SC6A9_HUMAN - dbPTM
SC6A9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SC6A9_HUMAN
UniProt AC P48067
Protein Name Sodium- and chloride-dependent glycine transporter 1
Gene Name SLC6A9
Organism Homo sapiens (Human).
Sequence Length 706
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission..
Protein Sequence MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16 (in isoform 2)Phosphorylation-11.6330631047
19 (in isoform 2)Phosphorylation-36.047595479
20 (in isoform 2)Ubiquitination-17.41-
65PhosphorylationLKVWHGAYNSGLLPQ
HHHHHHHHHCCHHHH		17.9122210691
67PhosphorylationVWHGAYNSGLLPQLM
HHHHHHHCCHHHHHH		20.3822210691
89PhosphorylationAQNGAVPSEATKRDQ
HHCCCCCCHHHHHHH		33.0122210691
92PhosphorylationGAVPSEATKRDQNLK
CCCCCHHHHHHHCCC		23.6622210691
196PhosphorylationSTYIGIYYNVVICIA
HHHHHHHHHHHHHHH		10.28-
237N-linked_GlycosylationAGVLDASNLTNGSRP
CCCCCHHHCCCCCCC		53.247721869
237N-linked_GlycosylationAGVLDASNLTNGSRP
CCCCCHHHCCCCCCC		53.247721869
240N-linked_GlycosylationLDASNLTNGSRPAAL
CCHHHCCCCCCCCCC		50.007721869
240N-linked_GlycosylationLDASNLTNGSRPAAL
CCHHHCCCCCCCCCC		50.00-
250N-linked_GlycosylationRPAALPSNLSHLLNH
CCCCCCCCHHHHHHH		43.567721869
250N-linked_GlycosylationRPAALPSNLSHLLNH
CCCCCCCCHHHHHHH		43.567721869
256N-linked_GlycosylationSNLSHLLNHSLQRTS
CCHHHHHHHCCCCCC		29.127721869
256N-linked_GlycosylationSNLSHLLNHSLQRTS
CCHHHHHHHCCCCCC		29.127721869
275UbiquitinationYWRLYVLKLSDDIGN
HHHEEEEEECCCCCC		35.58-
312PhosphorylationLIRGVKSSGKVVYFT
HHHCCCCCCCEEEEE		36.597595479
349PhosphorylationDGIMYYLTPQWDKIL
CCCCCHHCCCHHHHH		9.417595479
614 (in isoform 2)Ubiquitination-3.2621906983
633 (in isoform 3)Ubiquitination-3.7121906983
645AcetylationDTLLQRLKNATKPSR
HHHHHHHHHCCCCCC		46.8825953088
649UbiquitinationQRLKNATKPSRDWGP
HHHHHCCCCCCCCHH		38.29-
663PhosphorylationPALLEHRTGRYAPTI
HHHHHHCCCCCCCCC		28.117595479
673PhosphorylationYAPTIAPSPEDGFEV
CCCCCCCCCCCCCCC		31.7225159151
687UbiquitinationVQPLHPDKAQIPIVG
CCCCCCCCCCCCCCC		46.792190698
687 (in isoform 1)Ubiquitination-46.7921906983
695PhosphorylationAQIPIVGSNGSSRLQ
CCCCCCCCCCCCCCC		27.4225159151
698PhosphorylationPIVGSNGSSRLQDSR
CCCCCCCCCCCCCCC		19.288183239
699PhosphorylationIVGSNGSSRLQDSRI
CCCCCCCCCCCCCCC		38.1127251275
704PhosphorylationGSSRLQDSRI-----
CCCCCCCCCC-----		20.9321712546
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SC6A9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SC6A9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SC6A9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STX1A_HUMANSTX1Aphysical
10722844
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D10186 Bitopertin (USAN); Paliflutine
DrugBank
DB00145Glycine
Regulatory Network of SC6A9_HUMAN

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Related Literatures of Post-Translational Modification

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