dbPTM

B2CL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	B2CL2_HUMAN
UniProt AC	Q92843
Protein Name	Bcl-2-like protein 2
Gene Name	BCL2L2
Organism	Homo sapiens (Human).
Sequence Length	193
Subcellular Localization	Mitochondrion membrane Peripheral membrane protein . Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Protein Description	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX..
Protein Sequence	MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATPASAPD ------CCCCCCCCC	23.45	19413330
20	Phosphorylation	LVADFVGYKLRQKGY HHHHHHCHHHHHCCC	11.10	26437602
60	Phosphorylation	FETRFRRTFSDLAAQ HHHHHHHHHHHHHHH	24.20	28857561
62	Phosphorylation	TRFRRTFSDLAAQLH HHHHHHHHHHHHHHC	30.97	26657352
162 (in isoform 2)	Ubiquitination	-	4.94	-
164 (in isoform 2)	Ubiquitination	-	62.56	-
172	Phosphorylation	GNWASVRTVLTGAVA CCCHHHHHHHHHHHH	20.08	22817900
175	Phosphorylation	ASVRTVLTGAVALGA HHHHHHHHHHHHHHH	20.82	22817900
177 (in isoform 2)	Phosphorylation	-	4.34	20068231
192	Phosphorylation	TVGAFFASK------ HHHHHHCCC------	33.47	18187866
193	Ubiquitination	VGAFFASK------- HHHHHCCC-------	62.01	-
224 (in isoform 2)	Phosphorylation	-		-
234 (in isoform 2)	Acetylation	-		-
234 (in isoform 2)	Ubiquitination	-		-
244 (in isoform 2)	Phosphorylation	-		-
254 (in isoform 2)	Methylation	-		-
262 (in isoform 2)	Phosphorylation	-		24275569
265 (in isoform 2)	Methylation	-		-
267 (in isoform 2)	Methylation	-		-
286 (in isoform 2)	Methylation	-		24129315
290 (in isoform 2)	Methylation	-		24129315
294 (in isoform 2)	Dimethylation	-		-
304 (in isoform 2)	Methylation	-		-
314 (in isoform 2)	Methylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of B2CL2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of B2CL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of B2CL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2L11_HUMAN	BCL2L11	physical	9731710
BAD_HUMAN	BAD	physical	15694340
HRK_HUMAN	HRK	physical	15694340
BID_HUMAN	BID	physical	15694340
BAD_HUMAN	BAD	physical	12115603
PP1A_HUMAN	PPP1CA	physical	12115603
BAD_HUMAN	BAD	physical	11483855
BAX_HUMAN	BAX	physical	10381646
BAD_HUMAN	BAD	physical	10381646
BAK_HUMAN	BAK1	physical	10381646
BIK_HUMAN	BIK	physical	10381646
P53_HUMAN	TP53	physical	24491548
PRKN_HUMAN	PARK2	physical	24999239
PINK1_HUMAN	PINK1	physical	24999239
BIK_HUMAN	BIK	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
FATE1_HUMAN	FATE1	physical	25416956
BMF_HUMAN	BMF	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
BID_HUMAN	BID	physical	16697956
B2L11_HUMAN	BCL2L11	physical	16697956
BAD_HUMAN	BAD	physical	16697956
BIK_HUMAN	BIK	physical	16697956
BBC3B_HUMAN	BBC3	physical	28514442
BBC3_HUMAN	BBC3	physical	28514442
BAX_HUMAN	BAX	physical	28514442
BID_HUMAN	BID	physical	28514442
B2L11_HUMAN	BCL2L11	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
P53_HUMAN	TP53	physical	25115399
BAK_HUMAN	BAK1	physical	25115399

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D09935	Navitoclax (USAN/INN)
D09936	Navitoclax dihydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of B2CL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, AND MASSSPECTROMETRY.	18187866 [Abstract]