dbPTM

THOC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THOC2_HUMAN
UniProt AC	Q8NI27
Protein Name	THO complex subunit 2
Gene Name	THOC2
Organism	Homo sapiens (Human).
Sequence Length	1593
Subcellular Localization	Nucleus . Nucleus speckle .
Protein Description	Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development..
Protein Sequence	MAAAAVVVPAEWIKNWEKSGRGEFLHLCRILSENKSHDSSTYRDFQQALYELSYHVIKGNLKHEQASNVLSDISEFREDMPSILADVFCILDIETNCLEEKSKRDYFTQLVLACLYLVSDTVLKERLDPETLESLGLIKQSQQFNQKSVKIKTKLFYKQQKFNLLREENEGYAKLIAELGQDLSGSITSDLILENIKSLIGCFNLDPNRVLDVILEVFECRPEHDDFFISLLESYMSMCEPQTLCHILGFKFKFYQEPNGETPSSLYRVAAVLLQFNLIDLDDLYVHLLPADNCIMDEHKREIAEAKQIVRKLTMVVLSSEKMDEREKEKEKEEEKVEKPPDNQKLGLLEALLKIGDWQHAQNIMDQMPPYYAASHKLIALAICKLIHITIEPLYRRVGVPKGAKGSPVNALQNKRAPKQAESFEDLRRDVFNMFCYLGPHLSHDPILFAKVVRIGKSFMKEFQSDGSKQEDKEKTEVILSCLLSITDQVLLPSLSLMDCNACMSEELWGMFKTFPYQHRYRLYGQWKNETYNSHPLLVKVKAQTIDRAKYIMKRLTKENVKPSGRQIGKLSHSNPTILFDYILSQIQKYDNLITPVVDSLKYLTSLNYDVLAYCIIEALANPEKERMKHDDTTISSWLQSLASFCGAVFRKYPIDLAGLLQYVANQLKAGKSFDLLILKEVVQKMAGIEITEEMTMEQLEAMTGGEQLKAEGGYFGQIRNTKKSSQRLKDALLDHDLALPLCLLMAQQRNGVIFQEGGEKHLKLVGKLYDQCHDTLVQFGGFLASNLSTEDYIKRVPSIDVLCNEFHTPHDAAFFLSRPMYAHHISSKYDELKKSEKGSKQQHKVHKYITSCEMVMAPVHEAVVSLHVSKVWDDISPQFYATFWSLTMYDLAVPHTSYEREVNKLKVQMKAIDDNQEMPPNKKKKEKERCTALQDKLLEEEKKQMEHVQRVLQRLKLEKDNWLLAKSTKNETITKFLQLCIFPRCIFSAIDAVYCARFVELVHQQKTPNFSTLLCYDRVFSDIIYTVASCTENEASRYGRFLCCMLETVTRWHSDRATYEKECGNYPGFLTILRATGFDGGNKADQLDYENFRHVVHKWHYKLTKASVHCLETGEYTHIRNILIVLTKILPWYPKVLNLGQALERRVHKICQEEKEKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Ubiquitination	VVPAEWIKNWEKSGR EECHHHHHCHHHCCC	58.02	-
18	Acetylation	EWIKNWEKSGRGEFL HHHHCHHHCCCHHHH	50.23	26051181
18	Ubiquitination	EWIKNWEKSGRGEFL HHHHCHHHCCCHHHH	50.23	-
24 (in isoform 1)	Ubiquitination	-	6.08	21890473
35	2-Hydroxyisobutyrylation	CRILSENKSHDSSTY HHHHHCCCCCCCCHH	45.15	-
40 (in isoform 2)	Phosphorylation	-	35.20	21406692
43 (in isoform 2)	Phosphorylation	-	38.05	21406692
45 (in isoform 2)	Phosphorylation	-	4.25	21406692
54	Phosphorylation	QALYELSYHVIKGNL HHHHHHHHHHHHCCC	16.84	-
139	Acetylation	LESLGLIKQSQQFNQ HHHHCCHHHHHCCCC	49.27	25953088
139	Ubiquitination	LESLGLIKQSQQFNQ HHHHCCHHHHHCCCC	49.27	21906983
139 (in isoform 2)	Ubiquitination	-	49.27	21890473
147	Acetylation	QSQQFNQKSVKIKTK HHHCCCCCCCHHHHH	59.32	25953088
147	Ubiquitination	QSQQFNQKSVKIKTK HHHCCCCCCCHHHHH	59.32	27667366
154	Acetylation	KSVKIKTKLFYKQQK CCCHHHHHHHHHHHH	31.43	26051181
158	Acetylation	IKTKLFYKQQKFNLL HHHHHHHHHHHHHHH	38.63	26051181
158	Ubiquitination	IKTKLFYKQQKFNLL HHHHHHHHHHHHHHH	38.63	29967540
161	Acetylation	KLFYKQQKFNLLREE HHHHHHHHHHHHHHC	33.45	25953088
161	Ubiquitination	KLFYKQQKFNLLREE HHHHHHHHHHHHHHC	33.45	29967540
214 (in isoform 2)	Phosphorylation	-	2.44	21406692
238 (in isoform 2)	Phosphorylation	-	1.38	21406692
243 (in isoform 2)	Phosphorylation	-	41.91	21406692
253	Acetylation	HILGFKFKFYQEPNG HHHCCEEEEEECCCC	43.69	26051181
307	2-Hydroxyisobutyrylation	KREIAEAKQIVRKLT HHHHHHHHHHHHHHH	31.87	-
307	Acetylation	KREIAEAKQIVRKLT HHHHHHHHHHHHHHH	31.87	26822725
