HNRLL_HUMAN - dbPTM
HNRLL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRLL_HUMAN
UniProt AC Q8WVV9
Protein Name Heterogeneous nuclear ribonucleoprotein L-like
Gene Name HNRNPLL
Organism Homo sapiens (Human).
Sequence Length 542
Subcellular Localization
Protein Description RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC..
Protein Sequence MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRREATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSSSSPR
------CCCCCCCCC		38.6430266825
2Acetylation------MSSSSSSPR
------CCCCCCCCC		38.6419413330
3Phosphorylation-----MSSSSSSPRE
-----CCCCCCCCCC		32.7030266825
4Phosphorylation----MSSSSSSPRET
----CCCCCCCCCCH		27.2530266825
5Phosphorylation---MSSSSSSPRETY
---CCCCCCCCCCHH		36.4630266825
6Phosphorylation--MSSSSSSPRETYE
--CCCCCCCCCCHHH		46.4330266825
7Phosphorylation-MSSSSSSPRETYEE
-CCCCCCCCCCHHHH		29.8930266825
11PhosphorylationSSSSPRETYEEDREY
CCCCCCCHHHHHHHH		37.2026074081
12PhosphorylationSSSPRETYEEDREYE
CCCCCCHHHHHHHHH		16.7426074081
16MethylationRETYEEDREYESQAK
CCHHHHHHHHHHHHH		52.23115479465
18PhosphorylationTYEEDREYESQAKRL
HHHHHHHHHHHHHHH		23.0526074081
20PhosphorylationEEDREYESQAKRLKT
HHHHHHHHHHHHHCC		34.2426074081
23AcetylationREYESQAKRLKTEEG
HHHHHHHHHHCCCCC		51.1025953088
26SumoylationESQAKRLKTEEGEID
HHHHHHHCCCCCCCC		58.90-
26SumoylationESQAKRLKTEEGEID
HHHHHHHCCCCCCCC		58.9028112733
27PhosphorylationSQAKRLKTEEGEIDY
HHHHHHCCCCCCCCC		43.8123403867
34PhosphorylationTEEGEIDYSAEEGEN
CCCCCCCCCCCCCCC		18.5523927012
35PhosphorylationEEGEIDYSAEEGENR
CCCCCCCCCCCCCCC		26.0022167270
46PhosphorylationGENRREATPRGGGDG
CCCCCCCCCCCCCCC		14.5725159151
59PhosphorylationDGGGGGRSFSQPEAG
CCCCCCCCCCCCCCC		32.3125159151
61PhosphorylationGGGGRSFSQPEAGGS
CCCCCCCCCCCCCCC		46.1822322096
66 (in isoform 3)Ubiquitination-36.1521890473
66 (in isoform 4)Ubiquitination-36.1521890473
68PhosphorylationSQPEAGGSHHKVSVS
CCCCCCCCCCEEEEC		22.8530266825
71 (in isoform 2)Ubiquitination-30.6821890473
71UbiquitinationEAGGSHHKVSVSPVV
CCCCCCCEEEECCEE		30.6821890473
71AcetylationEAGGSHHKVSVSPVV
CCCCCCCEEEECCEE		30.6825953088
71UbiquitinationEAGGSHHKVSVSPVV
CCCCCCCEEEECCEE		30.6821890473
71 (in isoform 1)Ubiquitination-30.6821890473
73PhosphorylationGGSHHKVSVSPVVHV
CCCCCEEEECCEEEH		22.9829396449
75PhosphorylationSHHKVSVSPVVHVRG
CCCEEEECCEEEHHH		12.4125159151
84GlutathionylationVVHVRGLCESVVEAD
EEEHHHHHCHHHHHH		4.0022555962
154PhosphorylationYSTSKRITRPGNTDD
CCCCCCCCCCCCCCC		34.5428555341
222UbiquitinationVLCAQKAKAALNGAD
HHHHHHHHHHHCCCC		41.02-
227UbiquitinationKAKAALNGADIYAGC
HHHHHHCCCCEECCC		26.0221890473
238AcetylationYAGCCTLKIEYARPT
ECCCCEEEEEECCCC		18.4826051181
256 (in isoform 3)Ubiquitination-28.2721890473
256 (in isoform 4)Ubiquitination-28.2721890473
256PhosphorylationVIRNDNDSWDYTKPY
EEECCCCCCCCCCCC		28.2720873877
260PhosphorylationDNDSWDYTKPYLGRR
CCCCCCCCCCCCCCC		24.0720873877
261SumoylationNDSWDYTKPYLGRRD
CCCCCCCCCCCCCCC		25.99-
261AcetylationNDSWDYTKPYLGRRD
CCCCCCCCCCCCCCC		25.9923236377
261UbiquitinationNDSWDYTKPYLGRRD
CCCCCCCCCCCCCCC		25.9921890473
261 (in isoform 2)Ubiquitination-25.9921890473
261 (in isoform 1)Ubiquitination-25.9921890473
284PhosphorylationAILGEHPSSFRHDGY
HHHCCCCCCCCCCCC		43.9720873877
285PhosphorylationILGEHPSSFRHDGYG
