CD11B_HUMAN - dbPTM
CD11B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CD11B_HUMAN
UniProt AC P21127
Protein Name Cyclin-dependent kinase 11B
Gene Name CDK11B
Organism Homo sapiens (Human).
Sequence Length 795
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression..
Protein Sequence MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MGDEKDSWK
------CCCHHHHHH		52.3524719451
2 (in isoform 6)Phosphorylation-52.3524719451
2 (in isoform 9)Phosphorylation-52.3524719451
3 (in isoform 4)Phosphorylation-59.4825278378
5 (in isoform 4)Phosphorylation-62.9025278378
7 (in isoform 4)Phosphorylation-39.6025278378
8AcetylationMGDEKDSWKVKTLDE
CCCHHHHHHHCCHHH		21.4219608861
9PhosphorylationGDEKDSWKVKTLDEI
CCHHHHHHHCCHHHH		37.49-
9 (in isoform 6)Phosphorylation-37.49-
9 (in isoform 9)Phosphorylation-37.49-
11SumoylationEKDSWKVKTLDEILQ
HHHHHHHCCHHHHHH		39.38-
11SumoylationEKDSWKVKTLDEILQ
HHHHHHHCCHHHHHH		39.38-
11UbiquitinationEKDSWKVKTLDEILQ
HHHHHHHCCHHHHHH		39.38-
11 (in isoform 4)Phosphorylation-39.3825278378
12PhosphorylationKDSWKVKTLDEILQE
HHHHHHCCHHHHHHH		42.2921815630
13PhosphorylationDSWKVKTLDEILQEK
HHHHHCCHHHHHHHH		4.6329743597
13 (in isoform 6)Phosphorylation-4.6329743597
13 (in isoform 9)Phosphorylation-4.6329743597
14 (in isoform 4)Phosphorylation-46.2325278378
19 (in isoform 4)Phosphorylation-58.0425278378
20SumoylationLDEILQEKKRRKEQE
HHHHHHHHHHHHHHH		38.32-
20SumoylationLDEILQEKKRRKEQE
HHHHHHHHHHHHHHH		38.32-
20UbiquitinationLDEILQEKKRRKEQE
HHHHHHHHHHHHHHH		38.32-
20 (in isoform 1)Ubiquitination-38.3221890473
20 (in isoform 2)Ubiquitination-38.3221890473
20 (in isoform 3)Ubiquitination-38.3221890473
20 (in isoform 8)Ubiquitination-38.3221890473
21UbiquitinationDEILQEKKRRKEQEE
HHHHHHHHHHHHHHH		57.60-
24 (in isoform 4)Phosphorylation-68.7125278378
29SumoylationRRKEQEEKAEIKRLK
HHHHHHHHHHHHHHH		51.04-
29SumoylationRRKEQEEKAEIKRLK
HHHHHHHHHHHHHHH		51.04-
38PhosphorylationEIKRLKNSDDRDSKR
HHHHHHCCCCCHHHH		39.0220068231
39 (in isoform 12)Phosphorylation-65.4418220336
43PhosphorylationKNSDDRDSKRDSLEE
HCCCCCHHHHHHCHH		30.4030108239
47PhosphorylationDRDSKRDSLEEGELR
CCHHHHHHCHHCCCC		41.5319664994
47 (in isoform 10)Phosphorylation-41.5325849741
61PhosphorylationRDHRMEITIRNSPYR
CCCEEEEEECCCCCC		10.6923927012
65PhosphorylationMEITIRNSPYRREDS
EEEEECCCCCCCCCC		17.2922167270
67PhosphorylationITIRNSPYRREDSME
EEECCCCCCCCCCCC		23.3223927012
72PhosphorylationSPYRREDSMEDRGEE
CCCCCCCCCCCCCCC		21.2229255136
