PTPRG_HUMAN - dbPTM
PTPRG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTPRG_HUMAN
UniProt AC P23470
Protein Name Receptor-type tyrosine-protein phosphatase gamma
Gene Name PTPRG
Organism Homo sapiens (Human).
Sequence Length 1445
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description Possesses tyrosine phosphatase activity..
Protein Sequence MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYLFRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPTAASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGEKDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAESMESLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationWILFLKITSSVLHYV
HHHHHHHHHHHHHHH		17.2327174698
18PhosphorylationILFLKITSSVLHYVV
HHHHHHHHHHHHHHH		23.1727174698
19PhosphorylationLFLKITSSVLHYVVC
HHHHHHHHHHHHHHH		21.7627174698
23PhosphorylationITSSVLHYVVCFPAL
HHHHHHHHHHHHHHH		7.1627174698
31PhosphorylationVVCFPALTEGYVGAL
HHHHHHHCCCCCHHH		29.4827174698
34PhosphorylationFPALTEGYVGALHEN
HHHHCCCCCHHHCCC		6.8927174698
109N-linked_GlycosylationLQLDGFDNESSNKTW
CCCCCCCCCCCCCEE		49.11UniProtKB CARBOHYD
113N-linked_GlycosylationGFDNESSNKTWMKNT
CCCCCCCCCEECCCC		55.8716335952
132PhosphorylationAILLKDDYFVSGAGL
EEEEECCEECCCCCC		18.93-
156N-linked_GlycosylationEFHWGHSNGSAGSEH
EEEECCCCCCCCCCC		42.64UniProtKB CARBOHYD
320PhosphorylationHDRVVSKSAVRDSWN
HHHCCCHHHHHHCCC		25.21-
325PhosphorylationSKSAVRDSWNHDMTD
CHHHHHHCCCCCHHH		21.15-
359N-linked_GlycosylationHMKVQPLNQTALQVS
EEEEECCCCCEEECC		43.79UniProtKB CARBOHYD
397PhosphorylationNEDEKEKTFTKDSDK
CCCCCCCCCCCCCHH		37.3129083192
399PhosphorylationDEKEKTFTKDSDKDL
CCCCCCCCCCCHHHH		38.8929083192
419PhosphorylationHVSPDSLYLFRVQAV
CCCCCCEEEEEHHHH		14.03-
433PhosphorylationVCRNDMRSDFSQTML
HHCCCCCCCCCCEEE		36.05-
436PhosphorylationNDMRSDFSQTMLFQA
CCCCCCCCCEEEEEC		29.7222210691
438PhosphorylationMRSDFSQTMLFQANT
CCCCCCCEEEEECCC		18.0422210691
444N-linked_GlycosylationQTMLFQANTTRIFQG
CEEEEECCCCEEECC		31.0616335952
446PhosphorylationMLFQANTTRIFQGTR
EEEECCCCEEECCCE		22.9022210691
452PhosphorylationTTRIFQGTRIVKTGV
CCEEECCCEEEEECC		13.3629507054
514O-linked_GlycosylationVASVVTSTLLAGLGF
HHHHHHHHHHCCCCC		19.20OGP
561O-linked_GlycosylationATTEALASPGPDGDS
CCHHHHCCCCCCCCC		31.10OGP
577PhosphorylationPTKDGEGTEEGEKDE
CCCCCCCCCCCCCCC		26.9328509920
619N-linked_GlycosylationTHAAEERNQTEPSPT
CHHHHHHCCCCCCCC		57.30UniProtKB CARBOHYD
631N-linked_GlycosylationSPTPSSPNRTAEGGH
CCCCCCCCCCCCCCC		56.75UniProtKB CARBOHYD
633O-linked_GlycosylationTPSSPNRTAEGGHQT
CCCCCCCCCCCCCCC		35.3855824521
640O-linked_GlycosylationTAEGGHQTIPGHEQD
CCCCCCCCCCCCCCC		24.3855824527
649O-linked_GlycosylationPGHEQDHTAVPTDQT
CCCCCCCCCCCCCCC		37.3355824533
653O-linked_GlycosylationQDHTAVPTDQTGGRR
CCCCCCCCCCCCCCC		33.8555824537
656PhosphorylationTAVPTDQTGGRRDAG
CCCCCCCCCCCCCCC		44.4026074081
656O-linked_GlycosylationTAVPTDQTGGRRDAG
CCCCCCCCCCCCCCC		44.4055824543
672PhosphorylationGLDPDMVTSTQVPPT
CCCHHHCEECCCCCC		21.3026074081
673PhosphorylationLDPDMVTSTQVPPTA
CCHHHCEECCCCCCC		12.8726074081
674PhosphorylationDPDMVTSTQVPPTAT
CHHHCEECCCCCCCC		24.9926074081
679PhosphorylationTSTQVPPTATEEQYA
EECCCCCCCCHHHHC		39.8926074081
681PhosphorylationTQVPPTATEEQYAGS
CCCCCCCCHHHHCCC		42.4026074081
708O-linked_GlycosylationMSRGDRFSEDSRFIT
CCCCCCCCCCCCCEE		41.19OGP
715O-linked_GlycosylationSEDSRFITVNPAEKN
CCCCCCEECCCCCCC		16.1255833847
722N-linked_GlycosylationTVNPAEKNTSGMISR
ECCCCCCCCCCCCCC		30.86UniProtKB CARBOHYD
