dbPTM

ACOT8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACOT8_HUMAN
UniProt AC	O14734
Protein Name	Acyl-coenzyme A thioesterase 8
Gene Name	ACOT8
Organism	Homo sapiens (Human).
Sequence Length	319
Subcellular Localization	Cytoplasm . Peroxisome matrix . Predominantly localized in the peroxisome (PubMed:10092594, PubMed:15194431).
Protein Description	Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. [PubMed: 9299485]
Protein Sequence	MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPQAPED ------CCCCCCCCC	51.21	30108239
3	Phosphorylation	-----MSSPQAPEDG -----CCCCCCCCCC	21.52	25159151
52	Acetylation	RHYWVPAKRLFGGQI CCCEEECHHHCCCHH	43.49	19608861
52	Ubiquitination	RHYWVPAKRLFGGQI CCCEEECHHHCCCHH	43.49	19608861
91	Acetylation	FVRAGDPKLPVLYQV EEECCCCCCCEEEEE	70.89	23749302
96	Phosphorylation	DPKLPVLYQVERTRT CCCCCEEEEEEECCC	15.67	8281689
101	Phosphorylation	VLYQVERTRTGSSFS EEEEEEECCCCCCEE	21.05	28102081
103	Phosphorylation	YQVERTRTGSSFSVR EEEEECCCCCCEEEE	40.58	28102081
105	Phosphorylation	VERTRTGSSFSVRSV EEECCCCCCEEEEEE	27.83	23312004
106	Phosphorylation	ERTRTGSSFSVRSVK EECCCCCCEEEEEEE	23.92	28102081
111	Phosphorylation	GSSFSVRSVKAVQHG CCCEEEEEEEEEECC	26.30	22985185
169	Ubiquitination	LRDPNLQKRYPLALN HHCCCHHHHHCCHHH	58.00	-
188	Acetylation	QEVPIEIKPVNPSPL CCCCCEEECCCCCCH	30.07	26051181
188	Ubiquitination	QEVPIEIKPVNPSPL CCCCCEEECCCCCCH	30.07	-
311	Acetylation	QEGVIRVKPQVSESK CCCEEEEECCCCCCC	21.63	18525915
311	Malonylation	QEGVIRVKPQVSESK CCCEEEEECCCCCCC	21.63	26320211
315	Phosphorylation	IRVKPQVSESKL--- EEEECCCCCCCC---	30.79	30108239
317	Phosphorylation	VKPQVSESKL----- EECCCCCCCC-----	31.58	30108239
318	Acetylation	KPQVSESKL------ ECCCCCCCC------	54.91	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACOT8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACOT8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACOT8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEF_HV1H2	nef	physical	9153233
PML_HUMAN	PML	physical	26186194
KLH23_HUMAN	KLHL23	physical	26186194
PML_HUMAN	PML	physical	28514442
KLH23_HUMAN	KLHL23	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACOT8_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52 AND LYS-318, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND MASSSPECTROMETRY.	18691976 [Abstract]