dbPTM

MED20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MED20_HUMAN
UniProt AC	Q9H944
Protein Name	Mediator of RNA polymerase II transcription subunit 20
Gene Name	MED20
Organism	Homo sapiens (Human).
Sequence Length	212
Subcellular Localization	Nucleus .
Protein Description	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
Protein Sequence	MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRHDAVYGPADTMVQYMELFNKIRKQQQVPVAGIR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	QMPVAEGKSVQQTVE ECCCCCCCCHHHHHH	38.67	-
15	Ubiquitination	QMPVAEGKSVQQTVE ECCCCCCCCHHHHHH	38.67	-
27	Ubiquitination	TVELLTRKLEMLGAE HHHHHHHHHHHCCCC	43.49	-
38	Phosphorylation	LGAEKQGTFCVDCET CCCCCCCEEEEECCE	16.03	29759185
48	Phosphorylation	VDCETYHTAASTLGS EECCEEEECHHHCCC	17.32	29759185
51	Phosphorylation	ETYHTAASTLGSQGQ CEEEECHHHCCCCCC	23.00	29759185
52	Phosphorylation	TYHTAASTLGSQGQT EEEECHHHCCCCCCC	30.34	-
55	Phosphorylation	TAASTLGSQGQTGKL ECHHHCCCCCCCCCE	33.96	-
99	Ubiquitination	DVLMVKLKGFFQSAK CEEEEEEHHHHHHHH	48.21	-
106	Ubiquitination	KGFFQSAKASKIETR HHHHHHHHCCCCCCC	59.44	-
106	Acetylation	KGFFQSAKASKIETR HHHHHHHHCCCCCCC	59.44	25953088
128	Phosphorylation	DFLVKVGTVTMGPSA CEEEEEEEEEECCCC	18.78	20068231
130	Phosphorylation	LVKVGTVTMGPSARG EEEEEEEEECCCCCC	19.09	20068231
131	Sulfoxidation	VKVGTVTMGPSARGI EEEEEEEECCCCCCC	6.89	21406390
199	Acetylation	QYMELFNKIRKQQQV HHHHHHHHHHHHHCC	36.23	12655725
202	Acetylation	ELFNKIRKQQQVPVA HHHHHHHHHHCCCCC	56.80	12655737
202	Ubiquitination	ELFNKIRKQQQVPVA HHHHHHHHHHCCCCC	56.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MED20_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MED20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MED20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED18_HUMAN	MED18	physical	12584197
RPA2_HUMAN	POLR1B	physical	21988832
MED18_HUMAN	MED18	physical	25416956
NOG1_HUMAN	GTPBP4	physical	26344197
MED1_HUMAN	MED1	physical	26344197
MED10_HUMAN	MED10	physical	26344197
MED11_HUMAN	MED11	physical	26344197
MED14_HUMAN	MED14	physical	26344197
MED15_HUMAN	MED15	physical	26344197
MED17_HUMAN	MED17	physical	26344197
MED18_HUMAN	MED18	physical	26344197
MED19_HUMAN	MED19	physical	26344197
MED22_HUMAN	MED22	physical	26344197
MED24_HUMAN	MED24	physical	26344197
MED27_HUMAN	MED27	physical	26344197
MED4_HUMAN	MED4	physical	26344197
MED6_HUMAN	MED6	physical	26344197
MED8_HUMAN	MED8	physical	26344197
RPB1_HUMAN	POLR2A	physical	25281560
KCMF1_HUMAN	KCMF1	physical	25281560
MED4_HUMAN	MED4	physical	25281560
WASF1_HUMAN	WASF1	physical	25281560
MED30_HUMAN	MED30	physical	25281560
MED18_HUMAN	MED18	physical	25281560
PDIA6_HUMAN	PDIA6	physical	25281560
MED17_HUMAN	MED17	physical	25281560
RS10_HUMAN	RPS10	physical	25281560
MED8_HUMAN	MED8	physical	25281560
IPYR_HUMAN	PPA1	physical	25281560
MED27_HUMAN	MED27	physical	25281560
AT5F1_HUMAN	ATP5F1	physical	25281560
PDCD6_HUMAN	PDCD6	physical	25281560
SPTN1_HUMAN	SPTAN1	physical	25281560
THIC_HUMAN	ACAT2	physical	25281560
AFG32_HUMAN	AFG3L2	physical	25281560
