SUMO4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SUMO4_HUMAN
• UniProt AC: Q6EEV6
• Protein Name: Small ubiquitin-related modifier 4
• Gene Name: SUMO4
• Organism: Homo sapiens (Human).
• Sequence Length: 95
• Protein Description: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I..
• Protein Sequence: MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSMKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Sumoylation	EKPTEEVKTENNNHI CCCCHHHCCCCCCEE	54.09	-
11	Sumoylation	EKPTEEVKTENNNHI CCCCHHHCCCCCCEE	54.09	-
21	Ubiquitination	NNNHINLKVAGQDGS CCCEEEEEECCCCCC	26.08	22505724
28	Phosphorylation	KVAGQDGSVVQFKIK EECCCCCCEEEEEEE	27.66	30266825
33	Methylation	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	30796793
33	Acetylation	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	30796793
33	Sumoylation	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	-
33	Ubiquitination	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	21906983
33	Sumoylation	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	-
33	Neddylation	DGSVVQFKIKRQTPL CCCEEEEEEECCCCH	30.17	32015554
35	Ubiquitination	SVVQFKIKRQTPLSK CEEEEEEECCCCHHH	38.76	25015289
47	Phosphorylation	LSKLMKAYCEPRGLS HHHHHHHHHCCCCCC	7.57	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SUMO4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SUMO4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SUMO4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKBA_HUMAN	NFKBIA	physical	15247916
IKBA_HUMAN	NFKBIA	physical	19222990

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.