dbPTM

ZFHX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZFHX4_HUMAN
UniProt AC	Q86UP3
Protein Name	Zinc finger homeobox protein 4
Gene Name	ZFHX4
Organism	Homo sapiens (Human).
Sequence Length	3567
Subcellular Localization	Nucleus .
Protein Description	May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation..
Protein Sequence	METCDSPPISRQENGQSTSKLCGTTQLDNEVPEKVAGMEPDRENSSTDDNLKTDERKSEALLGFSVENAAATQVTSAKEIPCNECATSFPSLQKYMEHHCPNARLPVLKDDNESEISELEDSDVENLTGEIVYQPDGSAYIIEDSKESGQNAQTGANSKLFSTAMFLDSLASAGEKSDQSASAPMSFYPQIINTFHIASSLGKPFTADQAFPNTSALAGVGPVLHSFRVYDLRHKREKDYLTSDGSAKNSCVSKDVPNNVDLSKFDGCVSDGKRKPVLMCFLCKLSFGYIRSFVTHAVHDHRMTLNDEEQKLLSNKCVSAIIQGIGKDKEPLISFLEPKKSTSVYPHFSTTNLIGPDPTFRGLWSAFHVENGDSLPAGFAFLKGSASTSSSAEQPLGITQMPKAEVNLGGLSSLVVNTPITSVSLSHSSSESSKMSESKDQENNCERPKESNVLHPNGECPVKSEPTEPGDEDEEDAYSNELDDEEVLGELTDSIGNKDFPLLNQSISPLSSSVLKFIEKGTSSSSATVSDDTEKKKQTAAVRASGSVASNYGISGKDFADASASKDSATAAHPSEIARGDEDSSATPHQHGFTPSTPGTPGPGGDGSPGSGIECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKTGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNVQNLQNGNGEQVFGHSAPAPNTSLSGCGTPSPSKPKQKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMKQIQHNLHLGLAPAEAELYQYYLAQNIGLTGMKLENPADPQLMINPFQLDPATAAALAPGLGELSPYISDPALKLFQCAVCNKFTSDSLEALSVHVSSERSLPEEEWRAVIGDIYQCKLCNYNTQLKANFQLHCKTDKHMQKYQLVAHIKEGGKSNEWRLKCIAIGNPVHLKCNACDYYTNSVDKLRLHTTNHRHEAALKLYKHLQKQEGAVNPESCYYYCAVCDYTTKVKLNLVQHVRSVKHQQTEGLRKLQLHQQGLAPEEDNLSEIFFVKDCPPNELETASLGARTCDDDLTEQHEEAEGAIKPTAVAEDDEKDTSERDNSEGKNSNKDSVSVAGGTQPLLLAKEEDVATKRSKPTEDNKFCHEQFYQCPYCNYNSRDQSRIQMHVLSQHSVQPVICCPLCQDVLSNKMHLQLHLTHLHSVSPDCVEKLLMTVPVPDVMMPNSMLLPAAASEKSERDTPAAVTAEGSGKYSGESPMDDKSMAGLEDSKANVEVKNEEQKPTKEPLEVSEWNKNSSKDVKIPDTLQDQLNEQQKRQPLSVSDRHVYKYRCNHCSLAFKTMQKLQIHSQYHAIRAATMCNLCQRSFRTFQALKKHLEAGHPELSEAELQQLYASLPVNGELWAESETMSQDDHGLEQEMEREYEVDHEGKASPVGSDSSSIPDDMGSEPKRTLPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKKVLQEASSPVPQETNSNTDNKPYKCSICNVAYSQSSTLEIHMRSVLHQTKARAAKLEPSGHVAGGHSIAANVNSPGQGMLDSMSLAAVNSKDTHLDAKELNKKQTPDLISAQPAHHPPQSPAQIQMQLQHELQQQAAFFQPQFLNPAFLPHFPMTPEALLQFQQPQFLFPFYIPGTEFSLGPDLGLPGSATFGMPGMTGMAGSLLEDLKQQIQTQHHVGQTQLQILQQQAQQYQATQPQLQPQKQQQQPPPPQQQQQQQASKLLKQEQSNIVSADCQIMKDVPSYKEAEDISEKPEKPKQEFISEGEGLKEGKDTKKQKSLEPSIPPPRIASGARGNAAKALLENFGFELVIQYNENRQKVQKKGKSGEGENTDKLECGTCGKLFSNVLILKSHQEHVHGQFFPYAALEKFARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQMDALSADLTQLCQQQLGLDPNFLRHSQFKRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITVLEDIRIDPQPTSLEHYKSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKSYENQAETKDNEKRELTNERYIRTSNMQYQCKKCNVVFPRIFDLITHQKKQCYKDEDDDAQDESQTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQTPVPSSPLQISMTSLQNSLPPQLLQYQCDQCTVAFPTLELWQEHQHMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQASSSHTTAPTTVAASLKRKLDDKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYSLPPSPLISTEDGGESPQKYIYFDYPSLPLTKIDLSSENELASTVSTPVSKTAELSPKNLLSPSSFKAECSEDVENLNAPPAEAGYDQNKTDFDETSSINTAISDATTGDEGNTEMESTTGSSGDVKPALSPKEPKTLDTLPKPATTPTTEVCDDKFLFSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSSIADPSSPNPFGSSNPFKSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFKINIGKPFMINQGGTEGTKPECTLCGVKYSARLSIRDHIFSKQHISKVRETVGSQLDREKDYLAPTTVRQLMAQQELDRIKKASDVLGLTVQQPGMMDSSSLHGISLPTAYPGLPGLPPVLLPGMNGPSSLPGFPQNSNISAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSLSGQQTEQQNKESEKKQTKPNKVKKIKEEELEATKPEKHPKKEEKISSALSVLGKVVGETHVDPIQLQALQNAIAGDPASFIGGQFLPYFIPGFASYFTPQLPGTVQGGYFPPVCGMESLFPYGPTMPQTLAGLSPGALLQQYQQYQQNLQESLQKQQKQQQEQQQKPVQAKTSKVESDQPQNSNDASETKEDKSTATESTKEEPQLESKSADFSDTYVVPFVKYEFICRKCQMMFTDEDAAVNHQKSFCYFGQPLIDPQETVLRVPVSKYQCLACDVAISGNEALSQHLQSSLHKEKTIKQAMRNAKEHVRLLPHSVCSPNPNTTSTSQSAASSNNTYPHLSCFSMKSWPNILFQASARRAASPPSSPPSLSLPSTVTSSLCSTSGVQTSLPTESCSDESDSELSQKLEDLDNSLEVKAKPASGLDGNFNSIRMDMFSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METCDSPP -------CCCCCCCC	42.15	19413330
3	Phosphorylation	-----METCDSPPIS -----CCCCCCCCCC	33.21	27732954
6	Phosphorylation	--METCDSPPISRQE --CCCCCCCCCCCCC	34.42	29255136
10	Phosphorylation	TCDSPPISRQENGQS CCCCCCCCCCCCCCC	33.41	27732954
24	Phosphorylation	STSKLCGTTQLDNEV CCCCCCCCCCCCCCC	15.46	22210691
45	Phosphorylation	MEPDRENSSTDDNLK CCCCCCCCCCCCCCC	29.84	27732954
46	Phosphorylation	EPDRENSSTDDNLKT CCCCCCCCCCCCCCC	47.65	27732954
47	Phosphorylation	PDRENSSTDDNLKTD CCCCCCCCCCCCCCH	47.39	27732954
148	Phosphorylation	IIEDSKESGQNAQTG EEECCHHHCCCCCCC	49.79	28634120
154	Phosphorylation	ESGQNAQTGANSKLF HHCCCCCCCCCHHHH	35.53	29485707
263	Phosphorylation	VPNNVDLSKFDGCVS CCCCCCHHHCCCCCC	27.15	18088087
464	Phosphorylation	NGECPVKSEPTEPGD CCCCCCCCCCCCCCC	49.39	30377224
467	Phosphorylation	CPVKSEPTEPGDEDE CCCCCCCCCCCCCCC	51.24	30377224
478	Phosphorylation	DEDEEDAYSNELDDE CCCCCHHHHCCCCHH	25.09	30377224
479	Phosphorylation	EDEEDAYSNELDDEE CCCCHHHHCCCCHHH	26.08	30377224
506	Phosphorylation	DFPLLNQSISPLSSS CCCCCCCCCCCCCHH	24.78	29255136
508	Phosphorylation	PLLNQSISPLSSSVL CCCCCCCCCCCHHHH	25.65	29255136
508 (in isoform 5)	Phosphorylation	-	25.65	27251275
511	Phosphorylation	NQSISPLSSSVLKFI CCCCCCCCHHHHHHH	24.77	29255136
512	Phosphorylation	QSISPLSSSVLKFIE CCCCCCCHHHHHHHH	31.95	29255136
