MED21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED21_HUMAN
• UniProt AC: Q13503
• Protein Name: Mediator of RNA polymerase II transcription subunit 21
• Gene Name: MED21
• Organism: Homo sapiens (Human).
• Sequence Length: 144
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
• Protein Sequence: MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Ubiquitination	ALIARTAKDIDVLID HHHHHHHHHHCHHHH	55.38	-
91	Phosphorylation	ALQAASLYKLEEENH HHHHHHHHHHHHCCH	15.84	-
92	Ubiquitination	LQAASLYKLEEENHE HHHHHHHHHHHCCHH	55.50	-
131	Ubiquitination	DIAQSQLKTRSGTHS HHHHHHHHCCCCCCC	33.97	21890473
138	Phosphorylation	KTRSGTHSQSLPDS- HCCCCCCCCCCCCC-	22.69	24719451
144	Phosphorylation	HSQSLPDS------- CCCCCCCC-------	39.93	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T2EA_HUMAN	GTF2E1	physical	9159119
T2FA_HUMAN	GTF2F1	physical	9159119
TF2H4_HUMAN	GTF2H4	physical	9159119
CBP_HUMAN	CREBBP	physical	9710619
RPB1_HUMAN	POLR2A	physical	9710619
KAT2B_HUMAN	KAT2B	physical	9710619
SNF5_HUMAN	SMARCB1	physical	9710619
MED6_HUMAN	MED6	physical	9734358
MED14_HUMAN	MED14	physical	9734358
RPB1_HUMAN	POLR2A	physical	9315662
TF2B_HUMAN	GTF2B	physical	9315662
T2FA_HUMAN	GTF2F1	physical	9315662
CDK7_HUMAN	CDK7	physical	9315662
CDK8_HUMAN	CDK8	physical	9315662
TCRG1_HUMAN	TCERG1	physical	9315662
PHS2_HUMAN	PCBD2	physical	20211142
ZSCA1_HUMAN	ZSCAN1	physical	20211142
SKP1_HUMAN	SKP1	physical	22479149
MED29_HUMAN	MED29	physical	22939629
MED6_HUMAN	MED6	physical	22939629
MED22_HUMAN	MED22	physical	22939629
MED8_HUMAN	MED8	physical	22939629
MED24_HUMAN	MED24	physical	22939629
MED4_HUMAN	MED4	physical	22939629
MED28_HUMAN	MED28	physical	22939629
MED21_HUMAN	MED21	physical	25416956
BL1S6_HUMAN	BLOC1S6	physical	25416956
ZN655_HUMAN	ZNF655	physical	25416956
SRCRL_HUMAN	SSC5D	physical	25416956
MED7_HUMAN	MED7	physical	28514442
MED19_HUMAN	MED19	physical	28514442
MED1_HUMAN	MED1	physical	28514442
MED18_HUMAN	MED18	physical	28514442
CCNC_HUMAN	CCNC	physical	28514442
MED26_HUMAN	MED26	physical	28514442
MED27_HUMAN	MED27	physical	28514442
MED10_HUMAN	MED10	physical	28514442
MED30_HUMAN	MED30	physical	28514442
MED28_HUMAN	MED28	physical	28514442
MED17_HUMAN	MED17	physical	28514442
MED9_HUMAN	MED9	physical	28514442
MED13_HUMAN	MED13	physical	28514442
MED11_HUMAN	MED11	physical	28514442
DHRS3_HUMAN	DHRS3	physical	28514442
MED24_HUMAN	MED24	physical	28514442
MED14_HUMAN	MED14	physical	28514442
MD13L_HUMAN	MED13L	physical	28514442
MD12L_HUMAN	MED12L	physical	28514442
MED20_HUMAN	MED20	physical	28514442
MED6_HUMAN	MED6	physical	28514442
MED8_HUMAN	MED8	physical	28514442
MED22_HUMAN	MED22	physical	28514442
MED4_HUMAN	MED4	physical	28514442
MED12_HUMAN	MED12	physical	28514442
MED16_HUMAN	MED16	physical	28514442
FXL19_HUMAN	FBXL19	physical	28514442
CDK8_HUMAN	CDK8	physical	28514442
MED23_HUMAN	MED23	physical	28514442
CDK19_HUMAN	CDK19	physical	28514442
MED29_HUMAN	MED29	physical	28514442
MED25_HUMAN	MED25	physical	28514442
MED31_HUMAN	MED31	physical	28514442
MED15_HUMAN	MED15	physical	28514442
VAMP8_HUMAN	VAMP8	physical	28514442
VTI1B_HUMAN	VTI1B	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
SRC_HUMAN	SRC	physical	28514442
ULBP2_HUMAN	ULBP2	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
EEPD1_HUMAN	EEPD1	physical	28514442
PTPRG_HUMAN	PTPRG	physical	28514442
KIF2C_HUMAN	KIF2C	physical	28514442
RPB11_HUMAN	POLR2J	physical	28514442
FACE1_HUMAN	ZMPSTE24	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
FYN_HUMAN	FYN	physical	28514442
YES_HUMAN	YES1	physical	28514442
BRE1B_HUMAN	RNF40	physical	28514442
HPCL1_HUMAN	HPCAL1	physical	28514442
GNAZ_HUMAN	GNAZ	physical	28514442
ABLM1_HUMAN	ABLIM1	physical	28514442
PALM_HUMAN	PALM	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
NEUM_HUMAN	GAP43	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
KC1G3_HUMAN	CSNK1G3	physical	28514442
STX8_HUMAN	STX8	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
ASM3B_HUMAN	SMPDL3B	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
EFNA5_HUMAN	EFNA5	physical	28514442
SGPL1_HUMAN	SGPL1	physical	28514442
PHAG1_HUMAN	PAG1	physical	28514442
SCPDL_HUMAN	SCCPDH	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
I5P1_HUMAN	INPP5A	physical	28514442
RPB4_HUMAN	POLR2D	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
MYZAP_HUMAN	POLR2M	physical	28514442
GRL1A_HUMAN	POLR2M	physical	28514442
GL1AD_HUMAN	POLR2M	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
CNTN1_HUMAN	CNTN1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.