EAEQLAGKLRRLKGS HHHHHHHHHHHHHHH | 32.96 | - | |
| 6175 | Phosphorylation | KLRRLKGSLLELQRA HHHHHHHHHHHHHHH | 28.35 | 28857561 | |
| 6186 | Ubiquitination | LQRALHDKQLNMQGT HHHHHHHHCCCCCCC | 46.03 | - | |
| 6209 | Phosphorylation | VDLTATQSPGVQEWL CCCCCCCCCCHHHHH | 21.19 | 22199227 | |
| 6229 | Phosphorylation | TWTQQRQSSLQQQKE HHHHHHHHHHHHHHH | 34.89 | 26846344 | |
| 6230 | Phosphorylation | WTQQRQSSLQQQKEL HHHHHHHHHHHHHHH | 23.12 | 26657352 | |
| 6246 | Phosphorylation | QELAEQKSLLRSVAS HHHHHHHHHHHHHHH | 32.12 | 24719451 | |
| 6301 | Phosphorylation | QMRMKWESLHQEFST HHHHHHHHHHHHHHH | 30.00 | - | |
| 6326 | Phosphorylation | QEQEQVLYSRPNRLL HHHHHHHHCCCCCCC | 12.08 | 28796482 | |
| 6327 | Phosphorylation | EQEQVLYSRPNRLLS HHHHHHHCCCCCCCC | 36.78 | 24719451 | |
| 6334 | Phosphorylation | SRPNRLLSGVPLYKG CCCCCCCCCCCCCCC | 42.19 | 28555341 | |
| 6376 | Phosphorylation | SGGAKRQSIHLEQKL CCCCCCCEEECCHHH | 18.93 | 29691806 | |
| 6430 | Phosphorylation | AKDIKEMSEEMDKNK HHHHHHHHHHHHHCC | 31.34 | 26657352 | |
| 6437 | Acetylation | SEEMDKNKNLFSQAF HHHHHHCCCHHHHCC | 61.85 | 11922747 | |
| 6441 | Phosphorylation | DKNKNLFSQAFPENG HHCCCHHHHCCCCCC | 24.62 | 28270605 | |
| 6499 | Phosphorylation | DLKVLFTSLADNKYI HHHHHHHHCCCCCEE | 17.77 | - | |
| 6505 | Phosphorylation | TSLADNKYIILQKLA HHCCCCCEEHHHHHH | 10.23 | - | |
| 6544 | Ubiquitination | DAGIIELKRRGDKLQ CCHHHHHHHCCCCCC | 27.53 | - | |
| 6567 | Phosphorylation | LSKLQDMYDELMMII HHHHHHHHHHHHHHH | 17.98 | 24043423 | |
| 6604 | Phosphorylation | DLADLLETGQEKMAG HHHHHHHHCHHHHCC | 44.10 | 23186163 | |
| 6618 | Phosphorylation | GDQKIIVSSKEEIQQ CCCEEEECCHHHHHH | 25.86 | 23312004 | |
| 6619 | Phosphorylation | DQKIIVSSKEEIQQL CCEEEECCHHHHHHH | 32.94 | 23312004 | |
| 6660 | Phosphorylation | SFAVQKETQFHTELM HHHHHHCCHHCHHHH | 43.50 | - | |
| 6664 | Phosphorylation | QKETQFHTELMAQAS HHCCHHCHHHHHHHH | 31.91 | - | |
| 6742 | Phosphorylation | LKSSLNEYQPKLYQV HHHHHHHHCCHHEEE | 29.10 | 18083107 | |
| 6747 | Phosphorylation | NEYQPKLYQVLDDGK HHHCCHHEEECCCCC | 11.60 | 18083107 | |
| 6874 | Phosphorylation | LRLKKVDTATLRSEL HHEECCCHHHHHHHH | 25.24 | 22617229 | |
| 6876 | Phosphorylation | LKKVDTATLRSELSR EECCCHHHHHHHHHH | 25.46 | 23025827 | |
| 6882 | Phosphorylation | ATLRSELSRIDSQWT HHHHHHHHHHHHHHH | 24.12 | 22617229 | |