82PhosphorylationDRGEEDDSLAIKPPQ
CCCCCCCCCCCCCHH		31.8323403867
92PhosphorylationIKPPQQMSRKEKAHH
CCCHHHCCHHHHHHC		35.5423403867
101AcetylationKEKAHHRKDEKRKEK
HHHHHCHHHHHHHHH		66.9230582789
111 (in isoform 12)Ubiquitination-39.3621890473
113PhosphorylationKEKRRHRSHSAEGGK
HHHHHHHHHCCCCCC		18.7028176443
115PhosphorylationKRRHRSHSAEGGKHA
HHHHHHHCCCCCCCC		29.3028176443
133 (in isoform 4)Ubiquitination-51.8621890473
135AcetylationEREHERRKRHREEQD
HHHHHHHHHHHHHHH		59.7922368367
180AcetylationRKRERERKMREQQKE
HHHHHHHHHHHHHHH		37.24-
198 (in isoform 5)Ubiquitination-29.2621890473
210PhosphorylationKEREARREVSAHHRT
HHHHHHHHHHHHHHH		34.96-
212PhosphorylationREARREVSAHHRTMR
HHHHHHHHHHHHHHC		19.6818212344
213AcetylationEARREVSAHHRTMRE
HHHHHHHHHHHHHCH		14.0019608861
220 (in isoform 6)Phosphorylation-50.9425849741
221PhosphorylationHHRTMREDYSDKVKA
HHHHHCHHCCHHHHH		37.56-
221 (in isoform 12)Ubiquitination-37.5621890473
222PhosphorylationHRTMREDYSDKVKAS
HHHHCHHCCHHHHHH		17.6426074081
223AcetylationRTMREDYSDKVKASH
HHHCHHCCHHHHHHH		43.1919608861
223PhosphorylationRTMREDYSDKVKASH
HHHCHHCCHHHHHHH		43.1920068231
225AcetylationMREDYSDKVKASHWS
HCHHCCHHHHHHHCC		39.4323749302
227PhosphorylationEDYSDKVKASHWSRS
HHCCHHHHHHHCCCC		50.33-
229PhosphorylationYSDKVKASHWSRSPP
CCHHHHHHHCCCCCC		21.5528348404
230PhosphorylationSDKVKASHWSRSPPR
CHHHHHHHCCCCCCC		31.2425849741
230PhosphorylationSDKVKASHWSRSPPR
CHHHHHHHCCCCCCC		31.24-
230 (in isoform 9)Phosphorylation-31.2425849741
232PhosphorylationKVKASHWSRSPPRPP
HHHHHHCCCCCCCCC		19.9123401153
234PhosphorylationKASHWSRSPPRPPRE
HHHHCCCCCCCCCHH		33.4722167270
237 (in isoform 10)Ubiquitination-58.1821890473
243 (in isoform 4)Ubiquitination-8.5521890473
254 (in isoform 8)Phosphorylation-28.7725849741
263 (in isoform 3)Phosphorylation-34.0825849741
264PhosphorylationAPAQKPAQLKEEKME
CCCCCCHHHHHHHHH		62.6925849741
264PhosphorylationAPAQKPAQLKEEKME
CCCCCCHHHHHHHHH		62.6925849741
264SumoylationAPAQKPAQLKEEKME
CCCCCCHHHHHHHHH		62.69-
264 (in isoform 2)Phosphorylation-62.6925849741
266SumoylationAQKPAQLKEEKMEER
CCCCHHHHHHHHHHH		52.31-
270PhosphorylationAQLKEEKMEERDLLS
HHHHHHHHHHHHHHH		7.9627251275
275PhosphorylationEKMEERDLLSDLQDI
HHHHHHHHHHHHHHC		6.5419664994
277PhosphorylationMEERDLLSDLQDISD
HHHHHHHHHHHHCCH		43.5019664994
281PhosphorylationDLLSDLQDISDSERK
HHHHHHHHCCHHHHC		50.0519664994
283PhosphorylationLSDLQDISDSERKTS
HHHHHHCCHHHHCCC		43.2919664994
285PhosphorylationDLQDISDSERKTSSA
HHHHCCHHHHCCCCC		32.2929255136
