ZBTB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBTB6_HUMAN
• UniProt AC: Q15916
• Protein Name: Zinc finger and BTB domain-containing protein 6
• Gene Name: ZBTB6
• Organism: Homo sapiens (Human).
• Sequence Length: 424
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRDQFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCTEALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKDCEIIEISEDSPVNIDFHVKEEESNALQSTVESLTSERKEMKSPELSTVDIGFKDNEICILHVESISTAGVENGQFSQPCTSSKASMYFSETQHSLINSTVESRVAEVPGNQDQGLFCENTEGSYGTVSEIQNLEEGYSLRHQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKRQSLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Ubiquitination	QFLLTQSKHVRITIL HHHHHCCCCEEEEEE	35.98	-
96	Acetylation	YTGALEVKRKELLKY HHCCHHHCHHHHHHH	48.67	30593461
103	Phosphorylation	KRKELLKYLTAASYL CHHHHHHHHHHHHHH	14.84	-
105	Phosphorylation	KELLKYLTAASYLQM HHHHHHHHHHHHHHH	19.65	22210691
108	Phosphorylation	LKYLTAASYLQMVHI HHHHHHHHHHHHHHH	24.74	22210691
109	Phosphorylation	KYLTAASYLQMVHIV HHHHHHHHHHHHHHH	9.02	22210691
151	Sumoylation	QSSDPDVKNEDENSD HCCCCCCCCCCCCCC	63.10	-
151	Sumoylation	QSSDPDVKNEDENSD HCCCCCCCCCCCCCC	63.10	-
157	Phosphorylation	VKNEDENSDKDCEII CCCCCCCCCCCCEEE	43.95	28102081
167	Phosphorylation	DCEIIEISEDSPVNI CCEEEEECCCCCEEE	23.66	28102081
170	Phosphorylation	IIEISEDSPVNIDFH EEEECCCCCEEEEEE	27.05	28102081
183	Phosphorylation	FHVKEEESNALQSTV EEECHHHHHHHHHHH	30.59	27732954
188	Phosphorylation	EESNALQSTVESLTS HHHHHHHHHHHHHHH	34.96	27732954
189	Phosphorylation	ESNALQSTVESLTSE HHHHHHHHHHHHHHH	18.48	27732954
192	Phosphorylation	ALQSTVESLTSERKE HHHHHHHHHHHHHHH	32.39	27732954
194	Phosphorylation	QSTVESLTSERKEMK HHHHHHHHHHHHHHC	37.51	27732954
195	Phosphorylation	STVESLTSERKEMKS HHHHHHHHHHHHHCC	40.47	27732954
202	Phosphorylation	SERKEMKSPELSTVD HHHHHHCCCCCCEEE	23.46	30266825
206	Phosphorylation	EMKSPELSTVDIGFK HHCCCCCCEEEECCC	25.40	30266825
207	Phosphorylation	MKSPELSTVDIGFKD HCCCCCCEEEECCCC	34.52	30266825
298	Phosphorylation	QNLEEGYSLRHQCPR EECHHCCCCCCCCCC	29.77	24719451
324	Ubiquitination	LRHLKMHKLFLCLQC HHHHHHHHHHHHHHC	37.12	29967540
392	Ubiquitination	HCCDMDFKHKSALKK EECCCCCCCHHHHHH	45.95	-
395	Phosphorylation	DMDFKHKSALKKHLT CCCCCCHHHHHHHHH	38.25	-
408	Phosphorylation	LTSVHGRSSGEKLSR HHHHHCCCCCCCCCC	47.49	24719451
419	Ubiquitination	KLSRPDLKRQSLL-- CCCCCCHHHHHCC--	56.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBTB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBTB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBTB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBTB6_HUMAN	ZBTB6	physical	20211142
ZBT26_HUMAN	ZBTB26	physical	25416956
SAR1B_HUMAN	SAR1B	physical	26186194

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.