| UniProt ID | KMT2B_HUMAN | |
|---|---|---|
| UniProt AC | Q9UMN6 | |
| Protein Name | Histone-lysine N-methyltransferase 2B | |
| Gene Name | KMT2B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2715 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.. | |
| Protein Sequence | MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGKQLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAAAGGGS ------CCCCCCCCC | 19413330 | ||
| 9 | Phosphorylation | AAAAGGGSCPGPGSA CCCCCCCCCCCCCCC | 23532336 | ||
| 17 | Methylation | CPGPGSARGRFPGRP CCCCCCCCCCCCCCC | 115389341 | ||
| 49 | Methylation | RVRVALRRGGGATGP HHHEEEECCCCCCCC | 80701543 | ||
| 113 | Phosphorylation | GCVPEEESSDGESDE CCCCHHHCCCCCCCH | 30177828 | ||
| 114 | Phosphorylation | CVPEEESSDGESDEE CCCHHHCCCCCCCHH | 30177828 | ||
| 118 | Phosphorylation | EESSDGESDEEEFQG HHCCCCCCCHHHHCC | 30177828 | ||
| 128 | Phosphorylation | EEFQGFHSDEDVAPS HHHCCCCCCCCCCCH | 27422710 | ||
| 135 | Phosphorylation | SDEDVAPSSLRSALR CCCCCCCHHHHHHHH | 30177828 | ||
| 136 | Phosphorylation | DEDVAPSSLRSALRS CCCCCCHHHHHHHHH | 30177828 | ||
| 158 | Phosphorylation | GRGRKHKTTPLPPPR CCCCCCCCCCCCCCC | 20068231 | ||
| 159 | Phosphorylation | RGRKHKTTPLPPPRL CCCCCCCCCCCCCCH | 20068231 | ||
| 172 | Phosphorylation | RLADVAPTPPKTPAR CHHCCCCCCCCCCCH | 25159151 | ||
| 176 | Phosphorylation | VAPTPPKTPARKRGE CCCCCCCCCCHHCCH | 25159151 | ||
| 180 | Methylation | PPKTPARKRGEEGTE CCCCCCHHCCHHHHH | 116253951 | ||
| 181 | Methylation | PKTPARKRGEEGTER CCCCCHHCCHHHHHH | 24411467 | ||
| 188 | Methylation | RGEEGTERMVQALTE CCHHHHHHHHHHHHH | 24411475 | ||
| 214 | Phosphorylation | RSRACEPSTPRRSRG CCCCCCCCCCCCCCC | - | ||
| 219 | Phosphorylation | EPSTPRRSRGRPPGR CCCCCCCCCCCCCCC | 23312004 | ||
| 222 | Dimethylation | TPRRSRGRPPGRPAG CCCCCCCCCCCCCCC | - | ||
| 222 | Methylation | TPRRSRGRPPGRPAG CCCCCCCCCCCCCCC | 24412497 | ||
| 278 | Phosphorylation | GPGPGPGTPRRGGQS CCCCCCCCCCCCCCC | 29255136 | ||
| 280 | Methylation | GPGPGTPRRGGQSSR CCCCCCCCCCCCCCC | 80701535 | ||
| 286 | Phosphorylation | PRRGGQSSRGGRGGR CCCCCCCCCCCCCCC | - | ||
| 346 | Phosphorylation | VPQRRVGSGQGGSPC CCCCCCCCCCCCCCH | 28450419 | ||
| 351 | Phosphorylation | VGSGQGGSPCWKKQE CCCCCCCCCHHHHHH | 23401153 | ||
| 355 | Ubiquitination | QGGSPCWKKQEQKLD CCCCCHHHHHHHCCC | 32015554 | ||
| 475 | Phosphorylation | KRGRPPLTPSQRAER CCCCCCCCHHHHHHH | 30266825 | ||