| 6893 | Phosphorylation | SQWTDLLTNIPAVQE HHHHHHHHCCHHHHH | 38.10 | - | |
| 6912 | Phosphorylation | LQMDKLPSRHAISEV HCCCCCCCHHHHHHH | 47.32 | - | |
| 6943 | Phosphorylation | NIKNSIGYKAIHEYL HHHHHHHHHHHHHHH | 8.79 | - | |
| 6953 | Phosphorylation | IHEYLQKYKGFKIDI HHHHHHHCCCCCCCC | 11.90 | - | |
| 7097 | Phosphorylation | QNKKEDVSSIVMSTL CCCHHHHHHHHHHHH | 27.03 | 20068231 | |
| 7098 | Phosphorylation | NKKEDVSSIVMSTLR CCHHHHHHHHHHHHH | 21.03 | 20068231 | |
| 7102 | Phosphorylation | DVSSIVMSTLRELGQ HHHHHHHHHHHHHHH | 17.25 | 20068231 | |
| 7103 | Phosphorylation | VSSIVMSTLRELGQT HHHHHHHHHHHHHHH | 16.25 | 20068231 | |
| 7151 | Phosphorylation | SYLMEARYSLSRFRL HHHHHHHHCHHHHHH | 22.47 | 21214269 | |
| 7154 | Phosphorylation | MEARYSLSRFRLLTG HHHHHCHHHHHHHHC | 24.35 | 21214269 | |
| 7206 | Phosphorylation | KECHPPVTETLTNTL HHCCCCCHHHHHHHH | 29.09 | 30576142 | |
| 7208 | Phosphorylation | CHPPVTETLTNTLKE CCCCCHHHHHHHHHH | 29.53 | 30576142 | |
| 7270 | O-linked_Glycosylation | NELLKAATNKDIADD HHHHHHHHCCCCCCH | 47.89 | 30379171 | |
| 7295 | Phosphorylation | DLLKGLGTVKDSLFF HHHHHCCCHHHHHHH | 29.44 | 26074081 | |
| 7299 | Phosphorylation | GLGTVKDSLFFLHEL HCCCHHHHHHHHHHH | 22.74 | 26074081 | |
| 7317 | Phosphorylation | LKQQVDASAASAIQS HHHHHCHHHHHHHHH | 21.65 | 26074081 | |
| 7320 | Phosphorylation | QVDASAASAIQSDQL HHCHHHHHHHHHHCC | 26.14 | 26074081 | |
| 7324 | Phosphorylation | SAASAIQSDQLSLSQ HHHHHHHHHCCHHHH | 22.63 | 26074081 | |
| 7383 | Phosphorylation | QGQDPSHSSDLSTIQ CCCCCCCCCCHHHHH | 29.86 | 24275569 | |
| 7384 | Phosphorylation | GQDPSHSSDLSTIQE CCCCCCCCCHHHHHH | 36.83 | 24275569 | |
| 7404 | Phosphorylation | KGQMLKFSSMAPDLD HHCHHHHHHCCCCHH | 20.02 | 23532336 | |
| 7405 | Phosphorylation | GQMLKFSSMAPDLDR HCHHHHHHCCCCHHH | 23.30 | 23532336 | |
| 7467 | Phosphorylation | TFLEKCETWMEFLVQ HHHHHHHHHHHHHHH | 39.31 | 29888752 | |
| 7475 | Phosphorylation | WMEFLVQTEQKLAVE HHHHHHHCCHHHHHE | 32.67 | 29888752 | |
| 7584 | Phosphorylation | KWLVEVSYLPMSGLG HHHHHHHCCCCCCCC | 21.72 | - | |
| 7732 | Phosphorylation | TDDLTQLSLLKDTLS CCCHHHHHHHHHHHH | 23.10 | 24719451 | |
| 7769 | Phosphorylation | EELCHQLSLRRQQIG HHHHHHHHHHHHHHH | 17.17 | 24719451 | |
| 7786 | Phosphorylation | LNEWAVFSEKNKELC HHHHHHHCHHHHHHH | 40.85 | 29514088 | |
| 7847 | Phosphorylation | GERLAKASHESKASE HHHHHHHHCHHHHHH | 27.38 | 24719451 | |
