dbPTM

KDM5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDM5A_HUMAN
UniProt AC	P29375
Protein Name	Lysine-specific demethylase 5A
Gene Name	KDM5A {ECO:0000312\|HGNC:HGNC:9886}
Organism	Homo sapiens (Human).
Sequence Length	1690
Subcellular Localization	Nucleus, nucleolus . Nucleus . Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
Protein Description	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. [PubMed: 18270511 May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation]
Protein Sequence	MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYKLPMEDLKETS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Ubiquitination	RIRPLAEKTGICKIR CCCCCHHHHCCCCCC	46.58	29967540
46	Phosphorylation	IRPLAEKTGICKIRP CCCCHHHHCCCCCCC	24.23	20068231
50	Ubiquitination	AEKTGICKIRPPKDW HHHHCCCCCCCCCCC	39.57	29967540
106	Ubiquitination	ELQGSTLKIPVVERK HHCCCCEECCEECHH	45.08	29967540
113	Ubiquitination	KIPVVERKILDLYAL ECCEECHHHHHHHHH	33.83	29967540
127	Ubiquitination	LSKIVASKGGFEMVT HHHHHHCCCCCEEEE	54.00	29967540
134	Phosphorylation	KGGFEMVTKEKKWSK CCCCEEEECCCCHHH	31.98	-
135	Ubiquitination	GGFEMVTKEKKWSKV CCCEEEECCCCHHHC	57.01	29967540
137	Ubiquitination	FEMVTKEKKWSKVGS CEEEECCCCHHHCCH	62.18	-
148	Phosphorylation	KVGSRLGYLPGKGTG HCCHHCCCCCCCCCC	17.83	18083107
152	Ubiquitination	RLGYLPGKGTGSLLK HCCCCCCCCCCHHHH	51.89	22505724
154	Phosphorylation	GYLPGKGTGSLLKSH CCCCCCCCCHHHHHH	27.38	24719451
156	Phosphorylation	LPGKGTGSLLKSHYE CCCCCCCHHHHHHHH	30.30	24719451
159	Ubiquitination	KGTGSLLKSHYERIL CCCCHHHHHHHHHHH	40.24	29967540
160	Phosphorylation	GTGSLLKSHYERILY CCCHHHHHHHHHHHH	31.13	24719451
162	Phosphorylation	GSLLKSHYERILYPY CHHHHHHHHHHHHHH	17.62	24719451
191	Sumoylation	PNLDLKEKVEPEVLS CCCCHHHCCCHHHHC	50.76	-
191	Sumoylation	PNLDLKEKVEPEVLS CCCCHHHCCCHHHHC	50.76	28112733
191	Ubiquitination	PNLDLKEKVEPEVLS CCCCHHHCCCHHHHC	50.76	29967540
198	Phosphorylation	KVEPEVLSTDTQTSP CCCHHHHCCCCCCCC	29.43	23927012
199	Phosphorylation	VEPEVLSTDTQTSPE CCHHHHCCCCCCCCC	38.62	23927012
201	Phosphorylation	PEVLSTDTQTSPEPG HHHHCCCCCCCCCCC	33.56	30266825
203	Phosphorylation	VLSTDTQTSPEPGTR HHCCCCCCCCCCCCC	48.63	30266825
204	Phosphorylation	LSTDTQTSPEPGTRM HCCCCCCCCCCCCCC	19.90	29255136
209	Phosphorylation	QTSPEPGTRMNILPK CCCCCCCCCCCCCCC	37.14	30266825
222	Sumoylation	PKRTRRVKTQSESGD CCCCCCCCCCCCCCC	38.75	-
