MED1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED1_HUMAN
• UniProt AC: Q15648
• Protein Name: Mediator of RNA polymerase II transcription subunit 1
• Gene Name: MED1
• Organism: Homo sapiens (Human).
• Sequence Length: 1581
• Subcellular Localization: Nucleus . A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. [PubMed: 10406464]
• Protein Sequence: MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKAQGETEE ------CCCCCCCHH	61.80	25953088
2	Methylation	------MKAQGETEE ------CCCCCCCHH	61.80	115972939
7	Phosphorylation	-MKAQGETEESEKLS -CCCCCCCHHHHHHH	52.45	29083192
10	Phosphorylation	AQGETEESEKLSKMS CCCCCHHHHHHHHHH	33.52	29083192
12	Acetylation	GETEESEKLSKMSSL CCCHHHHHHHHHHHH	68.30	26051181
14	Phosphorylation	TEESEKLSKMSSLLE CHHHHHHHHHHHHHH	37.06	29083192
15	Acetylation	EESEKLSKMSSLLER HHHHHHHHHHHHHHH	53.92	19608861
15	Ubiquitination	EESEKLSKMSSLLER HHHHHHHHHHHHHHH	53.92	19608861
17	Phosphorylation	SEKLSKMSSLLERLH HHHHHHHHHHHHHHH	22.90	20068231
18	Phosphorylation	EKLSKMSSLLERLHA HHHHHHHHHHHHHHH	33.21	20068231
26	Ubiquitination	LLERLHAKFNQNRPW HHHHHHHHHHCCCCH	33.82	29967540
51	Phosphorylation	MEKRVVMSSGGHQHL HHHCEEECCCCHHHH	17.77	23312004
52	Phosphorylation	EKRVVMSSGGHQHLV HHCEEECCCCHHHHH	30.60	23312004
60	Phosphorylation	GGHQHLVSCLETLQK CCHHHHHHHHHHHHH	21.24	23312004
64	Phosphorylation	HLVSCLETLQKALKV HHHHHHHHHHHHHHH	22.88	23312004
145	Ubiquitination	LVQQLREKNFDEFSK HHHHHHHCCHHHHHH	57.38	29967540
151	Phosphorylation	EKNFDEFSKHLKGLV HCCHHHHHHHHHHHH	19.67	-
152	Methylation	KNFDEFSKHLKGLVN CCHHHHHHHHHHHHH	59.27	115972931
168	Sumoylation	YNLPGDNKLKTKMYL HCCCCCCHHHHHHHH	56.98	-
168	Ubiquitination	YNLPGDNKLKTKMYL HCCCCCCHHHHHHHH	56.98	32015554
174	Phosphorylation	NKLKTKMYLALQSLE CHHHHHHHHHHHHHH	7.15	25867546
179	Phosphorylation	KMYLALQSLEQDLSK HHHHHHHHHHHHHHH	34.42	20068231
185	Phosphorylation	QSLEQDLSKMAIMYW HHHHHHHHHHHHHHH	28.77	20068231
202	Ubiquitination	TNAGPLDKILHGSVG CCCCCHHHHHCCCCC	55.65	-
207	Phosphorylation	LDKILHGSVGYLTPR HHHHHCCCCCEECCC	11.13	24961811
212	Phosphorylation	HGSVGYLTPRSGGHL CCCCCEECCCCCCEE	14.26	-
224	Phosphorylation	GHLMNLKYYVSPSDL CEEEEEEEEECHHHH	16.56	19658100
225	Phosphorylation	HLMNLKYYVSPSDLL EEEEEEEEECHHHHC	7.89	19658100
235	Acetylation	PSDLLDDKTASPIIL HHHHCCCCCCCCEEE	45.73	26051181
235	Ubiquitination	PSDLLDDKTASPIIL HHHHCCCCCCCCEEE	45.73	-
236	Phosphorylation	SDLLDDKTASPIILH HHHCCCCCCCCEEEE	39.09	23917254
238	Phosphorylation	LLDDKTASPIILHEN HCCCCCCCCEEEECC	23.12	25159151
256	Phosphorylation	RSLGMNASVTIEGTS HHHCCCEEEEEECCC	18.13	22210691
258	Phosphorylation	LGMNASVTIEGTSAV HCCCEEEEEECCCCE	15.71	22210691
262	Phosphorylation	ASVTIEGTSAVYKLP EEEEEECCCCEEECC	10.75	-
378	Acetylation	QHCYFLNKDAPLPDG CEEEEECCCCCCCCC	58.37	26051181
378	Ubiquitination	QHCYFLNKDAPLPDG CEEEEECCCCCCCCC	58.37	29967540
387	Phosphorylation	APLPDGRSLQGTLVS CCCCCCCCCCCEEEE	30.49	20068231
391	Phosphorylation	DGRSLQGTLVSKITF CCCCCCCEEEEEEEC	15.83	20068231
394	Phosphorylation	SLQGTLVSKITFQHP CCCCEEEEEEECCCC	22.81	20068231
395	Acetylation	LQGTLVSKITFQHPG CCCEEEEEEECCCCC	37.98	25953088
426	Ubiquitination	TLIGSCVKRTILKED HHHHHHHHHHHCCCC	48.42	-
428	Phosphorylation	IGSCVKRTILKEDSP HHHHHHHHHCCCCCC	25.58	20068231
431	Acetylation	CVKRTILKEDSPGLL HHHHHHCCCCCCCEE	56.47	25953088
431	Ubiquitination	CVKRTILKEDSPGLL HHHHHHCCCCCCCEE	56.47	-
434	Phosphorylation	RTILKEDSPGLLQFE HHHCCCCCCCEEEEE	23.20	20068231
446	Phosphorylation	QFEVCPLSESRFSVS EEEEEECCCCCEEEE	20.76	20068231
448	Phosphorylation	EVCPLSESRFSVSFQ EEEECCCCCEEEEEC	34.94	20068231
472	Ubiquitination	VVMDVQDSTHVSCKL EEEECCCCCCEEEEC	11.88	24816145
481	Ubiquitination	HVSCKLYKGLSDALI CEEEECCCCCCCCEE	64.91	29967540
496	Ubiquitination	CTDDFIAKVVQRCMS ECHHHHHHHHHHHHC	37.82	-
503	Phosphorylation	KVVQRCMSIPVTMRA HHHHHHHCCCHHHHH	27.63	-
507	Phosphorylation	RCMSIPVTMRAIRRK HHHCCCHHHHHHHHH	8.79	-
519	Ubiquitination	RRKAETIQADTPALS HHHHHHHCCCCHHHH	40.37	24816145