307	Ubiquitination	KREIAEAKQIVRKLT HHHHHHHHHHHHHHH	31.87	24816145
307 (in isoform 2)	Phosphorylation	-	31.87	21406692
312	2-Hydroxyisobutyrylation	EAKQIVRKLTMVVLS HHHHHHHHHHHHHHC	37.10	-
314	Phosphorylation	KQIVRKLTMVVLSSE HHHHHHHHHHHHCHH	15.79	21406692
315	Sulfoxidation	QIVRKLTMVVLSSEK HHHHHHHHHHHCHHC	2.58	21406390
319	Phosphorylation	KLTMVVLSSEKMDER HHHHHHHCHHCCCHH	25.49	25850435
320	Phosphorylation	LTMVVLSSEKMDERE HHHHHHCHHCCCHHH	36.76	21406692
335 (in isoform 2)	Phosphorylation	-	64.59	21406692
339	Ubiquitination	KEEEKVEKPPDNQKL HHHHHCCCCCCHHHH	65.91	29967540
345	Ubiquitination	EKPPDNQKLGLLEAL CCCCCHHHHHHHHHH	51.26	21890473
353	Ubiquitination	LGLLEALLKIGDWQH HHHHHHHHHHCCHHH	4.97	24816145
390	Phosphorylation	ICKLIHITIEPLYRR HHHHHHHHHHHHHHH	12.72	20068231
391	Ubiquitination	CKLIHITIEPLYRRV HHHHHHHHHHHHHHH	5.19	21890473
395	Phosphorylation	HITIEPLYRRVGVPK HHHHHHHHHHHCCCC	13.69	20068231
405	Ubiquitination	VGVPKGAKGSPVNAL HCCCCCCCCCHHHHH	69.46	24816145
407	Phosphorylation	VPKGAKGSPVNALQN CCCCCCCCHHHHHCC	25.60	21815630
415	Acetylation	PVNALQNKRAPKQAE HHHHHCCCCCCHHCC	36.66	25953088
415	Ubiquitination	PVNALQNKRAPKQAE HHHHHCCCCCCHHCC	36.66	29967540
419	Ubiquitination	LQNKRAPKQAESFED HCCCCCCHHCCCHHH	62.24	24816145
423	Phosphorylation	RAPKQAESFEDLRRD CCCHHCCCHHHHHHH	36.63	-
451	Ubiquitination	HDPILFAKVVRIGKS CCHHHHHHHHHHCHH	33.65	24816145
457	Acetylation	AKVVRIGKSFMKEFQ HHHHHHCHHHHHHHH	37.84	7961011
457	Ubiquitination	AKVVRIGKSFMKEFQ HHHHHHCHHHHHHHH	37.84	-
461	Ubiquitination	RIGKSFMKEFQSDGS HHCHHHHHHHHCCCC	54.06	29967540
465	Ubiquitination	SFMKEFQSDGSKQED HHHHHHHCCCCCCCH	49.62	24816145
517	Phosphorylation	GMFKTFPYQHRYRLY HHHHHCCCHHCHHHH	16.86	-
528	Acetylation	YRLYGQWKNETYNSH HHHHHEECCCCCCCC	36.70	26051181
528	Ubiquitination	YRLYGQWKNETYNSH HHHHHEECCCCCCCC	36.70	-
540	Acetylation	NSHPLLVKVKAQTID CCCCEEEEEEEEHHH	37.68	25953088
540	Ubiquitination	NSHPLLVKVKAQTID CCCCEEEEEEEEHHH	37.68	29967540
542	2-Hydroxyisobutyrylation	HPLLVKVKAQTIDRA CCEEEEEEEEHHHHH	29.12	-
558	Ubiquitination	YIMKRLTKENVKPSG HHHHHHHHCCCCCCC	52.46	24816145
562	Ubiquitination	RLTKENVKPSGRQIG HHHHCCCCCCCCCCC	45.08	22505724
564	Phosphorylation	TKENVKPSGRQIGKL HHCCCCCCCCCCCCC	40.67	24667141
590	Phosphorylation	ILSQIQKYDNLITPV HHHHHHHHCCCHHHH	8.16	-
595	Phosphorylation	QKYDNLITPVVDSLK HHHCCCHHHHHHHHH	17.13	-
600	O-linked_Glycosylation	LITPVVDSLKYLTSL CHHHHHHHHHHHHCC	18.36	30379171
600	Phosphorylation	LITPVVDSLKYLTSL CHHHHHHHHHHHHCC	18.36	-
604	Ubiquitination	VVDSLKYLTSLNYDV HHHHHHHHHCCCHHH	2.22	24816145
608	Ubiquitination	LKYLTSLNYDVLAYC HHHHHCCCHHHHHHH	30.63	22505724
673	Phosphorylation	NQLKAGKSFDLLILK HHHHCCCCCHHHHHH	24.07	24670416
692	Phosphorylation	KMAGIEITEEMTMEQ HHCCCCCCCCCCHHH	17.07	27050516
696	Phosphorylation	IEITEEMTMEQLEAM CCCCCCCCHHHHHHH	22.34	27050516
730	Ubiquitination	KKSSQRLKDALLDHD HHHHHHHHHHHHCCC	43.05	-
761	Acetylation	IFQEGGEKHLKLVGK EEECCHHHHHHHHHH	58.47	25953088
761	Ubiquitination	IFQEGGEKHLKLVGK EEECCHHHHHHHHHH	58.47	29967540
764	Ubiquitination	EGGEKHLKLVGKLYD CCHHHHHHHHHHHHH	40.63	29967540
799	Phosphorylation	DYIKRVPSIDVLCNE HHHHHCCCHHHHHCC	28.67	-
