MED25_HUMAN - dbPTM
MED25_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MED25_HUMAN
UniProt AC Q71SY5
Protein Name Mediator of RNA polymerase II transcription subunit 25
Gene Name MED25
Organism Homo sapiens (Human).
Sequence Length 747
Subcellular Localization Nucleus .
Protein Description Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription..
Protein Sequence MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
181PhosphorylationGERGIHFSIVSPRKL
HHCCCCEEEECCCCC		14.1223312004
184PhosphorylationGIHFSIVSPRKLPAL
CCCEEEECCCCCHHH		19.8128450419
197UbiquitinationALRLLFEKAAPPALL
HHHHHHHHCCCCHHH		42.3821906983
197 (in isoform 5)Ubiquitination-42.3821890473
197 (in isoform 4)Ubiquitination-42.3821890473
197 (in isoform 2)Ubiquitination-42.3821890473
197 (in isoform 3)Ubiquitination-42.3821890473
211PhosphorylationLEPLQPPTDVSQDPR
HCCCCCCCCCCCCCC		56.5722210691
214PhosphorylationLQPPTDVSQDPRHMV
CCCCCCCCCCCCCEE		31.5122210691
234PhosphorylationVLPVGGGSAPGPLQS
EEEECCCCCCCCCCC		34.2727732954
238 (in isoform 1)Ubiquitination-26.6021890473
241PhosphorylationSAPGPLQSKQPVPLP
CCCCCCCCCCCCCCC		40.7227732954
271UbiquitinationPLPPVPPQYQVPGNL
CCCCCCCCCCCCCCC		34.9121890473
296UbiquitinationVEAAKNQKAGLGPRF
HHHHHHHCCCCCCCC		54.5429967540
413UbiquitinationLEWQEKPKPASVDAN
EEECCCCCCCCCCCC		65.3729967540
422UbiquitinationASVDANTKLTRSLPC
CCCCCCCCCCEECCC		47.9033845483
440UbiquitinationVNHGENLKTEQWPQK
EECCCCCCCCCCCHH		62.6929967540
467 (in isoform 5)Ubiquitination-27.0021890473
478UbiquitinationVQFHFTNKDLESLKG
EEEEECCCCHHHHHH		61.7123000965
484UbiquitinationNKDLESLKGLYRIMG
CCCHHHHHHHHHHHC		57.0323000965
484 (in isoform 4)Ubiquitination-57.0321890473
484 (in isoform 2)Ubiquitination-57.0321890473
484 (in isoform 3)Ubiquitination-57.0321890473
518UbiquitinationLMLLYSSKKKIFMGL
HHHHHHCCCEEEEEC		52.7433845483
519UbiquitinationMLLYSSKKKIFMGLI
HHHHHCCCEEEEECC		53.7222817900
520UbiquitinationLLYSSKKKIFMGLIP
HHHHCCCEEEEECCC		44.9322817900
525 (in isoform 1)Ubiquitination-2.0921890473
545AcetylationRQVITNHKQVQQQKL
HHHHHHCHHHHHHHH		54.997369571
545UbiquitinationRQVITNHKQVQQQKL
HHHHHHCHHHHHHHH		54.9927667366
551 (in isoform 3)Ubiquitination-50.05-
551UbiquitinationHKQVQQQKLEQQQRG
CHHHHHHHHHHHHHC		50.05-
725MethylationMLLSGGPRGPVPQPG
EEECCCCCCCCCCCC		66.38-
725Asymmetric dimethylarginineMLLSGGPRGPVPQPG
EEECCCCCCCCCCCC		66.38-
741 (in isoform 3)Phosphorylation-23.71-
744 (in isoform 3)Phosphorylation-3.94-
746 (in isoform 3)Phosphorylation-2.89-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MED25_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MED25_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MED25_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MED15_HUMANMED15physical
14983011
CDK8_HUMANCDK8physical
14983011
MED6_HUMANMED6physical
14983011
MED12_HUMANMED12physical
14657022
MED13_HUMANMED13physical
14657022
MED1_HUMANMED1physical
14657022
MED14_HUMANMED14physical
14657022
MED23_HUMANMED23physical
14657022
MED15_HUMANMED15physical
14657022
MED25_HUMANMED25physical
14657022
MED16_HUMANMED16physical
14657022
MED17_HUMANMED17physical
14657022
MED26_HUMANMED26physical
14657022
CDK8_HUMANCDK8physical
14657022
MED6_HUMANMED6physical
14657022
MED7_HUMANMED7physical
14657022
RXRA_HUMANRXRAphysical
17641689
THA_HUMANTHRAphysical
17641689
ESR1_HUMANESR1physical
17641689
GCR_HUMANNR3C1physical
17641689
RARA_HUMANRARAphysical
17641689
CBP_HUMANCREBBPphysical
17641689
MED1_HUMANMED1physical
17641689
MED6_HUMANMED6physical
17641689
VP16_HHV11UL48physical
24874105
DRE2A_ARATHDREB2Aphysical
24874105
ESR1_HUMANESR1physical
24960263
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
605589Charcot-Marie-Tooth disease 2B2 (CMT2B2)
616449Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MED25_HUMAN

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Related Literatures of Post-Translational Modification

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