| 477 | Phosphorylation | GRPPLTPSQRAEREA CCCCCCHHHHHHHHH | 30266825 | ||
| 492 | Phosphorylation | ARAGPEGTSPPTPTP HHHCCCCCCCCCCCC | 25159151 | ||
| 493 | Phosphorylation | RAGPEGTSPPTPTPS HHCCCCCCCCCCCCC | 25159151 | ||
| 496 | Phosphorylation | PEGTSPPTPTPSTAT CCCCCCCCCCCCCCC | 25159151 | ||
| 498 | Phosphorylation | GTSPPTPTPSTATGG CCCCCCCCCCCCCCC | 25159151 | ||
| 500 | Phosphorylation | SPPTPTPSTATGGPP CCCCCCCCCCCCCCC | 28450419 | ||
| 501 | Phosphorylation | PPTPTPSTATGGPPE CCCCCCCCCCCCCCC | 28464451 | ||
| 503 | Phosphorylation | TPTPSTATGGPPEDS CCCCCCCCCCCCCCC | 28450419 | ||
| 510 | Phosphorylation | TGGPPEDSPTVAPKS CCCCCCCCCCCCCCC | 22199227 | ||
| 512 | Phosphorylation | GPPEDSPTVAPKSTT CCCCCCCCCCCCCCH | 22199227 | ||
| 518 | Phosphorylation | PTVAPKSTTFLKNIR CCCCCCCCHHHHHHH | 23532336 | ||
| 519 | Phosphorylation | TVAPKSTTFLKNIRQ CCCCCCCHHHHHHHH | 23532336 | ||
| 533 | Phosphorylation | QFIMPVVSARSSRVI HHHHHHHCCCCCCCC | 28555341 | ||
| 541 | Methylation | ARSSRVIKTPRRFMD CCCCCCCCCCHHHCC | 116253967 | ||
| 542 | Phosphorylation | RSSRVIKTPRRFMDE CCCCCCCCCHHHCCC | - | ||
| 560 | Phosphorylation | KPPKVEVSPVLRPPI CCCCEEECCCCCCCC | 29255136 | ||
| 568 | Phosphorylation | PVLRPPITTSPPVPQ CCCCCCCCCCCCCCC | 26657352 | ||
| 569 | Phosphorylation | VLRPPITTSPPVPQE CCCCCCCCCCCCCCC | 29255136 | ||
| 570 | Phosphorylation | LRPPITTSPPVPQEP CCCCCCCCCCCCCCC | 29255136 | ||
| 582 | Phosphorylation | QEPAPVPSPPRAPTP CCCCCCCCCCCCCCC | 29255136 | ||
| 588 | Phosphorylation | PSPPRAPTPPSTPVP CCCCCCCCCCCCCCC | 30266825 | ||
| 591 | Phosphorylation | PRAPTPPSTPVPLPE CCCCCCCCCCCCCCH | 30278072 | ||
| 592 | Phosphorylation | RAPTPPSTPVPLPEK CCCCCCCCCCCCCHH | 30278072 | ||
| 602 | Phosphorylation | PLPEKRRSILREPTF CCCHHHHHHHCCCCC | 25159151 | ||
| 608 | Phosphorylation | RSILREPTFRWTSLT HHHHCCCCCEEECCC | 29759185 | ||
| 609 | Ubiquitination | SILREPTFRWTSLTR HHHCCCCCEEECCCC | 21890473 | ||
| 612 | Ubiquitination | REPTFRWTSLTRELP CCCCCEEECCCCCCC | 22817900 | ||
| 613 | Phosphorylation | EPTFRWTSLTRELPP CCCCEEECCCCCCCC | 29759185 | ||
| 615 | Phosphorylation | TFRWTSLTRELPPPP CCEEECCCCCCCCCC | 29759185 | ||
| 632 | Phosphorylation | PPPPPAPSPPPAPAT CCCCCCCCCCCCCCC | 30266825 | ||
| 639 | Phosphorylation | SPPPAPATSSRRPLL CCCCCCCCCCCCCEE | 30266825 | ||
| 640 | Phosphorylation | PPPAPATSSRRPLLL CCCCCCCCCCCCEEE | 30266825 | ||
| 641 | Phosphorylation | PPAPATSSRRPLLLR CCCCCCCCCCCEEEC | 30266825 | ||
