dbPTM

PSD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSD3_HUMAN
UniProt AC	Q9NYI0
Protein Name	PH and SEC7 domain-containing protein 3
Gene Name	PSD3
Organism	Homo sapiens (Human).
Sequence Length	1048
Subcellular Localization	Cell membrane . Cell projection, ruffle membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In interphase associated with the plasma membrane, in particular with membrane ruffling regions.
Protein Description	Guanine nucleotide exchange factor for ARF6..
Protein Sequence	MEGRSAAAETFVWVNNASAHSQSVAKAKYEFLFGRSEGKAPDTSDHGGSTLLPPNVTNEFPEYGTMEEGGEGLRASLEFDGEALPCHPQEQQGVQPLTGCHSGLDSVTEGPKDVREAPSQSHLKEQSLQPIDSLISALKATEARIISGTLQATKVLDQDAVSSFSVQQVEKELDTASRKTQRVNKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEISQIMNNGRKGAVCVQEPSCPLASLGSSAVTCHSAGSVGFLKEQRSALGREHPGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHLEKTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHVNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	QSVAKAKYEFLFGRS HHHHHHHHHHHHCCC	19.44	27259358
76	Phosphorylation	GGEGLRASLEFDGEA CCCCCCEEEEECCCC	23.23	24275569
121	Phosphorylation	VREAPSQSHLKEQSL HHHCCCHHHHCHHCC	34.81	-
127	Phosphorylation	QSHLKEQSLQPIDSL HHHHCHHCCHHHHHH	30.02	-
133	Phosphorylation	QSLQPIDSLISALKA HCCHHHHHHHHHHHH	28.46	30266825
136	Phosphorylation	QPIDSLISALKATEA HHHHHHHHHHHHHHH	32.61	27486199
180	Phosphorylation	LDTASRKTQRVNKTL HHHHHHHHHHHHCCC	22.09	-
186	Phosphorylation	KTQRVNKTLPAGQKN HHHHHHCCCCCCCCC	32.54	-
225	Phosphorylation	TALLTGDTQAEISQI HHHHHCCCHHHHHHH	30.90	18452278
324	Phosphorylation	QHPIDFETSLQRTAS CCCCCHHHHHHCCCC	34.43	29514088
325	Phosphorylation	HPIDFETSLQRTASP CCCCHHHHHHCCCCC	18.46	29514088
329	Phosphorylation	FETSLQRTASPDSKE HHHHHHCCCCCCCCC	20.66	29514088
331	Phosphorylation	TSLQRTASPDSKESS HHHHCCCCCCCCCCC	28.73	24719451
334	Phosphorylation	QRTASPDSKESSKVP HCCCCCCCCCCCCCC	41.53	29514088
337	Phosphorylation	ASPDSKESSKVPRHL CCCCCCCCCCCCHHH	38.91	23312004
338	Phosphorylation	SPDSKESSKVPRHLI CCCCCCCCCCCHHHH	38.47	23312004
347	Phosphorylation	VPRHLISSAGLCNSS CCHHHHHHCCCCCCC	21.25	28348404
353	Phosphorylation	SSAGLCNSSSLTENV HHCCCCCCCCCCCCC	21.95	28348404
354	Phosphorylation	SAGLCNSSSLTENVW HCCCCCCCCCCCCCC	18.51	23898821
355	Phosphorylation	AGLCNSSSLTENVWD CCCCCCCCCCCCCCC	38.85	23898821
357	Phosphorylation	LCNSSSLTENVWDES CCCCCCCCCCCCCCC	27.71	28348404
369	Phosphorylation	DESWKAPSERPGTSS CCCCCCCCCCCCCCC	51.61	28270605