522	Phosphorylation	AETIQADTPALSLIA HHHHCCCCHHHHHHH	17.30	-
537	Ubiquitination	ETVEDMVKKNLPPAS HHHHHHHHHCCCCCC	29.34	32015554
544	Phosphorylation	KKNLPPASSPGYGMT HHCCCCCCCCCCCCC	42.72	28348404
544 (in isoform 3)	Phosphorylation	-	42.72	26434776
545	Phosphorylation	KNLPPASSPGYGMTT HCCCCCCCCCCCCCC	25.17	28348404
545 (in isoform 3)	Phosphorylation	-	25.17	26434776
548	Phosphorylation	PPASSPGYGMTTGNN CCCCCCCCCCCCCCC	13.70	27251275
548 (in isoform 3)	Phosphorylation	-	13.70	26434776
551	Phosphorylation	SSPGYGMTTGNNPMS CCCCCCCCCCCCCCC	27.47	28348404
552	Phosphorylation	SPGYGMTTGNNPMSG CCCCCCCCCCCCCCC	29.08	28348404
558	Phosphorylation	TTGNNPMSGTTTPTN CCCCCCCCCCCCCCC	33.96	26074081
560	Phosphorylation	GNNPMSGTTTPTNTF CCCCCCCCCCCCCCC	21.86	26074081
561	Phosphorylation	NNPMSGTTTPTNTFP CCCCCCCCCCCCCCC	34.01	26074081
562	Phosphorylation	NPMSGTTTPTNTFPG CCCCCCCCCCCCCCC	28.14	26074081
564	Phosphorylation	MSGTTTPTNTFPGGP CCCCCCCCCCCCCCC	44.81	26074081
566	Phosphorylation	GTTTPTNTFPGGPIT CCCCCCCCCCCCCCE	33.41	26074081
588	Phosphorylation	SIKDRHESVGHGEDF EHHHHHHHCCCCCCH	27.55	29255136
596	O-linked_Glycosylation	VGHGEDFSKVSQNPI CCCCCCHHHHCCCHH	44.46	23301498
596	Phosphorylation	VGHGEDFSKVSQNPI CCCCCCHHHHCCCHH	44.46	29255136
599	Phosphorylation	GEDFSKVSQNPILTS CCCHHHHCCCHHHHH	28.16	27251275
605	Phosphorylation	VSQNPILTSLLQITG HCCCHHHHHHEEECC	20.32	27251275
606	Phosphorylation	SQNPILTSLLQITGN CCCHHHHHHEEECCC	24.52	27251275
611	Phosphorylation	LTSLLQITGNGGSTI HHHHEEECCCCCCCC	16.19	20068231
616	Phosphorylation	QITGNGGSTIGSSPT EECCCCCCCCCCCCC	20.46	20068231
617	Phosphorylation	ITGNGGSTIGSSPTP ECCCCCCCCCCCCCC	32.41	20068231
620	Phosphorylation	NGGSTIGSSPTPPHH CCCCCCCCCCCCCCC	29.33	30108239
621	Phosphorylation	GGSTIGSSPTPPHHT CCCCCCCCCCCCCCC	27.81	30108239
623	Phosphorylation	STIGSSPTPPHHTPP CCCCCCCCCCCCCCC	51.94	30108239
628	Phosphorylation	SPTPPHHTPPPVSSM CCCCCCCCCCCCHHH	34.16	28464451
633	Phosphorylation	HHTPPPVSSMAGNTK CCCCCCCHHHCCCCC	21.85	30108239
634	Phosphorylation	HTPPPVSSMAGNTKN CCCCCCHHHCCCCCC	16.94	30108239
639	Phosphorylation	VSSMAGNTKNHPMLM CHHHCCCCCCCHHHH	32.10	30108239
658	Phosphorylation	DNPAQDFSTLYGSSP CCCCCCHHHHHCCCC	26.28	23403867
659	Phosphorylation	NPAQDFSTLYGSSPL CCCCCHHHHHCCCCC	24.80	23403867
661	Phosphorylation	AQDFSTLYGSSPLER CCCHHHHHCCCCCHH	18.30	22115753
663	Phosphorylation	DFSTLYGSSPLERQN CHHHHHCCCCCHHCC	18.41	25159151
664	Phosphorylation	FSTLYGSSPLERQNS HHHHHCCCCCHHCCC	29.19	25159151
671	O-linked_Glycosylation	SPLERQNSSSGSPRM CCCHHCCCCCCCCCC	19.97	23301498
671	Phosphorylation	SPLERQNSSSGSPRM CCCHHCCCCCCCCCC	19.97	25884760
672	Phosphorylation	PLERQNSSSGSPRME CCHHCCCCCCCCCCE	46.39	25159151
673	O-linked_Glycosylation	LERQNSSSGSPRMEI CHHCCCCCCCCCCEE	43.01	23301498
673	Phosphorylation	LERQNSSSGSPRMEI CHHCCCCCCCCCCEE	43.01	25884760
675	Phosphorylation	RQNSSSGSPRMEICS HCCCCCCCCCCEECC	15.98	25159151
682	O-linked_Glycosylation	SPRMEICSGSNKTKK CCCCEECCCCCCCCC	51.41	23301498
682	Phosphorylation	SPRMEICSGSNKTKK CCCCEECCCCCCCCC	51.41	25159151
684	Phosphorylation	RMEICSGSNKTKKKK CCEECCCCCCCCCCC	20.89	21815630
686	Acetylation	EICSGSNKTKKKKSS EECCCCCCCCCCCCC	64.52	25953088
687	Phosphorylation	ICSGSNKTKKKKSSR ECCCCCCCCCCCCCC	52.96	21712546
691	Ubiquitination	SNKTKKKKSSRLPPE CCCCCCCCCCCCCCC	63.64	24816145
704	Phosphorylation	PEKPKHQTEDDFQRE CCCCCCCCHHHHHHH	40.89	-
719	Phosphorylation	LFSMDVDSQNPIFDV HHCCCCCCCCCCEEE	31.53	27362937
735	Phosphorylation	MTADTLDTPHITPAP ECCCCCCCCCCCCCC	21.63	26074081
739	Phosphorylation	TLDTPHITPAPSQCS CCCCCCCCCCCHHCC	15.46	26074081
743	Phosphorylation	PHITPAPSQCSTPPT CCCCCCCHHCCCCCC	46.02	26074081
746	Phosphorylation	TPAPSQCSTPPTTYP CCCCHHCCCCCCCCC	35.99	26074081
747	Phosphorylation	PAPSQCSTPPTTYPQ CCCHHCCCCCCCCCC	40.70	26074081
750	Phosphorylation	SQCSTPPTTYPQPVP HHCCCCCCCCCCCCC	39.92	26074081
751	Phosphorylation	QCSTPPTTYPQPVPH HCCCCCCCCCCCCCC	38.69	26074081