| 653 | Phosphorylation | LLRAPQFTPSEAHLK EECCCCCCCCHHHHH | 24719451 | ||
| 667 | Phosphorylation | KIYESVLTPPPLGAP HHHHHCCCCCCCCCC | 24719451 | ||
| 687 | Phosphorylation | EPPPADDSPAEPEPR CCCCCCCCCCCCCCC | 28348404 | ||
| 703 | Phosphorylation | VGRTNHLSLPRFAPV CCCCCCCCCCCCCCE | 25159151 | ||
| 712 | Phosphorylation | PRFAPVVTTPVKAEV CCCCCEECCCEEEEE | 29255136 | ||
| 713 | Phosphorylation | RFAPVVTTPVKAEVS CCCCEECCCEEEEEC | 29255136 | ||
| 782 | Phosphorylation | ARIAGVGSLPLSGVE HEECCCCCCCCCCHH | 23401153 | ||
| 786 | Phosphorylation | GVGSLPLSGVEEKMF CCCCCCCCCHHHHHH | - | ||
| 794 | Phosphorylation | GVEEKMFSLLKRAKV CHHHHHHHHHHHHCE | 24719451 | ||
| 797 | Methylation | EKMFSLLKRAKVQLF HHHHHHHHHHCEEEE | 44495097 | ||
| 797 | Ubiquitination | EKMFSLLKRAKVQLF HHHHHHHHHHCEEEE | 21890473 | ||
| 797 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 800 | Ubiquitination | FSLLKRAKVQLFKID HHHHHHHCEEEEECC | 22817900 | ||
| 805 | Sumoylation | RAKVQLFKIDQQQQQ HHCEEEEECCHHHHH | 28112733 | ||
| 817 | Phosphorylation | QQQKVAASMPLSPGG HHHHHHHCCCCCCCC | 30266825 | ||
| 821 | Phosphorylation | VAASMPLSPGGQMEE HHHCCCCCCCCHHHH | 29255136 | ||
| 837 | Phosphorylation | AGAVKQISDRGPVRS HHHHHHHHHCCCCCC | 23403867 | ||
| 844 | Phosphorylation | SDRGPVRSEDESVEA HHCCCCCCCCCCHHH | 23401153 | ||
| 848 | Phosphorylation | PVRSEDESVEAKRER CCCCCCCCHHHHHCC | 30266825 | ||
| 852 | Acetylation | EDESVEAKRERPSGP CCCCHHHHHCCCCCC | 25953088 | ||
| 857 | Phosphorylation | EAKRERPSGPESPVQ HHHHCCCCCCCCCCC | 29255136 | ||
| 861 | Phosphorylation | ERPSGPESPVQGPRI CCCCCCCCCCCCHHH | 29255136 | ||
| 894 | Phosphorylation | PEDVPRLSALPLRDR CCCCCCCCCCCCCCC | 28555341 | ||
| 906 | Phosphorylation | RDRQDLATEDTSSAS CCCHHHCCCCCCCCH | 28985074 | ||
| 909 | Phosphorylation | QDLATEDTSSASETE HHHCCCCCCCCHHCC | 30177828 | ||
| 910 | Phosphorylation | DLATEDTSSASETES HHCCCCCCCCHHCCC | 29116813 | ||
| 911 | Phosphorylation | LATEDTSSASETESV HCCCCCCCCHHCCCC | 30177828 | ||
| 913 | Phosphorylation | TEDTSSASETESVPS CCCCCCCHHCCCCCC | 30177828 | ||
| 915 | Phosphorylation | DTSSASETESVPSRS CCCCCHHCCCCCCCC | 30177828 | ||
| 917 | Phosphorylation | SSASETESVPSRSRR CCCHHCCCCCCCCCC | 29116813 | ||
| 920 | Phosphorylation | SETESVPSRSRRGKV HHCCCCCCCCCCCCC | 30177828 | ||
| 926 | Acetylation | PSRSRRGKVEAAGPG CCCCCCCCCEECCCC | 23954790 | ||
