FA50A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FA50A_HUMAN
• UniProt AC: Q14320
• Protein Name: Protein FAM50A
• Gene Name: FAM50A
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Subcellular Localization: Nucleus .
• Protein Description: May be a DNA-binding protein or transcriptional factor..
• Protein Sequence: MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAELKSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSLSFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSELRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDESHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQYKGAAS ------CCCCCHHHH	22.78	22814378
4	Phosphorylation	----MAQYKGAASEA ----CCCCCHHHHHH	11.23	-
5	Ubiquitination	---MAQYKGAASEAG ---CCCCCHHHHHHH	29.96	33845483
5	Sumoylation	---MAQYKGAASEAG ---CCCCCHHHHHHH	29.96	-
5	Acetylation	---MAQYKGAASEAG ---CCCCCHHHHHHH	29.96	25953088
5	Methylation	---MAQYKGAASEAG ---CCCCCHHHHHHH	29.96	23583077
5	Sumoylation	---MAQYKGAASEAG ---CCCCCHHHHHHH	29.96	-
9	Phosphorylation	AQYKGAASEAGRAMH CCCCHHHHHHHHHHH	27.69	28258704
32	Ubiquitination	REQMEQMKQRIAEEN HHHHHHHHHHHHHHH	35.80	29967540
41	Sulfoxidation	RIAEENIMKSNIDKK HHHHHHHHHHCCCHH	6.17	21406390
42	Ubiquitination	IAEENIMKSNIDKKF HHHHHHHHHCCCHHH	36.23	32015554
43	Phosphorylation	AEENIMKSNIDKKFS HHHHHHHHCCCHHHH	22.95	29978859
48	Sumoylation	MKSNIDKKFSAHYDA HHHCCCHHHHHHHHH	40.58	-
48	Sumoylation	MKSNIDKKFSAHYDA HHHCCCHHHHHHHHH	40.58	-
48	Ubiquitination	MKSNIDKKFSAHYDA HHHCCCHHHHHHHHH	40.58	33845483
48	Acetylation	MKSNIDKKFSAHYDA HHHCCCHHHHHHHHH	40.58	25953088
50	Phosphorylation	SNIDKKFSAHYDAVE HCCCHHHHHHHHHHH	24.02	26356563
53	Phosphorylation	DKKFSAHYDAVEAEL CHHHHHHHHHHHHHH	12.81	27273156
62	Phosphorylation	AVEAELKSSTVGLVT HHHHHHHHCCEEEEE	43.81	20068231
63	Phosphorylation	VEAELKSSTVGLVTL HHHHHHHCCEEEEEH	26.06	20068231
64	Phosphorylation	EAELKSSTVGLVTLN HHHHHHCCEEEEEHH	26.19	20068231
69	Phosphorylation	SSTVGLVTLNDMKAK HCCEEEEEHHHHHHH	25.53	20068231
73	Sulfoxidation	GLVTLNDMKAKQEAL EEEEHHHHHHHHHHH	4.41	21406390
74	Ubiquitination	LVTLNDMKAKQEALV EEEHHHHHHHHHHHH	56.12	29967540
76	Sumoylation	TLNDMKAKQEALVKE EHHHHHHHHHHHHHH	43.06	-
76	Sumoylation	TLNDMKAKQEALVKE EHHHHHHHHHHHHHH	43.06	-
76	Ubiquitination	TLNDMKAKQEALVKE EHHHHHHHHHHHHHH	43.06	33845483
91	Acetylation	REKQLAKKEQSKELQ HHHHHHHHHHHHHHH	56.21	18530519
94	Phosphorylation	QLAKKEQSKELQMKL HHHHHHHHHHHHHHH	29.23	20068231
95	Ubiquitination	LAKKEQSKELQMKLE HHHHHHHHHHHHHHH	63.24	24816145
95	Methylation	LAKKEQSKELQMKLE HHHHHHHHHHHHHHH	63.24	23644510
100	Sumoylation	QSKELQMKLEKLREK HHHHHHHHHHHHHHH	40.30	28112733
100	Sumoylation	QSKELQMKLEKLREK HHHHHHHHHHHHHHH	40.30	-
