TRI59_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI59_HUMAN
• UniProt AC: Q8IWR1
• Protein Name: Tripartite motif-containing protein 59
• Gene Name: TRIM59
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: May serve as a multifunctional regulator for innate immune signaling pathways..
• Protein Sequence: MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLKCPNCRSITEIAPTGIESLPVNFALRAIIEKYQQEDHPDIVTCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLEQLTDTHWTDLTHLIEKLKEQKSHSEKMIQGDKEAVLQYFKELNDTLEQKKKSFLTALCDVGNLINQEYTPQIERMKEIREQQLELMALTISLQEESPLKFLEKVDDVRQHVQILKQRPLPEVQPVEIYPRVSKILKEEWSRTEIGQIKNVLIPKMKISPKRMSCSWPGKDEKEVEFLKILNIVVVTLISVILMSILFFNQHIITFLSEITLIWFSEASLSVYQSLSNSLHKVKNILCHIFYLLKEFVWKIVSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	LKCPNCRSITEIAPT CCCCCCCCEEEECCC	35.74	27080861
63	Phosphorylation	CPNCRSITEIAPTGI CCCCCCEEEECCCCH	23.68	27080861
85	Ubiquitination	ALRAIIEKYQQEDHP HHHHHHHHHHCCCCC	37.64	33845483
171	Ubiquitination	IEKLKEQKSHSEKMI HHHHHHCCCCCHHHH	51.75	22817900
176	Ubiquitination	EQKSHSEKMIQGDKE HCCCCCHHHHHCCHH	44.30	22817900
182	Acetylation	EKMIQGDKEAVLQYF HHHHHCCHHHHHHHH	55.16	23236377
199	2-Hydroxyisobutyrylation	LNDTLEQKKKSFLTA HHHHHHHHHHHHHHH	53.44	-
246	Phosphorylation	TISLQEESPLKFLEK HHHCCCCCCHHHHHH	34.48	24719451
249	Ubiquitination	LQEESPLKFLEKVDD CCCCCCHHHHHHHHH	51.81	22817900
253	Ubiquitination	SPLKFLEKVDDVRQH CCHHHHHHHHHHHHH	53.78	21906983
278	Phosphorylation	EVQPVEIYPRVSKIL CCCCCEEHHHHHHHH	3.28	21552520
298	Ubiquitination	RTEIGQIKNVLIPKM CCCHHHHCCEEECCC	32.87	22817900
298	Acetylation	RTEIGQIKNVLIPKM CCCHHHHCCEEECCC	32.87	21339330
304	Acetylation	IKNVLIPKMKISPKR HCCEEECCCCCCCCC	45.92	21339330
306	Acetylation	NVLIPKMKISPKRMS CEEECCCCCCCCCCC	46.27	21339330
308	Phosphorylation	LIPKMKISPKRMSCS EECCCCCCCCCCCCC	20.89	24719451
310	Acetylation	PKMKISPKRMSCSWP CCCCCCCCCCCCCCC	54.68	7681813

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
308	S	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI59_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI59_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECSIT_HUMAN	ECSIT	physical	22588174
P53_HUMAN	TP53	physical	25046164

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.