294 (in isoform 10)Ubiquitination-29.34-
295PhosphorylationKTSSAESSSAESGSG
CCCCCCCCCCCCCCC		25.6920068231
301 (in isoform 10)Ubiquitination-48.72-
304 (in isoform 12)Ubiquitination-73.3121890473
308 (in isoform 5)Ubiquitination-74.1821890473
316 (in isoform 12)Ubiquitination-62.8221890473
320PhosphorylationEEEEGSTSEESEEEE
HHHCCCCCHHHHHHH		40.8520068231
326 (in isoform 4)Ubiquitination-67.6621890473
337PhosphorylationEEEEEEETGSNSEEA
HHHHHHHHCCCCHHH		49.5418452278
338 (in isoform 4)Ubiquitination-28.2721890473
347 (in isoform 10)Ubiquitination-45.5021890473
356PhosphorylationAEEVSEEEMSEDEER
HHHHCHHHHCHHHHH		43.91-
358PhosphorylationEVSEEEMSEDEEREN
HHCHHHHCHHHHHHH		45.2130177828
363 (in isoform 12)Ubiquitination-50.4121890473
375PhosphorylationHLLVVPESRFDRDSG
CEEEEEHHHCCCCCC		31.9818669648
379PhosphorylationVPESRFDRDSGESEE
EEHHHCCCCCCCCHH		36.9618669648
381PhosphorylationESRFDRDSGESEEAE
HHHCCCCCCCCHHHH		45.4125849741
382PhosphorylationSRFDRDSGESEEAEE
HHCCCCCCCCHHHHH		46.9018669648
384PhosphorylationFDRDSGESEEAEEEV
CCCCCCCCHHHHHHH		44.2425137130
385 (in isoform 12)Ubiquitination-57.8521890473
385 (in isoform 4)Ubiquitination-57.8521890473
391 (in isoform 5)Ubiquitination-10.8021890473
393PhosphorylationEAEEEVGEGTPQSSA
HHHHHHCCCCCCCCC		66.1418452278
395PhosphorylationEEEVGEGTPQSSALT
HHHHCCCCCCCCCCC		17.5325137130
398PhosphorylationVGEGTPQSSALTEGD
HCCCCCCCCCCCCCC		20.8426074081
399PhosphorylationGEGTPQSSALTEGDY
CCCCCCCCCCCCCCC		23.2720873877
400PhosphorylationEGTPQSSALTEGDYV
CCCCCCCCCCCCCCC		24.6118452278
402UbiquitinationTPQSSALTEGDYVPD
CCCCCCCCCCCCCCC		37.32-
402PhosphorylationTPQSSALTEGDYVPD
CCCCCCCCCCCCCCC		37.3225137130
403 (in isoform 5)Ubiquitination-51.4121890473
404PhosphorylationQSSALTEGDYVPDSP
CCCCCCCCCCCCCCC		26.72-
406PhosphorylationSALTEGDYVPDSPAL
CCCCCCCCCCCCCCC		25.4125137130
407 (in isoform 4)Ubiquitination-5.1621890473
408PhosphorylationLTEGDYVPDSPALSP
CCCCCCCCCCCCCCH		30.0818452278
410UbiquitinationEGDYVPDSPALSPIE
CCCCCCCCCCCCHHH		13.15-
410PhosphorylationEGDYVPDSPALSPIE
CCCCCCCCCCCCHHH		13.1525137130
410 (in isoform 6)Ubiquitination-13.1521890473
412PhosphorylationDYVPDSPALSPIELK
CCCCCCCCCCHHHHH		25.3218452278
414PhosphorylationVPDSPALSPIELKQE
CCCCCCCCHHHHHHH		26.4125137130
417SumoylationSPALSPIELKQELPK
CCCCCHHHHHHHHHH		53.98-
418UbiquitinationPALSPIELKQELPKY
CCCCHHHHHHHHHHH		7.80-
420 (in isoform 9)Ubiquitination-70.8121890473
421PhosphorylationSPIELKQELPKYLPA
CHHHHHHHHHHHHHH		66.5127251275