222	Sumoylation	PKRTRRVKTQSESGD CCCCCCCCCCCCCCC	38.75	-
222	Ubiquitination	PKRTRRVKTQSESGD CCCCCCCCCCCCCCC	38.75	29967540
223	Phosphorylation	KRTRRVKTQSESGDV CCCCCCCCCCCCCCC	34.17	23090842
225	Phosphorylation	TRRVKTQSESGDVSR CCCCCCCCCCCCCCC	38.67	25849741
227	Phosphorylation	RVKTQSESGDVSRNT CCCCCCCCCCCCCCH	45.61	27794612
238	Ubiquitination	SRNTELKKLQIFGAG CCCHHHEEEEEECCC	59.24	29967540
247	Ubiquitination	QIFGAGPKVVGLAMG EEECCCHHHEEEECC	48.94	-
272	Phosphorylation	RRKVTNRSDAFNMQM HHHCCCHHHHHHHHH	35.05	28555341
285	Phosphorylation	QMRQRKGTLSVNFVD HHHHHCCCCCEEEEE	20.92	-
287	Phosphorylation	RQRKGTLSVNFVDLY HHHCCCCCEEEEEEE	18.17	-
339	Ubiquitination	KGDWRCPKCVAEECS CCCCCCCHHHHHHCC	44.99	-
347	Ubiquitination	CVAEECSKPREAFGF HHHHHCCCHHHHCCH	60.81	-
361	Phosphorylation	FEQAVREYTLQSFGE HHHHHHHHHHHHHHH	11.37	25072903
362	Phosphorylation	EQAVREYTLQSFGEM HHHHHHHHHHHHHHH	17.36	25072903
365	Phosphorylation	VREYTLQSFGEMADN HHHHHHHHHHHHHHH	38.03	25072903
392	Ubiquitination	VPTELVEKEFWRLVS CCHHHHHHHHHHHHH	51.21	21963094
399	Phosphorylation	KEFWRLVSSIEEDVI HHHHHHHHCCCCCEE	30.14	-
425	Ubiquitination	FGSGFPVKDGRRKIL CCCCCCCCCCCCCCC	55.49	29967540
425 (in isoform 1)	Ubiquitination	-	55.49	21890473
425 (in isoform 2)	Ubiquitination	-	55.49	21890473
640	Phosphorylation	AMVCKELTLMTEEET HHHHHHHHCCCHHHH	18.64	23403867
643	Phosphorylation	CKELTLMTEEETRLR HHHHHCCCHHHHHHH	43.27	23403867
652	Phosphorylation	EETRLRESVVQMGVL HHHHHHHHHHHHCCC	22.58	22210691
661	Phosphorylation	VQMGVLMSEEEVFEL HHHCCCCCHHHHHHC	37.38	22210691
713	Ubiquitination	LCPCPMQKKCLRYRY CCCCCCCCHHHHCCC	38.92	22505724
714	Ubiquitination	CPCPMQKKCLRYRYP CCCCCCCHHHHCCCC	22.93	-
733	Ubiquitination	PSLLYGVKVRAQSYD HHHHHCEEEEEEEHH	22.95	22505724
757	Ubiquitination	LSANFNHKKDLIELR HHCCCCCCHHHHEHH	49.43	29967540
758	Ubiquitination	SANFNHKKDLIELRV HCCCCCCHHHHEHHH	50.66	-
774	Ubiquitination	LEDAEDRKYPENDLF HHCHHHCCCCCCHHH	76.97	29967540
789	Ubiquitination	RKLRDAVKEAETCAS HHHHHHHHHHHHHHH	53.58	-
804	Acetylation	VAQLLLSKKQKHRQS HHHHHHHHHHHHCCC	60.23	25953088
804	Ubiquitination	VAQLLLSKKQKHRQS HHHHHHHHHHHHCCC	60.23	29967540
805	Ubiquitination	AQLLLSKKQKHRQSP HHHHHHHHHHHCCCC	62.29	-
811	Phosphorylation	KKQKHRQSPDSGRTR HHHHHCCCCCCCCCC	30.54	30576142
820	Ubiquitination	DSGRTRTKLTVEELK CCCCCCCCCCHHHHH	38.58	29967540
847	Ubiquitination	ISQARQVKNLLDDVE HHHHHHHHHHHHHHH	33.27	29967540