782PhosphorylationRRFREVPSSGERGEK
CCCEECCCCCCCCCC		57.0323312004
783PhosphorylationRFREVPSSGERGEKG
CCEECCCCCCCCCCC		38.3123312004
801PhosphorylationCFQTAHFYVEDSSSP
CCCEEEEEEECCCCC		7.9627642862
802 (in isoform 2)Ubiquitination-6.87-
806 (in isoform 2)Ubiquitination-57.60-
815PhosphorylationPRVVPNESIPIIPIP
CCCCCCCCCCCEECC		40.0627050516
831UbiquitinationDMEAIPVKQFVKHIG
CCCCCCHHHHHHHHH		32.44-
835UbiquitinationIPVKQFVKHIGELYS
CCHHHHHHHHHHHHH		30.69-
841PhosphorylationVKHIGELYSNNQHGF
HHHHHHHHHCCCCCC		12.6827642862
873 (in isoform 2)Ubiquitination-71.9421906983
880PhosphorylationENKHKNRYINILAYD
CCCCCCCEEEEEEEC		14.0228152594
886PhosphorylationRYINILAYDHSRVKL
CEEEEEEECCCCCEE		15.6727642862
900 (in isoform 2)Ubiquitination-69.6821906983
902 (in isoform 1)Ubiquitination-58.2121906983
902UbiquitinationPLPGKDSKHSDYINA
CCCCCCCCCCCCCCC		58.2121906983
906PhosphorylationKDSKHSDYINANYVD
CCCCCCCCCCCCCCC		10.0927642862
911PhosphorylationSDYINANYVDGYNKA
CCCCCCCCCCCCHHH		9.4827642862
915PhosphorylationNANYVDGYNKAKAYI
CCCCCCCCHHHHEEH		14.7127642862
929UbiquitinationIATQGPLKSTFEDFW
HCCCCCCCHHHHHHH		51.0521906983
929 (in isoform 1)Ubiquitination-51.0521906983
967PhosphorylationKCDQYWPTENSEEYG
CCHHCCCCCCCHHHC		33.3829759185
995PhosphorylationCYTVRRFSIRNTKVK
EEEEEEEEEECCCCC		20.8729496963
1021PhosphorylationNERVVIQYHYTQWPD
CCEEEEEEEECCCCC		5.9118083107
1023PhosphorylationRVVIQYHYTQWPDMG
EEEEEEEECCCCCCC		8.8318083107
1034PhosphorylationPDMGVPEYALPVLTF
CCCCCCCHHHHHHHH		13.8418083107
1083UbiquitinationMLQQIKDKSTVNVLG
HHHHHCCCCHHHHHH		42.92-
1155UbiquitinationTRLEKQFKLVTQCNA
HHHHHHHHHHHHCCH		39.28-
1164PhosphorylationVTQCNAKYVECFSAQ
HHHCCHHHHHHHHHH		10.08-
1172MalonylationVECFSAQKECNKEKN
HHHHHHHHHHHCCCC		65.0426320211
1182PhosphorylationNKEKNRNSSVVPSER
HCCCCCCCCCCCHHH		22.6730266825
1183PhosphorylationKEKNRNSSVVPSERA
CCCCCCCCCCCHHHH		30.5930266825
1187PhosphorylationRNSSVVPSERARVGL
CCCCCCCHHHHCCCC		28.2730266825
1201AcetylationLAPLPGMKGTDYINA
CCCCCCCCCCCCCCH		65.6530591681
1307PhosphorylationLEATQDDYVLEVRHF
HHHHCCCEEEEEEEC		18.4120736484
1409PhosphorylationFIYKAMLSLVSTKEN
HHHHHHHHHHCCCCC		17.40-
1422PhosphorylationENGNGPMTVDKNGAV
CCCCCCEEECCCCCE		28.7825690035
1435PhosphorylationAVLIADESDPAESME
CEEEECCCCHHHHHH		49.8230266825
1440PhosphorylationDESDPAESMESLV--
CCCCHHHHHHHCC--		29.9229514088
1443PhosphorylationDPAESMESLV-----
CHHHHHHHCC-----		26.2829514088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTPRG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTPRG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTPRG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTPRG_HUMANPTPRGphysical
19167335
SC24A_HUMANSEC24Aphysical
27880917
FCHO2_HUMANFCHO2physical
27880917
CEP89_HUMANCEP89physical
27880917
MRCKB_HUMANCDC42BPBphysical
27880917
NIBL1_HUMANFAM129Bphysical
27880917
PSD3_HUMANPSD3physical
27880917
PALM_HUMANPALMphysical
27880917
CSKI2_HUMANCASKIN2physical
27880917
HS12A_HUMANHSPA12Aphysical
27880917
GRIN1_HUMANGPRIN1physical
27880917
MERL_HUMANNF2physical
27880917
RS15_HUMANRPS15physical
27880917
ICLN_HUMANCLNS1Aphysical
27880917
S39AA_HUMANSLC39A10physical
27880917
ADDB_HUMANADD2physical
27880917
FARP1_HUMANFARP1physical
27880917
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTPRG_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-113 AND ASN-444, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1435, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory