CXXC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXXC5_HUMAN
• UniProt AC: Q7LFL8
• Protein Name: CXXC-type zinc finger protein 5
• Gene Name: CXXC5
• Organism: Homo sapiens (Human).
• Sequence Length: 322
• Subcellular Localization: Nucleus . Cytoplasm. Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane..
• Protein Description: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). [PubMed: 23303788 May repress COX4I2 transactivation induced by CHCHD2 and RBPJ]
• Protein Sequence: MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AGGSSSSSTNGSGGS CCCCCCCCCCCCCCC	28.04	-
37	Acetylation	PKAGAADKSAVVAAA CCCCCCCHHHHHHHH	35.27	26051181
48	Phosphorylation	VAAAAPASVADDTPP HHHHCCCCCCCCCCC	19.44	23401153
53	Phosphorylation	PASVADDTPPPERRN CCCCCCCCCCCHHCC	37.94	23401153
62	Phosphorylation	PPERRNKSGIISEPL CCHHCCCCCCCCCCC	38.48	22199227
72	Phosphorylation	ISEPLNKSLRRSRPL CCCCCCHHHHHCCCC	26.49	24719451
76	Phosphorylation	LNKSLRRSRPLSHYS CCHHHHHCCCCCCCC	31.64	28555341
80	Phosphorylation	LRRSRPLSHYSSFGS HHHCCCCCCCCCCCC	24.06	23401153
82	Phosphorylation	RSRPLSHYSSFGSSG HCCCCCCCCCCCCCC	11.57	27642862
83	Phosphorylation	SRPLSHYSSFGSSGG CCCCCCCCCCCCCCC	17.48	27642862
84	Phosphorylation	RPLSHYSSFGSSGGS CCCCCCCCCCCCCCC	26.85	28348404
87	Phosphorylation	SHYSSFGSSGGSGGG CCCCCCCCCCCCCCC	24.65	28348404
88	Phosphorylation	HYSSFGSSGGSGGGS CCCCCCCCCCCCCCC	47.77	28348404
91	Phosphorylation	SFGSSGGSGGGSMMG CCCCCCCCCCCCCCC	37.48	28348404
95	Phosphorylation	SGGSGGGSMMGGESA CCCCCCCCCCCCCCC	14.63	22210691
101	Phosphorylation	GSMMGGESADKATAA CCCCCCCCCHHHHHH	45.07	22210691
143	Phosphorylation	HKSGAVASLLSKAER CCHHHHHHHHHHHHH	24.20	24719451
146	Phosphorylation	GAVASLLSKAERATE HHHHHHHHHHHHHHH	34.80	28348404
147	Ubiquitination	AVASLLSKAERATEL HHHHHHHHHHHHHHH	54.99	29901268
292	Ubiquitination	KTGHQICKFRKCEEL CCCCCHHHHHCCHHH	50.24	29967540
304	Phosphorylation	EELKKKPSAALEKVM HHHCCCCCHHHHHHH	34.74	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXXC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXXC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXXC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDR_HUMAN	VDR	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.