dbPTM

SUN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SUN1_HUMAN
UniProt AC	O94901
Protein Name	SUN domain-containing protein 1
Gene Name	SUN1
Organism	Homo sapiens (Human).
Sequence Length	812
Subcellular Localization	Nucleus inner membrane Single-pass type II membrane protein . At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Protein Description	As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis..
Protein Sequence	MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Ubiquitination	SSYSSDALDFETEHK CCCCCCCCCCCCCCC	10.46	32015554
48	Phosphorylation	KLDPVFDSPRMSRRS CCCCCCCCHHCCHHH	11.71	29255136
48 (in isoform 1)	Phosphorylation	-	11.71	27251275
48 (in isoform 9)	Phosphorylation	-	11.71	-
52	Phosphorylation	VFDSPRMSRRSLRLA CCCCHHCCHHHHHHH	26.31	25159151
55	Phosphorylation	SPRMSRRSLRLATTA CHHCCHHHHHHHEEE	19.41	-
64	Phosphorylation	RLATTACTLGDGEAV HHHEEEEECCCCCEE	31.17	27134283
75	Phosphorylation	GEAVGADSGTSSAVS CCEECCCCCCCCCHH	43.36	22199227
77	Phosphorylation	AVGADSGTSSAVSLK EECCCCCCCCCHHHH	24.38	22199227
78	Phosphorylation	VGADSGTSSAVSLKN ECCCCCCCCCHHHHH	21.59	22199227
79	Phosphorylation	GADSGTSSAVSLKNR CCCCCCCCCHHHHHH	32.31	21815630
79 (in isoform 1)	Phosphorylation	-	32.31	24719451
82	Phosphorylation	SGTSSAVSLKNRAAR CCCCCCHHHHHHHCH	33.09	22199227
84	Ubiquitination	TSSAVSLKNRAARTT CCCCHHHHHHHCHHH	36.56	32015554
96	Phosphorylation	RTTKQRRSTNKSAFS HHHHHHHHCCCCCCC	38.22	28152594
96	Ubiquitination	RTTKQRRSTNKSAFS HHHHHHHHCCCCCCC	38.22	32015554
96 (in isoform 1)	Phosphorylation	-	38.22	24719451
97	Phosphorylation	TTKQRRSTNKSAFSI HHHHHHHCCCCCCCH	44.87	28152594
100	Phosphorylation	QRRSTNKSAFSINHV HHHHCCCCCCCHHEE	36.29	25159151
103	Phosphorylation	STNKSAFSINHVSRQ HCCCCCCCHHEEEEE	23.38	25159151
103 (in isoform 1)	Phosphorylation	-	23.38	27251275
105	Ubiquitination	NKSAFSINHVSRQVT CCCCCCHHEEEEEEE	28.45	32015554
108	Phosphorylation	AFSINHVSRQVTSSG CCCHHEEEEEEECCC	14.94	30576142
109	Ubiquitination	FSINHVSRQVTSSGV CCHHEEEEEEECCCC	33.62	32015554
109 (in isoform 5)	Ubiquitination	-	33.62	-
112	Phosphorylation	NHVSRQVTSSGVSHG HEEEEEEECCCCCCC	14.61	21712546
113	Phosphorylation	HVSRQVTSSGVSHGG EEEEEEECCCCCCCC	26.66	29214152
113	Ubiquitination	HVSRQVTSSGVSHGG EEEEEEECCCCCCCC	26.66	23503661
114	Phosphorylation	VSRQVTSSGVSHGGT EEEEEECCCCCCCCE	33.57	25159151
117	Phosphorylation	QVTSSGVSHGGTVSL EEECCCCCCCCEEEH	21.68	21712546
121	Phosphorylation	SGVSHGGTVSLQDAV CCCCCCCEEEHHHCH	16.12	21712546
123	Phosphorylation	VSHGGTVSLQDAVTR CCCCCEEEHHHCHHC	21.83	24043423
