UniProt ID | RNF13_HUMAN | |
---|---|---|
UniProt AC | O43567 | |
Protein Name | E3 ubiquitin-protein ligase RNF13 | |
Gene Name | RNF13 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 381 | |
Subcellular Localization |
Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane Single-pass membrane protein. Lysosome membrane. Nucleus inner membrane. Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. |
|
Protein Description | E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.. | |
Protein Sequence | MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSESRSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
42 | Ubiquitination | DILAYNFENASQTFD CEEEECCCCHHCCCC | 48.53 | 22817900 | |
44 | Ubiquitination | LAYNFENASQTFDDL EEECCCCHHCCCCCC | 8.87 | 22817900 | |
45 | Ubiquitination | AYNFENASQTFDDLP EECCCCHHCCCCCCC | 41.14 | 21963094 | |
85 | Ubiquitination | EPIVPPPVKDNSSGT CCCCCCCCCCCCCCE | 17.52 | 25015289 | |
87 | Ubiquitination | IVPPPVKDNSSGTFI CCCCCCCCCCCCEEE | 61.55 | 25015289 | |
88 | N-linked_Glycosylation | VPPPVKDNSSGTFIV CCCCCCCCCCCEEEE | 32.15 | 18794910 | |
93 | Ubiquitination | KDNSSGTFIVLIRRL CCCCCCEEEEEEEEE | 4.08 | 33845483 | |
94 | Ubiquitination | DNSSGTFIVLIRRLD CCCCCEEEEEEEEEC | 2.18 | 33845483 | |
99 | Ubiquitination | TFIVLIRRLDCNFDI EEEEEEEEECCCCEE | 28.08 | 33845483 | |
101 | Ubiquitination | IVLIRRLDCNFDIKV EEEEEEECCCCEEEE | 24.41 | 22817900 | |
102 | Ubiquitination | VLIRRLDCNFDIKVL EEEEEECCCCEEEEC | 6.91 | 21963094 | |
105 | Ubiquitination | RRLDCNFDIKVLNAQ EEECCCCEEEECCHH | 26.30 | 33845483 | |
106 | Ubiquitination | RLDCNFDIKVLNAQR EECCCCEEEECCHHH | 2.66 | 33845483 | |
107 | Ubiquitination | LDCNFDIKVLNAQRA ECCCCEEEECCHHHC | 42.38 | - | |
111 | Ubiquitination | FDIKVLNAQRAGYKA CEEEECCHHHCCCEE | 8.97 | 33845483 | |
113 | Ubiquitination | IKVLNAQRAGYKAAI EEECCHHHCCCEEEE | 27.80 | 22817900 | |
113 | Ubiquitination | IKVLNAQRAGYKAAI EEECCHHHCCCEEEE | 27.80 | - | |
114 | Ubiquitination | KVLNAQRAGYKAAIV EECCHHHCCCEEEEE | 17.37 | - | |
114 | Ubiquitination | KVLNAQRAGYKAAIV EECCHHHCCCEEEEE | 17.37 | 21963094 | |
121 | Ubiquitination | AGYKAAIVHNVDSDD CCCEEEEEECCCHHH | 2.00 | 33845483 | |
133 | Ubiquitination | SDDLISMGSNDIEVL HHHHCCCCCCCHHHH | 19.26 | 33845483 | |
134 | Ubiquitination | DDLISMGSNDIEVLK HHHCCCCCCCHHHHH | 23.76 | 33845483 | |
142 | Ubiquitination | NDIEVLKKIDIPSVF CCHHHHHHCCCCEEE | 41.26 | 33845483 | |
144 | Ubiquitination | IEVLKKIDIPSVFIG HHHHHHCCCCEEECC | 56.47 | 25015289 | |
146 | Ubiquitination | VLKKIDIPSVFIGES HHHHCCCCEEECCCC | 22.23 | 33845483 | |
151 | Ubiquitination | DIPSVFIGESSANSL CCCEEECCCCCCCCC | 19.78 | 33845483 | |
154 | Ubiquitination | SVFIGESSANSLKDE EEECCCCCCCCCCCE | 27.45 | 33845483 | |
154 | Ubiquitination | SVFIGESSANSLKDE EEECCCCCCCCCCCE | 27.45 | - | |
156 | Ubiquitination | FIGESSANSLKDEFT ECCCCCCCCCCCEEE | 50.23 | 25015289 | |
157 | Ubiquitination | IGESSANSLKDEFTY CCCCCCCCCCCEEEE | 36.19 | - | |
163 | Ubiquitination | NSLKDEFTYEKGGHL CCCCCEEEEEECCEE | 28.82 | 33845483 | |
224 | Ubiquitination | RLRKDQLKKLPVHKF HCCHHHHHCCCCCCC | 46.78 | 33845483 | |
225 | Ubiquitination | LRKDQLKKLPVHKFK CCHHHHHCCCCCCCC | 67.62 | 33845483 | |
