VP16_HHV11 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VP16_HHV11
• UniProt AC: P06492
• Protein Name: Tegument protein VP16
• Gene Name: UL48
• Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
• Sequence Length: 490
• Subcellular Localization: Virion tegument . Host nucleus .
• Protein Description: Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection.; May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis..
• Protein Sequence: MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	DMNADGASPPPPRPA CCCCCCCCCCCCCCC	43.39	16297954
353	Phosphorylation	SYSSFTTSPSEAVMR CCCCCCCCHHHHHHH	24.30	16297954
411	Phosphorylation	AGHTRRLSTAPPTDV CCCCCCCCCCCCCCC	22.25	16297954
452	Phosphorylation	DMLGDGDSPGPGFTP HCCCCCCCCCCCCCC	36.97	16297954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VP16_HHV11 !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VP16_HHV11 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VP16_HHV11 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSTF2_HUMAN	CSTF2	physical	17135252
MED15_HUMAN	MED15	physical	17135252
MED25_HUMAN	MED25	physical	17135252
MED23_HUMAN	MED23	physical	10353252
MED7_HUMAN	MED7	physical	10353252
CCNC_HUMAN	CCNC	physical	10353252
IFRD1_HUMAN	IFRD1	physical	7809103

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphorylation of the VP16 transcriptional activator protein duringherpes simplex virus infection and mutational analysis of putativephosphorylation sites.";
Ottosen S., Herrera F.J., Doroghazi J.R., Hull A., Mittal S.,Lane W.S., Triezenberg S.J.;
Virology 345:468-481(2006).
Cited for: PHOSPHORYLATION AT SER-18; SER-353; SER-411 AND SER-452.
PubMed: 16297954