HS12A_HUMAN - dbPTM
HS12A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HS12A_HUMAN
UniProt AC O43301
Protein Name Heat shock 70 kDa protein 12A
Gene Name HSPA12A
Organism Homo sapiens (Human).
Sequence Length 675
Subcellular Localization
Protein Description
Protein Sequence MADKEAGGSDGPRETAPTSAYSSPARSLGDTGITPLSPSHIVNDTDSNVSEQQSFLVVVAVDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPERKFHSFGYAARDFYHDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFEKLLYKIFGEDFIEQFKIKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPLLQQAVQAAFGDQCRIIIPQDVGLTILKGAVLFGLDPAVIKVRRSPLTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYSSEHDNVSFITDPGVKKCGTLRLDLTGTSGTAVPARREIQTLMQFGDTEIKATAIDIATSKSVKVGIDFLNY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MADKEAGGS
------CCCCCCCCC		36.2622814378
9PhosphorylationADKEAGGSDGPRETA
CCCCCCCCCCCCCCC		38.1821945579
15PhosphorylationGSDGPRETAPTSAYS
CCCCCCCCCCCCCCC		38.9421945579
18PhosphorylationGPRETAPTSAYSSPA
CCCCCCCCCCCCCCC		24.4321945579
19PhosphorylationPRETAPTSAYSSPAR
CCCCCCCCCCCCCCC		24.9321945579
19O-linked_GlycosylationPRETAPTSAYSSPAR
CCCCCCCCCCCCCCC		24.9328657654
21PhosphorylationETAPTSAYSSPARSL
CCCCCCCCCCCCCCC		14.9521945579
22PhosphorylationTAPTSAYSSPARSLG
CCCCCCCCCCCCCCC		29.5721945579
23PhosphorylationAPTSAYSSPARSLGD
CCCCCCCCCCCCCCC		15.2021945579
73PhosphorylationTSSGYAYSFTKEPEC
CCCCEEEEECCCCCE		20.4724719451
99PhosphorylationPGVSNQKTPTTILLT
CCCCCCCCCCEEEEC		18.9928857561
110UbiquitinationILLTPERKFHSFGYA
EEECCCHHHHCCCCC		45.85-
113PhosphorylationTPERKFHSFGYAARD
CCCHHHHCCCCCCHH		24.4128857561
150PhosphorylationLHTTGDLTMDTDLTA
EECCCCCCCCCCCCC		20.1029083192
153PhosphorylationTGDLTMDTDLTAANG
CCCCCCCCCCCCCCC		23.3029083192
156PhosphorylationLTMDTDLTAANGKKV
CCCCCCCCCCCCCCC		26.9129083192
258PhosphorylationLHQMIELSSKAAVNG
HHHHHHHHCCHHHCC		19.59-
267PhosphorylationKAAVNGYSGSDTVGA
CHHHCCCCCCCCCCC		32.97-
311PhosphorylationELEEGDKYVVVDSGG
HCCCCCEEEEEECCC		11.8324043423
316PhosphorylationDKYVVVDSGGGTVDL
CEEEEEECCCCEEEE		27.9424043423
320PhosphorylationVVDSGGGTVDLTVHQ
EEECCCCEEEEEEEE		17.7024043423
324PhosphorylationGGGTVDLTVHQIRLP
CCCEEEEEEEEEECC		16.1024043423
353PhosphorylationYGSLGVDYEFEKLLY
CCCCCCCHHHHHHHH		21.80-
360PhosphorylationYEFEKLLYKIFGEDF
HHHHHHHHHHHCHHH		16.69-
420PhosphorylationYKKFRGHSVEHALRK
HHHHCCCCHHHHHHH		31.8328857561
437PhosphorylationVDFVKWSSQGMLRMS
CCEEEECCCCCHHCC		29.6428857561
573PhosphorylationDVFDKFISADQSVAL
HHHHHHHCCCHHHHH		29.00-
629PhosphorylationGTLRLDLTGTSGTAV
CEEEEEECCCCCCCC		37.7723312004
631PhosphorylationLRLDLTGTSGTAVPA
EEEEECCCCCCCCCC		20.8129116813
632PhosphorylationRLDLTGTSGTAVPAR
EEEECCCCCCCCCCH		35.1829116813
634PhosphorylationDLTGTSGTAVPARRE
EECCCCCCCCCCHHH		25.0125307156
663O-linked_GlycosylationTAIDIATSKSVKVGI
EEEEHHHCCCEEEEE		17.5728657654
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HS12A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HS12A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HS12A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HS12A_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HS12A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND MASSSPECTROMETRY.

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