dbPTM

GRIN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRIN1_HUMAN
UniProt AC	Q7Z2K8
Protein Name	G protein-regulated inducer of neurite outgrowth 1
Gene Name	GPRIN1
Organism	Homo sapiens (Human).
Sequence Length	1008
Subcellular Localization	Cell membrane Lipid-anchor. Cell projection, growth cone. Highly enriched in growth cone..
Protein Description	May be involved in neurite outgrowth..
Protein Sequence	MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LQLLQKDSSPPGPRP HHHHHHCCCCCCCCC	52.35	25159151
18	Phosphorylation	QLLQKDSSPPGPRPT HHHHHCCCCCCCCCC	45.29	27050516
25	Phosphorylation	SPPGPRPTAFFCPQD CCCCCCCCEEECCCC	37.06	29978859
45	Phosphorylation	GSSAMRDYCPSQQKA CHHHHHHHCCCCCCC	8.90	-
48	Phosphorylation	AMRDYCPSQQKASPA HHHHHCCCCCCCCCC	41.50	23312004
53	Phosphorylation	CPSQQKASPAPPRHT CCCCCCCCCCCCCCC	28.73	26657352
60	Phosphorylation	SPAPPRHTPDQSPGM CCCCCCCCCCCCCCC	29.82	21712546
64	Phosphorylation	PRHTPDQSPGMESRH CCCCCCCCCCCCCCC	30.70	29255136
69	Phosphorylation	DQSPGMESRHRSPSG CCCCCCCCCCCCCCC	25.21	27732954
73	Phosphorylation	GMESRHRSPSGAGEG CCCCCCCCCCCCCCC	19.79	29255136
75	Phosphorylation	ESRHRSPSGAGEGAS CCCCCCCCCCCCCCC	42.39	27273156
82	Phosphorylation	SGAGEGASCSDGPRG CCCCCCCCCCCCCCC	25.63	23403867
84	Phosphorylation	AGEGASCSDGPRGSL CCCCCCCCCCCCCCC	43.01	23403867
90	Phosphorylation	CSDGPRGSLACPSPT CCCCCCCCCCCCCCC	17.67	29255136
95	Phosphorylation	RGSLACPSPTCFSPQ CCCCCCCCCCCCCCC	32.50	29255136
97	Phosphorylation	SLACPSPTCFSPQES CCCCCCCCCCCCCCC	30.44	25884760
100	Phosphorylation	CPSPTCFSPQESPSK CCCCCCCCCCCCCCH	28.02	29255136
104	Phosphorylation	TCFSPQESPSKETLE CCCCCCCCCCHHHHH	29.26	25159151
106	Phosphorylation	FSPQESPSKETLEAH CCCCCCCCHHHHHHC	53.02	25159151
109	Phosphorylation	QESPSKETLEAHGAS CCCCCHHHHHHCCCC	33.37	22496350
116	Phosphorylation	TLEAHGASISGTPEA HHHHCCCCCCCCCCC	23.14	25159151
118	Phosphorylation	EAHGASISGTPEATT HHCCCCCCCCCCCCC	33.83	27050516
120	Phosphorylation	HGASISGTPEATTSG CCCCCCCCCCCCCCC	15.92	25849741
124	Phosphorylation	ISGTPEATTSGKPEP CCCCCCCCCCCCCCC	21.60	27251275
125	Phosphorylation	SGTPEATTSGKPEPV CCCCCCCCCCCCCCC	42.40	27251275
126	Phosphorylation	GTPEATTSGKPEPVS CCCCCCCCCCCCCCC	40.23	27251275
133	Phosphorylation	SGKPEPVSSVKTEPK CCCCCCCCCCCCCCC	39.88	25627689
134	Phosphorylation	GKPEPVSSVKTEPKS CCCCCCCCCCCCCCC	28.06	25627689