752	Phosphorylation	CSTPPTTYPQPVPHP CCCCCCCCCCCCCCC	11.44	26074081
762	Phosphorylation	PVPHPQPSIQRMVRL CCCCCCCCHHHHHHH	26.55	26074081
770	Phosphorylation	IQRMVRLSSSDSIGP HHHHHHHCCCCCCCC	19.75	30278072
771	Phosphorylation	QRMVRLSSSDSIGPD HHHHHHCCCCCCCCC	42.64	27273156
772	Phosphorylation	RMVRLSSSDSIGPDV HHHHHCCCCCCCCCH	31.81	30278072
774	Phosphorylation	VRLSSSDSIGPDVTD HHHCCCCCCCCCHHH	31.24	30278072
775	Ubiquitination	RLSSSDSIGPDVTDI HHCCCCCCCCCHHHH	12.78	24816145
780	Phosphorylation	DSIGPDVTDILSDIA CCCCCCHHHHHHHHH	25.38	30278072
784	Phosphorylation	PDVTDILSDIAEEAS CCHHHHHHHHHHHHH	27.57	17081983
789	Ubiquitination	ILSDIAEEASKLPST HHHHHHHHHHCCCCC	49.58	24816145
791	Phosphorylation	SDIAEEASKLPSTSD HHHHHHHHCCCCCCC	37.70	28464451
795	Phosphorylation	EEASKLPSTSDDCPA HHHHCCCCCCCCCCC	51.48	29255136
796	Phosphorylation	EASKLPSTSDDCPAI HHHCCCCCCCCCCCC	33.95	29255136
797	Phosphorylation	ASKLPSTSDDCPAIG HHCCCCCCCCCCCCC	35.47	29255136
805	Phosphorylation	DDCPAIGTPLRDSSS CCCCCCCCCCCCCCC	17.03	19664994
816	Phosphorylation	DSSSSGHSQSTLFDS CCCCCCCCCCCCCCC	29.38	17478428
822	Ubiquitination	HSQSTLFDSDVFQTN CCCCCCCCCCCCCCC	47.22	24816145
836	Ubiquitination	NNNENPYTDPADLIA CCCCCCCCCHHHHHH	36.44	24816145
848	Phosphorylation	LIADAAGSPSSDSPT HHHHHCCCCCCCCCC	19.51	27362937
850	Phosphorylation	ADAAGSPSSDSPTNH HHHCCCCCCCCCCCC	48.77	27362937
851	Phosphorylation	DAAGSPSSDSPTNHF HHCCCCCCCCCCCCC	45.55	27362937
853	Phosphorylation	AGSPSSDSPTNHFFH CCCCCCCCCCCCCCC	35.26	26074081
855	Phosphorylation	SPSSDSPTNHFFHDG CCCCCCCCCCCCCCC	45.32	26074081
872	Phosphorylation	FNPDLLNSQSQSGFG CCHHHHHCCCCCCCC	31.04	17478428
874	Phosphorylation	PDLLNSQSQSGFGEE HHHHHCCCCCCCCHH	26.57	17478428
876	Phosphorylation	LLNSQSQSGFGEEYF HHHCCCCCCCCHHHC	41.14	26074081
887	Phosphorylation	EEYFDESSQSGDNDD HHHCCCCCCCCCCCC	26.73	17478428
900	Phosphorylation	DDFKGFASQALNTLG CCHHHHHHHHHHHCC	17.45	27251275
928	Phosphorylation	KGNNQADTVDFSIIS CCCCCCCCCCEEEEE	25.62	-
939	Acetylation	SIISVAGKALAPADL EEEEECCCCCCCHHH	30.41	25953088
951	Phosphorylation	ADLMEHHSGSQGPLL HHHHHHCCCCCCCCC	41.89	23401153
953	Phosphorylation	LMEHHSGSQGPLLTT HHHHCCCCCCCCCCC	34.67	17525332
959	Phosphorylation	GSQGPLLTTGDLGKE CCCCCCCCCCCCCHH	36.09	28450419
960	Phosphorylation	SQGPLLTTGDLGKEK CCCCCCCCCCCCHHH	28.77	28450419
965	Acetylation	LTTGDLGKEKTQKRV CCCCCCCHHHHHHHH	64.43	26051181
973	Acetylation	EKTQKRVKEGNGTSN HHHHHHHHCCCCCCC	65.03	2403207
991	Acetylation	SGPGLDSKPGKRSRT CCCCCCCCCCCCCCC	58.41	23236377
994	Acetylation	GLDSKPGKRSRTPSN CCCCCCCCCCCCCCC	56.58	25953088
994	Ubiquitination	GLDSKPGKRSRTPSN CCCCCCCCCCCCCCC	56.58	24816145
996	Phosphorylation	DSKPGKRSRTPSNDG CCCCCCCCCCCCCCC	43.95	20068231
998	Phosphorylation	KPGKRSRTPSNDGKS CCCCCCCCCCCCCCC	32.11	28176443
1000	Phosphorylation	GKRSRTPSNDGKSKD CCCCCCCCCCCCCCC	47.11	20068231
1004	Acetylation	RTPSNDGKSKDKPPK CCCCCCCCCCCCCCC	58.14	7296857
1005	Phosphorylation	TPSNDGKSKDKPPKR CCCCCCCCCCCCCCC	52.17	26552605
1006	Methylation	PSNDGKSKDKPPKRK CCCCCCCCCCCCCCC	73.57	117956011
1008	Ubiquitination	NDGKSKDKPPKRKKA CCCCCCCCCCCCCCC	67.94	24816145
1011	Acetylation	KSKDKPPKRKKADTE CCCCCCCCCCCCCCC	82.47	7296867
1017	Phosphorylation	PKRKKADTEGKSPSH CCCCCCCCCCCCCCC	52.04	30576142
1021	Phosphorylation	KADTEGKSPSHSSSN CCCCCCCCCCCCCCC	42.35	23927012
1023	Phosphorylation	DTEGKSPSHSSSNRP CCCCCCCCCCCCCCC	42.99	23927012
1025	Phosphorylation	EGKSPSHSSSNRPFT CCCCCCCCCCCCCCC	39.54	23927012
1026	O-linked_Glycosylation	GKSPSHSSSNRPFTP CCCCCCCCCCCCCCC	26.63	23301498
1026	Phosphorylation	GKSPSHSSSNRPFTP CCCCCCCCCCCCCCC	26.63	25159151
1027	O-linked_Glycosylation	KSPSHSSSNRPFTPP CCCCCCCCCCCCCCC	39.61	23301498
1027	Phosphorylation	KSPSHSSSNRPFTPP CCCCCCCCCCCCCCC	39.61	23927012
1032	O-linked_Glycosylation	SSSNRPFTPPTSTGG CCCCCCCCCCCCCCC	30.92	23301498
1032	Phosphorylation	SSSNRPFTPPTSTGG CCCCCCCCCCCCCCC	30.92	23401153
1035	Phosphorylation	NRPFTPPTSTGGSKS CCCCCCCCCCCCCCC	39.87	23927012