129	Phosphorylation	VSLQDAVTRRPPVLD EEHHHCHHCCCCCCC	23.76	24043423
132	Ubiquitination	QDAVTRRPPVLDESW HHCHHCCCCCCCHHH	21.77	33845483
138	Phosphorylation	RPPVLDESWIREQTT CCCCCCHHHHCCCCC	27.72	25463755
138 (in isoform 1)	Phosphorylation	-	27.72	24719451
138 (in isoform 6)	Phosphorylation	-	27.72	25159151
138 (in isoform 9)	Phosphorylation	-	27.72	-
145	Ubiquitination	SWIREQTTVDHFWGL HHHCCCCCCCEECEE	24.51	21890473
145 (in isoform 5)	Ubiquitination	-	24.51	21890473
157	Ubiquitination	WGLDDDGDLKGGNKA CEECCCCCCCCCCCE	52.80	33845483
159	Ubiquitination	LDDDGDLKGGNKAAI ECCCCCCCCCCCEEE	70.30	21906983
159 (in isoform 1)	Ubiquitination	-	70.30	21890473
159 (in isoform 2)	Ubiquitination	-	70.30	21890473
159 (in isoform 3)	Ubiquitination	-	70.30	21890473
163	Ubiquitination	GDLKGGNKAAIQGNG CCCCCCCCEEEECCC	42.33	23503661
180	Ubiquitination	GAAAATAHNGFSCSN HHHHHHHCCCCCCCC	30.50	32015554
184	Ubiquitination	ATAHNGFSCSNCSML HHHCCCCCCCCCHHH	20.31	23503661
186	Phosphorylation	AHNGFSCSNCSMLSE HCCCCCCCCCHHHHC	39.41	25627689
189	Phosphorylation	GFSCSNCSMLSERKD CCCCCCCHHHHCCCC	27.32	21712546
195	Ubiquitination	CSMLSERKDVLTAHP CHHHHCCCCCCCCCC	48.41	21890473
195	Sumoylation	CSMLSERKDVLTAHP CHHHHCCCCCCCCCC	48.41	28112733
195	Ubiquitination	CSMLSERKDVLTAHP CHHHHCCCCCCCCCC	48.41	23000965
195 (in isoform 1)	Ubiquitination	-	48.41	21890473
195 (in isoform 2)	Ubiquitination	-	48.41	21890473
195 (in isoform 3)	Ubiquitination	-	48.41	21890473
199	Phosphorylation	SERKDVLTAHPAAPG HCCCCCCCCCCCCCC	23.83	28555341
204	Ubiquitination	VLTAHPAAPGPVSRV CCCCCCCCCCCCCEE	17.65	33845483
209	Phosphorylation	PAAPGPVSRVYSRDR CCCCCCCCEEEECCC	21.11	21712546
209 (in isoform 3)	Phosphorylation	-	21.11	25159151
209 (in isoform 9)	Phosphorylation	-	21.11	25159151
216	Ubiquitination	SRVYSRDRNQKCDDC CEEEECCCCCCCCCC	46.50	21890473
220	Ubiquitination	SRDRNQKCDDCKGKR ECCCCCCCCCCCCCC	3.72	33845483
222 (in isoform 2)	Phosphorylation	-	45.56	26657352
224 (in isoform 2)	Phosphorylation	-	74.57	26657352
227 (in isoform 2)	Phosphorylation	-	44.24	26657352
232	Ubiquitination	GKRHLDAHPGRAGTL CCCCCCCCCCCCHHH	25.64	32015554
237	Ubiquitination	DAHPGRAGTLWHIWA CCCCCCCHHHHHHHH	21.71	21890473
237	Ubiquitination	DAHPGRAGTLWHIWA CCCCCCCHHHHHHHH	21.71	21890473
243 (in isoform 7)	Phosphorylation	-	3.41	26657352
245 (in isoform 7)	Phosphorylation	-	1.49	26657352
248 (in isoform 7)	Phosphorylation	-	3.43	26657352
257	Ubiquitination	LLQILRRIGAVGQAV HHHHHHHHCCHHHHH	3.16	21890473
257 (in isoform 5)	Ubiquitination	-	3.16	21890473
259 (in isoform 3)	Phosphorylation	-	10.41	21815630