374	Phosphorylation	APSERPGTSSGTFSP CCCCCCCCCCCCCCC	23.54	27732954
375	Phosphorylation	PSERPGTSSGTFSPV CCCCCCCCCCCCCCE	32.46	26657352
376	Phosphorylation	SERPGTSSGTFSPVR CCCCCCCCCCCCCEE	41.51	27732954
378	Phosphorylation	RPGTSSGTFSPVRLD CCCCCCCCCCCEEEC	23.92	27732954
380	Phosphorylation	GTSSGTFSPVRLDES CCCCCCCCCEEECCC	23.48	25159151
387	Phosphorylation	SPVRLDESGEDEVFL CCEEECCCCCCCEEC	47.34	26657352
415	Phosphorylation	ERDRERISEQEEHVK HHHHHHHHHHHHHHC	39.17	23312004
479	Phosphorylation	FSFEMPLTPMIQQRI CEEECCCHHHHHHHH	12.63	24275569
496	Phosphorylation	GGQFLERTSGGGHQD HCCEEEECCCCCCCC	23.50	24275569
497	Phosphorylation	GQFLERTSGGGHQDI CCEEEECCCCCCCCE	41.48	24275569
517	Phosphorylation	DGGIVMGYSSGVTNG CCCEEEEECCCCCCC	4.99	24275569
522	Phosphorylation	MGYSSGVTNGLNDAS EEECCCCCCCCCCCC	27.39	24275569
533	Phosphorylation	NDASDSIYTKGTPEI CCCCCCCCCCCCCCE	13.32	25884760
537	Phosphorylation	DSIYTKGTPEIAFWG CCCCCCCCCCEEEEC	21.21	24275569
552	Phosphorylation	SNAGVKTTRLEAHSE CCCCCCCCHHHHHCC	27.78	-
558	Phosphorylation	TTRLEAHSEMGSTEI CCHHHHHCCCCCCHH	36.00	26657352
562	Phosphorylation	EAHSEMGSTEILEKE HHHCCCCCCHHHHCC	22.89	25849741
563	Phosphorylation	AHSEMGSTEILEKET HHCCCCCCHHHHCCC	22.70	25849741
601	Phosphorylation	QLDRFKRSDVAKHLG HHHHHCHHHHHHHHC	36.71	28555341
614	Phosphorylation	LGKNNEFSKLVAEEY HCCCCHHHHHHHHHH	20.92	30576142
615	Ubiquitination	GKNNEFSKLVAEEYL CCCCHHHHHHHHHHH	52.91	-
628	Phosphorylation	YLKFFDFTGMTLDQS HHHHCCCCCCCHHHH	28.08	-
729	Phosphorylation	DLLKALYNSIKNEKL HHHHHHHHHHHCCCC	37.80	27251275
730	Phosphorylation	LLKALYNSIKNEKLE HHHHHHHHHHCCCCC	22.76	27251275
747	Phosphorylation	VDDEEKKKSPSESTE CCHHHHCCCCCCCHH	77.87	18510355
748	Phosphorylation	DDEEKKKSPSESTEE CHHHHCCCCCCCHHH	42.40	18510355
752	Phosphorylation	KKKSPSESTEEKANG HCCCCCCCHHHHHCC	45.52	25332170
764	Phosphorylation	ANGTHPKTISRIGST HCCCCCCCCHHCCCC	28.74	-
769	Phosphorylation	PKTISRIGSTTNPFL CCCCHHCCCCCCCCC	20.17	24719451
770	Phosphorylation	KTISRIGSTTNPFLD CCCHHCCCCCCCCCC	29.68	25159151
771	Phosphorylation	TISRIGSTTNPFLDI CCHHCCCCCCCCCCC	25.94	25693802
772	Phosphorylation	ISRIGSTTNPFLDIP CHHCCCCCCCCCCCC	42.46	25693802
787	Phosphorylation	HDPNAAVYKSGFLAR CCCCCHHHHCCHHHH	8.49	23312004
804	Phosphorylation	HADMDGKKTPRGKRG EECCCCCCCCCCCCC	70.10	24719451
805	Phosphorylation	ADMDGKKTPRGKRGW ECCCCCCCCCCCCCH	23.00	24719451
816	Phosphorylation	KRGWKTFYAVLKGTV CCCHHHHHHHHHHHE	10.88	-
838	Phosphorylation	YKPEKALSEEDLKNA CCHHHCCCHHHHHHH	43.74	30622161