| 936 | Phosphorylation | AAGPGGESEPTGSGG ECCCCCCCCCCCCCC | 30266825 | ||
| 939 | Phosphorylation | PGGESEPTGSGGTLA CCCCCCCCCCCCCCC | 30266825 | ||
| 941 | Phosphorylation | GESEPTGSGGTLAHT CCCCCCCCCCCCCCC | 30266825 | ||
| 944 | Phosphorylation | EPTGSGGTLAHTPRR CCCCCCCCCCCCCCC | 29255136 | ||
| 948 | Phosphorylation | SGGTLAHTPRRSLPS CCCCCCCCCCCCCCC | 29255136 | ||
| 952 | Phosphorylation | LAHTPRRSLPSHHGK CCCCCCCCCCCCCCC | 26425664 | ||
| 955 | Phosphorylation | TPRRSLPSHHGKKMR CCCCCCCCCCCCCCC | 28348404 | ||
| 987 | Acetylation | SCVNCLDKPKFGGPN CHHHHCCCCCCCCCC | 25953088 | ||
| 989 | Acetylation | VNCLDKPKFGGPNTK HHHCCCCCCCCCCCC | 26051181 | ||
| 1022 | Phosphorylation | RLAKKGRTIVKTLLP HHHHCCCCCCHHCCC | 23403867 | ||
| 1026 | Phosphorylation | KGRTIVKTLLPWDSD CCCCCCHHCCCCCCC | 23927012 | ||
| 1032 | Phosphorylation | KTLLPWDSDESPEAS HHCCCCCCCCCCCCC | 23927012 | ||
| 1035 | Phosphorylation | LPWDSDESPEASPGP CCCCCCCCCCCCCCC | 23927012 | ||
| 1039 | Phosphorylation | SDESPEASPGPPGPR CCCCCCCCCCCCCCC | 26503892 | ||
| 1069 | Phosphorylation | PGPEEQDSLLQRKSA CCHHHHHHHHHHHHH | 25159151 | ||
| 1085 | Phosphorylation | RCVKQRPSYDIFEDS HHHHHCCCCCCCCCC | 20363803 | ||
| 1086 | Phosphorylation | CVKQRPSYDIFEDSD HHHHCCCCCCCCCCC | 23663014 | ||
| 1092 | Phosphorylation | SYDIFEDSDDSEPGG CCCCCCCCCCCCCCC | 26503892 | ||
| 1095 | Phosphorylation | IFEDSDDSEPGGPPA CCCCCCCCCCCCCCC | 26503892 | ||
| 1107 | Phosphorylation | PPAPRRRTPRENELP CCCCCCCCCCCCCCC | 28555341 | ||
| 1122 | Phosphorylation | LPEPEEQSRPRKPTL CCCHHHCCCCCCCCC | 24719451 | ||
| 1128 | Phosphorylation | QSRPRKPTLQPVLQL CCCCCCCCCHHHHHH | 24719451 | ||
| 1136 | Sumoylation | LQPVLQLKARRRLDK CHHHHHHHHHHCCCC | 28112733 | ||
| 1161 | Methylation | FPNGWTGKQKSPDGV CCCCCCCCCCCCCCC | 115973119 | ||
| 1164 | Phosphorylation | GWTGKQKSPDGVHRV CCCCCCCCCCCCEEE | 17081983 | ||
| 1178 | Ubiquitination | VRVDFKEDCDLENVW EEEECCCCCCCCCEE | 23000965 | ||
| 1184 | Ubiquitination | EDCDLENVWLMGGLS CCCCCCCEEEECCEE | 21890473 | ||
| 1275 | Phosphorylation | CERCRHAYHPACLGP CCCCCCCCCHHHHCC | - | ||
| 1284 | Phosphorylation | PACLGPSYPTRATRK HHHHCCCCCCCCCHH | - | ||
| 1376 | Phosphorylation | EGLSDEDYEILSGLP CCCCHHHHHHHHCCC | 30257219 | ||
| 1380 | Phosphorylation | DEDYEILSGLPDSVL HHHHHHHHCCCCCEE | 30257219 | ||
| 1440 | Acetylation | TQCGPDGKQLHPGPC EEECCCCCCCCCCCC | 26051181 | ||
| 1519 | Phosphorylation | DPKYWRRSTRLPNGV CHHHCCCCCCCCCCC | - | ||