259 (in isoform 9)	Phosphorylation	-	10.41	21815630
263 (in isoform 3)	Ubiquitination	-	8.70	21890473
265	Phosphorylation	GAVGQAVSRTAWSAL CCHHHHHHHHHHHHH	27.25	23532336
265 (in isoform 3)	Ubiquitination	-	27.25	21890473
266 (in isoform 3)	Phosphorylation	-	23.12	29083192
266 (in isoform 9)	Phosphorylation	-	23.12	29083192
268	Ubiquitination	GQAVSRTAWSALWLA HHHHHHHHHHHHHHH	9.34	33845483
269 (in isoform 3)	Phosphorylation	-	5.41	29083192
269 (in isoform 9)	Phosphorylation	-	5.41	29083192
270	Ubiquitination	AVSRTAWSALWLAVV HHHHHHHHHHHHHHH	15.83	33845483
274 (in isoform 3)	Phosphorylation	-	2.42	21815630
274 (in isoform 9)	Phosphorylation	-	2.42	21815630
276 (in isoform 3)	Phosphorylation	-	3.36	28102081
276 (in isoform 9)	Phosphorylation	-	3.36	28102081
277 (in isoform 3)	Phosphorylation	-	4.41	28102081
277 (in isoform 9)	Phosphorylation	-	4.41	28102081
279 (in isoform 3)	Phosphorylation	-	32.96	30631047
279 (in isoform 9)	Phosphorylation	-	32.96	30631047
284	Ubiquitination	VAPGKAASGVFWWLG HCCCCHHHCHHHHHH	40.11	33845483
289	Ubiquitination	AASGVFWWLGIGWYQ HHHCHHHHHHCCHHH	3.54	21890473
289	Ubiquitination	AASGVFWWLGIGWYQ HHHCHHHHHHCCHHH	3.54	23000965
289 (in isoform 3)	Phosphorylation	-	3.54	29691806
289 (in isoform 9)	Phosphorylation	-	3.54	29691806
290	Ubiquitination	ASGVFWWLGIGWYQF HHCHHHHHHCCHHHH	2.33	33845483
294	Ubiquitination	FWWLGIGWYQFVTLI HHHHHCCHHHHHHHH	5.05	33845483
307 (in isoform 3)	Phosphorylation	-	4.50	-
307 (in isoform 9)	Phosphorylation	-	4.50	21712546
309	Ubiquitination	SWLNVFLLTRCLRNI HHHHHHHHHHHHHHH	1.60	23000965
309 (in isoform 5)	Ubiquitination	-	1.60	21890473
314	Ubiquitination	FLLTRCLRNICKFLV HHHHHHHHHHHHHHH	33.81	33845483
317	Ubiquitination	TRCLRNICKFLVLLI HHHHHHHHHHHHHHH	2.66	33845483
318	Ubiquitination	RCLRNICKFLVLLIP HHHHHHHHHHHHHHH	37.63	33845483
326	Ubiquitination	FLVLLIPLFLLLAGL HHHHHHHHHHHHHHH	3.61	33845483
327	Ubiquitination	LVLLIPLFLLLAGLS HHHHHHHHHHHHHHH	3.66	33845483
327 (in isoform 9)	Phosphorylation	-	3.66	23927012
331 (in isoform 9)	Phosphorylation	-	19.49	29743597
333 (in isoform 9)	Phosphorylation	-	3.47	30266825
335	Ubiquitination	LLLAGLSLRGQGNFF HHHHHHHHCCCCCHH	9.55	33845483
339	Ubiquitination	GLSLRGQGNFFSFLP HHHHCCCCCHHHHHH	35.42	33845483
340	Ubiquitination	LSLRGQGNFFSFLPV HHHCCCCCHHHHHHC	27.23	21890473
344	Ubiquitination	GQGNFFSFLPVLNWA CCCCHHHHHHCCCHH	8.26	33845483
349	Ubiquitination	FSFLPVLNWASMHRT HHHHHCCCHHHHCCC	32.28	33845483
351	Ubiquitination	FLPVLNWASMHRTQR HHHCCCHHHHCCCCC	8.90	29967540
354	Ubiquitination	VLNWASMHRTQRVDD CCCHHHHCCCCCCCC	27.43	33845483