422UbiquitinationPIELKQELPKYLPAL
HHHHHHHHHHHHHHH		4.03-
430 (in isoform 10)Ubiquitination-51.5521890473
432PhosphorylationYLPALQGCRSVEEFQ
HHHHHCCCCCHHHHH		1.57-
434UbiquitinationPALQGCRSVEEFQCL
HHHCCCCCHHHHHHH		37.65-
434PhosphorylationPALQGCRSVEEFQCL
HHHCCCCCHHHHHHH		37.6523401153
442 (in isoform 10)Ubiquitination-50.9721890473
444 (in isoform 8)Ubiquitination-5.7121890473
446PhosphorylationQCLNRIEEGTYGVVY
HHHHCCCCCCCEEEE		55.23-
447PhosphorylationCLNRIEEGTYGVVYR
HHHCCCCCCCEEEEE		16.08-
448PhosphorylationLNRIEEGTYGVVYRA
HHCCCCCCCEEEEEE		22.0020860994
449PhosphorylationNRIEEGTYGVVYRAK
HCCCCCCCEEEEEEC		20.8422322096
450 (in isoform 5)Ubiquitination-11.4021890473
451PhosphorylationIEEGTYGVVYRAKDK
CCCCCCEEEEEECCC		2.11-
453PhosphorylationEGTYGVVYRAKDKKT
CCCCEEEEEECCCCC		11.4917360941
453 (in isoform 3)Ubiquitination-11.4921890473
454 (in isoform 2)Ubiquitination-24.4521890473
456AcetylationYGVVYRAKDKKTDEI
CEEEEEECCCCCCHH		62.1768645
457SumoylationGVVYRAKDKKTDEIV
EEEEEECCCCCCHHH		57.61-
457UbiquitinationGVVYRAKDKKTDEIV
EEEEEECCCCCCHHH		57.61-
458AcetylationVVYRAKDKKTDEIVA
EEEEECCCCCCHHHH		57.7968649
459SumoylationVYRAKDKKTDEIVAL
EEEECCCCCCHHHHH		71.93-
459AcetylationVYRAKDKKTDEIVAL
EEEECCCCCCHHHHH		71.9368653
459UbiquitinationVYRAKDKKTDEIVAL
EEEECCCCCCHHHHH		71.93-
465SumoylationKKTDEIVALKRLKME
CCCCHHHHHHHHHCH		17.02-
465UbiquitinationKKTDEIVALKRLKME
CCCCHHHHHHHHHCH		17.02-
467UbiquitinationTDEIVALKRLKMEKE
CCHHHHHHHHHCHHH		46.04-
467SumoylationTDEIVALKRLKMEKE
CCHHHHHHHHHCHHH		46.04-
467AcetylationTDEIVALKRLKMEKE
CCHHHHHHHHHCHHH		46.0425953088
467UbiquitinationTDEIVALKRLKMEKE
CCHHHHHHHHHCHHH		46.0421906983
467 (in isoform 1)Ubiquitination-46.0421890473
472 (in isoform 5)Ubiquitination-57.3821890473
473UbiquitinationLKRLKMEKEKEGFPI
HHHHHCHHHHCCCCC		71.26-
474UbiquitinationKRLKMEKEKEGFPIT
HHHHCHHHHCCCCCC		42.93-
475UbiquitinationRLKMEKEKEGFPITS
HHHCHHHHCCCCCCC		74.36-
480PhosphorylationKEKEGFPITSLREIN
HHHCCCCCCCHHHHH		3.6916327805
482PhosphorylationKEGFPITSLREINTI
HCCCCCCCHHHHHHH		26.5816327805
486PhosphorylationPITSLREINTILKAQ
CCCCHHHHHHHHHCC		4.4416327805
488PhosphorylationTSLREINTILKAQHP
CCHHHHHHHHHCCCC		33.0916327805
489SumoylationSLREINTILKAQHPN
CHHHHHHHHHCCCCC		3.00-
489UbiquitinationSLREINTILKAQHPN
CHHHHHHHHHCCCCC		3.00-
489 (in isoform 10)Ubiquitination-3.0021890473
491SumoylationREINTILKAQHPNIV
HHHHHHHHCCCCCEE		41.99-
491UbiquitinationREINTILKAQHPNIV
HHHHHHHHCCCCCEE		41.99-
