dbPTM

CSKI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSKI2_HUMAN
UniProt AC	Q8WXE0
Protein Name	Caskin-2
Gene Name	CASKIN2
Organism	Homo sapiens (Human).
Sequence Length	1202
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	QDLILAVKNGDVTGV CCEEEEEECCCCCCH	49.99	29967540
21	Ubiquitination	GDVTGVQKLVAKVKA CCCCCHHHHHHHHHH	42.39	29967540
27	Acetylation	QKLVAKVKATKTKLL HHHHHHHHHCCHHHC	50.02	7825383
30	Acetylation	VAKVKATKTKLLGST HHHHHHCCHHHCCCC	48.82	7825395
32	Ubiquitination	KVKATKTKLLGSTKR HHHHCCHHHCCCCCE	43.18	29967540
36	Phosphorylation	TKTKLLGSTKRLNVN CCHHHCCCCCEECCC	30.63	24719451
37	Phosphorylation	KTKLLGSTKRLNVNY CHHHCCCCCEECCCC	20.56	22210691
67	Ubiquitination	GSLELIALLLEAQAT CCHHHHHHHHHHHCC	4.43	29967540
138	Ubiquitination	SEMLLQHQSNPCLVN HHHHHHCCCCCCCCC	31.76	29967540
149	Ubiquitination	CLVNKAKKTPLDLAC CCCCCCCCCCHHHHH	61.30	29967540
203	Ubiquitination	AAKNGHREVIRQLLR HHHCCHHHHHHHHHH	36.30	29967540
220	Ubiquitination	IEINRQTKTGTALHE CEEECCCCCCCCHHH	36.30	29967540
239	Ubiquitination	GKTEVVRLLLEGGVD CCHHHHHHHHHCCCC	4.29	29967540
252	Phosphorylation	VDVNIRNTYNQTALD CCCEEECCCCCHHHH	17.63	21712546
253	Phosphorylation	DVNIRNTYNQTALDI CCEEECCCCCHHHHH	14.60	27273156
256	Phosphorylation	IRNTYNQTALDIVNQ EECCCCCHHHHHHHH	26.08	21712546
281	Phosphorylation	KQLLREASGILKVRA HHHHHHHHHCEEHHH	22.93	21406692
285	Ubiquitination	REASGILKVRALKDF HHHHHCEEHHHHHHH	27.96	29967540
321	Ubiquitination	QHPDGRWKGHIHESQ ECCCCCCCCEECHHH	38.97	29967540
327	Phosphorylation	WKGHIHESQRGTDRI CCCEECHHHCCCCCC	15.83	-
336	Phosphorylation	RGTDRIGYFPPGIVE CCCCCCCCCCCCHHH	15.56	21945579
355	Methylation	RVGIPAARLPSAPTP HCCCCHHHCCCCCCC	49.60	-
358	Phosphorylation	IPAARLPSAPTPLRP CCHHHCCCCCCCCCC	52.01	21712546
361	Phosphorylation	ARLPSAPTPLRPGFS HHCCCCCCCCCCCCC	34.37	28152594
364	Methylation	PSAPTPLRPGFSRTP CCCCCCCCCCCCCCC	30.42	-
368	Phosphorylation	TPLRPGFSRTPQPPA CCCCCCCCCCCCCCC	40.95	28111955
370	Phosphorylation	LRPGFSRTPQPPAEE CCCCCCCCCCCCCCC	25.69	21945579
383	Phosphorylation	EEPPHPLTYSQLPRV CCCCCCCCHHHCCCC	26.10	21945579
384	Phosphorylation	EPPHPLTYSQLPRVG CCCCCCCHHHCCCCC	11.34	21945579
385	Phosphorylation	PPHPLTYSQLPRVGL CCCCCCHHHCCCCCC	21.72	21945579
393	Phosphorylation	QLPRVGLSPDSPAGD HCCCCCCCCCCCCCC	22.26	30266825
396	Phosphorylation	RVGLSPDSPAGDRNS CCCCCCCCCCCCCCC	21.75	29255136
403	Phosphorylation	SPAGDRNSVGSEGSV CCCCCCCCCCCCCCC	28.84	29255136
406	Phosphorylation	GDRNSVGSEGSVGSI CCCCCCCCCCCCCCC	36.31	29255136
409	Phosphorylation	NSVGSEGSVGSIRSA CCCCCCCCCCCCEEC	21.18	30266825
412	Phosphorylation	GSEGSVGSIRSAGSG CCCCCCCCCEECCCC	16.81	30266825
453	Ubiquitination	DQVLPGLHPPSLADN CCCCCCCCCCCHHHC	37.83	29967540
462	Phosphorylation	PSLADNLSHRPLANC CCHHHCCCCCCCCCC	24.57	19369195
471	Phosphorylation	RPLANCRSGEQIFTQ CCCCCCCCCCEEECC	49.21	25159151