| 1520 | Phosphorylation | PKYWRRSTRLPNGVL HHHCCCCCCCCCCCC | 27174698 | ||
| 1535 | Phosphorylation | PNAVLPPSLDHVYAQ CCCCCCCCHHHHHHH | 27174698 | ||
| 1540 | Phosphorylation | PPSLDHVYAQWRQQE CCCHHHHHHHHHHCC | 27174698 | ||
| 1550 | Phosphorylation | WRQQEPETPESGQPP HHHCCCCCCCCCCCC | 26657352 | ||
| 1553 | Phosphorylation | QEPETPESGQPPGDP CCCCCCCCCCCCCCH | 27251275 | ||
| 1561 | Phosphorylation | GQPPGDPSAAFQGKD CCCCCCHHHHHCCCC | 25002506 | ||
| 1567 | Acetylation | PSAAFQGKDPAAFSH HHHHHCCCCHHHHHC | 23236377 | ||
| 1692 | Ubiquitination | HTDLLDGKEIVNPDG CCCCCCCCEEECCCC | 29967540 | ||
| 1707 | Phosphorylation | FDVLRRVYVDFEGIN CCHHEEEEECCCCCC | - | ||
| 1734 | Phosphorylation | AINVLIGSIRIDSLG HHHHHEEEEEECCCC | 24719451 | ||
| 1803 | Phosphorylation | EAAEENQTIVHSPAP HHHHHCCCEEECCCC | 28348404 | ||
| 1807 | Phosphorylation | ENQTIVHSPAPSSEP HCCCEEECCCCCCCC | 28348404 | ||
| 1811 | Phosphorylation | IVHSPAPSSEPPGGE EEECCCCCCCCCCCC | 28348404 | ||
| 1812 | Phosphorylation | VHSPAPSSEPPGGED EECCCCCCCCCCCCC | 28348404 | ||
| 1836 | Phosphorylation | PGAPERHSPIQNLDP CCCCCCCCCCCCCCC | 20873877 | ||
| 1866 | Trimethylation | SFSGARIKVPNYSPS CCCCCEEECCCCCCC | - | ||
| 1866 | Methylation | SFSGARIKVPNYSPS CCCCCEEECCCCCCC | 23644510 | ||
| 1870 | Phosphorylation | ARIKVPNYSPSRRPL CEEECCCCCCCCCCC | 24905233 | ||
| 1871 | Phosphorylation | RIKVPNYSPSRRPLG EEECCCCCCCCCCCC | 24905233 | ||
| 1873 | Phosphorylation | KVPNYSPSRRPLGGV ECCCCCCCCCCCCCC | 22210691 | ||
| 1881 | Phosphorylation | RRPLGGVSFGPLPSP CCCCCCCEECCCCCC | 28122231 | ||
| 1887 | Phosphorylation | VSFGPLPSPGSPSSL CEECCCCCCCCCHHH | 25850435 | ||
| 1890 | Phosphorylation | GPLPSPGSPSSLTHH CCCCCCCCCHHHCCC | 25849741 | ||
| 1892 | Phosphorylation | LPSPGSPSSLTHHIP CCCCCCCHHHCCCCC | 25850435 | ||
| 1893 | Phosphorylation | PSPGSPSSLTHHIPT CCCCCCHHHCCCCCC | 25850435 | ||
| 1895 | Phosphorylation | PGSPSSLTHHIPTVG CCCCHHHCCCCCCCC | 25850435 | ||
| 1900 | Phosphorylation | SLTHHIPTVGDPDFP HHCCCCCCCCCCCCC | 25850435 | ||
| 1913 | Phosphorylation | FPAPPRRSRRPSPLA CCCCCCCCCCCCCCC | 17081983 | ||
| 1917 | Phosphorylation | PRRSRRPSPLAPRPP CCCCCCCCCCCCCCC | 30266825 | ||
| 1926 | Phosphorylation | LAPRPPPSRWASPPL CCCCCCCCCCCCCCC | 26330541 | ||
| 1930 | Phosphorylation | PPPSRWASPPLKTSP CCCCCCCCCCCCCCC | 26055452 | ||
| 1934 | Acetylation | RWASPPLKTSPQLRV CCCCCCCCCCCCCCC | 25953088 | ||
