MORC4_HUMAN - dbPTM
MORC4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MORC4_HUMAN
UniProt AC Q8TE76
Protein Name MORC family CW-type zinc finger protein 4
Gene Name MORC4
Organism Homo sapiens (Human).
Sequence Length 937
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTIGYEGIHSPSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVEAPVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQMPRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLERVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationAFGIRLSTMSPRYLQ
CCCEEEECCCCCHHC		26.6829449344
36PhosphorylationGIRLSTMSPRYLQSN
CEEEECCCCCHHCCC		13.3029449344
87PhosphorylationNKSCLTFTDDGCGMT
CCCCEEECCCCCCCC		28.13-
94PhosphorylationTDDGCGMTPHKLHRM
CCCCCCCCHHHHHHH		13.92-
127PhosphorylationVFGNGFKSGSMRLGK
CCCCCCCCCCCCCCC		33.5624144214
129PhosphorylationGNGFKSGSMRLGKDA
CCCCCCCCCCCCCCE		14.0724144214
134UbiquitinationSGSMRLGKDALVFTK
CCCCCCCCCEEEEEE		44.41-
254PhosphorylationFDTEEKMTGGVTSEL
CCCCCCCCCCCCCCC		41.6823663014
258PhosphorylationEKMTGGVTSELPETE
CCCCCCCCCCCCCCH		21.5423663014
259PhosphorylationKMTGGVTSELPETEY
CCCCCCCCCCCCCHH		34.4323663014
264PhosphorylationVTSELPETEYSLRAF
CCCCCCCCHHHHHHH		37.9823663014
266PhosphorylationSELPETEYSLRAFCG
CCCCCCHHHHHHHHH		22.0323663014
267PhosphorylationELPETEYSLRAFCGI
CCCCCHHHHHHHHHH		12.7324719451
308UbiquitinationNVEYDTYKPTFTNKQ
CCCCEEECCCCCCCE		39.4121890473
383UbiquitinationKQDFEYTKEYRLTIN
CCCCCCCHHHHHHHH		52.4221890473
395UbiquitinationTINALAQKLNAYWKE
HHHHHHHHHHHHHHH		37.79-
403UbiquitinationLNAYWKEKTSQDNFE
HHHHHHHHCCCCCCC		50.1521890473
465PhosphorylationHPKYRRCSVPEEQEL
CCCCCCCCCCHHHCC		38.6123312004
506PhosphorylationNENHQVFSNPPKILT
CCCCCCCCCCCCEEE		49.9629116813
524PhosphorylationMAGLNNKTIGYEGIH
HCCCCCCCCCCCCCC		23.0429978859
527PhosphorylationLNNKTIGYEGIHSPS
CCCCCCCCCCCCCCC		13.7129978859
532PhosphorylationIGYEGIHSPSVLPSG
CCCCCCCCCCCCCCC		19.5629978859
534PhosphorylationYEGIHSPSVLPSGGE
CCCCCCCCCCCCCCC		39.0229978859
538PhosphorylationHSPSVLPSGGEESRS
CCCCCCCCCCCCCCC		56.0929449344
543PhosphorylationLPSGGEESRSPSLQL
CCCCCCCCCCCCCCC		33.4829449344
545PhosphorylationSGGEESRSPSLQLKP
CCCCCCCCCCCCCCC		28.2825627689
547PhosphorylationGEESRSPSLQLKPLD
CCCCCCCCCCCCCCC		29.9629449344
563UbiquitinationSVLQFSSKYKWILGE
HHHHHHHHCCCHHCC		50.0421890473
563UbiquitinationSVLQFSSKYKWILGE
HHHHHHHHCCCHHCC		50.0421890473
563UbiquitinationSVLQFSSKYKWILGE
HHHHHHHHCCCHHCC		50.0421890473
565SumoylationLQFSSKYKWILGEEP
HHHHHHCCCHHCCCC		31.34-
565SumoylationLQFSSKYKWILGEEP
HHHHHHCCCHHCCCC		31.34-
575UbiquitinationLGEEPVEKRRRLQNE
HCCCCHHHHHHHHHC		51.9821890473
587PhosphorylationQNEMTTPSLDYSMPA
HHCCCCCCCCCCCCC		31.6128348404
611 (in isoform 2)Phosphorylation-28.8525278378
613 (in isoform 2)Phosphorylation-52.9725278378
614UbiquitinationEGENSHDKSSSERST
CCCCCCCCCCCCCCC		46.98-
615PhosphorylationGENSHDKSSSERSTP
CCCCCCCCCCCCCCC		45.1929978859
616PhosphorylationENSHDKSSSERSTPP
CCCCCCCCCCCCCCC		41.7929978859
617PhosphorylationNSHDKSSSERSTPPY
CCCCCCCCCCCCCCC		44.0829978859
620PhosphorylationDKSSSERSTPPYLFP
CCCCCCCCCCCCCCC		41.0129978859
621PhosphorylationKSSSERSTPPYLFPE
CCCCCCCCCCCCCCC		34.2128985074
624PhosphorylationSERSTPPYLFPEYPE
CCCCCCCCCCCCCCH		23.3729978859
628 (in isoform 2)Phosphorylation-67.4025278378
629PhosphorylationPPYLFPEYPEASKNT
CCCCCCCCCHHHCCC		13.4529978859
631 (in isoform 2)Phosphorylation-65.7525278378
632 (in isoform 2)Phosphorylation-22.6925278378
633PhosphorylationFPEYPEASKNTGQNR
CCCCCHHHCCCCCCC		25.4429978859
636PhosphorylationYPEASKNTGQNREVS
CCHHHCCCCCCCEEE		43.8329978859
643PhosphorylationTGQNREVSILYPGAK
CCCCCEEEEECCCHH		11.3428555341
656PhosphorylationAKDQRQGSLLPEELE
HHCCCCCCCCCHHHH		20.5628348404
704PhosphorylationVAKGVRDSGAPIQLI
EEECCCCCCCCCEEE		26.7018187866
748UbiquitinationPAAAIGEKARGYEES
CHHHHCHHHCCCCCC		37.8621890473
760PhosphorylationEESEGHNTPKLKNQR
CCCCCCCCHHHCCHH		19.0028674419
775PhosphorylationELEELKRTTEKLERV
HHHHHHHHHHHHHHH		37.4126074081
776PhosphorylationLEELKRTTEKLERVL
HHHHHHHHHHHHHHH		34.8526074081
792UbiquitinationERNLFQQKVEELEQE
HCCHHHHHHHHHHHH		40.6121890473
808UbiquitinationNHWQSEFKKVQHELV
HHHHHHHHHCCEEEE		48.24-
843UbiquitinationQAEFQILKAELERTK
HHHHHHHHHHHHHHH		41.25-
863 (in isoform 3)Phosphorylation-44.5925278378
865 (in isoform 3)Phosphorylation-38.9025278378
880 (in isoform 3)Phosphorylation-34.2825278378
883 (in isoform 3)Phosphorylation-56.5125278378
884 (in isoform 3)Phosphorylation-62.3825278378
891UbiquitinationDLERALAKLTRLRIH
HHHHHHHHHHHHHHH		51.76-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MORC4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MORC4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MORC4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STAT3_HUMANSTAT3physical
21988832
AAPK1_HUMANPRKAA1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MORC4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704, AND MASSSPECTROMETRY.

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