507UbiquitinationVREIVVGSNMDKIYI
EEEEEECCCCCEEEE		19.85-
511PhosphorylationVVGSNMDKIYIVMNY
EECCCCCEEEEEEHH		27.0020068231
511 (in isoform 10)Ubiquitination-27.0021890473
513PhosphorylationGSNMDKIYIVMNYVE
CCCCCEEEEEEHHHH		8.0020068231
518PhosphorylationKIYIVMNYVEHDLKS
EEEEEEHHHHHHHHH		6.7920068231
520UbiquitinationYIVMNYVEHDLKSLM
EEEEHHHHHHHHHHH		22.71-
520 (in isoform 6)Ubiquitination-22.7121890473
523PhosphorylationMNYVEHDLKSLMETM
EHHHHHHHHHHHHHH		4.3520068231
525PhosphorylationYVEHDLKSLMETMKQ
HHHHHHHHHHHHHHC		40.0020068231
529PhosphorylationDLKSLMETMKQPFLP
HHHHHHHHHHCCCCC		18.7220068231
529UbiquitinationDLKSLMETMKQPFLP
HHHHHHHHHHCCCCC		18.72-
530 (in isoform 9)Ubiquitination-2.1221890473
541PhosphorylationFLPGEVKTLMIQLLR
CCCHHHHHHHHHHHH		27.0820068231
549UbiquitinationLMIQLLRGVKHLHDN
HHHHHHHCCCCHHHC		32.56-
554 (in isoform 8)Ubiquitination-26.5221890473
562SumoylationDNWILHRDLKTSNLL
HCEECCCCHHHHCCC		41.59-
562UbiquitinationDNWILHRDLKTSNLL
HCEECCCCHHHHCCC		41.59-
563 (in isoform 3)Ubiquitination-7.0421890473
564SumoylationWILHRDLKTSNLLLS
EECCCCHHHHCCCHH		54.95-
564UbiquitinationWILHRDLKTSNLLLS
EECCCCHHHHCCCHH		54.95-
564 (in isoform 2)Ubiquitination-54.9521890473
575UbiquitinationLLLSHAGILKVGDFG
CCHHHCCEEEECCCC		3.32-
576PhosphorylationLLSHAGILKVGDFGL
CHHHCCEEEECCCCH		3.4427251275
577UbiquitinationLSHAGILKVGDFGLA
HHHCCEEEECCCCHH		42.1021906983
577 (in isoform 1)Ubiquitination-42.1021890473
582PhosphorylationILKVGDFGLAREYGS
EEEECCCCHHHHHCC		24.1427251275
585PhosphorylationVGDFGLAREYGSPLK
ECCCCHHHHHCCCCC		42.5918452278
587PhosphorylationDFGLAREYGSPLKAY
CCCHHHHHCCCCCCC		19.8330183078
589PhosphorylationGLAREYGSPLKAYTP
CHHHHHCCCCCCCCC		26.5922167270
592UbiquitinationREYGSPLKAYTPVVV
HHHCCCCCCCCCEEE		42.61-
592PhosphorylationREYGSPLKAYTPVVV
HHHCCCCCCCCCEEE		42.6118669648
593PhosphorylationEYGSPLKAYTPVVVT
HHCCCCCCCCCEEEE		22.5518452278
594PhosphorylationYGSPLKAYTPVVVTL
HCCCCCCCCCEEEEE		15.2522167270
595PhosphorylationGSPLKAYTPVVVTLW
CCCCCCCCCEEEEEE		17.9222167270
600PhosphorylationAYTPVVVTLWYRAPE
CCCCEEEEEEECCHH		10.4422617229
603UbiquitinationPVVVTLWYRAPELLL
CEEEEEEECCHHHHH		10.46-
603PhosphorylationPVVVTLWYRAPELLL
CEEEEEEECCHHHHH		10.4625219547
603 (in isoform 6)Ubiquitination-10.4621890473
613 (in isoform 9)Ubiquitination-56.2221890473
615UbiquitinationLLLGAKEYSTAVDMW
HHHCCCCCCCHHHHH		15.60-
615PhosphorylationLLLGAKEYSTAVDMW
HHHCCCCCCCHHHHH		15.6020860994
615 (in isoform 6)Ubiquitination-15.6021890473
