PTN3_HUMAN - dbPTM
PTN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTN3_HUMAN
UniProt AC P26045
Protein Name Tyrosine-protein phosphatase non-receptor type 3
Gene Name PTPN3
Organism Homo sapiens (Human).
Sequence Length 913
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein Description May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity..
Protein Sequence MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
244PhosphorylationASAGVAVYRKYICTS
HHHCHHHHHHHHHHH		7.52-
262PhosphorylationWVNILKISFKRKKFF
HHEEEEEEECCHHHH		24.1124719451
306PhosphorylationKSCVEHHTFFQAKKL
HHHHHHHHHHHHHHH		28.2222210691
322PhosphorylationPQEKNVLSQYWTMGS
HHHHCHHHHHCCCCC		19.5521945579
324PhosphorylationEKNVLSQYWTMGSRN
HHCHHHHHCCCCCCC		10.2421945579
326PhosphorylationNVLSQYWTMGSRNTK
CHHHHHCCCCCCCCC		13.5121945579
329PhosphorylationSQYWTMGSRNTKKSV
HHHCCCCCCCCCHHH		16.1321945579
335PhosphorylationGSRNTKKSVNNQYCK
CCCCCCHHHCHHHHH		31.4728985074
340PhosphorylationKKSVNNQYCKKVIGG
CHHHCHHHHHHHHCH		14.3628102081
357PhosphorylationWNPAMRRSLSVEHLE
CCHHHHCCCCHHHHC		18.0330266825
359PhosphorylationPAMRRSLSVEHLETK
HHHHCCCCHHHHCCC		27.0629255136
365PhosphorylationLSVEHLETKSLPSRS
CCHHHHCCCCCCCCC		32.0923663014
367PhosphorylationVEHLETKSLPSRSPP
HHHHCCCCCCCCCCC		53.5927273156
370PhosphorylationLETKSLPSRSPPITP
HCCCCCCCCCCCCCC		51.1627273156
372PhosphorylationTKSLPSRSPPITPNW
CCCCCCCCCCCCCCC		39.0927273156
376PhosphorylationPSRSPPITPNWRSPR
CCCCCCCCCCCCCHH		19.1527273156
381PhosphorylationPITPNWRSPRLRHEI
CCCCCCCCHHHHHHH		13.1427273156
394PhosphorylationEIRKPRHSSADNLAN
HHCCCCCCCHHHHHH		28.6222617229
395PhosphorylationIRKPRHSSADNLANE
HCCCCCCCHHHHHHH		33.2523898821
404PhosphorylationDNLANEMTYITETED
HHHHHHCEEEEECCC		12.9527732954
405PhosphorylationNLANEMTYITETEDV
HHHHHCEEEEECCCE		12.4427251275
419PhosphorylationVFYTYKGSLAPQDSD
EEEEECCCCCCCCCC		19.7330266825
425PhosphorylationGSLAPQDSDSEVSQN
CCCCCCCCCCHHHCC		37.4830266825
427PhosphorylationLAPQDSDSEVSQNRS
CCCCCCCCHHHCCCC		43.8030266825
430PhosphorylationQDSDSEVSQNRSPHQ
CCCCCHHHCCCCCCC		20.0730266825
434PhosphorylationSEVSQNRSPHQESLS
CHHHCCCCCCCHHHC		33.9928985074
439PhosphorylationNRSPHQESLSENNPA
CCCCCCHHHCCCCHH		30.5330624053
441PhosphorylationSPHQESLSENNPAQS
CCCCHHHCCCCHHHH		47.7824043423
448PhosphorylationSENNPAQSYLTQKSS
CCCCHHHHHHCCCCC		24.9824043423
449PhosphorylationENNPAQSYLTQKSSS
CCCHHHHHHCCCCCC		11.1624043423
451PhosphorylationNPAQSYLTQKSSSSV
CHHHHHHCCCCCCCC		26.2224043423
454PhosphorylationQSYLTQKSSSSVSPS
HHHHCCCCCCCCCCC		26.1523663014
455PhosphorylationSYLTQKSSSSVSPSS
HHHCCCCCCCCCCCC		33.4023663014
456PhosphorylationYLTQKSSSSVSPSSN
HHCCCCCCCCCCCCC		41.6825849741
457PhosphorylationLTQKSSSSVSPSSNA
HCCCCCCCCCCCCCC		28.6723663014
459PhosphorylationQKSSSSVSPSSNAPG
CCCCCCCCCCCCCCC		22.4723663014
461PhosphorylationSSSSVSPSSNAPGSC
CCCCCCCCCCCCCCC		28.8123663014
462PhosphorylationSSSVSPSSNAPGSCS
CCCCCCCCCCCCCCC		40.1623663014
467PhosphorylationPSSNAPGSCSPDGVD
CCCCCCCCCCCCCCC		15.4623663014
469PhosphorylationSNAPGSCSPDGVDQQ
CCCCCCCCCCCCCHH		27.9423663014