| 1934 | Methylation | RWASPPLKTSPQLRV CCCCCCCCCCCCCCC | 116253959 | ||
| 1935 | Phosphorylation | WASPPLKTSPQLRVP CCCCCCCCCCCCCCC | 26055452 | ||
| 1936 | Phosphorylation | ASPPLKTSPQLRVPP CCCCCCCCCCCCCCC | 26055452 | ||
| 2002 | Ubiquitination | ASLLGTEPFQEEIVA HHHHCCCCCHHHHHH | 23000965 | ||
| 2008 | Ubiquitination | EPFQEEIVAAGAMGS CCCHHHHHHHCCCCC | 21890473 | ||
| 2034 | Phosphorylation | ESSPTSRYIHFPVTV CCCCCCCEEEEEEEE | 22210691 | ||
| 2050 | Phosphorylation | SAPGLAPSATPGAPR ECCCCCCCCCCCCCC | 22210691 | ||
| 2052 | Phosphorylation | PGLAPSATPGAPRIE CCCCCCCCCCCCCCH | 28555341 | ||
| 2068 | Phosphorylation | LDGVDDGTDSEAEAV CCCCCCCCCHHHHHH | 22617229 | ||
| 2070 | Phosphorylation | GVDDGTDSEAEAVQQ CCCCCCCHHHHHHHC | 22617229 | ||
| 2083 | Phosphorylation | QQPRGQGTPPSGPGV HCCCCCCCCCCCCCC | 29255136 | ||
| 2086 | Phosphorylation | RGQGTPPSGPGVVRA CCCCCCCCCCCCCCE | 30266825 | ||
| 2146 | Phosphorylation | APPLANGSQPSQGLT CCCCCCCCCCCCCCC | 25002506 | ||
| 2149 | Phosphorylation | LANGSQPSQGLTASP CCCCCCCCCCCCCCC | 25002506 | ||
| 2153 | Phosphorylation | SQPSQGLTASPADPT CCCCCCCCCCCCCCC | 25002506 | ||
| 2155 | Phosphorylation | PSQGLTASPADPTRT CCCCCCCCCCCCCCE | 25002506 | ||
| 2160 | Phosphorylation | TASPADPTRTFAWLP CCCCCCCCCEEEECC | 25002506 | ||
| 2176 | Phosphorylation | APGVRVLSLGPAPEP CCCEEEEEECCCCCC | 28555341 | ||
| 2185 | Ubiquitination | GPAPEPPKPATSKII CCCCCCCCCCCCEEE | 29967540 | ||
| 2190 | Acetylation | PPKPATSKIILVNKL CCCCCCCEEEEEECC | 26051181 | ||
| 2190 | Ubiquitination | PPKPATSKIILVNKL CCCCCCCEEEEEECC | 23000965 | ||
| 2196 | Acetylation | SKIILVNKLGQVFVK CEEEEEECCCCEEHH | 25953088 | ||
| 2196 | Ubiquitination | SKIILVNKLGQVFVK CEEEEEECCCCEEHH | 23000965 | ||
| 2196 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 2203 | Methylation | KLGQVFVKMAGEGEP CCCCEEHHHCCCCCC | 115973135 | ||
| 2261 | Phosphorylation | PPPPPPLTLVLSSGP CCCCCCEEEEECCCC | 20068231 | ||
| 2265 | Phosphorylation | PPLTLVLSSGPASPP CCEEEEECCCCCCCC | 26657352 | ||
| 2266 | Phosphorylation | PLTLVLSSGPASPPR CEEEEECCCCCCCCH | 29255136 | ||
| 2270 | Phosphorylation | VLSSGPASPPRQAIR EECCCCCCCCHHEEE | 29255136 | ||
| 2282 | Phosphorylation | AIRVKRVSTFSGRSP EEEEEEEECCCCCCC | 26074081 | ||
| 2283 | Phosphorylation | IRVKRVSTFSGRSPP EEEEEEECCCCCCCC | 30108239 | ||
| 2285 | Phosphorylation | VKRVSTFSGRSPPAP EEEEECCCCCCCCCC | 30108239 | ||