616UbiquitinationLLGAKEYSTAVDMWS
HHCCCCCCCHHHHHH		15.81-
616PhosphorylationLLGAKEYSTAVDMWS
HHCCCCCCCHHHHHH		15.8120860994
623PhosphorylationSTAVDMWSVGCIFGE
CCHHHHHHHHHHHHH		11.2920860994
625 (in isoform 9)Ubiquitination-8.0321890473
637 (in isoform 8)Ubiquitination-11.8721890473
639SumoylationLTQKPLFPGKSEIDQ
HCCCCCCCCCHHHHH		57.92-
639UbiquitinationLTQKPLFPGKSEIDQ
HCCCCCCCCCHHHHH		57.92-
641SumoylationQKPLFPGKSEIDQIN
CCCCCCCCHHHHHHH		45.19-
641SumoylationQKPLFPGKSEIDQIN
CCCCCCCCHHHHHHH		45.1928112733
642PhosphorylationKPLFPGKSEIDQINK
CCCCCCCHHHHHHHH		45.7825599653
646 (in isoform 3)Ubiquitination-46.9821890473
647SumoylationGKSEIDQINKVFKDL
CCHHHHHHHHHHHHH		4.83-
647UbiquitinationGKSEIDQINKVFKDL
CCHHHHHHHHHHHHH		4.83-
647 (in isoform 2)Ubiquitination-4.8321890473
649SumoylationSEIDQINKVFKDLGT
HHHHHHHHHHHHHCC		51.15-
649AcetylationSEIDQINKVFKDLGT
HHHHHHHHHHHHHCC		51.1525953088
649UbiquitinationSEIDQINKVFKDLGT
HHHHHHHHHHHHHCC		51.15-
649 (in isoform 8)Ubiquitination-51.1521890473
650SumoylationEIDQINKVFKDLGTP
HHHHHHHHHHHHCCC		6.61-
650UbiquitinationEIDQINKVFKDLGTP
HHHHHHHHHHHHCCC		6.61-
652SumoylationDQINKVFKDLGTPSE
HHHHHHHHHHCCCHH		55.84-
652AcetylationDQINKVFKDLGTPSE
HHHHHHHHHHCCCHH		55.8425953088
652UbiquitinationDQINKVFKDLGTPSE
HHHHHHHHHHCCCHH		55.84-
658UbiquitinationFKDLGTPSEKIWPGY
HHHHCCCHHHCCCCC		51.89-
658 (in isoform 3)Ubiquitination-51.8921890473
659 (in isoform 2)Ubiquitination-50.1721890473
660UbiquitinationDLGTPSEKIWPGYSE
HHCCCHHHCCCCCCC		55.1721890473
660 (in isoform 1)Ubiquitination-55.1721890473
662UbiquitinationGTPSEKIWPGYSELP
CCCHHHCCCCCCCCC		7.42-
662 (in isoform 6)Ubiquitination-7.4221890473
670UbiquitinationPGYSELPAVKKMTFS
CCCCCCCCCEECCCC		38.08-
671SumoylationGYSELPAVKKMTFSE
CCCCCCCCEECCCCC		6.06-
671UbiquitinationGYSELPAVKKMTFSE
CCCCCCCCEECCCCC		6.06-
672UbiquitinationYSELPAVKKMTFSEH
CCCCCCCEECCCCCC		38.6421906983
672 (in isoform 1)Ubiquitination-38.6421890473
672 (in isoform 9)Ubiquitination-38.6421890473
673SumoylationSELPAVKKMTFSEHP
CCCCCCEECCCCCCC		36.25-
673UbiquitinationSELPAVKKMTFSEHP
CCCCCCEECCCCCCC		36.25-
675PhosphorylationLPAVKKMTFSEHPYN
CCCCEECCCCCCCCC		32.6528270605
677PhosphorylationAVKKMTFSEHPYNNL
CCEECCCCCCCCCHH		26.3228270605
681PhosphorylationMTFSEHPYNNLRKRF
CCCCCCCCCHHHHHH		20.7028270605
684UbiquitinationSEHPYNNLRKRFGAL
CCCCCCHHHHHHHHH		6.42-
684 (in isoform 6)Ubiquitination-6.4221890473
694 (in isoform 9)Ubiquitination-53.2221890473
696 (in isoform 8)Ubiquitination-24.0321890473