513	Phosphorylation	SISPLSSSVLKFIEK CCCCCCHHHHHHHHC	28.26	29255136
545	Phosphorylation	QTAAVRASGSVASNY HHHHHHHCCCCHHHC	22.49	24670416
547	Phosphorylation	AAVRASGSVASNYGI HHHHHCCCCHHHCCC	16.41	23403867
552	Phosphorylation	SGSVASNYGISGKDF CCCCHHHCCCCCHHH	17.22	23403867
555	Phosphorylation	VASNYGISGKDFADA CHHHCCCCCHHHCCC	35.11	23403867
563	Phosphorylation	GKDFADASASKDSAT CHHHCCCCCCCCCCC	33.35	24719451
563 (in isoform 5)	Phosphorylation	-	33.35	24719451
575	Phosphorylation	SATAAHPSEIARGDE CCCCCCHHHHHCCCC	31.59	24719451
575 (in isoform 5)	Phosphorylation	-	31.59	24719451
584	Phosphorylation	IARGDEDSSATPHQH HHCCCCCCCCCCCCC	21.59	29978859
585	Phosphorylation	ARGDEDSSATPHQHG HCCCCCCCCCCCCCC	48.78	25002506
587	Phosphorylation	GDEDSSATPHQHGFT CCCCCCCCCCCCCCC	24.21	25002506
594	Phosphorylation	TPHQHGFTPSTPGTP CCCCCCCCCCCCCCC	22.41	29978859
596	Phosphorylation	HQHGFTPSTPGTPGP CCCCCCCCCCCCCCC	44.15	29978859
597	Phosphorylation	QHGFTPSTPGTPGPG CCCCCCCCCCCCCCC	27.26	25002506
600	Phosphorylation	FTPSTPGTPGPGGDG CCCCCCCCCCCCCCC	26.69	25002506
608	Phosphorylation	PGPGGDGSPGSGIEC CCCCCCCCCCCCCCC	30.72	25850435
611	Phosphorylation	GGDGSPGSGIECPKC CCCCCCCCCCCCCCC	39.73	25850435
620	Phosphorylation	IECPKCDTVLGSSRS CCCCCCCCEEECCCC	27.40	-
624	Phosphorylation	KCDTVLGSSRSLGGH CCCCEEECCCCCCCH	20.58	22210691
627	Phosphorylation	TVLGSSRSLGGHMTM CEEECCCCCCCHHHE	33.06	23403867
637	Phosphorylation	GHMTMMHSRNSCKTL CHHHEEECCCCCCCC	18.43	22210691
643	Phosphorylation	HSRNSCKTLKCPKCN ECCCCCCCCCCCCCC	35.46	22210691
691	Phosphorylation	PRLARGESYTCGYKP CCCCCCCCCCCCCCC	28.68	28857561
715	Phosphorylation	TTTKGNLSIHMQSDK CCCCCCEEEEECCCC	17.91	28555341
748	Phosphorylation	HSAPAPNTSLSGCGT CCCCCCCCCCCCCCC	29.95	29449344
749	Phosphorylation	SAPAPNTSLSGCGTP CCCCCCCCCCCCCCC	27.46	29449344
751	Phosphorylation	PAPNTSLSGCGTPSP CCCCCCCCCCCCCCC	31.63	29449344
755	Phosphorylation	TSLSGCGTPSPSKPK CCCCCCCCCCCCCCC	25.35	23898821
757	Phosphorylation	LSGCGTPSPSKPKQK CCCCCCCCCCCCCCC	41.46	23898821
759	Phosphorylation	GCGTPSPSKPKQKPT CCCCCCCCCCCCCCC	66.96	29449344
893 (in isoform 2)	Phosphorylation	-	15.49	27732954
893 (in isoform 5)	Phosphorylation	-	15.49	27732954
895 (in isoform 2)	Phosphorylation	-	19.75	27732954
895 (in isoform 5)	Phosphorylation	-	19.75	27732954
897 (in isoform 2)	Phosphorylation	-	15.46	27732954
897 (in isoform 5)	Phosphorylation	-	15.46	27732954
1069	Phosphorylation	APEEDNLSEIFFVKD CCCCCCCCEEEEEEC	34.60	27732954
1108	Acetylation	EEAEGAIKPTAVAED HHHCCCCCCCCEECC	35.46	30593507
1120	Phosphorylation	AEDDEKDTSERDNSE ECCCCCCCCCCCCCC	43.48	-
