I5P1_HUMAN - dbPTM
I5P1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I5P1_HUMAN
UniProt AC Q14642
Protein Name Type I inositol 1,4,5-trisphosphate 5-phosphatase
Gene Name INPP5A
Organism Homo sapiens (Human).
Sequence Length 412
Subcellular Localization Membrane
Lipid-anchor.
Protein Description Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction..
Protein Sequence MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45AcetylationYQVVHTHKPHFMALH
HHHHHHCCCCEEEEE		41.1530589509
70UbiquitinationASMSHVDKFVKELLS
HHHHHHHHHHHHHHC		51.4722817900
73UbiquitinationSHVDKFVKELLSSDA
HHHHHHHHHHHCCHH		45.8622817900
82UbiquitinationLLSSDAMKEYNRARV
HHCCHHHHHHHHHHH		59.7832015554
84PhosphorylationSSDAMKEYNRARVYL
CCHHHHHHHHHHHHC		12.3925690035
90PhosphorylationEYNRARVYLDENYKS
HHHHHHHHCCCCCCC		11.6822817900
137PhosphorylationVAGKEIYSDTLESTP
HCCCEECCCCCCCCC		29.76-
143PhosphorylationYSDTLESTPMLEKEK
CCCCCCCCCCCCCCC		11.89-
144UbiquitinationSDTLESTPMLEKEKF
CCCCCCCCCCCCCCC		34.3433845483
185UbiquitinationFDLVNIHLFHDASNL
HHEEEEEEEECCCCC		3.4532015554
201UbiquitinationAWETSPSVYSGIRHK
EECCCHHHHHCHHHH		5.1121890473
207UbiquitinationSVYSGIRHKALGYVL
HHHHCHHHHHHHHHH		20.1621890473
208UbiquitinationVYSGIRHKALGYVLD
HHHCHHHHHHHHHHH		35.1433845483
219UbiquitinationYVLDRIIDQRFEKVS
HHHHHHHHHHCCEEE		31.0922817900
220UbiquitinationVLDRIIDQRFEKVSY
HHHHHHHHHCCEEEE		41.3721890473
225UbiquitinationIDQRFEKVSYFVFGD
HHHHCCEEEEEEECC		4.4022817900
226UbiquitinationDQRFEKVSYFVFGDF
HHHCCEEEEEEECCC		24.7421890473
239PhosphorylationDFNFRLDSKSVVETL
CCCCCCCCHHHHHHH		31.2729083192
241PhosphorylationNFRLDSKSVVETLCT
CCCCCCHHHHHHHHH		35.0329083192
243UbiquitinationRLDSKSVVETLCTKA
CCCCHHHHHHHHHHH		6.3321890473
245PhosphorylationDSKSVVETLCTKATM
CCHHHHHHHHHHHHH		18.6128509920
248PhosphorylationSVVETLCTKATMQTV
HHHHHHHHHHHHHHH		27.1628509920
249UbiquitinationVVETLCTKATMQTVR
HHHHHHHHHHHHHHH		40.6421890473
265UbiquitinationADTNEVVKLIFRESD
CCCCCCEEEEEECCC		40.8321890473
271PhosphorylationVKLIFRESDNDRKVM
EEEEEECCCCCCCHH		37.1424961811
283UbiquitinationKVMLQLEKKLFDYFN
CHHHHHHHHHHHHHC		64.4722817900
284UbiquitinationVMLQLEKKLFDYFNQ
HHHHHHHHHHHHHCH		45.0421890473
288PhosphorylationLEKKLFDYFNQEVFR
HHHHHHHHHCHHHHC		9.3327642862
294UbiquitinationDYFNQEVFRDNNGTA
HHHCHHHHCCCCCCE		8.8121890473
300UbiquitinationVFRDNNGTALLEFDK
HHCCCCCCEEEEEHH		19.0921890473
307UbiquitinationTALLEFDKELSVFKD
CEEEEEHHHHHHHHH		66.9121890473
356PhosphorylationDRILMSPSAKELVLR
CHHHCCCCHHHHHHC		44.6725307156
358UbiquitinationILMSPSAKELVLRSE
HHCCCCHHHHHHCCC		56.7922817900
400"N6,N6-dimethyllysine"RIMPGAGKPHAHVHK
EECCCCCCCCCEEEE		32.85-
400MethylationRIMPGAGKPHAHVHK
EECCCCCCCCCEEEE		32.85-
407MethylationKPHAHVHKCCVVQ--
CCCCEEEECEEEC--		28.39-
407"N6,N6-dimethyllysine"KPHAHVHKCCVVQ--
CCCCEEEECEEEC--		28.39-
409MethylationHAHVHKCCVVQ----
CCEEEECEEEC----		3.91-
409FarnesylationHAHVHKCCVVQ----
CCEEEECEEEC----		3.918626616
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I5P1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I5P1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I5P1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TTC1_HUMANTTC1physical
26186194
RCCD1_HUMANRCCD1physical
26186194
ZG16B_HUMANZG16Bphysical
26186194
ITFG2_HUMANITFG2physical
26186194
ITFG2_HUMANITFG2physical
28514442
RCCD1_HUMANRCCD1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I5P1_HUMAN

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Related Literatures of Post-Translational Modification

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