700PhosphorylationSDQGFDLMNKFLTYF
HHHCHHHHHHHHHHC		5.7327251275
705 (in isoform 3)Ubiquitination-26.6721890473
706 (in isoform 2)Ubiquitination-15.2121890473
711PhosphorylationLTYFPGRRISAEDGL
HHHCCCCCCCCCCCC		32.8832645325
713PhosphorylationYFPGRRISAEDGLKH
HCCCCCCCCCCCCCC		24.6430108239
717SumoylationRRISAEDGLKHEYFR
CCCCCCCCCCCHHHC		28.29-
717UbiquitinationRRISAEDGLKHEYFR
CCCCCCCCCCCHHHC		28.29-
718 (in isoform 8)Ubiquitination-8.7221890473
719SumoylationISAEDGLKHEYFRET
CCCCCCCCCHHHCCC		39.66-
719UbiquitinationISAEDGLKHEYFRET
CCCCCCCCCHHHCCC		39.6621906983
719 (in isoform 1)Ubiquitination-39.6621890473
724PhosphorylationGLKHEYFRETPLPID
CCCCHHHCCCCCCCC		46.08-
726PhosphorylationKHEYFRETPLPIDPS
CCHHHCCCCCCCCHH		26.3524247654
727 (in isoform 3)Ubiquitination-31.2421890473
728 (in isoform 2)Ubiquitination-8.2921890473
738PhosphorylationDPSMFPTWPAKSEQQ
CHHHCCCCCCCCHHH		7.3527251275
739PhosphorylationPSMFPTWPAKSEQQR
HHHCCCCCCCCHHHH		32.0827251275
739SumoylationPSMFPTWPAKSEQQR
HHHCCCCCCCCHHHH		32.08-
739UbiquitinationPSMFPTWPAKSEQQR
HHHCCCCCCCCHHHH		32.08-
741SumoylationMFPTWPAKSEQQRVK
HCCCCCCCCHHHHHH		50.90-
741UbiquitinationMFPTWPAKSEQQRVK
HCCCCCCCCHHHHHH		50.902190698
741 (in isoform 1)Ubiquitination-50.9021890473
749PhosphorylationSEQQRVKRGTSPRPP
CHHHHHHCCCCCCCC		51.2519651622
750PhosphorylationEQQRVKRGTSPRPPE
HHHHHHCCCCCCCCC		25.4820068231
751PhosphorylationQQRVKRGTSPRPPEG
HHHHHCCCCCCCCCC		39.3229255136
752PhosphorylationQRVKRGTSPRPPEGG
HHHHCCCCCCCCCCC		23.0329255136
760PhosphorylationPRPPEGGLGYSQLGD
CCCCCCCCCCHHCCC		9.52-
761PhosphorylationRPPEGGLGYSQLGDD
CCCCCCCCCHHCCCC		24.2620166139
762PhosphorylationPPEGGLGYSQLGDDD
CCCCCCCCHHCCCCC		9.7830266825
763PhosphorylationPEGGLGYSQLGDDDL
CCCCCCCHHCCCCCH		19.6829255136
771PhosphorylationQLGDDDLKETGFHLT
HCCCCCHHHHCEEEE		61.29-
773PhosphorylationGDDDLKETGFHLTTT
CCCCHHHHCEEEEEC		43.4921082442
776PhosphorylationDLKETGFHLTTTNQG
CHHHHCEEEEECCCC		24.50-
778PhosphorylationKETGFHLTTTNQGAS
HHHCEEEEECCCCCC		24.0118669648
779PhosphorylationETGFHLTTTNQGASA
HHCEEEEECCCCCCC		30.0627174698
780PhosphorylationTGFHLTTTNQGASAA
HCEEEEECCCCCCCC		21.9527174698
783PhosphorylationHLTTTNQGASAAGPG
EEEECCCCCCCCCCC		24.46-
785PhosphorylationTTTNQGASAAGPGFS
EECCCCCCCCCCCCC		26.0225849741
790PhosphorylationGASAAGPGFSLKF--
CCCCCCCCCCCCC--		24.69-
792MethylationSAAGPGFSLKF----
CCCCCCCCCCC----		36.24-
792PhosphorylationSAAGPGFSLKF----
CCCCCCCCCCC----		36.2425159151
792SumoylationSAAGPGFSLKF----