1121	Phosphorylation	EDDEKDTSERDNSEG CCCCCCCCCCCCCCC	40.54	-
1126	Phosphorylation	DTSERDNSEGKNSNK CCCCCCCCCCCCCCC	52.60	-
1142	Phosphorylation	SVSVAGGTQPLLLAK CEEECCCCCCEEEEE	26.54	27282143
1149	Sumoylation	TQPLLLAKEEDVATK CCCEEEEEHHHHCCC	62.70	28112733
1155	Phosphorylation	AKEEDVATKRSKPTE EEHHHHCCCCCCCCC	27.17	-
1174 (in isoform 2)	Phosphorylation	-	1.44	30266825
1174 (in isoform 5)	Phosphorylation	-	1.44	30266825
1196	Phosphorylation	MHVLSQHSVQPVICC HHHHHHCCCCCEEEC	18.14	-
1237	Phosphorylation	CVEKLLMTVPVPDVM HHHHHHHCCCCCCCC	22.94	26074081
1248	Phosphorylation	PDVMMPNSMLLPAAA CCCCCCCCCCCCCHH	12.63	26074081
1259	Phosphorylation	PAAASEKSERDTPAA CCHHCCCCCCCCCCC	33.54	25850435
1263	Phosphorylation	SEKSERDTPAAVTAE CCCCCCCCCCCEECC	22.50	29255136
1272	Phosphorylation	AAVTAEGSGKYSGES CCEECCCCCCCCCCC	24.50	-
1279	Phosphorylation	SGKYSGESPMDDKSM CCCCCCCCCCCCCHH	29.11	28985074
1299	Sumoylation	SKANVEVKNEEQKPT CCCCCEECCCCCCCC	45.17	28112733
1313	Phosphorylation	TKEPLEVSEWNKNSS CCCCCCHHHCCCCCC	27.76	-
1324	Sumoylation	KNSSKDVKIPDTLQD CCCCCCCCCCHHHHH	59.67	28112733
1324 (in isoform 5)	Phosphorylation	-	59.67	27251275
1328	O-linked_Glycosylation	KDVKIPDTLQDQLNE CCCCCCHHHHHHHHH	22.44	30620550
1345	Phosphorylation	KRQPLSVSDRHVYKY HCCCCCCCHHHHHHE	26.08	22210691
1363	Phosphorylation	HCSLAFKTMQKLQIH CCHHHHHHHHHHHHH	20.55	24719451
1371	Phosphorylation	MQKLQIHSQYHAIRA HHHHHHHHHHHHHHH	33.78	22210691
1373	Phosphorylation	KLQIHSQYHAIRAAT HHHHHHHHHHHHHHH	9.02	22210691
1380	Phosphorylation	YHAIRAATMCNLCQR HHHHHHHHHHHHHHH	22.67	24719451
1446	Phosphorylation	EQEMEREYEVDHEGK HHHHHHHEECCCCCC	27.72	27732954
1455	Phosphorylation	VDHEGKASPVGSDSS CCCCCCCCCCCCCCC	24.49	22199227
1459	Phosphorylation	GKASPVGSDSSSIPD CCCCCCCCCCCCCCC	34.26	20363803
1461	Phosphorylation	ASPVGSDSSSIPDDM CCCCCCCCCCCCCCC	27.90	27732954
1462	Phosphorylation	SPVGSDSSSIPDDMG CCCCCCCCCCCCCCC	36.96	27732954
1463	Phosphorylation	PVGSDSSSIPDDMGS CCCCCCCCCCCCCCC	41.93	27732954
1470	Phosphorylation	SIPDDMGSEPKRTLP CCCCCCCCCCCCCCC	44.05	-
1475	Phosphorylation	MGSEPKRTLPFRKGP CCCCCCCCCCCCCCC	44.93	-
1485	Phosphorylation	FRKGPNFTMEKFLDP CCCCCCCCHHHHCCC	30.94	24144214
1532	Phosphorylation	KKVLQEASSPVPQET HHHHHHCCCCCCCCC	34.13	25850435
1533	Phosphorylation	KVLQEASSPVPQETN HHHHHCCCCCCCCCC	36.64	22496350
1539	Phosphorylation	SSPVPQETNSNTDNK CCCCCCCCCCCCCCC	38.40	27732954
1541	Phosphorylation	PVPQETNSNTDNKPY CCCCCCCCCCCCCCE	48.83	27732954
1543	Phosphorylation	PQETNSNTDNKPYKC CCCCCCCCCCCCEEE	40.55	27732954
1546	Sumoylation	TNSNTDNKPYKCSIC CCCCCCCCCEEEEEE	53.16	28112733