911	Phosphorylation	PFPAAIGSQKKFSRP CCCCCCCCCCCCCCC	32.48	25332170
916	Phosphorylation	IGSQKKFSRPLLPAT CCCCCCCCCCCCCCC	41.70	23312004
923	Phosphorylation	SRPLLPATTTKLSQE CCCCCCCCCCCCCHH	32.81	-
924	Phosphorylation	RPLLPATTTKLSQEE CCCCCCCCCCCCHHH	24.84	-
925	Phosphorylation	PLLPATTTKLSQEEQ CCCCCCCCCCCHHHH	26.15	-
941	Ubiquitination	KSHESKLKQITTELA HHHHHHHHHHHHHHH	43.31	-
943	Phosphorylation	HESKLKQITTELAEH HHHHHHHHHHHHHHH	5.00	18767875
944	Phosphorylation	ESKLKQITTELAEHR HHHHHHHHHHHHHHC	16.24	18767875
945	Phosphorylation	SKLKQITTELAEHRS HHHHHHHHHHHHHCC	30.54	18767875
960	Acetylation	YPPDKKVKAKDVDEY CCCCCCCCCCCCCHH	59.61	91081
962	Acetylation	PDKKVKAKDVDEYKL CCCCCCCCCCCHHHC	53.20	91083
981	Phosphorylation	LEFEKTRYEMYVSIL EEECCHHHHHHHHHH	15.41	23312004
986	Phosphorylation	TRYEMYVSILKEGGK HHHHHHHHHHHHCHH	12.52	24719451
996	Phosphorylation	KEGGKELLSNDESEA HHCHHHHHCCCHHHH	4.76	18510355
997	Phosphorylation	EGGKELLSNDESEAA HCHHHHHCCCHHHHH	55.66	18510355
1009	Phosphorylation	EAAGLKKSHSSPSLN HHHCCCCCCCCCCCC	27.32	30266825
1010	Phosphorylation	AAGLKKSHSSPSLNP HHCCCCCCCCCCCCC	40.97	20166139
1011	Phosphorylation	AGLKKSHSSPSLNPD HCCCCCCCCCCCCCC	51.54	23927012
1012	Phosphorylation	GLKKSHSSPSLNPDT CCCCCCCCCCCCCCC	17.06	30266825
1013	Phosphorylation	LKKSHSSPSLNPDTS CCCCCCCCCCCCCCC	45.94	24719451
1014	Phosphorylation	KKSHSSPSLNPDTSP CCCCCCCCCCCCCCC	42.60	30266825
1018	Phosphorylation	SSPSLNPDTSPITAK CCCCCCCCCCCCCHH	59.76	19651622
1019	Phosphorylation	SPSLNPDTSPITAKV CCCCCCCCCCCCHHH	37.35	19664994
1020	Phosphorylation	PSLNPDTSPITAKVK CCCCCCCCCCCHHHH	22.99	19664994
1022	Phosphorylation	LNPDTSPITAKVKRN CCCCCCCCCHHHHCC	6.15	18669648
1023	Phosphorylation	NPDTSPITAKVKRNV CCCCCCCCHHHHCCH	24.66	23927012
1030	Phosphorylation	TAKVKRNVSERKDHR CHHHHCCHHHCCCCC	7.94	24719451
1031	Phosphorylation	AKVKRNVSERKDHRP HHHHCCHHHCCCCCC	34.92	24719451
1039	Phosphorylation	ERKDHRPETPSIKQK HCCCCCCCCCCHHHC	73.61	24719451
1040	Phosphorylation	RKDHRPETPSIKQKV CCCCCCCCCCHHHCC	25.64	28985074
1042	Phosphorylation	DHRPETPSIKQKVT- CCCCCCCCHHHCCC-	50.25	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSD3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PSD3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSD3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1011 AND SER-1020, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-770, AND MASSSPECTROMETRY.	18220336 [Abstract]