1036	O-linked_Glycosylation	RPFTPPTSTGGSKSP CCCCCCCCCCCCCCC	30.72	23301498
1036	Phosphorylation	RPFTPPTSTGGSKSP CCCCCCCCCCCCCCC	30.72	23927012
1037	Phosphorylation	PFTPPTSTGGSKSPG CCCCCCCCCCCCCCC	48.30	23927012
1040	Phosphorylation	PPTSTGGSKSPGSAG CCCCCCCCCCCCCCC	31.16	23927012
1042	Phosphorylation	TSTGGSKSPGSAGRS CCCCCCCCCCCCCCC	35.87	25159151
1045	Phosphorylation	GGSKSPGSAGRSQTP CCCCCCCCCCCCCCC	30.82	23927012
1049	Phosphorylation	SPGSAGRSQTPPGVA CCCCCCCCCCCCCCC	37.17	25159151
1051	Phosphorylation	GSAGRSQTPPGVATP CCCCCCCCCCCCCCC	32.47	19664994
1057	Phosphorylation	QTPPGVATPPIPKIT CCCCCCCCCCCCEEE	27.47	23927012
1071	Phosphorylation	TIQIPKGTVMVGKPS EEEECCCEEEECCCC	16.14	23532336
1076	Acetylation	KGTVMVGKPSSHSQY CCEEEECCCCCCCCC	30.25	25953088
1078	Phosphorylation	TVMVGKPSSHSQYTS EEEECCCCCCCCCCC	44.14	23532336
1079	Phosphorylation	VMVGKPSSHSQYTSS EEECCCCCCCCCCCC	35.37	23532336
1081	Phosphorylation	VGKPSSHSQYTSSGS ECCCCCCCCCCCCCC	27.16	22144111
1084	Phosphorylation	PSSHSQYTSSGSVSS CCCCCCCCCCCCCCC	14.58	22144111
1085	Phosphorylation	SSHSQYTSSGSVSSS CCCCCCCCCCCCCCC	27.97	22144111
1086	Phosphorylation	SHSQYTSSGSVSSSG CCCCCCCCCCCCCCC	27.56	22144111
1088	Phosphorylation	SQYTSSGSVSSSGSK CCCCCCCCCCCCCCC	22.30	25159151
1090	Phosphorylation	YTSSGSVSSSGSKSH CCCCCCCCCCCCCCC	22.08	25159151
1091	Phosphorylation	TSSGSVSSSGSKSHH CCCCCCCCCCCCCCC	36.24	25159151
1092	Phosphorylation	SSGSVSSSGSKSHHS CCCCCCCCCCCCCCC	39.31	25159151
1094	Phosphorylation	GSVSSSGSKSHHSHS CCCCCCCCCCCCCCC	32.69	21712546
1096	Phosphorylation	VSSSGSKSHHSHSSS CCCCCCCCCCCCCCC	28.29	22210691
1116	Phosphorylation	STSGKMKSSKSEGSS CCCCCCCCCCCCCCC	39.23	23532336
1118	Acetylation	SGKMKSSKSEGSSSS CCCCCCCCCCCCCCC	60.67	26051181
1125	Phosphorylation	KSEGSSSSKLSSSMY CCCCCCCCHHCHHHC	39.29	30576142
1126	Acetylation	SEGSSSSKLSSSMYS CCCCCCCHHCHHHCC	55.10	25953088
1128	Phosphorylation	GSSSSKLSSSMYSSQ CCCCCHHCHHHCCCC	24.89	23186163
1129	Phosphorylation	SSSSKLSSSMYSSQG CCCCHHCHHHCCCCC	29.57	25159151
1130	Phosphorylation	SSSKLSSSMYSSQGS CCCHHCHHHCCCCCC	20.54	25159151
1132	Phosphorylation	SKLSSSMYSSQGSSG CHHCHHHCCCCCCCC	13.71	23186163
1133	Phosphorylation	KLSSSMYSSQGSSGS HHCHHHCCCCCCCCC	13.93	27174698
1134	Phosphorylation	LSSSMYSSQGSSGSS HCHHHCCCCCCCCCC	22.52	17525332
1137	Phosphorylation	SMYSSQGSSGSSQSK HHCCCCCCCCCCCCC	24.72	27174698
1138	Phosphorylation	MYSSQGSSGSSQSKN HCCCCCCCCCCCCCC	49.90	30576142
1140	Phosphorylation	SSQGSSGSSQSKNSS CCCCCCCCCCCCCCC	27.44	27174698
1141	Phosphorylation	SQGSSGSSQSKNSSQ CCCCCCCCCCCCCCC	41.83	17478428
1143	Phosphorylation	GSSGSSQSKNSSQSG CCCCCCCCCCCCCCC	35.43	27174698
1146	Phosphorylation	GSSQSKNSSQSGGKP CCCCCCCCCCCCCCC	33.23	23927012
1147	Phosphorylation	SSQSKNSSQSGGKPG CCCCCCCCCCCCCCC	37.45	23927012
1149	Phosphorylation	QSKNSSQSGGKPGSS CCCCCCCCCCCCCCC	52.00	22167270
1152	Acetylation	NSSQSGGKPGSSPIT CCCCCCCCCCCCCCC	50.13	26051181
1155	Phosphorylation	QSGGKPGSSPITKHG CCCCCCCCCCCCCCC	41.28	22167270
1156	Phosphorylation	SGGKPGSSPITKHGL CCCCCCCCCCCCCCC	26.66	22167270
1159	Phosphorylation	KPGSSPITKHGLSSG CCCCCCCCCCCCCCC	22.00	22167270
1160	Methylation	PGSSPITKHGLSSGS CCCCCCCCCCCCCCC	36.07	115972923
1173	Acetylation	GSSSTKMKPQGKPSS CCCCCCCCCCCCCHH	35.43	7823141
1177	Acetylation	TKMKPQGKPSSLMNP CCCCCCCCCHHHCCC	36.16	19608861
1179	Phosphorylation	MKPQGKPSSLMNPSL CCCCCCCHHHCCCCC	39.32	20068231
1180	Phosphorylation	KPQGKPSSLMNPSLS CCCCCCHHHCCCCCC	39.92	20068231
1185	Phosphorylation	PSSLMNPSLSKPNIS CHHHCCCCCCCCCCC	40.03	28450419
1187	Phosphorylation	SLMNPSLSKPNISPS HHCCCCCCCCCCCCC	50.86	22167270
1188	Acetylation	LMNPSLSKPNISPSH HCCCCCCCCCCCCCC	47.58	23954790
1192	Phosphorylation	SLSKPNISPSHSRPP CCCCCCCCCCCCCCC	27.30	23401153
1194	Phosphorylation	SKPNISPSHSRPPGG CCCCCCCCCCCCCCC	27.57	22167270
1196	Phosphorylation	PNISPSHSRPPGGSD CCCCCCCCCCCCCCC	51.31	22167270
1202	Phosphorylation	HSRPPGGSDKLASPM CCCCCCCCCCCCCCC	37.17	22167270
1207	Phosphorylation	GGSDKLASPMKPVPG CCCCCCCCCCCCCCC	35.64	19664994