829	Acetylation	YAHHISSKYDELKKS HHHHHHHHHHHHHHC	50.35	25953088
829	Ubiquitination	YAHHISSKYDELKKS HHHHHHHHHHHHHHC	50.35	19608861
848	Acetylation	KQQHKVHKYITSCEM HHHHHHHHHHCCCCE	41.14	26051181
923	2-Hydroxyisobutyrylation	NQEMPPNKKKKEKER CCCCCCCHHHHHHHH	72.28	-
923	Acetylation	NQEMPPNKKKKEKER CCCCCCCHHHHHHHH	72.28	26051181
923	Neddylation	NQEMPPNKKKKEKER CCCCCCCHHHHHHHH	72.28	32015554
928	Acetylation	PNKKKKEKERCTALQ CCHHHHHHHHHHHHH	60.38	20167786
937	Acetylation	RCTALQDKLLEEEKK HHHHHHHHHHHHHHH	41.85	25953088
937	Ubiquitination	RCTALQDKLLEEEKK HHHHHHHHHHHHHHH	41.85	29967540
943	Acetylation	DKLLEEEKKQMEHVQ HHHHHHHHHHHHHHH	52.14	25953088
957	Acetylation	QRVLQRLKLEKDNWL HHHHHHHHCCCCCEE	57.71	26051181
960	Acetylation	LQRLKLEKDNWLLAK HHHHHCCCCCEEEEC	67.79	25953088
960	Ubiquitination	LQRLKLEKDNWLLAK HHHHHCCCCCEEEEC	67.79	29967540
967	Ubiquitination	KDNWLLAKSTKNETI CCCEEEECCCCCHHH	59.64	21963094
969 (in isoform 1)	Ubiquitination	-	36.86	21890473
970	2-Hydroxyisobutyrylation	WLLAKSTKNETITKF EEEECCCCCHHHHHH	60.93	-
970	Acetylation	WLLAKSTKNETITKF EEEECCCCCHHHHHH	60.93	25953088
970	Ubiquitination	WLLAKSTKNETITKF EEEECCCCCHHHHHH	60.93	22817900
971	Ubiquitination	LLAKSTKNETITKFL EEECCCCCHHHHHHH	52.30	21963094
974	Ubiquitination	KSTKNETITKFLQLC CCCCCHHHHHHHHHH	3.00	22817900
1007	Acetylation	VELVHQQKTPNFSTL HHHHHCCCCCCCCHH	60.42	26051181
1007	Ubiquitination	VELVHQQKTPNFSTL HHHHHCCCCCCCCHH	60.42	-
1013	Ubiquitination	QKTPNFSTLLCYDRV CCCCCCCHHHHHHHH	21.44	21963094
1016	Ubiquitination	PNFSTLLCYDRVFSD CCCCHHHHHHHHHCC	3.60	22817900
1017	Ubiquitination	NFSTLLCYDRVFSDI CCCHHHHHHHHHCCH	13.52	21963094
1020	Ubiquitination	TLLCYDRVFSDIIYT HHHHHHHHHCCHHHH	5.00	22817900
1062	Acetylation	SDRATYEKECGNYPG HCHHCHHHHHCCCCC	48.14	26051181
1062	Ubiquitination	SDRATYEKECGNYPG HCHHCHHHHHCCCCC	48.14	21963094
1066	Ubiquitination	TYEKECGNYPGFLTI CHHHHHCCCCCHHHH	52.03	21963094
1067	Phosphorylation	YEKECGNYPGFLTIL HHHHHCCCCCHHHHH	7.04	20068231
1072	Phosphorylation	GNYPGFLTILRATGF CCCCCHHHHHHHHCC	18.72	20068231
1084	Acetylation	TGFDGGNKADQLDYE HCCCCCCCHHHCCHH	57.52	26051181
1084	Ubiquitination	TGFDGGNKADQLDYE HCCCCCCCHHHCCHH	57.52	21963094
1084 (in isoform 2)	Ubiquitination	-	57.52	21890473
1088	Ubiquitination	GGNKADQLDYENFRH CCCCHHHCCHHHHHH	8.56	21963094
1090	Phosphorylation	NKADQLDYENFRHVV CCHHHCCHHHHHHHH	22.74	-
1099	Acetylation	NFRHVVHKWHYKLTK HHHHHHHHHHHHHHH	24.85	26051181
1099	Ubiquitination	NFRHVVHKWHYKLTK HHHHHHHHHHHHHHH	24.85	29967540
1103	Acetylation	VVHKWHYKLTKASVH HHHHHHHHHHHHEEE	36.47	25825284
1106	Acetylation	KWHYKLTKASVHCLE HHHHHHHHHEEEHHH	49.45	25953088
1107	Phosphorylation	WHYKLTKASVHCLET HHHHHHHHEEEHHHC	16.14	15302935
1108	Phosphorylation	HYKLTKASVHCLETG HHHHHHHEEEHHHCC	17.60	-
1108	Ubiquitination	HYKLTKASVHCLETG HHHHHHHEEEHHHCC	17.60	21963094
1112	Ubiquitination	TKASVHCLETGEYTH HHHEEEHHHCCCCCH	3.89	21963094
1130	Ubiquitination	ILIVLTKILPWYPKV HHHHHHHHCCCCHHH	4.75	21963094
1134	Ubiquitination	LTKILPWYPKVLNLG HHHHCCCCHHHCCHH	7.40	21963094
1136	Ubiquitination	KILPWYPKVLNLGQA HHCCCCHHHCCHHHH	43.59	-
1150	Ubiquitination	ALERRVHKICQEEKE HHHHHHHHHHHHHHH	42.17	29967540