VATH_HUMAN	ATP6V1H	physical	25281560
CKAP2_HUMAN	CKAP2	physical	25281560
GNPI1_HUMAN	GNPDA1	physical	25281560
RAB10_HUMAN	RAB10	physical	25281560
SPART_HUMAN	SPG20	physical	25281560
SGT1_HUMAN	SUGT1	physical	25281560
TMED2_HUMAN	TMED2	physical	25281560
TPD54_HUMAN	TPD52L2	physical	25281560
TPPC5_HUMAN	TRAPPC5	physical	25281560
SRSF5_HUMAN	SRSF5	physical	25281560
CERU_HUMAN	CP	physical	25281560
THOC2_HUMAN	THOC2	physical	25281560
TRI25_HUMAN	TRIM25	physical	25281560
NCBP1_HUMAN	NCBP1	physical	25281560
CN37_HUMAN	CNP	physical	25281560
ARF4_HUMAN	ARF4	physical	25281560
VATE1_HUMAN	ATP6V1E1	physical	25281560
ES1_HUMAN	C21orf33	physical	25281560
FKB1A_HUMAN	FKBP1A	physical	25281560
MYH14_HUMAN	MYH14	physical	25281560
SERPH_HUMAN	SERPINH1	physical	25281560
RRP1_HUMAN	RRP1	physical	25281560
FA50A_HUMAN	FAM50A	physical	25281560
EXOS8_HUMAN	EXOSC8	physical	25281560
GBG12_HUMAN	GNG12	physical	25281560
ECH1_HUMAN	ECH1	physical	25281560
IF2B3_HUMAN	IGF2BP3	physical	25281560
RHOA_HUMAN	RHOA	physical	25281560
NLTP_HUMAN	SCP2	physical	25281560
VDAC1_HUMAN	VDAC1	physical	25281560
DNJB1_HUMAN	DNAJB1	physical	25281560
CSK22_HUMAN	CSNK2A2	physical	25281560
ATIF1_HUMAN	ATPIF1	physical	25281560
LRC47_HUMAN	LRRC47	physical	25281560
MED19_HUMAN	MED19	physical	25281560
PSA_HUMAN	NPEPPS	physical	25281560
T2FA_HUMAN	GTF2F1	physical	25281560
MANF_HUMAN	MANF	physical	25281560
ALBU_HUMAN	ALB	physical	25281560
MED10_HUMAN	MED10	physical	25281560
ALDR_HUMAN	AKR1B1	physical	25281560
RECQ1_HUMAN	RECQL	physical	25281560
SLTM_HUMAN	SLTM	physical	25281560
SUMO4_HUMAN	SUMO4	physical	25281560
CYC_HUMAN	CYCS	physical	25281560
RUXG_HUMAN	SNRPG	physical	25281560
TRA2B_HUMAN	TRA2B	physical	25281560
PSD10_HUMAN	PSMD10	physical	25281560
BAG6_HUMAN	BAG6	physical	25281560
ARF5_HUMAN	ARF5	physical	25281560
COR1C_HUMAN	CORO1C	physical	25281560
CO3_HUMAN	C3	physical	25281560
GSTO1_HUMAN	GSTO1	physical	25281560
CND3_HUMAN	NCAPG	physical	25281560
TCEA1_HUMAN	TCEA1	physical	25281560
RSRC2_HUMAN	RSRC2	physical	25281560
MED21_HUMAN	MED21	physical	25281560
MDHC_HUMAN	MDH1	physical	25281560
MED12_HUMAN	MED12	physical	25281560
TPIS_HUMAN	TPI1	physical	25281560
PHB_HUMAN	PHB	physical	25281560
PHB2_HUMAN	PHB2	physical	25281560
ATPG_HUMAN	ATP5C1	physical	25281560
CPSF7_HUMAN	CPSF7	physical	25281560
MED16_HUMAN	MED16	physical	25281560
FLII_HUMAN	FLII	physical	25281560
MED11_HUMAN	MED11	physical	25281560
MED22_HUMAN	MED22	physical	25281560
QPCT_HUMAN	QPCT	physical	25281560
MED29_HUMAN	MED29	physical	25281560
MED15_HUMAN	MED15	physical	25281560
UBB_HUMAN	UBB	physical	25281560
MED1_HUMAN	MED1	physical	25281560
MED6_HUMAN	MED6	physical	25281560
MED24_HUMAN	MED24	physical	25281560
MED23_HUMAN	MED23	physical	25281560
RD23A_HUMAN	RAD23A	physical	25281560
MED28_HUMAN	MED28	physical	25281560
RIOK1_HUMAN	RIOK1	physical	25281560
RD23B_HUMAN	RAD23B	physical	25281560
HUWE1_HUMAN	HUWE1	physical	25281560
MED14_HUMAN	MED14	physical	25281560

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MED20_HUMAN

Related Literatures of Post-Translational Modification