868	Phosphorylation	QEAMMDETPDSSKLQ HHHHCCCCCCCHHHH	28.29	20068231
871	Phosphorylation	MMDETPDSSKLQMLI HCCCCCCCHHHHHHH	30.49	20068231
895	Sumoylation	LPELPRLKQELQQAR CCCHHHHHHHHHHCC	42.90	-
895	Sumoylation	LPELPRLKQELQQAR CCCHHHHHHHHHHCC	42.90	-
895	Ubiquitination	LPELPRLKQELQQAR CCCHHHHHHHHHHCC	42.90	-
910	Phosphorylation	WLDEVRLTLSDPQQV CHHHHCCCCCCCCHH	17.41	29083192
912	Phosphorylation	DEVRLTLSDPQQVTL HHHCCCCCCCCHHHH	41.85	29083192
918	Phosphorylation	LSDPQQVTLDVMKKL CCCCCHHHHHHHHHH	16.95	-
924	Acetylation	VTLDVMKKLIDSGVG HHHHHHHHHHHCCCC	32.36	23749302
924	Ubiquitination	VTLDVMKKLIDSGVG HHHHHHHHHHHCCCC	32.36	29967540
960	Ubiquitination	ERWEEKAKVCLQARP HHHHHHHHHHHHCCC	44.54	29967540
970	Phosphorylation	LQARPRHSVASLESI HHCCCCCCHHCHHHH	22.21	24732914
973	Phosphorylation	RPRHSVASLESIVNE CCCCCHHCHHHHHHH	30.43	24732914
982	Ubiquitination	ESIVNEAKNIPAFLP HHHHHHHHCCCCHHH	49.59	-
993	Phosphorylation	AFLPNVLSLKEALQK CHHHHHHCHHHHHHH	32.86	24719451
995	Ubiquitination	LPNVLSLKEALQKAR HHHHHCHHHHHHHHH	37.25	29967540
1007	Sumoylation	KAREWTAKVEAIQSG HHHHHHHHHHHHHHC	32.98	28112733
1007	Ubiquitination	KAREWTAKVEAIQSG HHHHHHHHHHHHHHC	32.98	29967540
1029	Ubiquitination	QLESLSAKGRPIPVR HHHHHHCCCCCCCEE	52.67	29967540
1066	Phosphorylation	RTFLKKNSSHTLLQV CCEEECCCCCCCEEH	32.17	23911959
1067	Phosphorylation	TFLKKNSSHTLLQVL CEEECCCCCCCEEHH	29.86	23312004
1069	Phosphorylation	LKKNSSHTLLQVLSP EECCCCCCCEEHHCC	30.98	23911959
1075	Phosphorylation	HTLLQVLSPRTDIGV CCCEEHHCCCCCEEC	17.30	25159151
1085	Phosphorylation	TDIGVYGSGKNRRKK CCEECCCCCHHHHHH	28.98	21815630
1087	Ubiquitination	IGVYGSGKNRRKKVK EECCCCCHHHHHHHH	49.32	29967540
1094	2-Hydroxyisobutyrylation	KNRRKKVKELIEKEK HHHHHHHHHHHHHHH	56.54	-
1094	Ubiquitination	KNRRKKVKELIEKEK HHHHHHHHHHHHHHH	56.54	-
1103	Ubiquitination	LIEKEKEKDLDLEPL HHHHHHHCCCCCCCC	74.73	29967540
1111	Phosphorylation	DLDLEPLSDLEEGLE CCCCCCCCHHHHHHH	51.36	22167270
1120	Phosphorylation	LEEGLEETRDTAMVV HHHHHHHHHHHHHEE	25.19	24732914
1136	Ubiquitination	VFKEREQKEIEAMHS EHHHHHHHHHHHHHH	56.77	29967540
1143	Phosphorylation	KEIEAMHSLRAANLA HHHHHHHHHHHHHHH	13.38	23532336
1151	Ubiquitination	LRAANLAKMTMVDRI HHHHHHHHCCCCCHH	37.76	-
1206	Ubiquitination	KGSSWQAKEVKFLCP CCCCCHHHHHHHHHH	48.19	29967540
1209	Ubiquitination	SWQAKEVKFLCPLCM CCHHHHHHHHHHHHH	33.44	-
1225	Phosphorylation	SRRPRLETILSLLVS CCCHHHHHHHHHHHH	31.63	-