1174	Phosphorylation	MGYSGQLKSRKSYMI HCCCCCCCCCCCCCC	40.08	16964243
1178	Phosphorylation	GQLKSRKSYMIPENE CCCCCCCCCCCCCCC	20.87	28555341
1179	Phosphorylation	QLKSRKSYMIPENEF CCCCCCCCCCCCCCC	11.33	28555341
1189	Acetylation	PENEFHHKDPPPRNA CCCCCCCCCCCCCCC	64.46	26051181
1196	Ubiquitination	KDPPPRNAVASVQNG CCCCCCCCEECCCCC	10.26	21963094
1199	Phosphorylation	PPRNAVASVQNGPGG CCCCCEECCCCCCCC	20.03	30576142
1200	Ubiquitination	PRNAVASVQNGPGGG CCCCEECCCCCCCCC	3.55	21963094
1209	Phosphorylation	NGPGGGPSSSSIGSA CCCCCCCCHHCCCCC	46.24	23927012
1210	Phosphorylation	GPGGGPSSSSIGSAS CCCCCCCHHCCCCCC	31.10	23927012
1211	Phosphorylation	PGGGPSSSSIGSASK CCCCCCHHCCCCCCC	30.25	25159151
1212	Phosphorylation	GGGPSSSSIGSASKS CCCCCHHCCCCCCCC	32.68	25159151
1215	Phosphorylation	PSSSSIGSASKSDES CCHHCCCCCCCCCCC	27.91	23927012
1217	Phosphorylation	SSSIGSASKSDESST HHCCCCCCCCCCCCC	34.10	25159151
1219	Phosphorylation	SIGSASKSDESSTEE CCCCCCCCCCCCCCC	44.08	23927012
1222	Phosphorylation	SASKSDESSTEETDK CCCCCCCCCCCCCHH	47.77	25159151
1223	Phosphorylation	ASKSDESSTEETDKS CCCCCCCCCCCCHHH	37.48	23401153
1224	Phosphorylation	SKSDESSTEETDKSR CCCCCCCCCCCHHHH	47.31	23927012
1227	Phosphorylation	DESSTEETDKSRERS CCCCCCCCHHHHHHH	42.36	23927012
1229	Acetylation	SSTEETDKSRERSQC CCCCCCHHHHHHHHH	59.85	26051181
1229	Ubiquitination	SSTEETDKSRERSQC CCCCCCHHHHHHHHH	59.85	24816145
1230	Phosphorylation	STEETDKSRERSQCG CCCCCHHHHHHHHHC	42.03	23927012
1233	Ubiquitination	ETDKSRERSQCGVKA CCHHHHHHHHHCHHH	30.80	24816145
1239	Acetylation	ERSQCGVKAVNKASS HHHHHCHHHHHHCCC	31.72	26051181
1242	Ubiquitination	QCGVKAVNKASSTTP HHCHHHHHHCCCCCC	38.75	21963094
1245	Phosphorylation	VKAVNKASSTTPKGN HHHHHHCCCCCCCCC	29.81	23312004
1246	Phosphorylation	KAVNKASSTTPKGNS HHHHHCCCCCCCCCC	40.95	23312004
1246	Ubiquitination	KAVNKASSTTPKGNS HHHHHCCCCCCCCCC	40.95	21963094
1247	Phosphorylation	AVNKASSTTPKGNSS HHHHCCCCCCCCCCC	44.62	23312004
1248	Phosphorylation	VNKASSTTPKGNSSN HHHCCCCCCCCCCCC	25.58	23312004
1251	Ubiquitination	ASSTTPKGNSSNGNS CCCCCCCCCCCCCCC	40.22	24816145
1253	Phosphorylation	STTPKGNSSNGNSGS CCCCCCCCCCCCCCC	33.57	29255136
1254	Phosphorylation	TTPKGNSSNGNSGSN CCCCCCCCCCCCCCC	53.40	29255136
1255	Ubiquitination	TPKGNSSNGNSGSNS CCCCCCCCCCCCCCC	54.19	24816145
1258	Phosphorylation	GNSSNGNSGSNSNKA CCCCCCCCCCCCCCH	45.02	29255136
1260	Phosphorylation	SSNGNSGSNSNKAVK CCCCCCCCCCCCHHH	36.58	29255136
1262	Phosphorylation	NGNSGSNSNKAVKEN CCCCCCCCCCHHHHH	41.21	23312004
1275	Ubiquitination	ENDKEKGKEKEKEKK HHHHHHHHHHHHHHH	76.35	24816145
1279	Ubiquitination	EKGKEKEKEKKEKTP HHHHHHHHHHHCCCC	82.80	24816145
1285	Phosphorylation	EKEKKEKTPATTPEA HHHHHCCCCCCCHHH	21.17	23401153
1288	Phosphorylation	KKEKTPATTPEARVL HHCCCCCCCHHHHHC	44.05	29255136
1289	Phosphorylation	KEKTPATTPEARVLG HCCCCCCCHHHHHCC	22.65	23401153
1297	2-Hydroxyisobutyrylation	PEARVLGKDGKEKPK HHHHHCCCCCCCCCC	60.18	-
1297	Ubiquitination	PEARVLGKDGKEKPK HHHHHCCCCCCCCCC	60.18	24816145
1301	Ubiquitination	VLGKDGKEKPKEERP HCCCCCCCCCCCCCC	78.93	24816145
1302	Ubiquitination	LGKDGKEKPKEERPN CCCCCCCCCCCCCCC	65.95	24816145