| 7861 | Acetylation | EIEYKLGKVNDRWQH HHHHHHCCCCHHHHH | 48.58 | 25953088 | |
| 7962 | Phosphorylation | HDCDACATDAECDSI HCCCCCCCHHHCHHH | 35.31 | 20068231 | |
| 8027 | Phosphorylation | RTAAFPSSSGVIYTV CCCCCCCCCCCEEEE | 31.20 | 22468782 | |
| 8032 | Phosphorylation | PSSSGVIYTVAKEEL CCCCCCEEEEEHHHH | 7.86 | 20068231 | |
| 8033 | Phosphorylation | SSSGVIYTVAKEELK CCCCCEEEEEHHHHH | 11.67 | 20068231 | |
| 8061 | Malonylation | TQLELINKQYRRLAR HHHHHHHHHHHHHHH | 41.53 | 26320211 | |
| 8079 | Malonylation | TDSACSLKQMVHEGN CCCCHHHHHHHHHHH | 21.76 | 26320211 | |
| 8098 | Phosphorylation | NLQKRVTSILRRLKH HHHHHHHHHHHHHHH | 19.44 | 24719451 | |
| 8223 | Phosphorylation | PDDEHDLSDRELELE CCCCCCCCHHHHECC | 40.45 | 23401153 | |
| 8232 | Phosphorylation | RELELEDSAALSDLH HHHECCCHHHHHCCC | 13.18 | 27422710 | |
| 8236 | Phosphorylation | LEDSAALSDLHWHDR CCCHHHHHCCCCCCC | 33.14 | 27732954 | |
| 8244 | Phosphorylation | DLHWHDRSADSLLSP CCCCCCCCCCCCCCC | 42.35 | 28857561 | |
| 8247 | Phosphorylation | WHDRSADSLLSPQPS CCCCCCCCCCCCCCC | 30.81 | 28857561 | |
| 8250 | Phosphorylation | RSADSLLSPQPSSNL CCCCCCCCCCCCCCC | 27.12 | 29978859 | |
| 8254 | Phosphorylation | SLLSPQPSSNLSLSL CCCCCCCCCCCEECC | 26.98 | 28857561 | |
| 8255 | Phosphorylation | LLSPQPSSNLSLSLA CCCCCCCCCCEECCC | 48.77 | 28857561 | |
| 8258 | Phosphorylation | PQPSSNLSLSLAQPL CCCCCCCEECCCCCC | 21.84 | 25002506 | |
| 8260 | Phosphorylation | PSSNLSLSLAQPLRS CCCCCEECCCCCCCC | 20.48 | 28857561 | |
| 8261 | Phosphorylation | SSNLSLSLAQPLRSE CCCCEECCCCCCCCC | 6.60 | 27251275 | |
| 8261 (in isoform 4) | Phosphorylation | - | 6.60 | 22199227 | |
| 8267 | Phosphorylation | SLAQPLRSERSGRDT CCCCCCCCCCCCCCC | 45.07 | 29978859 | |
| 8270 | Phosphorylation | QPLRSERSGRDTPAS CCCCCCCCCCCCCCC | 33.84 | 22115753 | |
| 8274 | Phosphorylation | SERSGRDTPASVDSI CCCCCCCCCCCCCCC | 21.28 | 30266825 | |
| 8276 (in isoform 4) | Phosphorylation | - | 25.03 | 22199227 | |
| 8277 | Phosphorylation | SGRDTPASVDSIPLE CCCCCCCCCCCCCCC | 27.88 | 30266825 | |
| 8277 (in isoform 4) | Phosphorylation | - | 27.88 | 25850435 | |
| 8280 | Phosphorylation | DTPASVDSIPLEWDH CCCCCCCCCCCCCCC | 24.77 | 30266825 | |
| 8281 (in isoform 4) | Phosphorylation | - | 3.80 | 22199227 | |
| 8285 (in isoform 4) | Phosphorylation | - | 18.87 | 22199227 | |