1255	Phosphorylation	CLTERAMSWQDRARQ HHHHHHHCHHHHHHH	22.17	-
1275	Ubiquitination	ELSSALAKLSVLSQR HHHHHHHHHHHHHHH	41.99	-
1277	Phosphorylation	SSALAKLSVLSQRMV HHHHHHHHHHHHHHH	21.95	23909892
1280	Phosphorylation	LAKLSVLSQRMVEQA HHHHHHHHHHHHHHH	17.37	23909892
1292	Phosphorylation	EQAAREKTEKIISAE HHHHHHHHHHHHHHH	37.44	30108239
1294	Ubiquitination	AAREKTEKIISAELQ HHHHHHHHHHHHHHH	51.04	29967540
1297	Phosphorylation	EKTEKIISAELQKAA HHHHHHHHHHHHHHH	21.11	30108239
1302	Ubiquitination	IISAELQKAAANPDL HHHHHHHHHHCCCCC	53.25	29967540
1315	Phosphorylation	DLQGHLPSFQQSAFN CCCCCCHHHHHHHHH	41.89	28555341
1326	Phosphorylation	SAFNRVVSSVSSSPR HHHHHHHHCCCCCCC	23.36	30266825
1327	Phosphorylation	AFNRVVSSVSSSPRQ HHHHHHHCCCCCCCC	17.89	30266825
1329	Phosphorylation	NRVVSSVSSSPRQTM HHHHHCCCCCCCCCC	27.35	30266825
1330	Phosphorylation	RVVSSVSSSPRQTMD HHHHCCCCCCCCCCC	42.05	23401153
1331	Phosphorylation	VVSSVSSSPRQTMDY HHHCCCCCCCCCCCC	19.32	30266825
1335	Phosphorylation	VSSSPRQTMDYDDEE CCCCCCCCCCCCCCC	17.18	24114839
1338	Phosphorylation	SPRQTMDYDDEETDS CCCCCCCCCCCCCCC	17.93	29978859
1343	Phosphorylation	MDYDDEETDSDEDIR CCCCCCCCCCHHHHH	38.46	22115753
1345	Phosphorylation	YDDEETDSDEDIRET CCCCCCCCHHHHHHH	50.77	30576142
1352	Phosphorylation	SDEDIRETYGYDMKD CHHHHHHHHCCCCCC	16.64	27251275
1353	Phosphorylation	DEDIRETYGYDMKDT HHHHHHHHCCCCCCC	14.67	22115753
1355	Phosphorylation	DIRETYGYDMKDTAS HHHHHHCCCCCCCCC	11.49	22115753
1360	Phosphorylation	YGYDMKDTASVKSSS HCCCCCCCCCCCCCC	18.47	30177828
1362	Phosphorylation	YDMKDTASVKSSSSL CCCCCCCCCCCCCCC	31.97	29802988
1364	Ubiquitination	MKDTASVKSSSSLEP CCCCCCCCCCCCCCC	41.97	29967540
1365	Phosphorylation	KDTASVKSSSSLEPN CCCCCCCCCCCCCCC	33.04	25159151
1366	Phosphorylation	DTASVKSSSSLEPNL CCCCCCCCCCCCCCE	20.44	25159151
1367	Phosphorylation	TASVKSSSSLEPNLF CCCCCCCCCCCCCEE	46.14	27732954
1368	Phosphorylation	ASVKSSSSLEPNLFC CCCCCCCCCCCCEEC	38.40	25159151
1382	Sumoylation	CDEEIPIKSEEVVTH CCCCCCCCCHHHHHE	46.60	-
1382	Sumoylation	CDEEIPIKSEEVVTH CCCCCCCCCHHHHHE	46.60	-
1404	Phosphorylation	CAEHAYSSASKSCSQ HHHHHHHHHCCHHCC	24.72	25627689
1408	Phosphorylation	AYSSASKSCSQGSST HHHHHCCHHCCCCCC	19.26	26552605
1410	Phosphorylation	SSASKSCSQGSSTPR HHHCCHHCCCCCCCC	44.67	26552605
1413	Phosphorylation	SKSCSQGSSTPRKQP CCHHCCCCCCCCCCC	24.33	26552605
1414	Phosphorylation	KSCSQGSSTPRKQPR CHHCCCCCCCCCCCC	49.62	26552605