230 | Ubiquitination | LKKLPVHKFKKGDEY HHCCCCCCCCCCCCC | 60.14 | 33845483 | |
232 | Ubiquitination | KLPVHKFKKGDEYDV CCCCCCCCCCCCCCE | 61.73 | 22817900 | |
233 | Ubiquitination | LPVHKFKKGDEYDVC CCCCCCCCCCCCCEE | 74.79 | 21963094 | |
247 | Phosphorylation | CAICLDEYEDGDKLR EEEEEEECCCCCEEE | 20.98 | - | |
252 | Ubiquitination | DEYEDGDKLRILPCS EECCCCCEEEEEECC | 45.23 | 33845483 | |
265 | Ubiquitination | CSHAYHCKCVDPWLT CCCEEECEECCHHHC | 24.79 | 33845483 | |
273 | Ubiquitination | CVDPWLTKTKKTCPV ECCHHHCCCCCCCCC | 57.06 | 33845483 | |
275 | Ubiquitination | DPWLTKTKKTCPVCK CHHHCCCCCCCCCCC | 47.87 | 25015289 | |
276 | Ubiquitination | PWLTKTKKTCPVCKQ HHHCCCCCCCCCCCC | 61.67 | - | |
282 | Ubiquitination | KKTCPVCKQKVVPSQ CCCCCCCCCEECCCC | 54.08 | 33845483 | |
309 | Phosphorylation | ENEVTEHTPLLRPLA HHCHHCCCCCHHHHH | 14.92 | 24275569 | |
317 | Phosphorylation | PLLRPLASVSAQSFG CCHHHHHHHCHHHHC | 25.04 | 27732954 | |
319 | Phosphorylation | LRPLASVSAQSFGAL HHHHHHHCHHHHCCC | 20.35 | 26657352 | |
322 | Phosphorylation | LASVSAQSFGALSES HHHHCHHHHCCCCCC | 25.93 | 26657352 | |
327 | Phosphorylation | AQSFGALSESRSHQN HHHHCCCCCCCCCCC | 32.75 | 27732954 | |
329 | Phosphorylation | SFGALSESRSHQNMT HHCCCCCCCCCCCCC | 35.39 | 27732954 | |
380 | Phosphorylation | RDYNIANTV------ CCCCCCCCC------ | 20.69 | 23663014 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNF13_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNF13_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
LAMP2_HUMAN | LAMP2 | physical | 19292867 | |
CD63_HUMAN | CD63 | physical | 19292867 | |
PGRC1_HUMAN | PGRMC1 | physical | 19292867 | |
LMNB1_HUMAN | LMNB1 | physical | 20230530 | |
SNAPN_HUMAN | SNAPIN | physical | 22890573 | |
UB2D1_HUMAN | UBE2D1 | physical | 22890573 | |
ERN1_HUMAN | ERN1 | physical | 23378536 | |
AP3S2_HUMAN | AP3S2 | physical | 26186194 | |
AP3D1_HUMAN | AP3D1 | physical | 26186194 | |
HDGR3_HUMAN | HDGFRP3 | physical | 26186194 | |
AP3S1_HUMAN | AP3S1 | physical | 26186194 | |
TYK2_HUMAN | TYK2 | physical | 26186194 | |
COT2_HUMAN | NR2F2 | physical | 26186194 | |
COT1_HUMAN | NR2F1 | physical | 26186194 | |
CD63_HUMAN | CD63 | physical | 26186194 | |
TSN3_HUMAN | TSPAN3 | physical | 26186194 | |
CLCN7_HUMAN | CLCN7 | physical | 26186194 | |
AP3S2_HUMAN | AP3S2 | physical | 28514442 | |
AP3S1_HUMAN | AP3S1 | physical | 28514442 | |
TYK2_HUMAN | TYK2 | physical | 28514442 | |
AP3D1_HUMAN | AP3D1 | physical | 28514442 | |
TSN3_HUMAN | TSPAN3 | physical | 28514442 | |
RN167_HUMAN | RNF167 | physical | 28514442 | |
COT2_HUMAN | NR2F2 | physical | 28514442 | |
DCX_HUMAN | DCX | physical | 28514442 | |
AP1S2_HUMAN | AP1S2 | physical | 28514442 | |
CLCN7_HUMAN | CLCN7 | physical | 28514442 | |
HDGR3_HUMAN | HDGFRP3 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"RNF13: a novel RING-type ubiquitin ligase over-expressed inpancreatic cancer."; Zhang Q., Meng Y., Zhang L., Chen J., Zhu D.; Cell Res. 19:348-357(2009). Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,AUTOUBIQUITINATION, GLYCOSYLATION AT ASN-88, AND MUTAGENESIS OFASN-43; ASN-88; CYS-258; HIS-260 AND TRP-270. |