1210	Acetylation	DKLASPMKPVPGTPP CCCCCCCCCCCCCCC	46.37	23954790
1215	Phosphorylation	PMKPVPGTPPSSKAK CCCCCCCCCCCHHCC	26.42	19664994
1218	Phosphorylation	PVPGTPPSSKAKSPI CCCCCCCCHHCCCCC	45.75	29255136
1219	Phosphorylation	VPGTPPSSKAKSPIS CCCCCCCHHCCCCCC	42.26	30266825
1223	Phosphorylation	PPSSKAKSPISSGSG CCCHHCCCCCCCCCC	32.12	25159151
1226	Phosphorylation	SKAKSPISSGSGGSH HHCCCCCCCCCCCCC	31.84	23927012
1227	Phosphorylation	KAKSPISSGSGGSHM HCCCCCCCCCCCCCC	37.38	23927012
1229	Phosphorylation	KSPISSGSGGSHMSG CCCCCCCCCCCCCCC	41.76	23927012
1232	Phosphorylation	ISSGSGGSHMSGTSS CCCCCCCCCCCCCCC	21.39	23927012
1235	Phosphorylation	GSGGSHMSGTSSSSG CCCCCCCCCCCCCCC	33.23	20068231
1237	Phosphorylation	GGSHMSGTSSSSGMK CCCCCCCCCCCCCCC	20.37	20068231
1238	Phosphorylation	GSHMSGTSSSSGMKS CCCCCCCCCCCCCCC	31.57	23927012
1239	Phosphorylation	SHMSGTSSSSGMKSS CCCCCCCCCCCCCCC	28.50	20068231
1240	Phosphorylation	HMSGTSSSSGMKSSS CCCCCCCCCCCCCCC	30.58	30576142
1241	Phosphorylation	MSGTSSSSGMKSSSG CCCCCCCCCCCCCCC	44.87	23927012
1245	Phosphorylation	SSSSGMKSSSGLGSS CCCCCCCCCCCCCCC	22.35	28450419
1246	Phosphorylation	SSSGMKSSSGLGSSG CCCCCCCCCCCCCCC	23.94	28450419
1247	Phosphorylation	SSGMKSSSGLGSSGS CCCCCCCCCCCCCCC	45.16	30576142
1251	Phosphorylation	KSSSGLGSSGSLSQK CCCCCCCCCCCCCCC	36.25	30278072
1252	Phosphorylation	SSSGLGSSGSLSQKT CCCCCCCCCCCCCCC	30.51	30278072
1254	Phosphorylation	SGLGSSGSLSQKTPP CCCCCCCCCCCCCCC	27.13	30278072
1256	Phosphorylation	LGSSGSLSQKTPPSS CCCCCCCCCCCCCCC	31.18	28450419
1259	O-linked_Glycosylation	SGSLSQKTPPSSNSC CCCCCCCCCCCCCCC	32.56	23301498
1259	Phosphorylation	SGSLSQKTPPSSNSC CCCCCCCCCCCCCCC	32.56	23663014
1262	Phosphorylation	LSQKTPPSSNSCTAS CCCCCCCCCCCCCCC	43.27	23663014
1263	Phosphorylation	SQKTPPSSNSCTASS CCCCCCCCCCCCCCC	38.24	23663014
1265	Phosphorylation	KTPPSSNSCTASSSS CCCCCCCCCCCCCCC	18.13	23663014
1267	Phosphorylation	PPSSNSCTASSSSFS CCCCCCCCCCCCCCC	29.42	23663014
1269	Phosphorylation	SSNSCTASSSSFSSS CCCCCCCCCCCCCCC	16.76	23663014
1270	Phosphorylation	SNSCTASSSSFSSSG CCCCCCCCCCCCCCC	27.77	23663014
1271	Phosphorylation	NSCTASSSSFSSSGS CCCCCCCCCCCCCCC	32.67	23663014
1272	Phosphorylation	SCTASSSSFSSSGSS CCCCCCCCCCCCCCC	30.97	23663014
1274	Phosphorylation	TASSSSFSSSGSSMS CCCCCCCCCCCCCCC	26.07	23663014
1275	Phosphorylation	ASSSSFSSSGSSMSS CCCCCCCCCCCCCCC	36.39	23663014
1276	Phosphorylation	SSSSFSSSGSSMSSS CCCCCCCCCCCCCCC	41.31	23663014
1278	Phosphorylation	SSFSSSGSSMSSSQN CCCCCCCCCCCCCCC	25.47	23663014
1279	Phosphorylation	SFSSSGSSMSSSQNQ CCCCCCCCCCCCCCC	26.64	23663014
1281	Phosphorylation	SSSGSSMSSSQNQHG CCCCCCCCCCCCCCC	28.87	23663014
1282	Phosphorylation	SSGSSMSSSQNQHGS CCCCCCCCCCCCCCC	27.57	23663014
1283	Phosphorylation	SGSSMSSSQNQHGSS CCCCCCCCCCCCCCC	26.33	23663014
1289	Phosphorylation	SSQNQHGSSKGKSPS CCCCCCCCCCCCCCC	27.10	23663014
1290	Phosphorylation	SQNQHGSSKGKSPSR CCCCCCCCCCCCCCC	50.44	23663014
1294	Phosphorylation	HGSSKGKSPSRNKKP CCCCCCCCCCCCCCC	36.45	26074081
1296	Phosphorylation	SSKGKSPSRNKKPSL CCCCCCCCCCCCCCH	56.42	26074081
1302	Phosphorylation	PSRNKKPSLTAVIDK CCCCCCCCHHHHHHH	47.43	25159151
1304	Phosphorylation	RNKKPSLTAVIDKLK CCCCCCHHHHHHHHH	24.18	29116813
1309	Acetylation	SLTAVIDKLKHGVVT CHHHHHHHHHCCEEC	48.59	23954790
1316	Phosphorylation	KLKHGVVTSGPGGED HHHCCEECCCCCCCC	26.09	23532336
1342	Phosphorylation	SSSHPMSSKHNMSGG CCCCCCCCCCCCCCC	31.51	23532336
1343	Acetylation	SSHPMSSKHNMSGGE CCCCCCCCCCCCCCC	31.52	25953088
1347	Phosphorylation	MSSKHNMSGGEFQGK CCCCCCCCCCCCCCC	49.30	25159151
1354	Acetylation	SGGEFQGKREKSDKD CCCCCCCCCCCCCCC	46.75	23749302
1366	Phosphorylation	DKDKSKVSTSGSSVD CCCCCCCCCCCCCCC	22.16	20068231
1367	Phosphorylation	KDKSKVSTSGSSVDS CCCCCCCCCCCCCCC	39.84	20068231
1368	Phosphorylation	DKSKVSTSGSSVDSS CCCCCCCCCCCCCCC	29.22	18691976
1370	Phosphorylation	SKVSTSGSSVDSSKK CCCCCCCCCCCCCCC	27.27	20068231
1371	Phosphorylation	KVSTSGSSVDSSKKT CCCCCCCCCCCCCCC	33.21	28348404