CCCCCCCCCCC----		36.24-
792UbiquitinationSAAGPGFSLKF----
CCCCCCCCCCC----		36.24-
794SumoylationAGPGFSLKF------
CCCCCCCCC------		48.07-
794MethylationAGPGFSLKF------
CCCCCCCCC------		48.07-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
285SPhosphorylationKinaseCK2-FAMILY-GPS
370TPhosphorylationKinaseCDK11A ISO10Q9UQ88-10
PSP
482SPhosphorylationKinaseCDK7P50613
Uniprot
488TPhosphorylationKinaseCDK7P50613
Uniprot
595TPhosphorylationKinaseCDK7P50613
PSP
752SPhosphorylationKinaseCHEK2O96017
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
115SPhosphorylation

15883043
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CD11B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCND3_HUMANCCND3physical
12082095
HS90A_HUMANHSP90AA1physical
15344906
HSP74_HUMANHSPA4physical
15344906
HSP7C_HUMANHSPA8physical
15344906
CDC37_HUMANCDC37physical
15344906
KAT7_HUMANKAT7physical
15963510
VDR_HUMANVDRphysical
19538938
PO2F1_HUMANPOU2F1physical
21897860
ESR1_HUMANESR1physical
19122208
EIF3F_HUMANEIF3Fphysical
19245811
RBM25_HUMANRBM25physical
22939629
RAP1A_HUMANRAP1Aphysical
22939629
MOES_HUMANMSNphysical
21988832
RS27A_HUMANRPS27Aphysical
21988832
TPPP_HUMANTPPPphysical
21988832
KAT7_HUMANKAT7physical
21988832
CD11B_HUMANCDK11Bphysical
15344906
CD11B_HUMANCDK11Bphysical
14511641
RANB9_HUMANRANBP9physical
14511641
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CD11B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-589; THR-595;THR-751 AND SER-752, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-381; SER-384;THR-395; SER-410; SER-414; TYR-594 AND THR-595, AND MASS SPECTROMETRY.
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND SER-234, AND MASSSPECTROMETRY.
"Dichotomous but stringent substrate selection by the dual-functionCdk7 complex revealed by chemical genetics.";
Larochelle S., Batliner J., Gamble M.J., Barboza N.M., Kraybill B.C.,Blethrow J.D., Shokat K.M., Fisher R.P.;
Nat. Struct. Mol. Biol. 13:55-62(2006).
Cited for: PHOSPHORYLATION AT SER-482 AND THR-488 BY CDK7.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND THR-595, ANDMASS SPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-589 ANDTHR-595, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-595, AND MASSSPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-595, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-595, AND MASSSPECTROMETRY.

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