ASM3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASM3B_HUMAN
• UniProt AC: Q92485
• Protein Name: Acid sphingomyelinase-like phosphodiesterase 3b
• Gene Name: SMPDL3B
• Organism: Homo sapiens (Human).
• Sequence Length: 455
• Subcellular Localization: Secreted. Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Lipid-modulating phosphodiesterase. [PubMed: 26095358 Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity]
• Protein Sequence: MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQVDIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	N-linked_Glycosylation	DSPWALINSSIYAMK CCHHHHHHHHHEEEC	30.47	UniProtKB CARBOHYD
116	Phosphorylation	LEIVERLTKLIREVF HHHHHHHHHHHHHHC	29.99	-
164	N-linked_Glycosylation	LWKPWLSNESIALFK HHHHHHCCCCHHHEC	44.88	UniProtKB CARBOHYD
176	Phosphorylation	LFKKGAFYCEKLPGP HECCCCEEEECCCCC	10.12	22817900
248	Acetylation	FFEKTQNKAWFREGF HHHHHCCHHHHHHCC	36.86	30592543
295	Phosphorylation	DDAGVPISAMFITPG CCCCCCEEEEEECCC	13.96	-
343	N-linked_Glycosylation	DMVTYFMNLSQANAQ HHHHHHHCHHHHCCC	27.00	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASM3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASM3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASM3B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ASM3B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.