355	Ubiquitination	LNWASMHRTQRVDDP CCHHHHCCCCCCCCH	24.74	33845483
356	Ubiquitination	NWASMHRTQRVDDPQ CHHHHCCCCCCCCHH	13.17	33845483
357	Ubiquitination	WASMHRTQRVDDPQD HHHHCCCCCCCCHHH	43.27	33845483
359	Ubiquitination	SMHRTQRVDDPQDVF HHCCCCCCCCHHHCC	7.61	29967540
367	Ubiquitination	DDPQDVFKPTTSRLK CCHHHCCCCCCCCCC	41.10	21890473
368	Ubiquitination	DPQDVFKPTTSRLKQ CHHHCCCCCCCCCCC	29.46	33845483
369	Phosphorylation	PQDVFKPTTSRLKQP HHHCCCCCCCCCCCC	37.68	21406692
370	Phosphorylation	QDVFKPTTSRLKQPL HHCCCCCCCCCCCCC	22.00	21406692
371	Phosphorylation	DVFKPTTSRLKQPLQ HCCCCCCCCCCCCCC	37.79	28112733
371	Ubiquitination	DVFKPTTSRLKQPLQ HCCCCCCCCCCCCCC	37.79	29967540
376	Ubiquitination	TTSRLKQPLQGDSEA CCCCCCCCCCCCCCC	25.68	33845483
377	Ubiquitination	TSRLKQPLQGDSEAF CCCCCCCCCCCCCCC	9.12	21890473
377	Ubiquitination	TSRLKQPLQGDSEAF CCCCCCCCCCCCCCC	9.12	33845483
377 (in isoform 1)	Ubiquitination	-	9.12	21890473
379	Ubiquitination	RLKQPLQGDSEAFPW CCCCCCCCCCCCCCH	48.36	29967540
383	Ubiquitination	PLQGDSEAFPWHWMS CCCCCCCCCCHHHCC	21.54	33845483
384	Ubiquitination	LQGDSEAFPWHWMSG CCCCCCCCCHHHCCC	6.22	33845483
392	Ubiquitination	PWHWMSGVEQQVASL CHHHCCCHHHHHHHH	4.75	23000965
393	Ubiquitination	WHWMSGVEQQVASLS HHHCCCHHHHHHHHH	38.53	33845483
399	Ubiquitination	VEQQVASLSGQCHHH HHHHHHHHHCCCCCC	4.87	33845483
400	Ubiquitination	EQQVASLSGQCHHHG HHHHHHHHCCCCCCC	25.07	33845483
401	Ubiquitination	QQVASLSGQCHHHGE HHHHHHHCCCCCCCC	39.15	33845483
404	Ubiquitination	ASLSGQCHHHGENLR HHHHCCCCCCCCHHH	14.21	33845483
405	Ubiquitination	SLSGQCHHHGENLRE HHHCCCCCCCCHHHH	37.97	33845483
406	Ubiquitination	LSGQCHHHGENLREL HHCCCCCCCCHHHHH	22.92	33845483
409	Ubiquitination	QCHHHGENLRELTTL CCCCCCCHHHHHHHH	49.33	33845483
410	Ubiquitination	CHHHGENLRELTTLL CCCCCCHHHHHHHHH	3.81	33845483
413	Ubiquitination	HGENLRELTTLLQKL CCCHHHHHHHHHHHH	3.42	33845483
414	Ubiquitination	GENLRELTTLLQKLQ CCHHHHHHHHHHHHH	15.62	33845483
419	Ubiquitination	ELTTLLQKLQARVDQ HHHHHHHHHHHHHHH	42.40	21890473
420	Ubiquitination	LTTLLQKLQARVDQM HHHHHHHHHHHHHHC	2.88	33845483
421	Ubiquitination	TTLLQKLQARVDQME HHHHHHHHHHHHHCC	33.87	33845483
427	Sulfoxidation	LQARVDQMEGGAAGP HHHHHHHCCCCCCCC	4.46	28465586
427	Ubiquitination	LQARVDQMEGGAAGP HHHHHHHCCCCCCCC	4.46	33845483
429	Ubiquitination	ARVDQMEGGAAGPSA HHHHHCCCCCCCCCC	26.20	21890473
429 (in isoform 1)	Ubiquitination	-	26.20	21890473
433	Ubiquitination	QMEGGAAGPSASVRD HCCCCCCCCCCCHHH	19.03	33845483
434	Ubiquitination	MEGGAAGPSASVRDA CCCCCCCCCCCHHHH	23.23	33845483
435	Phosphorylation	EGGAAGPSASVRDAV CCCCCCCCCCHHHHC	32.05	20860994
