| UniProt ID | VDR_HUMAN | |
|---|---|---|
| UniProt AC | P11473 | |
| Protein Name | Vitamin D3 receptor | |
| Gene Name | VDR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 427 | |
| Subcellular Localization | Nucleus . Cytoplasm . Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3. | |
| Protein Description | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.. | |
| Protein Sequence | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MEAMAASTSLPDPG -CCCCCCCCCCCCCC | 14.70 | 28122231 | |
| 8 | Phosphorylation | MEAMAASTSLPDPGD CCCCCCCCCCCCCCC | 29.56 | 28122231 | |
| 9 | Phosphorylation | EAMAASTSLPDPGDF CCCCCCCCCCCCCCC | 35.10 | 28122231 | |
| 9 (in isoform 2) | Phosphorylation | - | 35.10 | - | |
| 13 (in isoform 2) | Phosphorylation | - | 42.17 | - | |
| 51 | Phosphorylation | CKGFFRRSMKRKALF CCHHHHHHCCCCEEE | 25.13 | 1656468 | |
| 117 | Ubiquitination | RKEEEALKDSLRPKL HHHHHHHHHHHCCCC | 52.93 | - | |
| 123 | Ubiquitination | LKDSLRPKLSEEQQR HHHHHCCCCCHHHHH | 59.20 | - | |
| 165 | Phosphorylation | RVNDGGGSHPSRPNS EECCCCCCCCCCCCC | 35.18 | 23898821 | |
| 168 | Phosphorylation | DGGGSHPSRPNSRHT CCCCCCCCCCCCCCC | 55.75 | 27251275 | |
| 172 | Phosphorylation | SHPSRPNSRHTPSFS CCCCCCCCCCCCCCC | 28.28 | 10687851 | |
| 175 | Phosphorylation | SRPNSRHTPSFSGDS CCCCCCCCCCCCCCC | 21.37 | 10687851 | |
| 182 | Phosphorylation | TPSFSGDSSSSCSDH CCCCCCCCCCCCCCC | 35.33 | 22817900 | |
| 208 | Phosphorylation | SFSNLDLSEEDSDDP CCCCCCCCCCCCCCC | 38.31 | 22817900 | |
| 222 (in isoform 2) | Phosphorylation | - | 21.50 | 27251275 | |
| 293 | Phosphorylation | WTCGNQDYKYRVSDV CCCCCCCEEEEHHHC | 10.52 | - | |
| 302 | Ubiquitination | YRVSDVTKAGHSLEL EEHHHCCCCCCCHHH | 52.82 | 21906983 | |
| 380 | Phosphorylation | PPGSHLLYAKMIQKL CCCCHHHHHHHHHHH | 15.55 | - | |
| 386 | Ubiquitination | LYAKMIQKLADLRSL HHHHHHHHHHHHHHC | 34.42 | - | |
| 392 | Phosphorylation | QKLADLRSLNEEHSK HHHHHHHHCCHHHHH | 42.73 | 24719451 | |
| 399 | Ubiquitination | SLNEEHSKQYRCLSF HCCHHHHHHHCEEEC | 53.94 | - | |
| 411 | Phosphorylation | LSFQPECSMKLTPLV EECCCCHHCCCCHHH | 19.79 | 24719451 | |
| 442 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 461 (in isoform 2) | Phosphorylation | - | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 51 | S | Phosphorylation | Kinase | PRKCA | P17252 | GPS |
| 51 | S | Phosphorylation | Kinase | PRKCB | P68403 | GPS |
| 182 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 182 | S | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 182 | S | Phosphorylation | Kinase | PKA_GROUP | - | PhosphoELM |
| 208 | S | Phosphorylation | Kinase | CSNK2A1 | P68399 | GPS |
| 208 | S | Phosphorylation | Kinase | CSK21 | P68400 | PhosphoELM |
| 208 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| 208 | S | Phosphorylation | Kinase | CK2_GROUP | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VDR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VDR_HUMAN !! | ||||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| 277440 | Rickets vitamin D-dependent 2A (VDDR2A) |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB01436 | Alfacalcidol |
| DB00146 | Calcidiol |
| DB02300 | Calcipotriol |
| DB00136 | Calcitriol |
| DB00169 | Cholecalciferol |
| DB01070 | Dihydrotachysterol |
| DB00153 | Ergocalciferol |
| DB00910 | Paricalcitol |
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