HPCL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPCL1_HUMAN
• UniProt AC: P37235
• Protein Name: Hippocalcin-like protein 1
• Gene Name: HPCAL1
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation..
• Protein Sequence: MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRSEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGKQNSKLR ------CCCCCCCCC	40.01	-
2	Myristoylation	------MGKQNSKLR ------CCCCCCCCC	40.01	25255805
7	Ubiquitination	-MGKQNSKLRPEVLQ -CCCCCCCCCHHHHH	56.94	21890473
23	Phosphorylation	LRENTEFTDHELQEW HHHCCCCCHHHHHHH	30.16	-
31	Phosphorylation	DHELQEWYKGFLKDC HHHHHHHHHHHHHCC	10.65	23663014
32	Ubiquitination	HELQEWYKGFLKDCP HHHHHHHHHHHHCCC	44.23	-
36	Ubiquitination	EWYKGFLKDCPTGHL HHHHHHHHCCCCCCC	55.83	-
49	Acetylation	HLTVDEFKKIYANFF CCCHHHHHHHHHHCC	35.89	27452117
49	2-Hydroxyisobutyrylation	HLTVDEFKKIYANFF CCCHHHHHHHHHHCC	35.89	-
50	Methylation	LTVDEFKKIYANFFP CCHHHHHHHHHHCCC	46.39	16209589
50	Ubiquitination	LTVDEFKKIYANFFP CCHHHHHHHHHHCCC	46.39	-
52	Phosphorylation	VDEFKKIYANFFPYG HHHHHHHHHHCCCCC	12.36	-
58	Phosphorylation	IYANFFPYGDASKFA HHHHCCCCCCHHHHH	23.60	27642862
63	Ubiquitination	FPYGDASKFAEHVFR CCCCCHHHHHHHHHH	50.76	21890473
102	Methylation	GKLEQKLKWAFSMYD CHHHHHHHHCCEEEE	43.44	23644510
106	Phosphorylation	QKLKWAFSMYDLDGN HHHHHCCEEEECCCC	14.53	-
115	Phosphorylation	YDLDGNGYISRSEML EECCCCCEECHHHHH	10.34	22817900
119	Phosphorylation	GNGYISRSEMLEIVQ CCCEECHHHHHHHHH	22.14	21712546
129	Phosphorylation	LEIVQAIYKMVSSVM HHHHHHHHHHHHHHH	8.96	-
137	Ubiquitination	KMVSSVMKMPEDEST HHHHHHHCCCCCCCC	49.50	21890473
143	Phosphorylation	MKMPEDESTPEKRTD HCCCCCCCCCCHHHH	62.68	29255136
144	Phosphorylation	KMPEDESTPEKRTDK CCCCCCCCCCHHHHH	33.16	29255136
174	Ubiquitination	EEFIRGAKSDPSIVR HHHHHHCCCCHHHHH	59.21	-
174	Malonylation	EEFIRGAKSDPSIVR HHHHHHCCCCHHHHH	59.21	26320211
175	Phosphorylation	EFIRGAKSDPSIVRL HHHHHCCCCHHHHHH	54.97	26657352
178	Phosphorylation	RGAKSDPSIVRLLQC HHCCCCHHHHHHHCC	38.41	27251275
191	Phosphorylation	QCDPSSASQF----- CCCCCCCCCC-----	33.78	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPCL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPCL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPCL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DTX2_HUMAN	DTX2	physical	16189514
HM20A_HUMAN	HMG20A	physical	16189514
KRA59_HUMAN	KRTAP5-9	physical	25416956
HM20A_HUMAN	HMG20A	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
C1QT2_HUMAN	C1QTNF2	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.