435	Ubiquitination	EGGAAGPSASVRDAV CCCCCCCCCCHHHHC	32.05	33845483
437	Phosphorylation	GAAGPSASVRDAVGQ CCCCCCCCHHHHCCC	23.25	20860994
437	Ubiquitination	GAAGPSASVRDAVGQ CCCCCCCCHHHHCCC	23.25	33845483
438	Ubiquitination	AAGPSASVRDAVGQP CCCCCCCHHHHCCCC	6.85	33845483
440	Ubiquitination	GPSASVRDAVGQPPR CCCCCHHHHCCCCCC	43.37	33845483
441	Ubiquitination	PSASVRDAVGQPPRE CCCCHHHHCCCCCCC	9.22	23503661
442	Ubiquitination	SASVRDAVGQPPRET CCCHHHHCCCCCCCC	9.54	33845483
443	Ubiquitination	ASVRDAVGQPPRETD CCHHHHCCCCCCCCC	35.68	33845483
445	Ubiquitination	VRDAVGQPPRETDFM HHHHCCCCCCCCCCC	24.80	33845483
446	Ubiquitination	RDAVGQPPRETDFMA HHHCCCCCCCCCCCH	38.56	33845483
447	Ubiquitination	DAVGQPPRETDFMAF HHCCCCCCCCCCCHH	67.16	33845483
449	O-linked_Glycosylation	VGQPPRETDFMAFHQ CCCCCCCCCCCHHHH	35.50	30379171
449	Ubiquitination	VGQPPRETDFMAFHQ CCCCCCCCCCCHHHH	35.50	33845483
450	Ubiquitination	GQPPRETDFMAFHQE CCCCCCCCCCHHHHH	26.94	33845483
454	Ubiquitination	RETDFMAFHQEHEVR CCCCCCHHHHHHHHH	4.03	29967540
455	Ubiquitination	ETDFMAFHQEHEVRM CCCCCHHHHHHHHHH	23.68	33845483
459	Ubiquitination	MAFHQEHEVRMSHLE CHHHHHHHHHHHHHH	30.94	33845483
460	Ubiquitination	AFHQEHEVRMSHLED HHHHHHHHHHHHHHH	7.21	33845483
461	Ubiquitination	FHQEHEVRMSHLEDI HHHHHHHHHHHHHHH	20.22	23503661
461 (in isoform 5)	Ubiquitination	-	20.22	-
462	Ubiquitination	HQEHEVRMSHLEDIL HHHHHHHHHHHHHHH	3.41	29967540
463	Phosphorylation	QEHEVRMSHLEDILG HHHHHHHHHHHHHHH	17.85	24961811
463	Ubiquitination	QEHEVRMSHLEDILG HHHHHHHHHHHHHHH	17.85	33845483
464	Ubiquitination	EHEVRMSHLEDILGK HHHHHHHHHHHHHHH	24.72	33845483
469	Ubiquitination	MSHLEDILGKLREKS HHHHHHHHHHHHHHH	8.39	33845483
470	Ubiquitination	SHLEDILGKLREKSE HHHHHHHHHHHHHHH	27.56	33845483
471	Ubiquitination	HLEDILGKLREKSEA HHHHHHHHHHHHHHH	40.71	33845483
473	Ubiquitination	EDILGKLREKSEAIQ HHHHHHHHHHHHHHH	53.43	33845483
474	Ubiquitination	DILGKLREKSEAIQK HHHHHHHHHHHHHHH	71.95	33845483
475	Ubiquitination	ILGKLREKSEAIQKE HHHHHHHHHHHHHHH	47.35	33845483
476	Ubiquitination	LGKLREKSEAIQKEL HHHHHHHHHHHHHHH	27.75	33845483
478	Ubiquitination	KLREKSEAIQKELEQ HHHHHHHHHHHHHHH	19.32	33845483
481	Ubiquitination	EKSEAIQKELEQTKQ HHHHHHHHHHHHHHH	59.14	21906983
482	Ubiquitination	KSEAIQKELEQTKQK HHHHHHHHHHHHHHH	40.96	33845483
483	Ubiquitination	SEAIQKELEQTKQKT HHHHHHHHHHHHHHH	8.34	33845483
485	Ubiquitination	AIQKELEQTKQKTIS HHHHHHHHHHHHHHH	67.62	33845483
486	Ubiquitination	IQKELEQTKQKTISA HHHHHHHHHHHHHHH	26.52	33845483
487	Ubiquitination	QKELEQTKQKTISAV HHHHHHHHHHHHHHH	49.87	33845483
488	Ubiquitination	KELEQTKQKTISAVG HHHHHHHHHHHHHHH	52.06	33845483
