RCCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCCD1_HUMAN
• UniProt AC: A6NED2
• Protein Name: RCC1 domain-containing protein 1
• Gene Name: RCCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Chromosome . Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).
• Protein Description: Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3. [PubMed: 24981860 Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8]
• Protein Sequence: MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Methylation	GQELGSGRGRQVHSP CCCCCCCCCCCCCCC	38.53	115383225
27	Methylation	ELGSGRGRQVHSPSP CCCCCCCCCCCCCCC	33.71	115383231
31	Phosphorylation	GRGRQVHSPSPLRAG CCCCCCCCCCCCCCC	28.37	29396449
33	Phosphorylation	GRQVHSPSPLRAGVD CCCCCCCCCCCCCCC	39.31	29396449
45	Phosphorylation	GVDICRVSASWSYTA CCCEEEEECCEEEEE	9.38	24043423
47	Phosphorylation	DICRVSASWSYTAFV CEEEEECCEEEEEEE	14.73	24043423
49	Phosphorylation	CRVSASWSYTAFVTR EEEECCEEEEEEEEE	15.31	24043423
50	Phosphorylation	RVSASWSYTAFVTRG EEECCEEEEEEEEEC	8.88	24043423
51	Phosphorylation	VSASWSYTAFVTRGG EECCEEEEEEEEECC	14.22	24043423
55	Phosphorylation	WSYTAFVTRGGRLEL EEEEEEEEECCEEEE	19.69	24043423
56	Methylation	SYTAFVTRGGRLELS EEEEEEEECCEEEEE	40.02	30760837
74	Ubiquitination	SGAAGRCKDAWASEG CCCCCCCCHHHHHCC	49.47	-
141	Hydroxylation	LPLLPCARAYVSPRA CCCHHCCCCCCCCCC	32.92	29563586
145	Phosphorylation	PCARAYVSPRAPFYR HCCCCCCCCCCCCCC	8.94	24719451
181	Phosphorylation	DAAGQVFSWGGGRHG HHCCCEEEECCCCCC	26.42	-
261	Phosphorylation	ETVAREATELNEDGS CHHHHHHHHHCCCCC	35.93	29507054
268	Phosphorylation	TELNEDGSQVKRTGG HHHCCCCCCEEECCC	44.09	26699800
271	Ubiquitination	NEDGSQVKRTGGAED CCCCCCEEECCCCCC	36.28	21890473
304	Ubiquitination	PMGSDAVKASCGSRH CCCCHHHHHHCCCCC	35.98	-
328	Ubiquitination	LYTWGWGKYGQLGHE EEEECCCCCCCCCCC	39.43	-
352	Ubiquitination	RVEYFVDKQLQVKAV CEEEEECCCCEEEEE	47.83	-
373	Ubiquitination	TYVYAVEKGKS---- EEEEEECCCCC----	66.11	21890473
375	Ubiquitination	VYAVEKGKS------ EEEECCCCC------	65.15	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCCD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
141	R	Hydroxylation	Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8.	29563586

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCTD9_HUMAN	KCTD9	physical	28514442
KDM8_HUMAN	KDM8	physical	28514442
JIP3_HUMAN	MAPK8IP3	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
T22D3_HUMAN	TSC22D3	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
DDHD2_HUMAN	DDHD2	physical	28514442
CE034_HUMAN	C5orf34	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
RB3GP_HUMAN	RAB3GAP1	physical	28514442
ZN609_HUMAN	ZNF609	physical	28514442
SALL2_HUMAN	SALL2	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
GLI3_HUMAN	GLI3	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.