1306	Ubiquitination	GKEKPKEERPNKDEK CCCCCCCCCCCHHHH	78.53	24816145
1321	Phosphorylation	ARETKERTPKSDKEK HHHHHHCCCCCHHHH	35.84	30576142
1324	Ubiquitination	TKERTPKSDKEKEKF HHHCCCCCHHHHHHH	55.93	24816145
1328	Acetylation	TPKSDKEKEKFKKEE CCCCHHHHHHHHHHH	72.45	18530657
1328	Ubiquitination	TPKSDKEKEKFKKEE CCCCHHHHHHHHHHH	72.45	24816145
1336	Acetylation	EKFKKEEKAKDEKFK HHHHHHHHHHCHHHC	62.92	18530665
1344	Phosphorylation	AKDEKFKTTVPNAES HHCHHHCCCCCCCCC	35.84	26074081
1345	Phosphorylation	KDEKFKTTVPNAESK HCHHHCCCCCCCCCC	34.26	26074081
1348	Ubiquitination	KFKTTVPNAESKSTQ HHCCCCCCCCCCHHH	52.59	24816145
1351	Phosphorylation	TTVPNAESKSTQERE CCCCCCCCCHHHHHH	29.51	26074081
1352	Ubiquitination	TVPNAESKSTQERER CCCCCCCCHHHHHHH	49.37	24816145
1353	Phosphorylation	VPNAESKSTQERERE CCCCCCCHHHHHHHH	44.60	26074081
1354	Phosphorylation	PNAESKSTQEREREK CCCCCCHHHHHHHHH	37.88	26074081
1364	Phosphorylation	REREKEPSRERDIAK HHHHHCCHHHHHHHH	48.11	25159151
1370	Ubiquitination	PSRERDIAKEMKSKE CHHHHHHHHHHHHHC	13.17	24816145
1374	Ubiquitination	RDIAKEMKSKENVKG HHHHHHHHHHCCCCC	60.51	24816145
1375	Phosphorylation	DIAKEMKSKENVKGG HHHHHHHHHCCCCCC	43.84	23312004
1376	Ubiquitination	IAKEMKSKENVKGGE HHHHHHHHCCCCCCC	48.03	24816145
1380	Ubiquitination	MKSKENVKGGEKTPV HHHHCCCCCCCCCCC	73.17	24816145
1384	Acetylation	ENVKGGEKTPVSGSL CCCCCCCCCCCCCCC	62.49	25953088
1384	Ubiquitination	ENVKGGEKTPVSGSL CCCCCCCCCCCCCCC	62.49	24816145
1385	Phosphorylation	NVKGGEKTPVSGSLK CCCCCCCCCCCCCCC	25.31	25159151
1388	Phosphorylation	GGEKTPVSGSLKSPV CCCCCCCCCCCCCCC	24.70	30266825
1388	Ubiquitination	GGEKTPVSGSLKSPV CCCCCCCCCCCCCCC	24.70	24816145
1390	Phosphorylation	EKTPVSGSLKSPVPR CCCCCCCCCCCCCCH	25.72	23927012
1392	Acetylation	TPVSGSLKSPVPRSD CCCCCCCCCCCCHHH	55.18	25953088
1393	Phosphorylation	PVSGSLKSPVPRSDI CCCCCCCCCCCHHHC	36.10	25159151
1398	Phosphorylation	LKSPVPRSDIPEPER CCCCCCHHHCCCCHH	33.55	26074081
1398	Ubiquitination	LKSPVPRSDIPEPER CCCCCCHHHCCCCHH	33.55	24816145
1401	Phosphorylation	PVPRSDIPEPEREQK CCCHHHCCCCHHHHH	56.96	15302935
1402	Ubiquitination	VPRSDIPEPEREQKR CCHHHCCCCHHHHHH	61.19	24816145
1406	Ubiquitination	DIPEPEREQKRRKID HCCCCHHHHHHHCCC	59.81	24816145
1408	Ubiquitination	PEPEREQKRRKIDTH CCCHHHHHHHCCCCC	49.79	24816145
1410	Ubiquitination	PEREQKRRKIDTHPS CHHHHHHHCCCCCCC	47.52	24816145
1412	Ubiquitination	REQKRRKIDTHPSPS HHHHHHCCCCCCCCC	7.58	24816145
1414	Phosphorylation	QKRRKIDTHPSPSHS HHHHCCCCCCCCCCC	38.88	30266825
1417	Phosphorylation	RKIDTHPSPSHSSTV HCCCCCCCCCCCCCH	31.28	29255136
1419	Phosphorylation	IDTHPSPSHSSTVKD CCCCCCCCCCCCHHH	40.10	29255136
1421	Phosphorylation	THPSPSHSSTVKDSL CCCCCCCCCCHHHHH	31.85	25159151
1422	Phosphorylation	HPSPSHSSTVKDSLI CCCCCCCCCHHHHHH	31.62	23927012
1422	Ubiquitination	HPSPSHSSTVKDSLI CCCCCCCCCHHHHHH	31.62	24816145
1423	Phosphorylation	PSPSHSSTVKDSLIE CCCCCCCCHHHHHHH	34.29	23927012
1426	Ubiquitination	SHSSTVKDSLIELKE CCCCCHHHHHHHHHH	44.32	24816145
1427	Phosphorylation	HSSTVKDSLIELKES CCCCHHHHHHHHHHH	26.06	24732914
1430	Ubiquitination	TVKDSLIELKESSAK CHHHHHHHHHHHCCE	60.11	24816145
1432	Ubiquitination	KDSLIELKESSAKLY HHHHHHHHHHCCEEE	42.64	32015554