| 2288 | Phosphorylation | VSTFSGRSPPAPPPY EECCCCCCCCCCCCC | 30266825 | ||
| 2295 | Phosphorylation | SPPAPPPYKAPRLDE CCCCCCCCCCCCCCC | 26074081 | ||
| 2296 | Acetylation | PPAPPPYKAPRLDED CCCCCCCCCCCCCCC | 19608861 | ||
| 2310 | Phosphorylation | DGEASEDTPQVPGLG CCCCCCCCCCCCCCC | 28555341 | ||
| 2318 | Phosphorylation | PQVPGLGSGGFSRVR CCCCCCCCCCCCCCE | 25159151 | ||
| 2348 | Phosphorylation | GEPAGEESPGPLQER CCCCCCCCCCCCCCC | 23401153 | ||
| 2437 | Phosphorylation | SLEGAWRTLIEKVQE HHCCHHHHHHHHHHH | 28060719 | ||
| 2441 | Acetylation | AWRTLIEKVQEARGH HHHHHHHHHHHHHCC | 25953088 | ||
| 2441 | Ubiquitination | AWRTLIEKVQEARGH HHHHHHHHHHHHHCC | 33845483 | ||
| 2455 | Phosphorylation | HARLRHLSFSGMSGA CCCCCCEEECCCCCC | 28450419 | ||
| 2457 | Phosphorylation | RLRHLSFSGMSGARL CCCCEEECCCCCCHH | 28450419 | ||
| 2460 | Phosphorylation | HLSFSGMSGARLLGI CEEECCCCCCHHCCC | 23186163 | ||
| 2556 | Phosphorylation | LRSTRRATSLELPMA HHHHHCCCCCHHHHH | 28555341 | ||
| 2557 | Phosphorylation | RSTRRATSLELPMAM HHHHCCCCCHHHHHH | 28555341 | ||
| 2572 | Phosphorylation | RFRHLKKTSKEAVGV HHHHHHHCCHHHHHH | 21406692 | ||
| 2573 | Phosphorylation | FRHLKKTSKEAVGVY HHHHHHCCHHHHHHH | 21406692 | ||
| 2580 | Phosphorylation | SKEAVGVYRSAIHGR CHHHHHHHHHHHCCC | 21406692 | ||
| 2604 | Phosphorylation | AGEMVIEYSGIVIRS CCCEEEEECCEEEEE | 19835603 | ||
| 2605 | Phosphorylation | GEMVIEYSGIVIRSV CCEEEEECCEEEEEH | 19835603 | ||
| 2611 | O-linked_Glycosylation | YSGIVIRSVLTDKRE ECCEEEEEHHHCCCH | 30379171 | ||
| 2691 | Ubiquitination | EELTYDYKFPIEDAS CCCCEEECCCHHHCC | - | ||
| 2700 | Ubiquitination | PIEDASNKLPCNCGA CHHHCCCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KMT2B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KMT2B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KMT2B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NCOA6_HUMAN | NCOA6 | physical | 17021013 | |
| PAXI1_HUMAN | PAXIP1 | physical | 17500065 | |
| RBBP5_HUMAN | RBBP5 | physical | 17500065 | |
| ASH2L_HUMAN | ASH2L | physical | 17500065 | |
| WDR5_HUMAN | WDR5 | physical | 22665483 | |
| H32_HUMAN | HIST2H3C | physical | 22266653 | |
| H31_HUMAN | HIST1H3A | physical | 23870121 | |
| WDR5_HUMAN | WDR5 | physical | 27563068 | |
| RBBP5_HUMAN | RBBP5 | physical | 27563068 | |
| ASH2L_HUMAN | ASH2L | physical | 27563068 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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