163	Phosphorylation	KSSKQADSTSIGKED CCCCCCCCCCCCCCC	27.37	26074081
164	Phosphorylation	SSKQADSTSIGKEDP CCCCCCCCCCCCCCC	25.55	26074081
165	Phosphorylation	SKQADSTSIGKEDPG CCCCCCCCCCCCCCC	33.04	26074081
173	Phosphorylation	IGKEDPGSSRKADPM CCCCCCCCCCCCCCC	32.15	26074081
174	Phosphorylation	GKEDPGSSRKADPMF CCCCCCCCCCCCCCC	43.65	26074081
182	Phosphorylation	RKADPMFTGKAEPEI CCCCCCCCCCCCHHH	31.36	-
225	Phosphorylation	DPLCSSKTYTVSPRK CCCCCCCEEEECCCC	26.77	25884760
226	Phosphorylation	PLCSSKTYTVSPRKE CCCCCCEEEECCCCC	14.64	28796482
227	Phosphorylation	LCSSKTYTVSPRKED CCCCCEEEECCCCCC	21.53	29900121
229	Phosphorylation	SSKTYTVSPRKEDPG CCCEEEECCCCCCCC	15.93	25159151
237	Phosphorylation	PRKEDPGSLRKVDPV CCCCCCCCCCCCCCC	30.32	23312004
276	Phosphorylation	SSEKVAPTSAEKVDL CCCCCCCCCHHHCCE	30.72	29214152
277	Phosphorylation	SEKVAPTSAEKVDLV CCCCCCCCHHHCCEE	33.11	29214152
286	Phosphorylation	EKVDLVLSGKRDPGP HHCCEEEECCCCCCC	34.49	25159151
313	Phosphorylation	DSASTGKTEPGLLGK CCCCCCCCCCCCCCE	49.08	-
334	Phosphorylation	GKNGPVSSGTGAPGS CCCCCCCCCCCCCCC	40.38	-
336	Phosphorylation	NGPVSSGTGAPGSLG CCCCCCCCCCCCCCC	31.92	-
341	Phosphorylation	SGTGAPGSLGRLDPT CCCCCCCCCCCCCCC	26.96	27050516
381	Phosphorylation	LGKMDPASSGEGRPV CCCCCCCCCCCCCCC	44.24	30266825
382	Phosphorylation	GKMDPASSGEGRPVS CCCCCCCCCCCCCCC	42.86	28857561
389	Phosphorylation	SGEGRPVSGHTDTTA CCCCCCCCCCCCCCC	27.78	25849741
392	Phosphorylation	GRPVSGHTDTTASAK CCCCCCCCCCCCCCC	38.27	30266825
394	Phosphorylation	PVSGHTDTTASAKTD CCCCCCCCCCCCCCC	25.97	30266825
395	Phosphorylation	VSGHTDTTASAKTDL CCCCCCCCCCCCCCC	22.79	25850435
397	Phosphorylation	GHTDTTASAKTDLTS CCCCCCCCCCCCCHH	28.36	25850435
403	Phosphorylation	ASAKTDLTSLKNVDP CCCCCCCHHCCCCCC	34.52	22210691
404	Phosphorylation	SAKTDLTSLKNVDPM CCCCCCHHCCCCCCC	44.64	22210691
429	Phosphorylation	GKMDPMCSGKPELLS CCCCCCCCCCCCCCC	43.53	23186163
436	Phosphorylation	SGKPELLSPGQAERV CCCCCCCCCCCCCEE	39.34	22199227
444	Phosphorylation	PGQAERVSVGKAGTV CCCCCEEECCCCCCC	31.23	25159151
450	Phosphorylation	VSVGKAGTVSPGKED EECCCCCCCCCCCCC	23.75	21712546
452	Phosphorylation	VGKAGTVSPGKEDPV CCCCCCCCCCCCCCC	27.98	29255136
460	Phosphorylation	PGKEDPVSSRREDPI CCCCCCCCCCCCCCC	24.42	23403867
461	Phosphorylation	GKEDPVSSRREDPIS CCCCCCCCCCCCCCC	35.27	23403867
468	Phosphorylation	SRREDPISAGSRKTS CCCCCCCCCCCCCCC	31.78	24719451
471	Phosphorylation	EDPISAGSRKTSSEK CCCCCCCCCCCCCCC	30.25	25002506
