dbPTM

VTI1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VTI1B_HUMAN
UniProt AC	Q9UEU0
Protein Name	Vesicle transport through interaction with t-SNAREs homolog 1B
Gene Name	VTI1B
Organism	Homo sapiens (Human).
Sequence Length	232
Subcellular Localization	Early endosome membrane Single-pass type IV membrane protein . Late endosome membrane Single-pass type IV membrane protein . Lysosome membrane . Cytoplasmic granule . Recycling endosome membrane Single-pass type IV membrane protein .
Protein Description	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence..
Protein Sequence	MASSAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGTEEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREVRSTPLTATPGGRGDMKYGIYAVENEHMNRLQSQRAMLLQGTESLNRATQSIERSHRIATETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIIILLELAILGGLVYYKFFRSH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSAASSE ------CCCCHHCHH	16.52	22223895
3	Phosphorylation	-----MASSAASSEH -----CCCCHHCHHH	21.15	24173317
4	Phosphorylation	----MASSAASSEHF ----CCCCHHCHHHH	20.51	24173317
13 (in isoform 1)	Ubiquitination	-	54.95	21890473
13	Malonylation	ASSEHFEKLHEIFRG HCHHHHHHHHHHHHH	54.95	26320211
13	Ubiquitination	ASSEHFEKLHEIFRG HCHHHHHHHHHHHHH	54.95	23000965
38	Phosphorylation	RLLGTAGTEEKKKLI HHHCCCCCHHHHHHH	38.21	21815630
41	2-Hydroxyisobutyrylation	GTAGTEEKKKLIRDF CCCCCHHHHHHHHCH	49.31	-
51	Ubiquitination	LIRDFDEKQQEANET HHHCHHHHHHHHHHH	60.16	29967540
72	Phosphorylation	ELRYAPLSFRNPMMS HHHHCCCCCCCHHHH	22.54	29523821
79	Phosphorylation	SFRNPMMSKLRNYRK CCCCHHHHHHHHHHH	23.45	29523821
80	Malonylation	FRNPMMSKLRNYRKD CCCHHHHHHHHHHHH	33.30	30639696
84	Phosphorylation	MMSKLRNYRKDLAKL HHHHHHHHHHHHHHH	16.77	22817900
90	Ubiquitination	NYRKDLAKLHREVRS HHHHHHHHHHHHHHC	52.72	29967540
97	Phosphorylation	KLHREVRSTPLTATP HHHHHHHCCCCCCCC	39.28	24719451
98	Phosphorylation	LHREVRSTPLTATPG HHHHHHCCCCCCCCC	16.26	27251275
101	Phosphorylation	EVRSTPLTATPGGRG HHHCCCCCCCCCCCC	29.68	29396449
103	Phosphorylation	RSTPLTATPGGRGDM HCCCCCCCCCCCCCC	19.75	25159151
107	Methylation	LTATPGGRGDMKYGI CCCCCCCCCCCCCEE	43.80	24129315
111	Ubiquitination	PGGRGDMKYGIYAVE CCCCCCCCCEEEEEC	45.10	33845483
112	Phosphorylation	GGRGDMKYGIYAVEN CCCCCCCCEEEEECC	11.34	21945579
115	Phosphorylation	GDMKYGIYAVENEHM CCCCCEEEEECCHHH	10.55	21945579
127	Phosphorylation	EHMNRLQSQRAMLLQ HHHHHHHHHHHHHHH	26.65	28509920
136	Phosphorylation	RAMLLQGTESLNRAT HHHHHHCHHHHHHHH	14.94	30266825
138	Phosphorylation	MLLQGTESLNRATQS HHHHCHHHHHHHHHH	30.68	30266825
143	Phosphorylation	TESLNRATQSIERSH HHHHHHHHHHHHHHH	21.44	29978859
145	Phosphorylation	SLNRATQSIERSHRI HHHHHHHHHHHHHCC	23.28	24719451
149	Phosphorylation	ATQSIERSHRIATET HHHHHHHHHCCCCCH	12.34	24706070
154	Phosphorylation	ERSHRIATETDQIGS HHHHCCCCCHHHHHH	36.73	20873877
156	Phosphorylation	SHRIATETDQIGSEI HHCCCCCHHHHHHHH	28.93	20873877
161	Phosphorylation	TETDQIGSEIIEELG CCHHHHHHHHHHHHH	27.53	29116813
177	O-linked_Glycosylation	QRDQLERTKSRLVNT HHHHHHHHHHHHHCC	24.81	29237092
179	Phosphorylation	DQLERTKSRLVNTSE HHHHHHHHHHHCCCH	30.18	25159151
179	O-linked_Glycosylation	DQLERTKSRLVNTSE HHHHHHHHHHHCCCH	30.18	29237092
184	Phosphorylation	TKSRLVNTSENLSKS HHHHHHCCCHHHHHH	29.91	25262027
185	Phosphorylation	KSRLVNTSENLSKSR HHHHHCCCHHHHHHH	21.20	30266825
189	Phosphorylation	VNTSENLSKSRKILR HCCCHHHHHHHHHHH	39.92	19664995
190	Ubiquitination	NTSENLSKSRKILRS CCCHHHHHHHHHHHH	58.40	23000965
193	Ubiquitination	ENLSKSRKILRSMSR HHHHHHHHHHHHHCC	53.86	23000965