HHCCCCCCCCCCCCC		30.6523312004
293PhosphorylationFRHDGYGSHGPLLPL
CCCCCCCCCCCCCCC		19.4528348404
302PhosphorylationGPLLPLPSRYRMGSR
CCCCCCCCCCCCCCC		50.0227080861
304PhosphorylationLLPLPSRYRMGSRDT
CCCCCCCCCCCCCCC		14.8627080861
308PhosphorylationPSRYRMGSRDTPELV
CCCCCCCCCCCCHHE		20.0329978859
311PhosphorylationYRMGSRDTPELVAYP
CCCCCCCCCHHEEEE		19.9729978859
369UbiquitinationIEKVKFMKTIPGTAL
EEEEEEEEECCCCEE		46.57-
396UbiquitinationVTHLNNVKLFGKRLN
HHHHHCCEEECEEEC		39.98-
396AcetylationVTHLNNVKLFGKRLN
HHHHHCCEEECEEEC		39.9825953088
396MalonylationVTHLNNVKLFGKRLN
HHHHHCCEEECEEEC		39.9826320211
405GlutathionylationFGKRLNVCVSKQHSV
ECEEECEEEECCCCC		2.5222555962
408UbiquitinationRLNVCVSKQHSVVPS
EECEEEECCCCCCHH		31.47-
408AcetylationRLNVCVSKQHSVVPS
EECEEEECCCCCCHH		31.4726051181
411PhosphorylationVCVSKQHSVVPSQIF
EEEECCCCCCHHHEE		23.4723186163
415PhosphorylationKQHSVVPSQIFELED
CCCCCCHHHEEEECC		25.0523186163
424PhosphorylationIFELEDGTSSYKDFA
EEEECCCCCHHHHHH		27.1623186163
425PhosphorylationFELEDGTSSYKDFAM
EEECCCCCHHHHHHH		36.8823186163
426PhosphorylationELEDGTSSYKDFAMS
EECCCCCHHHHHHHH		35.7223186163
427PhosphorylationLEDGTSSYKDFAMSK
ECCCCCHHHHHHHHC		17.8423186163
428UbiquitinationEDGTSSYKDFAMSKN
CCCCCHHHHHHHHCC		48.60-
434UbiquitinationYKDFAMSKNNRFTSA
HHHHHHHCCCCCCCC		45.19-
445PhosphorylationFTSAGQASKNIIQPP
CCCCCCCCCCCCCCC		20.5322210691
484UbiquitinationHEVLTFIKYKVFDAK
HHHEEEEEEEEECCC		34.52-
484AcetylationHEVLTFIKYKVFDAK
HHHEEEEEEEEECCC		34.5226051181
486UbiquitinationVLTFIKYKVFDAKPS
HEEEEEEEEECCCCC		31.27-
486AcetylationVLTFIKYKVFDAKPS
HEEEEEEEEECCCCC		31.2726051181
491UbiquitinationKYKVFDAKPSAKTLS
EEEEECCCCCCCHHH		41.15-
491SumoylationKYKVFDAKPSAKTLS
EEEEECCCCCCCHHH		41.1528112733
491SumoylationKYKVFDAKPSAKTLS
EEEEECCCCCCCHHH		41.15-
527PhosphorylationQIRVPNGSNPYTLKL
EEECCCCCCCEEEEE		41.0728450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRLL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRLL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRLL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HNRLL_HUMANHNRNPLLphysical
25416956
CCNB2_HUMANCCNB2physical
26344197
SETD2_HUMANSETD2physical
28514442
ZFHX4_HUMANZFHX4physical
28514442
ESRP2_HUMANESRP2physical
28514442
PPHLN_HUMANPPHLN1physical
28514442
SAM11_HUMANSAMD11physical
28514442
PHYD1_HUMANPHYHD1physical
28514442
MBNL2_HUMANMBNL2physical
28514442
RAVR2_HUMANRAVER2physical
28514442
NCOR1_HUMANNCOR1physical
28514442
F208B_HUMANFAM208Bphysical
28514442
TBX3_HUMANTBX3physical
28514442
QKI_HUMANQKIphysical
28514442
PDIA6_HUMANPDIA6physical
28514442
BRE1B_HUMANRNF40physical
28514442
JMJD4_HUMANJMJD4physical
28514442
HDAC3_HUMANHDAC3physical
28514442
MCM9_HUMANMCM9physical
28514442
TASOR_HUMANFAM208Aphysical
28514442
N42L2_HUMANN4BP2L2physical
28514442
RAVR1_HUMANRAVER1physical
28514442
ANGE2_HUMANANGEL2physical
28514442
WDR33_HUMANWDR33physical
28514442
PJA1_HUMANPJA1physical
28514442
NSUN5_HUMANNSUN5physical
28514442
UBR5_HUMANUBR5physical
28514442
PAF1_HUMANPAF1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRLL_HUMAN

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Related Literatures of Post-Translational Modification

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