485PhosphorylationLDDFHRVTKGGSTED
HHCCCHHCCCCCCCC		24.7523312004
486UbiquitinationDDFHRVTKGGSTEDA
HCCCHHCCCCCCCCH		59.42-
489PhosphorylationHRVTKGGSTEDASQY
CHHCCCCCCCCHHHH		36.9725159151
490PhosphorylationRVTKGGSTEDASQYY
HHCCCCCCCCHHHHE		40.9525849741
494PhosphorylationGGSTEDASQYYCDKN
CCCCCCHHHHEEECC		30.9130624053
496PhosphorylationSTEDASQYYCDKNDN
CCCCHHHHEEECCCC		11.9930624053
497PhosphorylationTEDASQYYCDKNDNG
CCCHHHHEEECCCCC		6.1230624053
526AcetylationGKFGFNLKGGVDQKM
CCCCEECCCCCCCCC		55.5119829845
538PhosphorylationQKMPLVVSRINPESP
CCCCEEEEECCCCCC		21.6924719451
544PhosphorylationVSRINPESPADTCIP
EEECCCCCCCCCCCC		27.0128857561
548PhosphorylationNPESPADTCIPKLNE
CCCCCCCCCCCCCCC		17.9127251275
601PhosphorylationIRRRAVRSFADFKSE
HHHHHHHHHHCCCCH		20.4222210691
607PhosphorylationRSFADFKSEDELNQL
HHHHCCCCHHHHHHH		50.7222210691
633PhosphorylationGGDTLEGSMAQLKKG
CCCCHHHHHHHHHHH		11.1122210691
677UbiquitinationNLDKNRYKDVLPYDT
CCCCCCCCCCCCCCC		37.82-
682PhosphorylationRYKDVLPYDTTRVLL
CCCCCCCCCCHHHEE		23.0427642862
684PhosphorylationKDVLPYDTTRVLLQG
CCCCCCCCHHHEECC		15.6222461510
695PhosphorylationLLQGNEDYINASYVN
EECCCCCCCCCCEEC		7.0127642862
700PhosphorylationEDYINASYVNMEIPA
CCCCCCCEECCCCCH		8.0727642862
752PhosphorylationTLTERGRTKCHQYWP
HCHHHCCCCCHHCCC		40.6322210691
776PhosphorylationGFHIQCQSEDCTIAY
CEEEEECCCCCEEEE		42.9222210691
783PhosphorylationSEDCTIAYVSREMLV
CCCCEEEEEEHHHEE		8.6322210691
785PhosphorylationDCTIAYVSREMLVTN
CCEEEEEEHHHEEEC		15.1722210691
835PhosphorylationVRSLRVDSEPVLVHC
HHHCCCCCCCEEEEE		40.739341175
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
359SPhosphorylationKinaseMAP3K7O43318
GPS
459SPhosphorylationKinaseMAPK12P53778
GPS
-KUbiquitinationE3 ubiquitin ligaseUBE3AQ05086
PMID:17166906
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433B_HUMANYWHABphysical
9341175
WDR6_HUMANWDR6physical
25416956
DIP2A_HUMANDIP2Aphysical
25416956
ZCH10_HUMANZCCHC10physical
25416956
NXT2_HUMANNXT2physical
25416956
ACOT8_HUMANACOT8physical
27880917
KCTD3_HUMANKCTD3physical
27880917
SHKB1_HUMANSHKBP1physical
27880917
AAAT_HUMANSLC1A5physical
27880917
SRRM2_HUMANSRRM2physical
27880917
VANG1_HUMANVANGL1physical
27880917
1433B_HUMANYWHABphysical
27880917
1433E_HUMANYWHAEphysical
27880917
1433G_HUMANYWHAGphysical
27880917
1433F_HUMANYWHAHphysical
27880917
1433T_HUMANYWHAQphysical
27880917
1433Z_HUMANYWHAZphysical
27880917
PTN3_HUMANPTPN3physical
27432908
KCTD3_HUMANKCTD3physical
27432908
VANG1_HUMANVANGL1physical
27432908
SHKB1_HUMANSHKBP1physical
27432908
1433F_HUMANYWHAHphysical
27432908
CYBP_HUMANCACYBPphysical
27432908
1433G_HUMANYWHAGphysical
27432908
ACOT8_HUMANACOT8physical
27432908
1433B_HUMANYWHABphysical
27432908
1433T_HUMANYWHAQphysical
27432908
1433Z_HUMANYWHAZphysical
27432908
1433E_HUMANYWHAEphysical
27432908
AAAT_HUMANSLC1A5physical
27432908
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTN3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359; SER-367; SER-370;SER-372; THR-376 AND SER-381, AND MASS SPECTROMETRY.

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