1434	Ubiquitination	SLIELKESSAKLYIN HHHHHHHHCCEEEEC	33.73	24816145
1437	Acetylation	ELKESSAKLYINHTP HHHHHCCEEEECCCC	43.71	25953088
1437	Ubiquitination	ELKESSAKLYINHTP HHHHHCCEEEECCCC	43.71	29967540
1439	Phosphorylation	KESSAKLYINHTPPP HHHCCEEEECCCCCC	10.04	23927012
1443	Phosphorylation	AKLYINHTPPPLSKS CEEEECCCCCCCCHH	32.76	25159151
1444	Ubiquitination	KLYINHTPPPLSKSK EEEECCCCCCCCHHH	22.44	24816145
1448	Phosphorylation	NHTPPPLSKSKEREM CCCCCCCCHHHCHHC	40.43	23401153
1448	Ubiquitination	NHTPPPLSKSKEREM CCCCCCCCHHHCHHC	40.43	24816145
1450	Phosphorylation	TPPPLSKSKEREMDK CCCCCCHHHCHHCCH	36.05	23401153
1452	Ubiquitination	PPLSKSKEREMDKKD CCCCHHHCHHCCHHH	62.05	24816145
1454	Ubiquitination	LSKSKEREMDKKDLD CCHHHCHHCCHHHHH	53.47	24816145
1456	Ubiquitination	KSKEREMDKKDLDKS HHHCHHCCHHHHHHH	50.53	24816145
1458	Ubiquitination	KEREMDKKDLDKSRE HCHHCCHHHHHHHHH	60.29	24816145
1463	Phosphorylation	DKKDLDKSRERSRER CHHHHHHHHHHHHHH	38.75	26425664
1467	Phosphorylation	LDKSRERSREREKKD HHHHHHHHHHHHHHH	33.47	20068231
1476	Ubiquitination	EREKKDEKDRKERKR HHHHHHHHHHHHHHH	73.33	24816145
1479	Ubiquitination	KKDEKDRKERKRDHS HHHHHHHHHHHHHCC	72.50	24816145
1480	Ubiquitination	KDEKDRKERKRDHSN HHHHHHHHHHHHCCC	65.41	24816145
1483	Ubiquitination	KDRKERKRDHSNNDR HHHHHHHHHCCCCCC	53.77	24816145
1486	Phosphorylation	KERKRDHSNNDREVP HHHHHHCCCCCCCCC	41.43	23401153
1497	Phosphorylation	REVPPDLTKRRKEEN CCCCCCHHHHHHHHC	29.86	23403867
1498	Ubiquitination	EVPPDLTKRRKEENG CCCCCHHHHHHHHCC	58.46	-
1510	Phosphorylation	ENGTMGVSKHKSESP HCCCCCCCCCCCCCC	24.26	-
1511	Ubiquitination	NGTMGVSKHKSESPC CCCCCCCCCCCCCCC	53.28	24816145
1514	Phosphorylation	MGVSKHKSESPCESP CCCCCCCCCCCCCCC	42.92	22167270
1515	Ubiquitination	GVSKHKSESPCESPY CCCCCCCCCCCCCCC	64.60	24816145
1516	Phosphorylation	VSKHKSESPCESPYP CCCCCCCCCCCCCCC	41.77	19664994
1520	Phosphorylation	KSESPCESPYPNEKD CCCCCCCCCCCCHHH	36.13	25159151
1522	Phosphorylation	ESPCESPYPNEKDKE CCCCCCCCCCHHHHH	28.15	23927012
1529	Ubiquitination	YPNEKDKEKNKSKSS CCCHHHHHCCCCCCC	72.50	24816145
1533	Ubiquitination	KDKEKNKSKSSGKEK HHHHCCCCCCCCCCC	47.35	24816145
1537	Ubiquitination	KNKSKSSGKEKGSDS CCCCCCCCCCCCCCC	49.59	24816145
1547	Phosphorylation	KGSDSFKSEKMDKIS CCCCCHHHHHHHHHC	40.20	28258704
1551	Ubiquitination	SFKSEKMDKISSGGK CHHHHHHHHHCCCCC	57.09	24816145
1555	Phosphorylation	EKMDKISSGGKKESR HHHHHHCCCCCCCCH	55.85	-
1556	Ubiquitination	KMDKISSGGKKESRH HHHHHCCCCCCCCHH	45.19	24816145
1557	Ubiquitination	MDKISSGGKKESRHD HHHHCCCCCCCCHHC	39.55	24816145
1561	Phosphorylation	SSGGKKESRHDKEKI CCCCCCCCHHCHHHH	43.74	28258704
1561	Ubiquitination	SSGGKKESRHDKEKI CCCCCCCCHHCHHHH	43.74	24816145
1571	Ubiquitination	DKEKIEKKEKRDSSG CHHHHHHHHHHCCCC	56.53	24816145
1575	Ubiquitination	IEKKEKRDSSGGKEE HHHHHHHCCCCCHHH	59.22	24816145
1576	Phosphorylation	EKKEKRDSSGGKEEK HHHHHHCCCCCHHHH	34.61	21857030
1577	Phosphorylation	KKEKRDSSGGKEEKK HHHHHCCCCCHHHHH	56.72	-
1578	Ubiquitination	KEKRDSSGGKEEKKH HHHHCCCCCHHHHHC	55.96	24816145
1579	Ubiquitination	EKRDSSGGKEEKKHH HHHCCCCCHHHHHCC	35.83	24816145
1583	Ubiquitination	SSGGKEEKKHHKSSD CCCCHHHHHCCCCCC	59.50	24816145