203	Phosphorylation	RSMSRKVTTNKLLLS HHHCCCHHHHHHHHH	27.90	-
210	Phosphorylation	TTNKLLLSIIILLEL HHHHHHHHHHHHHHH	16.23	-
225	Phosphorylation	AILGGLVYYKFFRSH HHHHHHHHHHHHCCC	13.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VTI1B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VTI1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VTI1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN5_HUMAN	PTPN5	physical	25416956
SYNE4_HUMAN	SYNE4	physical	25416956
TRI59_HUMAN	TRIM59	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
LRAD1_HUMAN	LDLRAD1	physical	25416956
CAND2_HUMAN	CAND2	physical	26186194
EI2BE_HUMAN	EIF2B5	physical	26186194
RNF13_HUMAN	RNF13	physical	26186194
EI2BA_HUMAN	EIF2B1	physical	26186194
CCDC9_HUMAN	CCDC9	physical	26186194
EI2BD_HUMAN	EIF2B4	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
IPO9_HUMAN	IPO9	physical	26186194
STX18_HUMAN	STX18	physical	26186194
IF4A3_HUMAN	EIF4A3	physical	26186194
NBAS_HUMAN	NBAS	physical	26186194
SNAG_HUMAN	NAPG	physical	26186194
CWC27_HUMAN	CWC27	physical	26186194
CWC22_HUMAN	CWC22	physical	26186194
STX6_HUMAN	STX6	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
CALL3_HUMAN	CALML3	physical	26186194
STX7_HUMAN	STX7	physical	26186194
ACINU_HUMAN	ACIN1	physical	26186194
ECD_HUMAN	ECD	physical	26186194
AP3B1_HUMAN	AP3B1	physical	26186194
S10A3_HUMAN	S100A3	physical	26186194
STX12_HUMAN	STX12	physical	26186194
AP3M1_HUMAN	AP3M1	physical	26186194
VPS45_HUMAN	VPS45	physical	26186194
SESD1_HUMAN	SESTD1	physical	26186194
UBF1_HUMAN	UBTF	physical	26186194
EI2BB_HUMAN	EIF2B2	physical	26186194
STXB5_HUMAN	STXBP5	physical	26186194
EI2BG_HUMAN	EIF2B3	physical	26186194
STX8_HUMAN	STX8	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
FHL2_HUMAN	FHL2	physical	26186194
ARL10_HUMAN	ARL10	physical	26186194
STX10_HUMAN	STX10	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
CASC3_HUMAN	CASC3	physical	26186194
PPAL_HUMAN	ACP2	physical	26186194
CS025_HUMAN	C19orf25	physical	26186194
2A5E_HUMAN	PPP2R5E	physical	26186194
STX8_HUMAN	STX8	physical	21516116
SNAG_HUMAN	NAPG	physical	28514442
STX12_HUMAN	STX12	physical	28514442
STX7_HUMAN	STX7	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
STX6_HUMAN	STX6	physical	28514442
SESD1_HUMAN	SESTD1	physical	28514442
STX18_HUMAN	STX18	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
EPN4_HUMAN	CLINT1	physical	28514442
STXB5_HUMAN	STXBP5	physical	28514442
SNAA_HUMAN	NAPA	physical	28514442
CCDC9_HUMAN	CCDC9	physical	28514442
CWC27_HUMAN	CWC27	physical	28514442
STX8_HUMAN	STX8	physical	28514442
IPO9_HUMAN	IPO9	physical	28514442
FHL2_HUMAN	FHL2	physical	28514442
EI2BA_HUMAN	EIF2B1	physical	28514442
EI2BB_HUMAN	EIF2B2	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
VPS45_HUMAN	VPS45	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
UBF1_HUMAN	UBTF	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
ASPH_HUMAN	ASPH	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
AP3M1_HUMAN	AP3M1	physical	28514442
CAND2_HUMAN	CAND2	physical	28514442
STX10_HUMAN	STX10	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
NBAS_HUMAN	NBAS	physical	28514442
IF4A3_HUMAN	EIF4A3	physical	28514442
IPO7_HUMAN	IPO7	physical	28514442
ECD_HUMAN	ECD	physical	28514442
CASC3_HUMAN	CASC3	physical	28514442
EXOC1_HUMAN	EXOC1	physical	27173435
DCTN2_HUMAN	DCTN2	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VTI1B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-103, AND MASSSPECTROMETRY.	18691976 [Abstract]