DDHD2_HUMAN - dbPTM
DDHD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDHD2_HUMAN
UniProt AC O94830
Protein Name Phospholipase DDHD2
Gene Name DDHD2
Organism Homo sapiens (Human).
Sequence Length 711
Subcellular Localization Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERG
Protein Description Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane..
Protein Sequence MSSVQSQQEQLSQSDPSPSPNSCSSFELIDMDAGSLYEPVSPHWFYCKIIDSKETWIPFNSEDSQQLEEAYSSGKGCNGRVVPTDGGRYDVHLGERMRYAVYWDELASEVRRCTWFYKGDKDNKYVPYSESFSQVLEETYMLAVTLDEWKKKLESPNREIIILHNPKLMVHYQPVAGSDDWGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHSTGVDVDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKDSLGDIDSEKDSLNIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNSMGIKRPAPQPASGANIPKESEFCSSSNTRNGDYLDVGIGQVSVKYPRLIYKPEIFFAFGSPIGMFLTVRGLKRIDPNYRFPTCKGFFNIYHPFDPVAYRIEPMVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53UbiquitinationYCKIIDSKETWIPFN
EEEECCCCCCEECCC		56.25-
75UbiquitinationEEAYSSGKGCNGRVV
HHHHHCCCCCCCEEE		63.34-
128PhosphorylationKDNKYVPYSESFSQV
CCCCEEECCHHHHHH		18.28-
129PhosphorylationDNKYVPYSESFSQVL
CCCEEECCHHHHHHH		22.24-
155PhosphorylationEWKKKLESPNREIII
HHHHHCCCCCCEEEE		37.6028555341
178PhosphorylationHYQPVAGSDDWGSTP
EEECCCCCCCCCCCC		23.7429978859
183PhosphorylationAGSDDWGSTPTEQGR
CCCCCCCCCCCCCCC		27.2729978859
184PhosphorylationGSDDWGSTPTEQGRP
CCCCCCCCCCCCCCC		30.2329978859
186PhosphorylationDDWGSTPTEQGRPRT
CCCCCCCCCCCCCCC		40.8229978859
206UbiquitinationENISVDIHCGEPLQI
CEEEEEEECCCCEEC		14.7421890473
218UbiquitinationLQIDHLVFVVHGIGP
EECCEEEEEECCCCC		6.30-
254MethylationNLLQTHFKKAQENQQ
HHHHHHHHHHHHHCC		39.33-
373PhosphorylationDSLGDIDSEKDSLNI
CCCCCCCCCCCCEEE		47.0527251275
413UbiquitinationFEKEKVDKEALALCT
HHHHCCCHHHHHHHC		48.12-
447PhosphorylationYFSTRKNSMGIKRPA
HHHCCCCCCCCCCCC		22.7826657352
480PhosphorylationSNTRNGDYLDVGIGQ
CCCCCCCEEEECCEE		13.24-
525PhosphorylationLKRIDPNYRFPTCKG
CCCCCCCCCCCCCCC		21.0122210691
580PhosphorylationLELREGLTRMSMDLK
HHHHHHHHHHCHHHH		34.8728842319
583PhosphorylationREGLTRMSMDLKNNL
HHHHHHHCHHHHHCH		13.0723684312
587UbiquitinationTRMSMDLKNNLLGSL
HHHCHHHHHCHHHHH		39.2521890473
587MethylationTRMSMDLKNNLLGSL
HHHCHHHHHCHHHHH		39.25-
587UbiquitinationTRMSMDLKNNLLGSL
HHHCHHHHHCHHHHH		39.2521890473
593PhosphorylationLKNNLLGSLRMAWKS
HHHCHHHHHHHHHHH		16.8723401153
599UbiquitinationGSLRMAWKSFTRAPY
HHHHHHHHHHHCCCC		26.59-
600PhosphorylationSLRMAWKSFTRAPYP
HHHHHHHHHHCCCCH		22.5828857561
602PhosphorylationRMAWKSFTRAPYPAL
HHHHHHHHCCCCHHH		32.7724719451
637PhosphorylationSDVNTEETSVAVKEE
CCCCCCCCEEEEEEC		23.4427732954
638PhosphorylationDVNTEETSVAVKEEV
CCCCCCCEEEEEECC		16.0327732954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDHD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDHD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDHD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
S23IP_HUMANSEC23IPphysical
26186194
EF1A2_HUMANEEF1A2physical
26186194
S23IP_HUMANSEC23IPphysical
28514442
CH3L1_HUMANCHI3L1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615033Spastic paraplegia 54, autosomal recessive (SPG54)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDHD2_HUMAN

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Related Literatures of Post-Translational Modification

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