100	Ubiquitination	QSKELQMKLEKLREK HHHHHHHHHHHHHHH	40.30	29967540
100	Acetylation	QSKELQMKLEKLREK HHHHHHHHHHHHHHH	40.30	25953088
118	Phosphorylation	KEAKRKISSLSFTLE HHHHHHHHHCEEECC	28.41	29802988
119	Phosphorylation	EAKRKISSLSFTLEE HHHHHHHHCEEECCH	31.35	27251275
121	Phosphorylation	KRKISSLSFTLEEEE HHHHHHCEEECCHHH	20.38	27422710
123	Phosphorylation	KISSLSFTLEEEEEG HHHHCEEECCHHHCC	29.86	27251275
140	Phosphorylation	EEEEAAMYEEEMERE HHHHHHHHHHHHHHH	18.57	27642862
158	Ubiquitination	TKKRKLGKNPDVDTS HHHHHHCCCCCCCCC	75.61	29967540
164	Phosphorylation	GKNPDVDTSFLPDRD CCCCCCCCCCCCCCC	22.64	25850435
165	Phosphorylation	KNPDVDTSFLPDRDR CCCCCCCCCCCCCCH	21.96	25159151
170	Methylation	DTSFLPDRDREEEEN CCCCCCCCCHHHHHH	42.84	-
190	Ubiquitination	LRQEWEAKQEKIKSE HHHHHHHHHHHHCCC	47.69	29967540
195	Acetylation	EAKQEKIKSEEIEIT HHHHHHHCCCCEEEE	63.98	7373255
219	Ubiquitination	RRTVKMRKGNTMQQF CEEEECCCCCHHHHH	53.68	29967540
236	Ubiquitination	KALEILRKDFSELRS HHHHHHHHCHHHHHH	60.73	29967540
236	Methylation	KALEILRKDFSELRS HHHHHHHHCHHHHHH	60.73	-
239	Phosphorylation	EILRKDFSELRSAGV HHHHHCHHHHHHCCH	45.94	24719451
242	Methylation	RKDFSELRSAGVEQL HHCHHHHHHCCHHHH	22.02	-
271	Ubiquitination	FYDFIVTKARGKSGP HHHEEEEECCCCCCC	25.78	21890473
271	Ubiquitination	FYDFIVTKARGKSGP HHHEEEEECCCCCCC	25.78	21890473
275	Ubiquitination	IVTKARGKSGPLFNF EEEECCCCCCCCCCC	46.84	32015554
275	Sumoylation	IVTKARGKSGPLFNF EEEECCCCCCCCCCC	46.84	-
276	Phosphorylation	VTKARGKSGPLFNFD EEECCCCCCCCCCCC	48.76	25159151
292	Phosphorylation	HDDVRLLSDATVEKD CCCCCHHCCCEEECC	29.77	28555341
298	Acetylation	LSDATVEKDESHAGK HCCCEEECCHHHCCH	63.56	25953088
298	2-Hydroxyisobutyrylation	LSDATVEKDESHAGK HCCCEEECCHHHCCH	63.56	-
298	Ubiquitination	LSDATVEKDESHAGK HCCCEEECCHHHCCH	63.56	33845483
305	Malonylation	KDESHAGKVVLRSWY CCHHHCCHHHHHHHH	29.92	26320211
305	Acetylation	KDESHAGKVVLRSWY CCHHHCCHHHHHHHH	29.92	27452117
305	Ubiquitination	KDESHAGKVVLRSWY CCHHHCCHHHHHHHH	29.92	32015554
305	Sumoylation	KDESHAGKVVLRSWY CCHHHCCHHHHHHHH	29.92	-
305	Sumoylation	KDESHAGKVVLRSWY CCHHHCCHHHHHHHH	29.92	-
309	Methylation	HAGKVVLRSWYEKNK HCCHHHHHHHHHHCC	17.34	-
316	Ubiquitination	RSWYEKNKHIFPASR HHHHHHCCCCCCHHH	49.50	-
331	Ubiquitination	WEPYDPEKKWDKYTI CCCCCHHHCCCCCCC	65.63	29967540
336	Phosphorylation	PEKKWDKYTIR---- HHHCCCCCCCC----	12.62	-
337	Phosphorylation	EKKWDKYTIR----- HHCCCCCCCC-----	18.93	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FA50A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FA50A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FA50A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MET16_HUMAN	METTL16	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.