WDR90_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR90_HUMAN
• UniProt AC: Q96KV7
• Protein Name: WD repeat-containing protein 90
• Gene Name: WDR90
• Organism: Homo sapiens (Human).
• Sequence Length: 1748
• Protein Sequence: MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKSSTQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPLVLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCYGHLKSIRLCASLLVRNLYTSDLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDRYIHVRFPSESLKVPSKPIEKSCSPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTASGRAALAPRPFPEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEKIPLPFFAMSLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFTPSARLLFTAARNEILVWEVPGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	DEWKRSAKQGDVAVV HHHHHHHCCCCEEEE	56.94	29967540
34	Phosphorylation	QGDVAVVTDKTLKGA CCCEEEEECCCCCCE	25.77	29083192
36	Ubiquitination	DVAVVTDKTLKGAVY CEEEEECCCCCCEEE	46.52	29967540
37	Phosphorylation	VAVVTDKTLKGAVYR EEEEECCCCCCEEEE	36.19	29083192
48	Phosphorylation	AVYRIRGSVSAANYI EEEEEECCCCCCCEE	11.75	29978859
50	Phosphorylation	YRIRGSVSAANYIQL EEEECCCCCCCEEEC	24.30	29978859
54	Phosphorylation	GSVSAANYIQLPKSS CCCCCCCEEECCCCC	5.82	29978859
71	Phosphorylation	SLGLTGRYLYVLFRP CCCCCCEEEEEEEEE	12.06	-
73	Phosphorylation	GLTGRYLYVLFRPLP CCCCEEEEEEEEECC	6.03	-
81	Phosphorylation	VLFRPLPSKHFVIHL EEEEECCCCCEEEEE	46.58	24719451
111	Phosphorylation	NLFKEFKSTATWLQF HHHHHHHHCCHHHHC	28.70	27732954
112	Phosphorylation	LFKEFKSTATWLQFP HHHHHHHCCHHHHCC	28.79	27732954
114	Phosphorylation	KEFKSTATWLQFPLV HHHHHCCHHHHCCEE	27.14	27732954
126	Phosphorylation	PLVLEARTPQRDLVG CEEEEECCCCCCCEE	30.71	28555341
199	Phosphorylation	QWAKLPVTPMPREMA CCCCCCCCCCCHHHC	16.36	23403867
226	Phosphorylation	YIHVRFPSESLKVPS EEEEECCCHHCCCCC	36.79	26657352
228	Phosphorylation	HVRFPSESLKVPSKP EEECCCHHCCCCCCC	37.52	26657352
239	Phosphorylation	PSKPIEKSCSPPEAV CCCCCCCCCCCCCEE	13.67	24719451
241	Phosphorylation	KPIEKSCSPPEAVLL CCCCCCCCCCCEEEE	51.05	25159151
270	Phosphorylation	KPVRFSVSPVVQTPS CCCEEEEECCCCCCC	15.69	28348404
275	Phosphorylation	SVSPVVQTPSPTASG EEECCCCCCCCCCCC	17.71	27251275
277	Phosphorylation	SPVVQTPSPTASGRA ECCCCCCCCCCCCCE	37.97	24719451
347	Phosphorylation	AEVPVARTGSCEGFL CCCCCCCCCCCCCCC	24.57	28450419
349	Phosphorylation	VPVARTGSCEGFLPD CCCCCCCCCCCCCCC	14.37	21130716
413	Phosphorylation	LGHTDKVSALALDGS CCCCCCCEEEEECCC	24.25	27542207
420	Phosphorylation	SALALDGSSSLLASA EEEEECCCHHHHHHH	19.20	27542207
421	Phosphorylation	ALALDGSSSLLASAQ EEEECCCHHHHHHHH	30.45	27542207
422	Phosphorylation	LALDGSSSLLASAQA EEECCCHHHHHHHHH	29.15	27542207
426	Phosphorylation	GSSSLLASAQARAPS CCHHHHHHHHHCCCC	22.38	27542207
433	Phosphorylation	SAQARAPSVMRLWDF HHHHCCCCCEEHHHC	27.79	22617229
522	Phosphorylation	FDETRMASCGQGSVR CCCCCCCCCCCCCEE	14.94	-
603	Phosphorylation	RRLLPTRTPGGPHPQ HHHCCCCCCCCCCCC	28.85	-
854	Phosphorylation	LLAFVGPSRCTVTVM EEEEECCCCEEEEEE	33.78	17192257
903	Phosphorylation	ALGHLLVSTSSNRVV HHHHHEEECCCCEEE	23.65	22210691
1046	Phosphorylation	VPKPCQASPPRLGVC CCCCCCCCCCCCEEE	15.01	23403867
1084	Phosphorylation	LASCKAFTPARVSCS EEECCCCCCCEEEEC	22.39	24719451
1091	Phosphorylation	TPARVSCSPHSAKGT CCCEEEECCCCCCCC	20.38	28348404
1223	Phosphorylation	PDDRLLVTLGDHDGR CCCCEEEEEECCCCC	25.62	25332170
1286	Phosphorylation	QQRGADISLQVRREP EECCCCEEEEEECCC	17.19	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR90_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR90_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR90_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGT1_HUMAN	SUGT1	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
DPP8_HUMAN	DPP8	physical	26186194
CLU_HUMAN	CLUH	physical	28514442
DPP8_HUMAN	DPP8	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-854, AND MASSSPECTROMETRY.
PubMed: 18691976