1548	Phosphorylation	SNTDNKPYKCSICNV CCCCCCCEEEEEEEE	26.66	27732954
1790	Sumoylation	QQASKLLKQEQSNIV HHHHHHHHHHHHCHH	63.32	28112733
1809	O-linked_Glycosylation	QIMKDVPSYKEAEDI HHHHCCCCCHHHHHH	49.00	30620550
1888	Acetylation	ENRQKVQKKGKSGEG HHHHHHHHCCCCCCC	67.49	7666273
1891	Acetylation	QKVQKKGKSGEGENT HHHHHCCCCCCCCCC	65.25	7666285
1892	Phosphorylation	KVQKKGKSGEGENTD HHHHCCCCCCCCCCC	51.23	17287340
1900	Acetylation	GEGENTDKLECGTCG CCCCCCCCCCCCHHH	44.11	7666297
1937	Phosphorylation	YAALEKFARQYREAY HHHHHHHHHHHHHHH	14.56	17287340
1951	Phosphorylation	YDKLYPISPSSPETP HHHHCCCCCCCCCCC	17.77	30377224
1953	Phosphorylation	KLYPISPSSPETPPP HHCCCCCCCCCCCCC	52.30	30377224
1954	Phosphorylation	LYPISPSSPETPPPP HCCCCCCCCCCCCCC	30.09	30377224
1957	Phosphorylation	ISPSSPETPPPPPPP CCCCCCCCCCCCCCC	44.47	30377224
1975	O-linked_Glycosylation	PPAPPQPSSMGPVKI CCCCCCCCCCCCCCC	27.92	30620550
2092	Phosphorylation	KRPRTRITDDQLKIL CCCCCCCCHHHHHHH	30.17	22210691
2146	Phosphorylation	ERQRNKDSPYNFSNP HHHHCCCCCCCCCCC	30.78	20068231
2148	Phosphorylation	QRNKDSPYNFSNPPI HHCCCCCCCCCCCCE	32.56	18669648
2151	Phosphorylation	KDSPYNFSNPPITVL CCCCCCCCCCCEEEE	44.80	27732954
2178	Phosphorylation	EHYKSDASFSKRSSR HHHCCCCCCCCCCCC	34.73	24719451
2239	Phosphorylation	ARQKARKSYENQAET HHHHHHHHHHCCCCC	31.93	24144214
2240	Phosphorylation	RQKARKSYENQAETK HHHHHHHHHCCCCCC	23.18	24144214
2320	Phosphorylation	QVVYKHCTVSGQTDA CEEEECCEECCCCHH	19.89	22210691
2322	Phosphorylation	VYKHCTVSGQTDAAK EEECCEECCCCHHHH	13.66	22210691
2325	Phosphorylation	HCTVSGQTDAAKNAA CCEECCCCHHHHHHC	31.00	22210691
2337	Phosphorylation	NAAAPAASSGSGTST HHCCCHHHCCCCCCC	37.02	27732954
2338	Phosphorylation	AAAPAASSGSGTSTP HCCCHHHCCCCCCCC	32.05	30576142
2340	Phosphorylation	APAASSGSGTSTPLI CCHHHCCCCCCCCCC	40.63	30619164
2342	Phosphorylation	AASSGSGTSTPLIPS HHHCCCCCCCCCCCC	30.99	30619164
2343	Phosphorylation	ASSGSGTSTPLIPSP HHCCCCCCCCCCCCC	31.39	27732954
2344	Phosphorylation	SSGSGTSTPLIPSPK HCCCCCCCCCCCCCC	23.19	27732954
2349	Phosphorylation	TSTPLIPSPKPEPEK CCCCCCCCCCCCCCC	38.26	27732954
2357	Phosphorylation	PKPEPEKTSPKPEYP CCCCCCCCCCCCCCC	48.91	25022875
2358	Phosphorylation	KPEPEKTSPKPEYPA CCCCCCCCCCCCCCC	41.83	24173317
2363	Phosphorylation	KTSPKPEYPAEKPKQ CCCCCCCCCCCCCCC	19.10	25022875
2532	Phosphorylation	APTTVAASLKRKLDD CCHHHHHHHHHHCCC	25.37	24719451
2546	Phosphorylation	DKEDNNCSEKEGGNS CCCCCCCCCCCCCCC	54.55	29449344
2579	Phosphorylation	LEILYEKYLLDSNPT HHHHHHHHHCCCCCH	10.68	27762562
2583	Phosphorylation	YEKYLLDSNPTRKML HHHHHCCCCCHHHHH	44.68	21815630
