TBCD8_HUMAN - dbPTM
TBCD8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBCD8_HUMAN
UniProt AC O95759
Protein Name TBC1 domain family member 8
Gene Name TBC1D8
Organism Homo sapiens (Human).
Sequence Length 1140
Subcellular Localization
Protein Description May act as a GTPase-activating protein for Rab family protein(s)..
Protein Sequence MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGEGGGRLTGRLVGALDAVLDSNARVAPFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYLSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDEVFKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAFFRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPMASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFKAFVSCLDIMYNGEMNEKIKLLYRLHIPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDAVDYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRASAPSPEDSVFADTGKTPQDSQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQYNLKTFEMSHQSQSELKLSNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32 (in isoform 2)Ubiquitination-43.58-
119UbiquitinationSFVKGKVKALIAEET
HHHHHHHHHHHHHHH		40.75-
139UbiquitinationEQEEEPEKFREALVK
HCCCCCHHHHHHHHH		61.51-
223PhosphorylationLTDTIRITTQNKERD
EECEEEEECCCCCCC		16.6930622161
224PhosphorylationTDTIRITTQNKERDF
ECEEEEECCCCCCCC		27.9830622161
251PhosphorylationMEQLADVTLRRLLDN
HHHHHHHHHHHHHCC		18.3324719451
271PhosphorylationDPDLQEPSQITKRDL
CCCCCCCHHCCHHHH		33.2022210691
274PhosphorylationLQEPSQITKRDLEAR
CCCCHHCCHHHHHHH		16.6422210691
275UbiquitinationQEPSQITKRDLEARA
CCCHHCCHHHHHHHH		45.6121906983
445PhosphorylationEESEKEKSPLMHPDA
CHHHHHCCCCCCHHH		25.1023898821
455PhosphorylationMHPDALVTAFQQSGS
CCHHHHHHHHHHCCC		23.7023898821
460PhosphorylationLVTAFQQSGSQSPDS
HHHHHHHCCCCCCCC		29.6323090842
462PhosphorylationTAFQQSGSQSPDSRM
HHHHHCCCCCCCCCC		32.5026657352
464PhosphorylationFQQSGSQSPDSRMSR
HHHCCCCCCCCCCCH		32.1625159151
467PhosphorylationSGSQSPDSRMSREQI
CCCCCCCCCCCHHHH		33.0125850435
509PhosphorylationVAMGIPESLRGRLWL
HHCCCCHHHHHHHHH		20.2920068231
527 (in isoform 2)Ubiquitination-37.20-
578PhosphorylationAALRRVLTAYAHRNP
HHHHHHHHHHHCCCC		18.1129083192
580PhosphorylationLRRVLTAYAHRNPKI
HHHHHHHHHCCCCCC		9.5629083192
589PhosphorylationHRNPKIGYCQSMNIL
CCCCCCCHHHHHHHH		7.2620201521
592PhosphorylationPKIGYCQSMNILTSV
CCCCHHHHHHHHHHH		15.3827050516
597PhosphorylationCQSMNILTSVLLLYT
HHHHHHHHHHHHHHC		17.0020201521
598PhosphorylationQSMNILTSVLLLYTK
HHHHHHHHHHHHHCC		13.8120201521
725PhosphorylationGQALMILSRFLDHIK
HHHHHHHHHHHHHHC		15.29-
767PhosphorylationISDLIRDSYEKFGDQ
HHHHHHHHHHHHCCC		25.9125690035
768PhosphorylationSDLIRDSYEKFGDQS
HHHHHHHHHHHCCCC		27.6825690035
770UbiquitinationLIRDSYEKFGDQSVE
HHHHHHHHHCCCCHH		46.55-
799UbiquitinationQGHEDTTKQNVLRVV
ECCCCCCCCCEEEEE		41.802190698
936PhosphorylationLTENDRDSQSPLRNP
HCCCCCCCCCCCCCC		33.1926699800
938PhosphorylationENDRDSQSPLRNPLL
CCCCCCCCCCCCCCC		29.8326699800
1035PhosphorylationGEVGQRGSSSGSCSQ
CCCCCCCCCCCCCCH		24.4223663014
1036PhosphorylationEVGQRGSSSGSCSQE
CCCCCCCCCCCCCHH		41.3523663014
1037PhosphorylationVGQRGSSSGSCSQEC
CCCCCCCCCCCCHHH		36.1023663014
1039PhosphorylationQRGSSSGSCSQECGE
CCCCCCCCCCHHHHH		16.7323663014
1041PhosphorylationGSSSGSCSQECGEEL
CCCCCCCCHHHHHHH		30.6130177828
1051PhosphorylationCGEELRASAPSPEDS
HHHHHHHCCCCCCCC		33.9923927012
1054PhosphorylationELRASAPSPEDSVFA
HHHHCCCCCCCCCCC		40.4121815630
1058PhosphorylationSAPSPEDSVFADTGK
CCCCCCCCCCCCCCC		19.9223927012
1131PhosphorylationTFEMSHQSQSELKLS
HHHCCCCCHHHHHHC		30.1928348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBCD8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBCD8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBCD8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TBCD8_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBCD8_HUMAN

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Related Literatures of Post-Translational Modification

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