PHYD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHYD1_HUMAN
• UniProt AC: Q5SRE7
• Protein Name: Phytanoyl-CoA dioxygenase domain-containing protein 1
• Gene Name: PHYHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Protein Description: Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA. Isoform 2 and isoform 3 probably lack enzyme activity..
• Protein Sequence: MACLSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MACLSPSQLQKF ---CCCCCHHHHHHH	23.53	28348404
55	Phosphorylation	HCRTEFSTQEEEQLR EEECCCCCHHHHHHH	45.37	17525332
102	Acetylation	PPEKSINKIGHALHA CCHHHHHHHHHHHHC	48.68	7460727
116	Phosphorylation	AHDPVFKSITHSFKV CCCHHHHHHCHHHHH	22.66	24719451
125	Phosphorylation	THSFKVQTLARSLGL CHHHHHHHHHHHCCC	25.93	-
129	Phosphorylation	KVQTLARSLGLQMPV HHHHHHHHCCCCCCE	22.60	-
140	Phosphorylation	QMPVVVQSMYIFKQP CCCEEEEEEEEEECC	11.27	-
154	Phosphorylation	PHFGGEVSPHQDASF CCCCCCCCCCCCCCE	16.62	28857561
160	Phosphorylation	VSPHQDASFLYTEPL CCCCCCCCEEECCCH	24.87	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHYD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHYD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHYD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-55, AND MASSSPECTROMETRY.
PubMed: 17525332