1374	Phosphorylation	TSGSSVDSSKKTSES CCCCCCCCCCCCCCC	41.73	20068231
1375	Phosphorylation	SGSSVDSSKKTSESK CCCCCCCCCCCCCCC	33.44	21815630
1376	Acetylation	GSSVDSSKKTSESKN CCCCCCCCCCCCCCC	65.11	26051181
1378	Phosphorylation	SVDSSKKTSESKNVG CCCCCCCCCCCCCCC	41.27	22817900
1379	Phosphorylation	VDSSKKTSESKNVGS CCCCCCCCCCCCCCC	49.07	28509920
1387	Phosphorylation	ESKNVGSTGVAKIII CCCCCCCCCEEEEEE	29.73	22817900
1391	Acetylation	VGSTGVAKIIISKHD CCCCCEEEEEEEECC	31.84	25953088
1395	Phosphorylation	GVAKIIISKHDGGSP CEEEEEEEECCCCCC	17.33	26074081
1396	Acetylation	VAKIIISKHDGGSPS EEEEEEEECCCCCCC	34.99	25953088
1401	Phosphorylation	ISKHDGGSPSIKAKV EEECCCCCCCEEEEE	22.47	29255136
1403	Phosphorylation	KHDGGSPSIKAKVTL ECCCCCCCEEEEEEE	38.12	29255136
1412	Acetylation	KAKVTLQKPGESSGE EEEEEEECCCCCCCC	59.09	26051181
1416	Phosphorylation	TLQKPGESSGEGLRP EEECCCCCCCCCCCH	49.94	28555341
1417	Phosphorylation	LQKPGESSGEGLRPQ EECCCCCCCCCCCHH	36.24	28555341
1427	O-linked_Glycosylation	GLRPQMASSKNYGSP CCCHHHCCCCCCCCC	36.18	23301498
1427	Phosphorylation	GLRPQMASSKNYGSP CCCHHHCCCCCCCCC	36.18	29978859
1428	Phosphorylation	LRPQMASSKNYGSPL CCHHHCCCCCCCCCC	18.51	29978859
1431	Phosphorylation	QMASSKNYGSPLISG HHCCCCCCCCCCCCC	23.79	22167270
1433	Phosphorylation	ASSKNYGSPLISGST CCCCCCCCCCCCCCC	13.23	22167270
1437	Phosphorylation	NYGSPLISGSTPKHE CCCCCCCCCCCCCCC	34.08	30266825
1439	Phosphorylation	GSPLISGSTPKHERG CCCCCCCCCCCCCCC	34.44	30266825
1440	Phosphorylation	SPLISGSTPKHERGS CCCCCCCCCCCCCCC	39.62	30266825
1447	Phosphorylation	TPKHERGSPSHSKSP CCCCCCCCCCCCCCC	29.47	23927012
1449	Phosphorylation	KHERGSPSHSKSPAY CCCCCCCCCCCCCCC	41.93	30278072
1451	Phosphorylation	ERGSPSHSKSPAYTP CCCCCCCCCCCCCCC	38.88	23663014
1453	Phosphorylation	GSPSHSKSPAYTPQN CCCCCCCCCCCCCCC	20.13	30278072
1456	Phosphorylation	SHSKSPAYTPQNLDS CCCCCCCCCCCCCCC	23.49	23927012
1457	Phosphorylation	HSKSPAYTPQNLDSE CCCCCCCCCCCCCCC	22.09	25159151
1463	Phosphorylation	YTPQNLDSESESGSS CCCCCCCCCCCCCCC	46.30	28355574
1465	Phosphorylation	PQNLDSESESGSSIA CCCCCCCCCCCCCHH	40.80	25159151
1467	Phosphorylation	NLDSESESGSSIAEK CCCCCCCCCCCHHHH	53.94	25159151
1469	Phosphorylation	DSESESGSSIAEKSY CCCCCCCCCHHHHHH	28.05	23927012
1470	Phosphorylation	SESESGSSIAEKSYQ CCCCCCCCHHHHHHC	29.37	23927012
1475	Phosphorylation	GSSIAEKSYQNSPSS CCCHHHHHHCCCCCC	24.37	23927012
1476	Phosphorylation	SSIAEKSYQNSPSSD CCHHHHHHCCCCCCC	23.84	23927012
1479	Phosphorylation	AEKSYQNSPSSDDGI HHHHHCCCCCCCCCC	15.61	23927012
1481	Phosphorylation	KSYQNSPSSDDGIRP HHHCCCCCCCCCCCC	46.34	23927012
1482	Phosphorylation	SYQNSPSSDDGIRPL HHCCCCCCCCCCCCC	43.00	23927012
1492	Phosphorylation	GIRPLPEYSTEKHKK CCCCCCCCCHHHHHH	20.96	23927012
1493	Phosphorylation	IRPLPEYSTEKHKKH CCCCCCCCHHHHHHH	28.55	23927012
1494	Phosphorylation	RPLPEYSTEKHKKHK CCCCCCCHHHHHHHH	48.42	23927012
1502	Acetylation	EKHKKHKKEKKKVKD HHHHHHHHHHHCCCC	74.59	69211
1504	Acetylation	HKKHKKEKKKVKDKD HHHHHHHHHCCCCCC	67.77	69215
1525	Phosphorylation	KDRDKKKSHSIKPES HHHHHHHHHCCCCCH	31.20	26074081
1527	Phosphorylation	RDKKKSHSIKPESWS HHHHHHHCCCCCHHC	39.12	26074081
1529	Acetylation	KKKSHSIKPESWSKS HHHHHCCCCCHHCCC	45.83	19608861
1532	Phosphorylation	SHSIKPESWSKSPIS HHCCCCCHHCCCCCC	45.22	25159151
1534	Phosphorylation	SIKPESWSKSPISSD CCCCCHHCCCCCCCC	32.32	25159151
1536	Phosphorylation	KPESWSKSPISSDQS CCCHHCCCCCCCCCC	23.19	25849741
1539	Phosphorylation	SWSKSPISSDQSLSM HHCCCCCCCCCCCCC	31.11	26074081
1540	Phosphorylation	WSKSPISSDQSLSMT HCCCCCCCCCCCCCC	40.15	26074081
1548	Phosphorylation	DQSLSMTSNTILSAD CCCCCCCCCCEECCC	24.27	-
1550	Phosphorylation	SLSMTSNTILSADRP CCCCCCCCEECCCCC	24.06	-
1558	Phosphorylation	ILSADRPSRLSPDFM EECCCCCCCCCCCCC	46.90	26074081
1561	Phosphorylation	ADRPSRLSPDFMIGE CCCCCCCCCCCCCCC	22.70	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
704	T	Phosphorylation	Kinase	CHEK1	O14757	GPS
816	S	Phosphorylation	Kinase	ATM	Q13315	PSP