491	Ubiquitination	EQTKQKTISAVGEQL HHHHHHHHHHHHHHH	2.99	33845483
491 (in isoform 1)	Ubiquitination	-	2.99	21890473
495	Ubiquitination	QKTISAVGEQLLPTV HHHHHHHHHHHHHHH	19.36	33845483
496	Ubiquitination	KTISAVGEQLLPTVE HHHHHHHHHHHHHHH	31.30	33845483
497	Ubiquitination	TISAVGEQLLPTVEH HHHHHHHHHHHHHHH	42.23	33845483
500	Ubiquitination	AVGEQLLPTVEHLQL HHHHHHHHHHHHHHH	42.88	33845483
501	Ubiquitination	VGEQLLPTVEHLQLE HHHHHHHHHHHHHHH	38.20	23503661
503	Ubiquitination	EQLLPTVEHLQLELD HHHHHHHHHHHHHHH	41.16	33845483
504	Ubiquitination	QLLPTVEHLQLELDQ HHHHHHHHHHHHHHH	17.97	33845483
505	Ubiquitination	LLPTVEHLQLELDQL HHHHHHHHHHHHHHH	3.83	33845483
507	Ubiquitination	PTVEHLQLELDQLKS HHHHHHHHHHHHHHH	9.93	23503661
510	Ubiquitination	EHLQLELDQLKSELS HHHHHHHHHHHHHHH	42.25	33845483
511	Ubiquitination	HLQLELDQLKSELSS HHHHHHHHHHHHHHH	64.51	33845483
512	Ubiquitination	LQLELDQLKSELSSW HHHHHHHHHHHHHHH	7.04	33845483
513	Ubiquitination	QLELDQLKSELSSWR HHHHHHHHHHHHHHH	35.93	33845483
520	Ubiquitination	KSELSSWRHVKTGCE HHHHHHHHHHHCCCC	27.03	33845483
521	Ubiquitination	SELSSWRHVKTGCET HHHHHHHHHHCCCCH	21.11	33845483
522	Ubiquitination	ELSSWRHVKTGCETV HHHHHHHHHCCCCHH	4.45	33845483
523	Ubiquitination	LSSWRHVKTGCETVD HHHHHHHHCCCCHHH	32.83	33845483
524	Ubiquitination	SSWRHVKTGCETVDA HHHHHHHCCCCHHHH	46.07	33845483
525	Ubiquitination	SWRHVKTGCETVDAV HHHHHHCCCCHHHHH	11.10	33845483
526	Ubiquitination	WRHVKTGCETVDAVQ HHHHHCCCCHHHHHH	4.85	33845483
527	Ubiquitination	RHVKTGCETVDAVQE HHHHCCCCHHHHHHH	53.89	23503661
527 (in isoform 5)	Ubiquitination	-	53.89	-
530	Ubiquitination	KTGCETVDAVQERVD HCCCCHHHHHHHHHH	48.73	33845483
532	Ubiquitination	GCETVDAVQERVDVQ CCCHHHHHHHHHHHH	5.41	33845483
533	Ubiquitination	CETVDAVQERVDVQV CCHHHHHHHHHHHHH	34.20	33845483
539	Ubiquitination	VQERVDVQVREMVKL HHHHHHHHHHHHHHH	24.88	33845483
540	Ubiquitination	QERVDVQVREMVKLL HHHHHHHHHHHHHHH	5.86	33845483
541	Ubiquitination	ERVDVQVREMVKLLF HHHHHHHHHHHHHHC	14.81	33845483
544	Ubiquitination	DVQVREMVKLLFSED HHHHHHHHHHHCCCC	3.19	23503661
546	Ubiquitination	QVREMVKLLFSEDQQ HHHHHHHHHCCCCCC	3.87	33845483
549	Ubiquitination	EMVKLLFSEDQQGGS HHHHHHCCCCCCCCC	39.99	33845483
553	Ubiquitination	LLFSEDQQGGSLEQL HHCCCCCCCCCHHHH	71.22	33845483
554	Ubiquitination	LFSEDQQGGSLEQLL HCCCCCCCCCHHHHH	23.25	33845483
556	Ubiquitination	SEDQQGGSLEQLLQR CCCCCCCCHHHHHHH	35.24	33845483
557	Ubiquitination	EDQQGGSLEQLLQRF CCCCCCCHHHHHHHH	5.71	33845483
560	Ubiquitination	QGGSLEQLLQRFSSQ CCCCHHHHHHHHHHC	3.00	33845483
561	Ubiquitination	GGSLEQLLQRFSSQF CCCHHHHHHHHHHCC	3.25	33845483