477	Phosphorylation	RSGEQIFTQDVRPEQ CCCCEEECCCCCHHH	26.03	26552605
523	Ubiquitination	DVPTISRMTPEDLTA CCCCCCCCCHHHHHH	6.14	29967540
535	Ubiquitination	LTAIGVTKPGHRKKI HHHCCCCCCCCHHHH	46.74	29967540
581	Phosphorylation	QYHKQLVSSGYDSMG HHHHHHHHCCCCCCC	27.00	23663014
582	Phosphorylation	YHKQLVSSGYDSMGL HHHHHHHCCCCCCCC	33.61	23663014
584	Phosphorylation	KQLVSSGYDSMGLVA HHHHHCCCCCCCCCE	13.54	23663014
586	Phosphorylation	LVSSGYDSMGLVADL HHHCCCCCCCCCEEC	13.28	23663014
594	Phosphorylation	MGLVADLTWEELQEI CCCCEECCHHHHHHH	31.23	23663014
605	Ubiquitination	LQEIGVNKLGHQKKL HHHHCCCCCCHHHHH	54.14	29967540
615	Phosphorylation	HQKKLMLGVKRLAEL HHHHHHHHHHHHHHH	14.67	32142685
618	Phosphorylation	KLMLGVKRLAELRRG HHHHHHHHHHHHHHH	36.40	33259812
659	Phosphorylation	ENGEGPATAGPRLLT CCCCCCCCCCCEEEE	34.97	26699800
670	Phosphorylation	RLLTFQGSELSPELQ EEEEEECCCCCHHHH	25.28	28176443
673	Phosphorylation	TFQGSELSPELQAAM EEECCCCCHHHHHHH	16.57	28176443
695	Phosphorylation	LPLPPARSPSQESIG CCCCCCCCCCCCCCC	30.89	29255136
697	Phosphorylation	LPPARSPSQESIGAR CCCCCCCCCCCCCCC	48.07	23401153
700	Phosphorylation	ARSPSQESIGARSRG CCCCCCCCCCCCCCC	20.77	30266825
705	Phosphorylation	QESIGARSRGSGHSQ CCCCCCCCCCCCCCC	40.22	30266825
708	Phosphorylation	IGARSRGSGHSQEQP CCCCCCCCCCCCCCC	32.02	30266825
711	Phosphorylation	RSRGSGHSQEQPAPQ CCCCCCCCCCCCCCC	38.65	30266825
720	Phosphorylation	EQPAPQPSGGDPSPP CCCCCCCCCCCCCCC	50.60	30266825
725	Phosphorylation	QPSGGDPSPPQERNL CCCCCCCCCCHHCCC	54.69	23401153
798	Phosphorylation	PPRPKRRSHSLSRPG CCCCCCCCCCCCCCC	22.81	23927012
800	Phosphorylation	RPKRRSHSLSRPGPT CCCCCCCCCCCCCCC	29.32	23401153
802	Phosphorylation	KRRSHSLSRPGPTEG CCCCCCCCCCCCCCC	39.17	23927012
807	Phosphorylation	SLSRPGPTEGDAEGE CCCCCCCCCCCCCCC	59.52	23927012
821	Phosphorylation	EAEGPVGSTLGSYAT CCCCCCCCCCCCEEE	22.23	30576142
822	Phosphorylation	AEGPVGSTLGSYATL CCCCCCCCCCCEEEE	29.25	23927012
825	Phosphorylation	PVGSTLGSYATLTRR CCCCCCCCEEEEECC	18.08	28796482
826	Phosphorylation	VGSTLGSYATLTRRP CCCCCCCEEEEECCC	11.21	28796482
828	Phosphorylation	STLGSYATLTRRPGR CCCCCEEEEECCCCC	22.04	25849741
830	Phosphorylation	LGSYATLTRRPGRSA CCCEEEEECCCCCCC	21.93	29255136
836	Phosphorylation	LTRRPGRSALVRTSP EECCCCCCCEEECCC	31.69	23403867
841	Phosphorylation	GRSALVRTSPSVTPT CCCCEEECCCCCCCC	37.19	30266825
842	Phosphorylation	RSALVRTSPSVTPTP CCCEEECCCCCCCCC	12.47	30266825
844	Phosphorylation	ALVRTSPSVTPTPAR CEEECCCCCCCCCCC	38.09	30266825
846	Phosphorylation	VRTSPSVTPTPARGT EECCCCCCCCCCCCC	26.28	30266825
848	Phosphorylation	TSPSVTPTPARGTPR CCCCCCCCCCCCCCC	21.88	22199227
851	Methylation	SVTPTPARGTPRSQS CCCCCCCCCCCCHHH	51.20	-
853	Phosphorylation	TPTPARGTPRSQSFA CCCCCCCCCCHHHHH	15.24	30576142
856	Phosphorylation	PARGTPRSQSFALRA CCCCCCCHHHHHHHH	31.23	22167270