1603	Ubiquitination	----------------- -----------------		24816145
1607	Ubiquitination	--------------------- ---------------------		24816145
1621	Ubiquitination	----------------------------------- -----------------------------------		24816145
1625	Ubiquitination	--------------------------------------- ---------------------------------------		24816145
1629	Ubiquitination	------------------------------------------- -------------------------------------------		24816145
1643	Ubiquitination	--------------------------------------------------------- ---------------------------------------------------------		24816145
1648	Ubiquitination	-------------------------------------------------------------- --------------------------------------------------------------		24816145
1649	Ubiquitination	--------------------------------------------------------------- ---------------------------------------------------------------		24816145
1653	Ubiquitination	------------------------------------------------------------------- -------------------------------------------------------------------		24816145
1670	Ubiquitination	------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------		24816145
1671	Ubiquitination	------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------		24816145
1675	Ubiquitination	----------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THOC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THOC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THOC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DX39B_HUMAN	DDX39B	physical	15998806
THOC5_HUMAN	THOC5	physical	15998806
THOC1_HUMAN	THOC1	physical	15998806
THOC3_HUMAN	THOC3	physical	15998806
THOC6_HUMAN	THOC6	physical	15998806
THOC7_HUMAN	THOC7	physical	15998806
THOC4_HUMAN	ALYREF	physical	15998806
STF1_HUMAN	NR5A1	physical	17190602
SMAD4_HUMAN	SMAD4	physical	17190602
NCBP1_HUMAN	NCBP1	physical	17190602
THOC4_HUMAN	ALYREF	physical	17190602
DX39B_HUMAN	DDX39B	physical	17190602
THOC5_HUMAN	THOC5	physical	17190602
THOC1_HUMAN	THOC1	physical	17190602
THOC3_HUMAN	THOC3	physical	17190602
THOC6_HUMAN	THOC6	physical	17190602
THOC3_HUMAN	THOC3	physical	22939629
DX39B_HUMAN	DDX39B	physical	22939629
THOC5_HUMAN	THOC5	physical	22939629
THOC6_HUMAN	THOC6	physical	22939629
THOC7_HUMAN	THOC7	physical	22939629
ZCRB1_HUMAN	ZCRB1	physical	22939629
ZC3HF_HUMAN	ZC3H15	physical	22939629
UTRO_HUMAN	UTRN	physical	22939629
UBE3C_HUMAN	UBE3C	physical	22939629
XPO4_HUMAN	XPO4	physical	22939629
THYN1_HUMAN	THYN1	physical	22939629
BUD23_HUMAN	WBSCR22	physical	22939629
VIME_HUMAN	VIM	physical	22939629
TTC1_HUMAN	TTC1	physical	22939629
VPS53_HUMAN	VPS53	physical	22939629
TPM1_HUMAN	TPM1	physical	22939629
ZMYM3_HUMAN	ZMYM3	physical	22939629
THOC4_HUMAN	ALYREF	physical	23222130
DX39B_HUMAN	DDX39B	physical	23222130
THOC3_HUMAN	THOC3	physical	23222130
NCBP1_HUMAN	NCBP1	physical	23222130
THOC5_HUMAN	THOC5	physical	23222130
THOC1_HUMAN	THOC1	physical	23222130
THOC7_HUMAN	THOC7	physical	23222130
PDCD4_HUMAN	PDCD4	physical	26344197
