CRIPT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRIPT_HUMAN
• UniProt AC: Q9P021
• Protein Name: Cysteine-rich PDZ-binding protein
• Gene Name: CRIPT
• Organism: Homo sapiens (Human).
• Sequence Length: 101
• Subcellular Localization: Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine. Colocalizes with DLG4 in asymmetric synapses..
• Protein Description: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses..
• Protein Sequence: MVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	VCEKCEKKLGTVITP CCHHCHHHCCCEECC	29.83	32142685
12	Phosphorylation	KCEKKLGTVITPDTW HCHHHCCCEECCCCC	21.12	27251275
15	Phosphorylation	KKLGTVITPDTWKDG HHCCCEECCCCCCCC	15.69	21815630
18	Phosphorylation	GTVITPDTWKDGARN CCEECCCCCCCCCCC	35.30	27251275
20	Ubiquitination	VITPDTWKDGARNTT EECCCCCCCCCCCCC	48.66	23000965
26	Phosphorylation	WKDGARNTTESGGRK CCCCCCCCCCCCCEE	26.79	27251275
27	Phosphorylation	KDGARNTTESGGRKL CCCCCCCCCCCCEEC	31.53	27251275
29	Phosphorylation	GARNTTESGGRKLNE CCCCCCCCCCEECCC	44.44	27251275
33	Ubiquitination	TTESGGRKLNENKAL CCCCCCEECCCCCCC	59.96	29967540
38	Ubiquitination	GRKLNENKALTSKKA CEECCCCCCCCCCCC	38.30	33845483
50	Phosphorylation	KKARFDPYGKNKFST CCCCCCCCCCCCCCC	42.44	-
52	Ubiquitination	ARFDPYGKNKFSTCR CCCCCCCCCCCCCCC	51.63	33845483
54	Ubiquitination	FDPYGKNKFSTCRIC CCCCCCCCCCCCCCC	44.15	29967540
57	Phosphorylation	YGKNKFSTCRICKSS CCCCCCCCCCCCCCC	14.67	-
64	Phosphorylation	TCRICKSSVHQPGSH CCCCCCCCCCCCCCC	14.76	29457462
79	Acetylation	YCQGCAYKKGICAMC CCCCCHHHCCCHHHC	26.46	26051181
79	Ubiquitination	YCQGCAYKKGICAMC CCCCCHHHCCCHHHC	26.46	29967540
80	Ubiquitination	CQGCAYKKGICAMCG CCCCHHHCCCHHHCC	40.61	33845483
88	Acetylation	GICAMCGKKVLDTKN CCHHHCCCEEECCCC	34.48	25953088
94	Ubiquitination	GKKVLDTKNYKQTSV CCEEECCCCCCCCCC	58.93	33845483
97	Ubiquitination	VLDTKNYKQTSV--- EECCCCCCCCCC---	57.40	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRIPT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRIPT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRIPT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG1_HUMAN	DLG1	physical	12070168
DLG4_HUMAN	DLG4	physical	9581762
CA123_HUMAN	C1orf123	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.