2586	Phosphorylation	YLLDSNPTRKMLDHI HHCCCCCHHHHHHHH	47.36	26270265
2662	Phosphorylation	NEGKQAGYSLPPSPL CCCCCCCCCCCCCCC	15.28	23663014
2663	Phosphorylation	EGKQAGYSLPPSPLI CCCCCCCCCCCCCCE	33.22	28112733
2667	Phosphorylation	AGYSLPPSPLISTED CCCCCCCCCCEECCC	30.33	23663014
2671	Phosphorylation	LPPSPLISTEDGGES CCCCCCEECCCCCCC	33.17	23663014
2672	Phosphorylation	PPSPLISTEDGGESP CCCCCEECCCCCCCC	30.97	23663014
2678	Phosphorylation	STEDGGESPQKYIYF ECCCCCCCCCEEEEE	35.59	23663014
2682	Phosphorylation	GGESPQKYIYFDYPS CCCCCCEEEEEECCC	8.80	23663014
2684	Phosphorylation	ESPQKYIYFDYPSLP CCCCEEEEEECCCCC	6.31	23663014
2687	Phosphorylation	QKYIYFDYPSLPLTK CEEEEEECCCCCCEE	5.70	23663014
2689	Phosphorylation	YIYFDYPSLPLTKID EEEEECCCCCCEEEC	36.07	23663014
2693	Phosphorylation	DYPSLPLTKIDLSSE ECCCCCCEEECCCCC	24.82	23663014
2706	Phosphorylation	SENELASTVSTPVSK CCCCHHCCCCCCCHH	16.93	29978859
2707	Phosphorylation	ENELASTVSTPVSKT CCCHHCCCCCCCHHC	5.78	18669648
2708	Phosphorylation	NELASTVSTPVSKTA CCHHCCCCCCCHHCC	27.38	29978859
2709	Phosphorylation	ELASTVSTPVSKTAE CHHCCCCCCCHHCCC	24.31	29978859
2712	O-linked_Glycosylation	STVSTPVSKTAELSP CCCCCCCHHCCCCCC	26.03	30620550
2712	Phosphorylation	STVSTPVSKTAELSP CCCCCCCHHCCCCCC	26.03	29978859
2714	Phosphorylation	VSTPVSKTAELSPKN CCCCCHHCCCCCCCC	20.18	28102081
2718	Phosphorylation	VSKTAELSPKNLLSP CHHCCCCCCCCCCCH	25.90	28102081
2724	Phosphorylation	LSPKNLLSPSSFKAE CCCCCCCCHHHHHHH	26.38	30266825
2726	Phosphorylation	PKNLLSPSSFKAECS CCCCCCHHHHHHHCC	45.06	30266825
2727	Phosphorylation	KNLLSPSSFKAECSE CCCCCHHHHHHHCCC	33.86	30266825
2729	Phosphorylation	LLSPSSFKAECSEDV CCCHHHHHHHCCCCH	45.27	18669648
2748	Phosphorylation	APPAEAGYDQNKTDF CCCHHHCCCCCCCCC	22.77	18083107
2763 (in isoform 5)	Phosphorylation	-	24.57	24719451
2769	Phosphorylation	NTAISDATTGDEGNT HHHHHCCCCCCCCCC	35.98	19413330
2769 (in isoform 5)	Phosphorylation	-	35.98	24719451
2793	Phosphorylation	GDVKPALSPKEPKTL CCCCCCCCCCCCCCC	35.71	24719451
2802	Phosphorylation	KEPKTLDTLPKPATT CCCCCCCCCCCCCCC	48.34	25850435
2808	Phosphorylation	DTLPKPATTPTTEVC CCCCCCCCCCCCCCC	41.66	29507054
2809	Phosphorylation	TLPKPATTPTTEVCD CCCCCCCCCCCCCCC	22.27	29507054
2811	Phosphorylation	PKPATTPTTEVCDDK CCCCCCCCCCCCCCC	33.23	25850435
2812	Phosphorylation	KPATTPTTEVCDDKF CCCCCCCCCCCCCCE	27.85	27251275
2822	Phosphorylation	CDDKFLFSLTSPSIH CCCCEEEECCCCEEE	32.65	22199227
2824	Phosphorylation	DKFLFSLTSPSIHFN CCEEEECCCCEEECC	37.08	22199227
2825	Phosphorylation	KFLFSLTSPSIHFND CEEEECCCCEEECCC	23.18	22199227
2827	Phosphorylation	LFSLTSPSIHFNDKD EEECCCCEEECCCCC	28.58	22199227