THOC1_HUMAN	THOC1	physical	26344197
THOC6_HUMAN	THOC6	physical	26344197
THOC7_HUMAN	THOC7	physical	26344197
UBP7_HUMAN	USP7	physical	26344197
ACDSB_HUMAN	ACADSB	physical	26496610
DSRAD_HUMAN	ADAR	physical	26496610
B2CL2_HUMAN	BCL2L2	physical	26496610
KCC2G_HUMAN	CAMK2G	physical	26496610
DHX9_HUMAN	DHX9	physical	26496610
GNAS3_HUMAN	GNAS	physical	26496610
GNAS2_HUMAN	GNAS	physical	26496610
ALEX_HUMAN	GNAS	physical	26496610
GNAS1_HUMAN	GNAS	physical	26496610
MP2K1_HUMAN	MAP2K1	physical	26496610
CTIP_HUMAN	RBBP8	physical	26496610
RS21_HUMAN	RPS21	physical	26496610
B3A2_HUMAN	SLC4A2	physical	26496610
SC6A9_HUMAN	SLC6A9	physical	26496610
STX3_HUMAN	STX3	physical	26496610
SURF4_HUMAN	SURF4	physical	26496610
TERF1_HUMAN	TERF1	physical	26496610
TPD52_HUMAN	TPD52	physical	26496610
DX39B_HUMAN	DDX39B	physical	26496610
FXR1_HUMAN	FXR1	physical	26496610
THOC5_HUMAN	THOC5	physical	26496610
MTMR3_HUMAN	MTMR3	physical	26496610
TOP3B_HUMAN	TOP3B	physical	26496610
PMYT1_HUMAN	PKMYT1	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
COG1_HUMAN	COG1	physical	26496610
CRIPT_HUMAN	CRIPT	physical	26496610
KMT2B_HUMAN	KMT2B	physical	26496610
IF4A3_HUMAN	EIF4A3	physical	26496610
ZC11A_HUMAN	ZC3H11A	physical	26496610
THOC1_HUMAN	THOC1	physical	26496610
AKAP9_HUMAN	AKAP9	physical	26496610
THOC4_HUMAN	ALYREF	physical	26496610
DX39A_HUMAN	DDX39A	physical	26496610
KIF1C_HUMAN	KIF1C	physical	26496610
TBCD8_HUMAN	TBC1D8	physical	26496610
KIF1B_HUMAN	KIF1B	physical	26496610
RT27_HUMAN	MRPS27	physical	26496610
ECM29_HUMAN	KIAA0368	physical	26496610
TM131_HUMAN	TMEM131	physical	26496610
ZN346_HUMAN	ZNF346	physical	26496610
VIR_HUMAN	KIAA1429	physical	26496610
CCDC9_HUMAN	CCDC9	physical	26496610
CHTOP_HUMAN	CHTOP	physical	26496610
ATP5S_HUMAN	ATP5S	physical	26496610
CAB45_HUMAN	SDF4	physical	26496610
RM27_HUMAN	MRPL27	physical	26496610
NCBP3_HUMAN	C17orf85	physical	26496610
GPAM1_HUMAN	GPALPP1	physical	26496610
GNPTA_HUMAN	GNPTAB	physical	26496610
THOC6_HUMAN	THOC6	physical	26496610
PKHF2_HUMAN	PLEKHF2	physical	26496610
ZC3HE_HUMAN	ZC3H14	physical	26496610
THOC7_HUMAN	THOC7	physical	26496610
RAM_HUMAN	FAM103A1	physical	26496610
UIF_HUMAN	FYTTD1	physical	26496610
PDIP3_HUMAN	POLDIP3	physical	26496610
THOC3_HUMAN	THOC3	physical	26496610
SARNP_HUMAN	SARNP	physical	26496610
CS047_HUMAN	C19orf47	physical	26496610
WDR90_HUMAN	WDR90	physical	26496610
F102B_HUMAN	FAM102B	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THOC2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1486, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1516 AND SER-1520, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1385; SER-1393;SER-1417; THR-1443 AND SER-1486, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1385 AND SER-1390, ANDMASS SPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1364; SER-1417;THR-1443; SER-1448 AND SER-1486, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1222; THR-1289 ANDSER-1516, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1443, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1289, AND MASSSPECTROMETRY.	16964243 [Abstract]