476	Phosphorylation	AGSRKTSSEKVNPES CCCCCCCCCCCCHHH	46.82	22964224
483	Phosphorylation	SEKVNPESSGKTNPV CCCCCHHHCCCCCCC	45.72	22964224
484	Phosphorylation	EKVNPESSGKTNPVS CCCCHHHCCCCCCCC	42.52	23312004
487	Phosphorylation	NPESSGKTNPVSSGP CHHHCCCCCCCCCCC	48.56	23312004
491	Phosphorylation	SGKTNPVSSGPGDPR CCCCCCCCCCCCCHH	30.73	23312004
492	Phosphorylation	GKTNPVSSGPGDPRS CCCCCCCCCCCCHHH	49.60	23312004
499	Phosphorylation	SGPGDPRSLGTAGPP CCCCCHHHCCCCCCC	36.22	23312004
502	Phosphorylation	GDPRSLGTAGPPSAV CCHHHCCCCCCCCCC	33.46	23312004
507	Phosphorylation	LGTAGPPSAVKAEPA CCCCCCCCCCCCCCC	49.15	25159151
515	Phosphorylation	AVKAEPATGGKGDPL CCCCCCCCCCCCCCC	58.12	-
540	Phosphorylation	GKAAPTASGKAEPLA CCCCCCCCCCCCCCC	43.22	-
564	Phosphorylation	GKADAGPSGQGDSVS CCCCCCCCCCCCCEE	42.71	22210691
569	Phosphorylation	GPSGQGDSVSIGKVV CCCCCCCCEEEEEEE	25.29	22210691
571	Phosphorylation	SGQGDSVSIGKVVST CCCCCCEEEEEEEEC	29.58	25159151
577	Phosphorylation	VSIGKVVSTPGKTVP EEEEEEEECCCCEEE	31.69	22210691
578	Phosphorylation	SIGKVVSTPGKTVPV EEEEEEECCCCEEEC	25.17	22210691
608	Phosphorylation	IPEGKVGSLPLEKGS CCCCCCCCEECCCCC	29.78	30266825
615	Phosphorylation	SLPLEKGSPVTTTKA CEECCCCCCCCCCCC	27.54	22167270
618	Phosphorylation	LEKGSPVTTTKADPR CCCCCCCCCCCCCCC	31.93	30266825
619	Phosphorylation	EKGSPVTTTKADPRA CCCCCCCCCCCCCCC	26.91	22167270
620	Phosphorylation	KGSPVTTTKADPRAS CCCCCCCCCCCCCCC	18.18	22167270
634	Phosphorylation	SGKAQPQSGGKAETK CCCCCCCCCCCCCCC	57.08	-
683	Phosphorylation	RKAEPLASGKGEPVS CCCCCCCCCCCCCCC	49.04	30387612
690	Phosphorylation	SGKGEPVSLGKADSA CCCCCCCCCCCCCCC	41.96	23403867
696	Phosphorylation	VSLGKADSAPSRKTE CCCCCCCCCCCCCCC	47.11	23403867
699	Phosphorylation	GKADSAPSRKTESPS CCCCCCCCCCCCCCC	46.24	23403867
702	Phosphorylation	DSAPSRKTESPSLGK CCCCCCCCCCCCCCC	40.35	30266825
704	Phosphorylation	APSRKTESPSLGKVV CCCCCCCCCCCCCEE	25.64	30266825
706	Phosphorylation	SRKTESPSLGKVVPL CCCCCCCCCCCEEEC	60.06	30266825
714	Phosphorylation	LGKVVPLSLEKTKPS CCCEEECCCCCCCCC	28.54	30266825
734	Phosphorylation	LDRKALGSARSPEGA HHHHHHHCCCCCCCC	22.74	25159151
734 (in isoform 2)	Phosphorylation	-	22.74	29507054
737	Phosphorylation	KALGSARSPEGARGS HHHHCCCCCCCCCCC	27.33	25159151
744	Phosphorylation	SPEGARGSEGRVEPK CCCCCCCCCCCCCCC	31.18	-
756	Phosphorylation	EPKAEPVSSTEASSL CCCCCCCCCHHHHHH	42.11	23312004