2853 (in isoform 5)	Phosphorylation	-	33.70	27251275
2854	Phosphorylation	PDDNADRSETSSIAD CCCCCCHHHCCCCCC	45.86	19413330
2857	Phosphorylation	NADRSETSSIADPSS CCCHHHCCCCCCCCC	18.72	24505115
2863	Phosphorylation	TSSIADPSSPNPFGS CCCCCCCCCCCCCCC	60.00	27732954
2864	Phosphorylation	SSIADPSSPNPFGSS CCCCCCCCCCCCCCC	33.80	27732954
2870 (in isoform 5)	Phosphorylation	-	27.59	27251275
2948	Acetylation	KFKINIGKPFMINQG EEEEEECCCEEECCC	31.14	22424773
2965	Phosphorylation	EGTKPECTLCGVKYS CCCCCCEEECCCEEE	24.34	27251275
2972	Phosphorylation	TLCGVKYSARLSIRD EECCCEEEEEEHHHH	10.95	27251275
2983	Phosphorylation	SIRDHIFSKQHISKV HHHHHHCCHHHHHHH	30.70	24719451
2988	Phosphorylation	IFSKQHISKVRETVG HCCHHHHHHHHHHHH	23.99	29083192
2993	Phosphorylation	HISKVRETVGSQLDR HHHHHHHHHHHHHHH	21.43	28985074
2996	Phosphorylation	KVRETVGSQLDREKD HHHHHHHHHHHHHCC	24.19	28985074
3008	Phosphorylation	EKDYLAPTTVRQLMA HCCCCCHHHHHHHHH	32.11	23312004
3009	Phosphorylation	KDYLAPTTVRQLMAQ CCCCCHHHHHHHHHH	16.78	23312004
3010 (in isoform 5)	Phosphorylation	-	3.95	27251275
3017 (in isoform 5)	Phosphorylation	-	43.62	27251275
3154	Sumoylation	PNKVKKIKEEELEAT CCHHHHHHHHHHHHC	68.87	28112733
3305	Phosphorylation	AKTSKVESDQPQNSN HHHHHCCCCCCCCCC	44.53	-
3311	Phosphorylation	ESDQPQNSNDASETK CCCCCCCCCCCHHCC	30.73	-
3315	Phosphorylation	PQNSNDASETKEDKS CCCCCCCHHCCCCCC	48.97	-
3325	Phosphorylation	KEDKSTATESTKEEP CCCCCCCCCCCCCCC	30.47	30576142
3327	Phosphorylation	DKSTATESTKEEPQL CCCCCCCCCCCCCCH	40.19	30576142
3364	Phosphorylation	RKCQMMFTDEDAAVN CCCCCEECCHHHHHH	22.15	28509920
3454	Phosphorylation	SPNPNTTSTSQSAAS CCCCCCCCCCHHHHH	24.83	30576142
3456	Phosphorylation	NPNTTSTSQSAASSN CCCCCCCCHHHHHCC	23.16	30576142
3473	Phosphorylation	YPHLSCFSMKSWPNI CCCCCHHCCCCCCCH	29.63	24719451
3542	Phosphorylation	KLEDLDNSLEVKAKP HHHHHHCCCEEEEEC	26.10	25159151
3551	Phosphorylation	EVKAKPASGLDGNFN EEEEECCCCCCCCCC	48.71	27251275
3600 (in isoform 5)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZFHX4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZFHX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZFHX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CHD4_HUMAN	CHD4	physical	24440720

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZFHX4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-6; SER-508; SER-2724 AND THR-2809, AND MASSSPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-6; SER-508; SER-2724 AND THR-2809, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1892, AND MASSSPECTROMETRY.	17287340 [Abstract]