| 8289 | Phosphorylation | PLEWDHDYDLSRDLE CCCCCCCCCHHHHHH | 18.50 | 28796482 | |
| 8292 | Phosphorylation | WDHDYDLSRDLESAM CCCCCCHHHHHHHHH | 22.35 | 28796482 | |
| 8297 | Phosphorylation | DLSRDLESAMSRALP CHHHHHHHHHHHCCC | 36.25 | 20068231 | |
| 8305 | Phosphorylation | AMSRALPSEDEEGQD HHHHCCCCCCCCCCC | 59.54 | 29255136 | |
| 8317 | Phosphorylation | GQDDKDFYLRGAVGL CCCCCCCHHHHCCCC | 12.96 | 23403867 | |
| 8325 | Phosphorylation | LRGAVGLSGDHSALE HHHCCCCCCCHHHHH | 35.92 | 28674419 | |
| 8329 | Phosphorylation | VGLSGDHSALESQIR CCCCCCHHHHHHHHH | 39.01 | 28674419 | |
| 8333 | Phosphorylation | GDHSALESQIRQLGK CCHHHHHHHHHHHHH | 31.58 | - | |
| 8345 | Phosphorylation | LGKALDDSRFQIQQT HHHHHCCCCCHHHHH | 34.36 | 28258704 | |
| 8352 | Phosphorylation | SRFQIQQTENIIRSK CCCHHHHHHHHHHCC | 18.02 | 20068231 | |
| 8358 | Phosphorylation | QTENIIRSKTPTGPE HHHHHHHCCCCCCCC | 30.39 | 30266825 | |
| 8360 | Phosphorylation | ENIIRSKTPTGPELD HHHHHCCCCCCCCCC | 27.59 | 23401153 | |
| 8362 | Phosphorylation | IIRSKTPTGPELDTS HHHCCCCCCCCCCCC | 71.28 | 30266825 | |
| 8368 | Phosphorylation | PTGPELDTSYKGYMK CCCCCCCCCHHHHHH | 46.72 | 30266825 | |
| 8369 | Phosphorylation | TGPELDTSYKGYMKL CCCCCCCCHHHHHHH | 25.23 | 30266825 | |
| 8370 | Phosphorylation | GPELDTSYKGYMKLL CCCCCCCHHHHHHHH | 15.55 | 26074081 | |
| 8373 | Phosphorylation | LDTSYKGYMKLLGEC CCCCHHHHHHHHHHC | 6.21 | 23532336 | |
| 8386 | Phosphorylation | ECSSSIDSVKRLEHK HCCCCHHHHHHHHHH | 28.06 | 28555341 | |
| 8393 | Acetylation | SVKRLEHKLKEEEES HHHHHHHHHHHHHHC | 52.45 | 28642235 | |
| 8395 | Acetylation | KRLEHKLKEEEESLP HHHHHHHHHHHHCCC | 68.81 | 28642239 | |
| 8400 | Phosphorylation | KLKEEEESLPGFVNL HHHHHHHCCCCCCEE | 43.05 | 24275569 | |
| 8431 | Acetylation | LQAQALSKELRMKQN HHHHHHCHHHHHHHH | 62.71 | 28642243 | |
| 8472 | Phosphorylation | QLQRLELSTDIQTIE HHHHHCCCCCHHHHH | 18.04 | - | |
| 8486 | Acetylation | ELQIKKLKELQKAVD HHHHHHHHHHHHHHH | 66.32 | 7932647 | |
| 8490 | Acetylation | KKLKELQKAVDHRKA HHHHHHHHHHHHHHH | 64.10 | 7932655 | |
| 8599 | Ubiquitination | HKQLMQIKHELLESQ HHHHHHHHHHHHHHH | 17.71 | - | |
| 8647 | Malonylation | NRLKLLLKEVSRHIK HHHHHHHHHHHHHHH | 56.91 | 26320211 | |
| 8665 | Phosphorylation | KLLDVSSSQQDLSSW HHHCCCCCCCCHHHC | 25.10 | 30576142 | |