757	Phosphorylation	PKAEPVSSTEASSLG CCCCCCCCHHHHHHC	30.42	23312004
758	O-linked_Glycosylation	KAEPVSSTEASSLGQ CCCCCCCHHHHHHCH	28.23	28657654
758	Phosphorylation	KAEPVSSTEASSLGQ CCCCCCCHHHHHHCH	28.23	23312004
761	Phosphorylation	PVSSTEASSLGQKDL CCCCHHHHHHCHHHH	21.62	23312004
762	Phosphorylation	VSSTEASSLGQKDLE CCCHHHHHHCHHHHH	43.50	28985074
776	Phosphorylation	EAAGAERSPCPEAAA HHCCCCCCCCCHHCC	23.51	30266825
799	Phosphorylation	DNFTKAPSWEASAPP CCCCCCCCCCCCCCC	42.27	29978859
803	Phosphorylation	KAPSWEASAPPPPRE CCCCCCCCCCCCCCC	29.78	27732954
850	Phosphorylation	QAAPRAPSPPSRRDA EECCCCCCCCCHHHC	48.75	30266825
853	Phosphorylation	PRAPSPPSRRDAGLQ CCCCCCCCHHHCCCE	43.25	20166139
862	O-linked_Glycosylation	RDAGLQVSLGAAETR HHCCCEEEECCCCCC	14.23	28657654
862	Phosphorylation	RDAGLQVSLGAAETR HHCCCEEEECCCCCC	14.23	29978859
868	Phosphorylation	VSLGAAETRSVATGP EEECCCCCCCCCCCC	24.42	26852163
870	Phosphorylation	LGAAETRSVATGPMT ECCCCCCCCCCCCCC	24.43	29978859
873	Phosphorylation	AETRSVATGPMTPQA CCCCCCCCCCCCCCC	39.40	30266825
877	Phosphorylation	SVATGPMTPQAAAPP CCCCCCCCCCCCCCC	18.51	30266825
895	Phosphorylation	EVRVRPGSALAAAVA CCEECCCCHHHEEEC	23.85	30266825
914	Phosphorylation	AEPVRDVSWDEKGMT CCCCCCCCCCCCCCC	32.85	21815630
962	Methylation	PAPPPAARAGPGRSG CCCCCHHHCCCCCCC	42.03	-
967	Methylation	AARAGPGRSGSVRTA HHHCCCCCCCCCCCC	40.76	-
968	Phosphorylation	ARAGPGRSGSVRTAP HHCCCCCCCCCCCCC	41.14	22199227
970	Phosphorylation	AGPGRSGSVRTAPPD CCCCCCCCCCCCCCC	15.07	22199227
973	Phosphorylation	GRSGSVRTAPPDGAA CCCCCCCCCCCCCHH	41.16	28985074
981	Ubiquitination	APPDGAAKRPPGLFR CCCCCHHHCCCCHHH	65.97	32142685
993	Phosphorylation	LFRALLQSVRRPRCC HHHHHHHHHCCCCHH	19.98	17974005
999	S-palmitoylation	QSVRRPRCCSRAGPT HHHCCCCHHCCCCCC	2.47	-
1000	S-palmitoylation	SVRRPRCCSRAGPTA HHCCCCHHCCCCCCC	3.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GRIN1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
999	C	Palmitoylation	-
Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
1000	C	Palmitoylation	-
Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRIN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GRIN1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRIN1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-862, AND MASSSPECTROMETRY.	19690332 [Abstract]

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