872	S	Phosphorylation	Kinase	ATM	Q13315	PSP
874	S	Phosphorylation	Kinase	ATM	Q13315	PSP
887	S	Phosphorylation	Kinase	ATM	Q13315	PSP
953	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1032	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1032	T	Phosphorylation	Kinase	ERK1	P27361	PSP
1032	T	Phosphorylation	Kinase	ERK2	P28482	PSP
1134	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1141	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1147	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1207	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1215	T	Phosphorylation	Kinase	CDK2	P24941	PSP
1457	T	Phosphorylation	Kinase	MK01	P28482	PhosphoELM
1457	T	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
1457	T	Phosphorylation	Kinase	PRKDC	P78527	GPS
1457	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRGC1_HUMAN	PPARGC1A	physical	14636573
TGS1_HUMAN	TGS1	physical	11912212
GCR_HUMAN	NR3C1	physical	10508170
P53_HUMAN	TP53	physical	9444950
MED1_HUMAN	MED1	physical	9444950
TR150_HUMAN	THRAP3	physical	9653119
MED24_HUMAN	MED24	physical	9653119
ANDR_HUMAN	AR	physical	12218053
MED13_HUMAN	MED13	physical	15989967
MED6_HUMAN	MED6	physical	15989967
MED16_HUMAN	MED16	physical	15989967
MED17_HUMAN	MED17	physical	15989967
MED20_HUMAN	MED20	physical	15989967
MED10_HUMAN	MED10	physical	15989967
MED14_HUMAN	MED14	physical	15989967
MED12_HUMAN	MED12	physical	15989967
MED23_HUMAN	MED23	physical	15989967
MED27_HUMAN	MED27	physical	15989967
MED4_HUMAN	MED4	physical	15989967
MED7_HUMAN	MED7	physical	15989967
MED8_HUMAN	MED8	physical	15989967
MED30_HUMAN	MED30	physical	15989967
MED22_HUMAN	MED22	physical	15989967
MED31_HUMAN	MED31	physical	15989967
MED24_HUMAN	MED24	physical	15989967
CDK8_HUMAN	CDK8	physical	15989967
MED15_HUMAN	MED15	physical	15989967
MED19_HUMAN	MED19	physical	15989967
MED18_HUMAN	MED18	physical	15989967
MED11_HUMAN	MED11	physical	15989967
MED25_HUMAN	MED25	physical	15989967
RPB1_HUMAN	POLR2A	physical	15989967
MED1_HUMAN	MED1	physical	15989967
MED21_HUMAN	MED21	physical	15989967
RPAB2_HUMAN	POLR2F	physical	15989967
GABPA_HUMAN	GABPA	physical	16574658
GATA1_HUMAN	GATA1	physical	17132730
GATA2_HUMAN	GATA2	physical	16396960
PIT1_HUMAN	POU1F1	physical	16396960
PPARG_HUMAN	PPARG	physical	10935544
RXRA_HUMAN	RXRA	physical	10935544
ESR1_HUMAN	ESR1	physical	10770935
ESR2_HUMAN	ESR2	physical	10770935
VDR_HUMAN	VDR	physical	10733574
THA_HUMAN	THRA	physical	10733574
MED16_HUMAN	MED16	physical	17967894
KAT2A_HUMAN	KAT2A	physical	17967894
SUPT3_HUMAN	SUPT3H	physical	17967894
ST65G_HUMAN	SUPT7L	physical	17967894
MED17_HUMAN	MED17	physical	17967894
MED12_HUMAN	MED12	physical	20133760
MED13_HUMAN	MED13	physical	20133760
CCNC_HUMAN	CCNC	physical	20133760
MED25_HUMAN	MED25	physical	20133760
MED16_HUMAN	MED16	physical	20133760
MED17_HUMAN	MED17	physical	20133760
MED1_HUMAN	MED1	physical	20133760
MED28_HUMAN	MED28	physical	20133760
MED24_HUMAN	MED24	physical	20133760
MED22_HUMAN	MED22	physical	20133760
MED23_HUMAN	MED23	physical	20133760
MED4_HUMAN	MED4	physical	20133760
MED29_HUMAN	MED29	physical	20133760
MED8_HUMAN	MED8	physical	20133760
MED15_HUMAN	MED15	physical	20133760
MED6_HUMAN	MED6	physical	20133760
MED14_HUMAN	MED14	physical	20133760
CDK19_HUMAN	CDK19	physical	20133760
MED30_HUMAN	MED30	physical	20133760
MED18_HUMAN	MED18	physical	20133760
RPAB1_HUMAN	POLR2E	physical	20133760
MED27_HUMAN	MED27	physical	20133760
MED20_HUMAN	MED20	physical	20133760
CDK9_HUMAN	CDK9	physical	20133760
MED19_HUMAN	MED19	physical	20133760
CDK8_HUMAN	CDK8	physical	20098423
MED12_HUMAN	MED12	physical	20098423
MED13_HUMAN	MED13	physical	20098423
MED14_HUMAN	MED14	physical	20098423
MED23_HUMAN	MED23	physical	20098423
MED22_HUMAN	MED22	physical	20098423
MED15_HUMAN	MED15	physical	20098423
MED16_HUMAN	MED16	physical	20098423
MED9_HUMAN	MED9	physical	20098423
MED17_HUMAN	MED17	physical	20098423
MED26_HUMAN	MED26	physical	20098423