1415	Phosphorylation	SCSQGSSTPRKQPRK HHCCCCCCCCCCCCC	28.89	28985074
1423	Phosphorylation	PRKQPRKSPLVPRSL CCCCCCCCCCCCCCC	25.42	30266825
1429	Phosphorylation	KSPLVPRSLEPPVLE CCCCCCCCCCCCEEE	30.89	30266825
1438	Phosphorylation	EPPVLELSPGAKAQL CCCEEECCCCHHHHH	16.35	30266825
1488	Phosphorylation	LHIMEDDSMEEKPLK EECCCCCCCCCCCCC	40.18	29255136
1539	Ubiquitination	KPRKKKLKLGADKSK CCHHHHHCCCCHHHH	54.47	-
1579	Phosphorylation	KVELVKESTEKKREK HHHHHHHHHHHHHHH	35.83	28258704
1580	Phosphorylation	VELVKESTEKKREKK HHHHHHHHHHHHHHH	53.57	28258704
1593	Phosphorylation	KKVLDIPSKYDWSGA HHHCCCCCCCCCCCC	44.15	30576142
1595	Phosphorylation	VLDIPSKYDWSGAEE HCCCCCCCCCCCCCC	27.29	28450419
1598	Phosphorylation	IPSKYDWSGAEESDD CCCCCCCCCCCCCCC	25.81	23927012
1603	Phosphorylation	DWSGAEESDDENAVC CCCCCCCCCCHHCCH	41.70	23927012
1666	Phosphorylation	AKKQGPVSPGPAPPP HHHCCCCCCCCCCCC	27.54	23401153
1674	Phosphorylation	PGPAPPPSFIMSYKL CCCCCCCCCEEEEEC	32.93	26074081
1678	Phosphorylation	PPPSFIMSYKLPMED CCCCCEEEEECCHHH	17.82	29759185
1679	Phosphorylation	PPSFIMSYKLPMEDL CCCCEEEEECCHHHH	10.12	29759185
1698	Phosphorylation	--------------- ---------------		15302935

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
225	S	Phosphorylation	Kinase	AKT1	P31749	PSP
285	T	Phosphorylation	Kinase	AKT1	P31749	PSP
287	S	Phosphorylation	Kinase	AKT1	P31749	PSP
1225	T	Phosphorylation	Kinase	AKT1	P31749	PSP
1255	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KDM5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDM5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBTN2_HUMAN	LMO2	physical	9129143
RB_HUMAN	RB1	physical	7935440
EZH2_HUMAN	EZH2	physical	18483221
EED_HUMAN	EED	physical	18483221
MO4L1_HUMAN	MORF4L1	physical	17573780
SIN3B_HUMAN	SIN3B	physical	17573780
HDAC2_HUMAN	HDAC2	physical	17573780
SUH_HUMAN	RBPJ	physical	20231316
RB_HUMAN	RB1	physical	15949438
EMSY_HUMAN	C11orf30	physical	26841866
GATD1_HUMAN	GATAD1	physical	26841866
ZN131_HUMAN	ZNF131	physical	26841866

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDM5A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1111; THR-1343 ANDSER-1345, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1111 AND SER-1331, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1111; SER-1598 ANDSER-1603, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1331 AND SER-1666, ANDMASS SPECTROMETRY.	15302935 [Abstract]