858	Phosphorylation	RGTPRSQSFALRARR CCCCCHHHHHHHHHH	17.46	23401153
862	Methylation	RSQSFALRARRKGPP CHHHHHHHHHHCCCC	23.71	-
877	Phosphorylation	PPPPKRLSSVSGPSP CCCCCCCCCCCCCCC	32.50	23401153
878	Phosphorylation	PPPKRLSSVSGPSPE CCCCCCCCCCCCCCC	25.54	25690035
880	Phosphorylation	PKRLSSVSGPSPEPP CCCCCCCCCCCCCCC	47.11	28348404
883	Phosphorylation	LSSVSGPSPEPPPLD CCCCCCCCCCCCCCC	45.48	26657352
892	Phosphorylation	EPPPLDESPGPKEGA CCCCCCCCCCCCCCC	34.52	18669648
906	Phosphorylation	ATGPRRRTLSEPAGP CCCCCCCCCCCCCCC	32.59	30177828
908	Phosphorylation	GPRRRTLSEPAGPSE CCCCCCCCCCCCCCC	40.70	29507054
914	Phosphorylation	LSEPAGPSEPPGPPA CCCCCCCCCCCCCCC	62.91	26852163
927	Phosphorylation	PAPAGPASDTEEEEP CCCCCCCCCCCCCCC	48.47	26657352
929	Phosphorylation	PAGPASDTEEEEPGP CCCCCCCCCCCCCCC	42.68	30576142
939	Phosphorylation	EEPGPEGTPPSRGSS CCCCCCCCCCCCCCC	30.29	28985074
942	Phosphorylation	GPEGTPPSRGSSGEG CCCCCCCCCCCCCCC	50.94	28270605
945	Phosphorylation	GTPPSRGSSGEGLPF CCCCCCCCCCCCCCC	33.78	30278072
946	Phosphorylation	TPPSRGSSGEGLPFA CCCCCCCCCCCCCCC	43.62	26657352
959	Phosphorylation	FAEEGNLTIKQRPKP CCCCCCEEEECCCCC	30.08	29255136
974	Phosphorylation	AGPPPRETPVPPGLD CCCCCCCCCCCCCCC	30.76	28122231
985	Phosphorylation	PGLDFNLTESDTVKR CCCCCCCCCCHHHCC	34.25	28122231
987	Phosphorylation	LDFNLTESDTVKRRP CCCCCCCCHHHCCCC	33.09	29255136
989	Phosphorylation	FNLTESDTVKRRPKC CCCCCCHHHCCCCCH	36.89	29255136
1106	O-linked_Glycosylation	GTAPKPVSVACTQLA CCCCCCCEEEEEHHH	16.72	30059200
1126	Methylation	LAPRLGPRPVPPPRP CCCCCCCCCCCCCCC	42.95	-
1135	Phosphorylation	VPPPRPESTGTVGPG CCCCCCCCCCCCCCH	34.52	23403867
1136	Phosphorylation	PPPRPESTGTVGPGQ CCCCCCCCCCCCCHH	34.90	28122231
1138	Phosphorylation	PRPESTGTVGPGQAQ CCCCCCCCCCCHHHH	23.52	30576142
1164	Acetylation	AALRAAEKSIGTKEQ HHHHHHHHHHCCCCC	42.52	25953088
1164	Ubiquitination	AALRAAEKSIGTKEQ HHHHHHHHHHCCCCC	42.52	-
1169	Ubiquitination	AEKSIGTKEQEGTPS HHHHHCCCCCCCCCC	52.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CSKI2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CSKI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSKI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CSKI2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSKI2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396 AND SER-471, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-396; SER-471;SER-858; SER-878; SER-883 AND SER-892, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403; SER-406; SER-409AND SER-412, AND MASS SPECTROMETRY.	17081983 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-336, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-253, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-384, AND MASSSPECTROMETRY.	16094384 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-384, AND MASSSPECTROMETRY.	15592455 [Abstract]