NR1H2_HUMAN	NR1H2	physical	15604093
KIF1A_HUMAN	KIF1A	physical	15604093
PPARG_HUMAN	PPARG	physical	15604093
VDR_HUMAN	VDR	physical	12796488
PPARG_HUMAN	PPARG	physical	17468099
MDM2_HUMAN	MDM2	physical	15848166
MED8_HUMAN	MED8	physical	22939629
MED29_HUMAN	MED29	physical	22939629
MED4_HUMAN	MED4	physical	22939629
MED27_HUMAN	MED27	physical	22939629
MED24_HUMAN	MED24	physical	22939629
MED6_HUMAN	MED6	physical	22939629
MED21_HUMAN	MED21	physical	22939629
ZN281_HUMAN	ZNF281	physical	22939629
ZN326_HUMAN	ZNF326	physical	22939629
RALY_HUMAN	RALY	physical	22939629
SETD7_HUMAN	SETD7	physical	22939629
MED12_HUMAN	MED12	physical	23322298
MED13_HUMAN	MED13	physical	23322298
MD13L_HUMAN	MED13L	physical	23322298
MED1_HUMAN	MED1	physical	23322298
CDK8_HUMAN	CDK8	physical	23322298
PPARG_HUMAN	PPARG	physical	17704298
MED12_HUMAN	MED12	physical	26344197
MED17_HUMAN	MED17	physical	26344197
MED27_HUMAN	MED27	physical	26344197
MED4_HUMAN	MED4	physical	26344197
MED6_HUMAN	MED6	physical	26344197
MED6_HUMAN	MED6	physical	28514442
MED26_HUMAN	MED26	physical	28514442
CDK8_HUMAN	CDK8	physical	28514442
MED13_HUMAN	MED13	physical	28514442
CDK19_HUMAN	CDK19	physical	28514442
MED14_HUMAN	MED14	physical	28514442
MED24_HUMAN	MED24	physical	28514442
MED31_HUMAN	MED31	physical	28514442
MED30_HUMAN	MED30	physical	28514442
MD12L_HUMAN	MED12L	physical	28514442
MED17_HUMAN	MED17	physical	28514442
MED27_HUMAN	MED27	physical	28514442
MED9_HUMAN	MED9	physical	28514442
MD13L_HUMAN	MED13L	physical	28514442
MED4_HUMAN	MED4	physical	28514442
MED10_HUMAN	MED10	physical	28514442
MED28_HUMAN	MED28	physical	28514442
MED22_HUMAN	MED22	physical	28514442
MED8_HUMAN	MED8	physical	28514442
MED12_HUMAN	MED12	physical	28514442
MED20_HUMAN	MED20	physical	28514442
MED23_HUMAN	MED23	physical	28514442
MED15_HUMAN	MED15	physical	28514442
MED11_HUMAN	MED11	physical	28514442
MED16_HUMAN	MED16	physical	28514442
MED29_HUMAN	MED29	physical	28514442
MED25_HUMAN	MED25	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
RPB4_HUMAN	POLR2D	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
PLK1_HUMAN	PLK1	physical	27173435
SPAG5_HUMAN	SPAG5	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-15; LYS-1177; LYS-1354 ANDLYS-1529, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664; SER-1049; THR-1051;THR-1057; SER-1433; THR-1440; SER-1463; SER-1479; SER-1481 ANDSER-1482, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664; SER-770; SER-771;SER-772; SER-774; THR-805; SER-1049; THR-1051; THR-1215; SER-1232;SER-1433; SER-1479; SER-1481 AND SER-1482, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1049; THR-1051;THR-1057; SER-1207; THR-1215; SER-1223; SER-1252; SER-1433; SER-1439;THR-1440; SER-1463; SER-1479 AND SER-1482, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664; THR-1051; THR-1057;SER-1207; THR-1215; SER-1463; SER-1479; SER-1481 AND SER-1482, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-664; SER-770; SER-771;SER-772; THR-805; THR-1051; THR-1057; SER-1155; SER-1207; THR-1215;SER-1403 AND SER-1433, AND MASS SPECTROMETRY.
PubMed: 18691976

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953 AND SER-1134, ANDMASS SPECTROMETRY.
PubMed: 17525332

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-795; THR-805; THR-1051AND THR-1057, AND MASS SPECTROMETRY.
PubMed: 16964243

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-770; SER-771; SER-772AND SER-774, AND MASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-805 ANDTHR-1051, AND MASS SPECTROMETRY.
PubMed: 15302935

"Activation of TRAP/mediator subunit TRAP220/Med1 is regulated bymitogen-activated protein kinase-dependent phosphorylation.";
Pandey P.K., Udayakumar T.S., Lin X., Sharma D., Shapiro P.S.,Fondell J.D.;
Mol. Cell. Biol. 25:10695-10710(2005).
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-1032 AND THR-1457, ANDMUTAGENESIS OF THR-1032 AND THR-1457.
PubMed: 16314496