| 8670 | Phosphorylation | SSSQQDLSSWSSADE CCCCCCHHHCCCCCC | 37.74 | 30576142 | |
| 8674 | Phosphorylation | QDLSSWSSADELDTS CCHHHCCCCCCCCCC | 33.22 | 30576142 | |
| 8685 | Phosphorylation | LDTSGSVSPTSGRST CCCCCCCCCCCCCCC | 24.94 | 24275569 | |
| 8688 | Phosphorylation | SGSVSPTSGRSTPNR CCCCCCCCCCCCCCC | 35.28 | 24275569 | |
| 8704 | Phosphorylation | KTPRGKCSLSQPGPS CCCCCCCCCCCCCCC | 34.24 | 26657352 | |
| 8706 | Phosphorylation | PRGKCSLSQPGPSVS CCCCCCCCCCCCCCC | 20.31 | 26657352 | |
| 8711 | Phosphorylation | SLSQPGPSVSSPHSR CCCCCCCCCCCCCCC | 40.31 | 22199227 | |
| 8713 | Phosphorylation | SQPGPSVSSPHSRST CCCCCCCCCCCCCCC | 42.35 | 26657352 | |
| 8714 | Phosphorylation | QPGPSVSSPHSRSTK CCCCCCCCCCCCCCC | 25.20 | 22199227 | |
| 8717 | Phosphorylation | PSVSSPHSRSTKGGS CCCCCCCCCCCCCCC | 31.17 | 22199227 | |
| 8724 | Phosphorylation | SRSTKGGSDSSLSEP CCCCCCCCCCCCCCC | 42.88 | 23663014 | |
| 8726 | Phosphorylation | STKGGSDSSLSEPGP CCCCCCCCCCCCCCC | 34.57 | 23663014 | |
| 8727 | Phosphorylation | TKGGSDSSLSEPGPG CCCCCCCCCCCCCCC | 40.69 | 23401153 | |
| 8729 | Phosphorylation | GGSDSSLSEPGPGRS CCCCCCCCCCCCCCC | 43.63 | 23663014 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYNE1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYNE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYNE1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SYNE1_HUMAN | SYNE1 | physical | 12163176 | |
| MUSK_HUMAN | MUSK | physical | 10878022 | |
| LMNA_HUMAN | LMNA | physical | 12163176 | |
| EMD_HUMAN | EMD | physical | 12163176 | |
| SUN1_HUMAN | SUN1 | physical | 22632968 | |
| SUN2_HUMAN | SUN2 | physical | 22632968 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00063 | Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) | |||||
| H00563 | Emery-Dreifuss muscular dystrophy | |||||
| OMIM Disease | ||||||
| 610743 | Spinocerebellar ataxia, autosomal recessive, 8 (SCAR8) | |||||
| 612998 | Emery-Dreifuss muscular dystrophy 4, autosomal dominant (EDMD4) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2377, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1327; SER-8223;SER-8270; THR-8274; SER-8277; SER-8280 AND SER-8345, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3891, AND MASSSPECTROMETRY. | |
| "Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2091, AND MASSSPECTROMETRY. | |