562	Ubiquitination	GSLEQLLQRFSSQFV CCHHHHHHHHHHCCC	53.62	33845483
563	Ubiquitination	SLEQLLQRFSSQFVS CHHHHHHHHHHCCCC	33.12	33845483
566	Ubiquitination	QLLQRFSSQFVSKGD HHHHHHHHCCCCHHH	25.56	33845483
571	Ubiquitination	FSSQFVSKGDLQTML HHHCCCCHHHHHHHH	51.66	21906983
576	Ubiquitination	VSKGDLQTMLRDLQL CCHHHHHHHHHHHHH	26.01	33845483
577	Ubiquitination	SKGDLQTMLRDLQLQ CHHHHHHHHHHHHHH	1.54	33845483
581 (in isoform 1)	Ubiquitination	-	4.41	21890473
589	Ubiquitination	QLQILRNVTHHVSVT HHHHHHHCCCCCEEE	4.33	33845483
590	O-linked_Glycosylation	LQILRNVTHHVSVTK HHHHHHCCCCCEEEC	15.15	30379171
590	Phosphorylation	LQILRNVTHHVSVTK HHHHHHCCCCCEEEC	15.15	20860994
590	Ubiquitination	LQILRNVTHHVSVTK HHHHHHCCCCCEEEC	15.15	33845483
591	Ubiquitination	QILRNVTHHVSVTKQ HHHHHCCCCCEEECC	18.31	33845483
593	Ubiquitination	LRNVTHHVSVTKQLP HHHCCCCCEEECCCC	3.70	33845483
594	Phosphorylation	RNVTHHVSVTKQLPT HHCCCCCEEECCCCC	21.51	20860994
598	Ubiquitination	HHVSVTKQLPTSEAV CCCEEECCCCCCHHH	43.22	33845483
599	Ubiquitination	HVSVTKQLPTSEAVV CCEEECCCCCCHHHH	5.49	33845483
601	O-linked_Glycosylation	SVTKQLPTSEAVVSA EEECCCCCCHHHHHH	48.03	OGP
604	Ubiquitination	KQLPTSEAVVSAVSE CCCCCCHHHHHHHHH	13.53	23503661
610	Ubiquitination	EAVVSAVSEAGASGI HHHHHHHHHHCCCCC	22.80	23503661
626	Ubiquitination	EAQARAIVNSALKLY HHHHHHHHHHHHHHH	4.52	33845483
627	Ubiquitination	AQARAIVNSALKLYS HHHHHHHHHHHHHHC	18.56	33845483
634	Ubiquitination	NSALKLYSQDKTGMV HHHHHHHCCCCCCCC	42.19	33845483
637	Ubiquitination	LKLYSQDKTGMVDFA HHHHCCCCCCCCEEE	39.06	2190698
647 (in isoform 1)	Ubiquitination	-	43.52	21890473
701	Phosphorylation	NCWAFKGSQGYLVVR CCEEEECCCCEEEEE	22.48	-
704	Phosphorylation	AFKGSQGYLVVRLSM EEECCCCEEEEEEEE	6.67	-
710	Phosphorylation	GYLVVRLSMMIHPAA CEEEEEEEEEECCHH	8.85	-
728	Phosphorylation	EHIPKTLSPTGNISS HHCCCCCCCCCCCCC	26.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	S	Phosphorylation	Kinase	CDK1	P06493	PSP
55	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
138	S	Phosphorylation	Kinase	PLK1	P53350	PSP
333	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SUN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SUN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN507_HUMAN	ZNF507	physical	26186194
TYW5_HUMAN	TYW5	physical	26186194
TRIP6_HUMAN	TRIP6	physical	26186194
TYW5_HUMAN	TYW5	physical	28514442
TRIP6_HUMAN	TRIP6	physical	28514442
ZN507_HUMAN	ZNF507	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SUN1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND MASSSPECTROMETRY.	17081983 [Abstract]